Long-term calibration considerations during subcutaneous microdialysis sampling in mobile rats
Open accessAbstract
The level at which implanted sensors and sampling devices maintain their calibration is an important research area. In this work, microdialysis probes with identical geometry and different membranes, polycarbonate/polyether (PC) or polyethersulfone (PES), were used with internal standards (Vitamin B(12) (MW 1355), antipyrine (MW 188) and 2-deoxyglucose (2-DG, MW 164)) and endogenous glucose to investigate changes in their long-term calibration after implantation into the subcutaneous space of Sprague-Dawley rats. Histological analysis confirmed an inflammatory response to the microdialysis probes and the presence of a collagen capsule. The membrane extraction efficiency (percentage delivered to the tissue space) for antipyrine and 2-DG was not altered throughout the implant lifetime for either PC- or PES membranes. Yet, Vitamin B(12) extraction efficiency and collected glucose concentrations decreased during the implant lifetime. Antipyrine was administered i.v. and its concentrations obtained in both PC- and PES-membrane probes were significantly reduced between the implant day and seven (PC) or 10 (PES) days post-implantation suggesting that solute supply is critical for in vivo extraction efficiency. For the low molecular weight solutes such as antipyrine and glucose, localized delivery is not affected by the foreign body reaction, but recovery is significantly reduced. For Vitamin B(12), a larger solute, the fibrotic capsule formed around the probe significantly restricts diffusion from the implanted microdialysis probes.
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Microdialysis avoids direct sensor implantation, but in vivo glucose recovery is erratic because of the foreign body response.
“Microdialysis avoids direct implantation of a sensor but the glucose measurement (i.e., recovery) remains erratic in vivo due to the foreign body response.19,24–25”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [25]
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Sorted by citations
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- Authors
- Mou, X., Lennartz, M. R., Loegering, D. J., & Stenken, J. A.
- Affiliations
- Rensselaer Polytechnic Institute (US)
- Albany Medical College (US)
- University of Arkansas at Fayetteville (US)
- Corresponding author
- Stenken, Julie A.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 31
- Issue
- 16
- Pages
- 4530-4539
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC3547652
- OpenAlex
- W2084752937
- Cited by
- 33
- References
- 45
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 4 · 2013: 7 · 2012: 2
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (EB001441)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Keywords
- polycarbonate membranes, polyethersulfone membranes, foreign body reaction, collagen capsule, extraction efficiency, solute diffusion, antipyrine, 2-deoxyglucose, vitamin B12
- MeSH terms
- Animals, Antipyrine, Calibration, Deoxyglucose, Glucose, Injections, Subcutaneous, Polymers, Vitamin B 12, Biosensing Techniques, Rats, Sprague-Dawley, Microdialysis, Implants, Experimental, Rats
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