Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin, an inhibitor of processing glucosidases

Saunier, B; Kilker, R D; Tkacz, J S; Quaroni, A; Herscovics, A

doi:10.1016/s0021-9258(19)45358-1

Cited by 285Glycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisFungal and yeast genetics research

Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin, an inhibitor of processing glucosidases

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Saunier, B, Kilker, R D, Tkacz, J S, Quaroni, A, Herscovics, A·1982·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(19)45358-1

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Abstract

H3G I Y6Glucosidase activities which remove glucose residues from GlcZMangGlcNAcz and GlclManyGlcNAcz oligosaccharides were obtained in soluble form from Saccharomyces cerevisiae X-2180 without detergent.These two enzyme activities were clearly separated from the GlcsMangGlcNAcz oligosaccharide glucosidase which was shown previously to remove the terminal glucose residue from GlcsMan9GlcNAcz oligosaccharide (Kilker,

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GII inhibitors include the pyranose sugar analogues 1-deoxynojirimycin, N-5-carboxypentyl-dNM, and castanospermine, all iminosugars.
“GII inhibitors include the pyranose sugar analogues 1-deoxynojirimycin, N-5-carboxypentyl-dNM, and castanospermine, all iminosugars [218,376,377].”
From GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review (2022) · cites this paper as [377]

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Authors: Saunier, B., Kilker, R. D., Tkacz, J. S., Quaroni, A., & Herscovics, A.
Affiliations: Harvard University (US)
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1982-12
Volume: 257
Issue: 23
Pages: 14155-14161
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(19)45358-1
OpenAlex: W1515555384
Cited by: 283
References: 26
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 1 · 2019: 3 · 2018: 7 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 2
FWCI: 8.46
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 13845 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: 1-deoxynojirimycin, glucosidase inhibitors, Saccharomyces cerevisiae, oligosaccharide processing
MeSH terms: Glucosamine, Glucosidases, Glycoproteins, Kinetics, Oligosaccharides, Saccharomyces cerevisiae, Sucrase, 1-Deoxynojirimycin

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Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin, an inhibitor of processing glucosidases

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