The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis
Open accessAbstract
The structural gene encoding aromatase cytochrome P-450 (P-450AROM) was isolated from human genomic DNA. The gene spans at least 52 kilobases and is composed of 10 exons, the first of which is untranslated. Analysis of the transcription initiation site of human P-450AROM mRNA reveals the differential use of 1 of 3 consecutive G residues at the cap site. DNA sequence analysis indicates that the gene has a putative TATA (ATAAAA) sequence at -23 base pairs (bp) and putative CAAT binding sequences beginning at -41, -67, and -83 bp. The 5'-flanking region contains sequences similar to consensus sequences of cis-acting elements defined as regulators of aromatase gene expression. These putative sequences include a cAMP regulatory element at -211 bp, an AP1 (protein kinase C) site at -54 bp, and glucocorticoid regulatory elements at -352 bp and within the first intron at +346 bp. There appears to be only one gene encoding P-450AROM in the human genome. Two major species of human P-450AROM mRNA (3.4 and 2.9 kilobases) are derived from the use of two polyadenylation signals.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
HEMSELL, D. L., GRODIN, J. M., BRENNER, P. F., SIITERI, P. K., & MACDONALD, P. C. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-3-476 · Cited by 444
Distribution and regulation of aromatase activity in the rat hypothalamus and limbic system
ROSELLI, C. E., HORTON, L. E., & RESKO, J. A. (1985) · Endocrinology · doi:10.1210/endo-117-6-2471 · Cited by 415
Gene structure of human cytochrome P-450(scc), cholesterol desmolase
MOROHASHI, K.-I., SOGAWA, K., OMURA, T., & FUJII-KURIYAMA, Y. (1987) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a121955 · Cited by 189
Cited by
Morishima, A., Grumbach, M. M., Simpson, E. R., Fisher, C., & Qin, K. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.12.8530621 · Cited by 1,416
Self-citationNeurosteroids: biosynthesis and function of these novel neuromodulators
Compagnone, N. A., & Mellon, S. H. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0188 · Cited by 820
Simpson, E. R., Clyne, C., Rubin, G., Boon, W. C., Robertson, K., Britt, K., Speed, C., & Jones, M. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081601.142703 · Cited by 773
Self-citationMahendroo, M. S., Mendelson, C. R., & Simpson, E. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36538-x · Cited by 304
Self-citationEstrogen—the Good, the Bad, and the Unexpected
Simpson, E. R., Misso, M., Hewitt, K. N., Hill, R. A., Boon, W. C., Jones, M. E., Kovacic, A., Zhou, J., & Clyne, C. D. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0020 · Cited by 266
Self-citationMeans, G. D., Kilgore, M. W., Mahendroo, M. S., Mendelson, C. R., & Simpson, E. R. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-12-2005 · Cited by 258
Self-citationMechanisms in tissue-specific regulation of estrogen biosynthesis in humans
Kamat, A., Hinshelwood, M. M., Murry, B. A., & Mendelson, C. R. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(02)00567-2 · Cited by 215
Self-citationMahendroo, M. S., Means, G. D., Mendelson, C. R., & Simpson, E. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99159-3 · Cited by 175
Self-citationEffect of estrogen deficiency in the male: the ArKO mouse model
Murata, Y., Robertson, K. M., Jones, M. E. E., & Simpson, E. R. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00090-4 · Cited by 111
Self-citationRoselli, C. E., Klosterman, S., & Resko, J. A. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1343 · Cited by 91
Labrie, F., Simard, J., Luu-The, V., Pelletier, G., Belghmi, K., & Bélanger, A. (1994) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80261-7 · Cited by 78
Aromatase cytochrome P450 gene expression in endometrial carcinoma
Sasano, H., Kaga, K., Sato, S., Yajima, A., Nagura, H., & Harada, N. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.586 · Cited by 32
Aromatase expression and activity in the human leukaemic cell line FLG 29.1
Fiorelli, G., Frediani, U., Martineti, V., Franchi, A., Gori, F., Franceschelli, F., Tanini, A., Serio, M., & Brandi, M. L. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00050-8 · Cited by 13
Association between single nucleotide polymorphism of the CYP19A1 and ESR2 genes and endometriosis
Smolarz, B., & Romanowicz, H. (2021) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-021-06051-5 · Cited by 7
Metadata
- Authors
- Means, G. D., Mahendroo, M. S., Corbin, C. J., Mathis, J. M., Powell, F. E., Mendelson, C. R., & Simpson, E. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1989-11
- Volume
- 264
- Issue
- 32
- Pages
- 19385-19391
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2138855579
- Cited by
- 318
- References
- 4
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
