The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Self-Assembly Combining Two Bioactive Peptide-Amphiphile Molecules into Nanofibers by Electrostatic Attraction
Abstract
We describe a new approach to peptide-amphiphile (PA) nanofiber preparation that allows PAs with different bioactive amino acid sequences to be combined into a single fiber. Oppositely charged PAs are synthesized separately and then mixed to produce gels of nanofiber networks at physiological pH. Transmission electron microscopy reveals the formation of fibers approximately 7 nm in diameter and several micrometers long in these dimeric systems. On the basis of NMR and microscopy, we suggest that these nanofibers are cylindrical micelles of mixed composition, formed due to electrostatic attraction between the oppositely charged PAs. This strategy for self-assembly may be useful in cell therapies that can be implemented without invasive surgery or in in vitro tissue engineering.
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Metadata
- Authors
- Niece, K. L., Hartgerink, J. D., Donners, J. J. J. M., & Stupp, S. I.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-05-23
- Volume
- 125
- Issue
- 24
- Pages
- 7146-7147
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2055124743
- Cited by
- 462
- References
- 10
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Niece, K. L., Hartgerink, J. D., Donners, J. J. J. M., & Stupp, S. I. (2003). Self-Assembly Combining Two Bioactive Peptide-Amphiphile Molecules into Nanofibers by Electrostatic Attraction. Journal of the American Chemical Society. https://doi.org/10.1021/ja028215r
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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