The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Synthetic Peptide Containing the IKVAV Sequence from the A Chain of Laminin Mediates Cell Attachment, Migration, and Neurite Outgrowth
Open accessAbstract
Laminin is a basement membrane glycoprotein which consists of A, B1, and B2 chains. Laminin has diverse biological activities including promoting cell adhesion, migration, differentiation, growth, and neurite extension. Synthetic peptides from the active region of the A chain were prepared and tested for their biological activity. A 19-mer peptide (designated PA22-2), from just above the carboxyl globule on the long arm of the A chain, was found to promote cell adhesion, spreading, migration, and neurite outgrowth. By testing smaller sequences within the 19-mer peptide, a constituent pentapeptide, IKVAV (Ile-Lys-Val-Ala-Val), was identified as the active site for cell adhesion and neurite outgrowth. These data suggest that this sequence is one of the principle sites in laminin which regulate cellular behavior.
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Cites
Laminin–a glycoprotein from basement membranes
Timpl, R., Rohde, H., Robey, P. G., Rennard, S. I., Foidart, J. M., & Martin, G. R. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83607-4 · Cited by 2,378
Self-citationBasement membrane complexes with biological activity
Kleinman, H. K., McGarvey, M. L., Hassell, J. R., Star, V. L., Cannon, F. B., Laurie, G. W., & Martin, G. R. (1986) · Biochemistry · doi:10.1021/bi00350a005 · Cited by 1,502
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Cited by
Extracellular Matrix Molecules And Their Receptors: Functions In Neural Development
Reichardt, L. F., & Tomaselli, K. J. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002531 · Cited by 750
Ren, X., Feng, Y., Guo, J., Wang, H., Li, Q., Yang, J., Hao, X., Lv, J., Ma, N., & Li, W. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00483c · Cited by 573
Nicolas, J., Magli, S., Rabbachin, L., Sampaolesi, S., Nicotra, F., & Russo, L. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00045 · Cited by 509
Niece, K. L., Hartgerink, J. D., Donners, J. J. J. M., & Stupp, S. I. (2003) · Journal of the American Chemical Society · doi:10.1021/ja028215r · Cited by 462
Cell attachment functionality of bioactive conducting polymers for neural interfaces
Green, R. A., Lovell, N. H., & Poole-Warren, L. A. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.03.043 · Cited by 258
Metadata
- Authors
- Tashiro, K., Sephel, G. C., Weeks, B., Sasaki, M., Martin, G. R., Kleinman, H. K., & Yamada, Y.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1989-09
- Volume
- 264
- Issue
- 27
- Pages
- 16174-16182
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1569253487
- Cited by
- 643
- References
- 2
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tashiro, K., Sephel, G. C., Weeks, B., Sasaki, M., Martin, G. R., Kleinman, H. K., & Yamada, Y. (1989). A Synthetic Peptide Containing the IKVAV Sequence from the A Chain of Laminin Mediates Cell Attachment, Migration, and Neurite Outgrowth. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)71604-9
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