The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
The composition of sleep-promoting factor isolated from human urine.
Open accessAbstract
A sleep-promoting substance, Factor S, has been extracted and purified from large volumes of human urine. Urinary Factor S is a small glycopeptide; amino acid-amino sugar analyses of the purified material revealed a substance composed of glutamic acid, alanine, diaminopimelic acid, and muramic acid in molar ratios of 2:2:1:1. The active glycopeptide resembles bacterial peptidoglycans but the composition suggests that it is not simply of adventitious origin. Other reasons for this conclusion are also given. Infusions into the lateral ventricle of the brain of about 5 pmol/kg of body weight induce a 50% increase in slow wave sleep in rabbits. The excess sleep is normal as judged by electrophysiological and behavioral criteria; it resembles the deep sleep that occurs when animals are allowed to sleep following prolonged sleep deprivation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“They can activate the immune system through binding to respective PRRs, which likely leads to systemic increases of sleep regulatory substances, such as TNF and IL-1 (303, 305).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [305]
Citations
Cites
Peptidoglycan types of bacterial cell walls and their taxonomic implications
SCHLEIFER, K. H., & Kandler, O. (1972) · Bacteriological Reviews · doi:10.1128/br.36.4.407-477.1972 · Cited by 4,203
Sleep-deprivation: Effects on sleep and EEG in the rat
Borb�ly, A. A., & Neuhaus, H. U. (1979) · Journal of Comparative Physiology A · doi:10.1007/bf00663111 · Cited by 284
Blake, H., & Gerard, R. W. (1937) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1937.119.4.692 · Cited by 276
Pappenheimer, J. R., Koski, G., Fencl, V., Karnovsky, M. L., & Krueger, J. M. (1975) · Journal of Neurophysiology · doi:10.1152/jn.1975.38.6.1299 · Cited by 270
Self-citationSynthetic immunostimulants derived from the bacterial cell wall
LEDERER, E. (1980) · Journal of Medicinal Chemistry · doi:10.1021/jm00182a001 · Cited by 194
Sleep-promoting effects of cerebrospinal fluid from sleep-deprived goats.
Pappenheimer, J. R., Miller, T. B., & Goodrich, C. A. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.58.2.513 · Cited by 175
Self-citationFactors in cerebrospinal fluid from goats that affect sleep and activity in rats*
Fencl, V., Koski, G., & Pappenheimer, J. R. (1971) · The Journal of Physiology · doi:10.1113/jphysiol.1971.sp009541 · Cited by 128
Self-citationCharacterization of a delta-electroencephalogram (-sleep)-inducing peptide.
Schoenenberger, G. A., & Monnier, M. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.3.1282 · Cited by 112
Pavel, S. I., Psatta, D., & Goldstein, R. (1977) · Brain Research Bulletin · doi:10.1016/0361-9230(77)90080-6 · Cited by 108
A naturally occurring delta-EEG enhancing nonapeptide in rabbits
Schoenenberger, G. A., Maier, P. F., Tobler, H. J., & Monnier, M. (1977) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00591565 · Cited by 75
Research works printed but not linked: 7
- Pappenheimer, 1979, The Johns Hopkins Med. J., 145, 49
- Krueger, 1980, Am. J. Physiol., 238, E116
- Krueger, 1981, Fed. Proc., 40, 274
- Nagasaki, 1974, Proc. Jpn. Acad. Ser. B Phys. Biol. Sci., 50, 241
- Krysciak, 1980, Folia Biol. (Crakow), 28, 47
- Masek, 1975, Z. Immunitaetsforsch., 149, 273
- Masek, 1978, Toxicon, 991
Cited by
Sorted by citations
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
“As outlined in the next section, the release of IL-1 and TNF appear to be key mediators of this effect.”
BackgroundInfluentialHow (and why) the immune system makes us sleep
Imeri, L., & Opp, M. R. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2576 · Cited by 710
5 Analysis of the Chemical Composition and Primary Structure of Murein
Schleifer, K. H. (1985) · Methods in microbiology · doi:10.1016/s0580-9517(08)70474-4 · Cited by 711
Role of sleep deprivation in immune-related disease risk and outcomes
Garbarino, S., Lanteri, P., Bragazzi, N. L., Magnavita, N., & Scoditti, E. (2021) · Communications Biology · doi:10.1038/s42003-021-02825-4 · Cited by 665
Sleep, circadian rhythm, and gut microbiota
Matenchuk, B. A., Mandhane, P. J., & Kozyrskyj, A. L. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101340 · Cited by 495
Sleep-promoting effects of endogenous pyrogen (interleukin-1)
Krueger, J. M., Walter, J., Dinarello, C. A., Wolff, S. M., & CHEDID, L. A. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.6.r994 · Cited by 456
Self-citationPeptidoglycan Recognition Proteins
Liu, C., Xu, Z., Gupta, D., & Dziarski, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105566200 · Cited by 398
Opp, M. R. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.01.002 · Cited by 393
Microbial interactions: ecology in a molecular perspective
Braga, R. M., Dourado, M. N., & Araújo, W. L. (2016) · Brazilian Journal of Microbiology · doi:10.1016/j.bjm.2016.10.005 · Cited by 397
Biochemical regulation of non-rapid-eye-movement sleep
Krueger, J. M. (2003) · Frontiers in Bioscience · doi:10.2741/1033 · Cited by 329
Self-citationXu, X.-L., Lee, R. T. H., Fang, H.-M., Wang, Y.-M., Li, R., Zou, H., Zhu, Y., & Wang, Y. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.05.014 · Cited by 289
Sleep-promoting effects of muramyl peptides.
Krueger, J. M., Pappenheimer, J. R., & Karnovsky, M. L. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.19.6102 · Cited by 228
Self-citationProstaglandin D2, a cerebral sleep-inducing substance in monkeys.
Onoe, H., Ueno, R., Fujita, I., Nishino, H., Oomura, Y., & Hayaishi, O. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.4082 · Cited by 225
The role of peptidoglycan in pathogenesis
Boneca, I. G. (2005) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.12.008 · Cited by 207
Fatigue, sleep disturbance, disability, and indices of progression of HIV infection
Darko, D. F., McCutchan, J. A., Kripke, D. F., Gillin, J. C., & Golshan, S. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.4.514 · Cited by 182
Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells
Basu, S., & Srivastava, P. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407780102 · Cited by 170
Alteration of sleep in rabbits by Staphylococcus aureus infection
Toth, L. A., & Krueger, J. M. (1988) · Infection and Immunity · doi:10.1128/iai.56.7.1785-1791.1988 · Cited by 159
Self-citationBiochemical Regulation of Sleep and Sleep Biomarkers
Clinton, J. M., Davis, C. J., Zielinski, M. R., Jewett, K. A., & Krueger, J. M. (2011) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.1360 · Cited by 159
Self-citationSleep-wake regulation by prostaglandins D2 and E2.
Hayaishi, O. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68073-1 · Cited by 155
[20] Isolation of peptidoglycan and soluble peptidoglycan fragments
Rosenthal, R. S., & Dziarski, R. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(94)35146-5 · Cited by 152
Neuroanatomy and neurochemistry of sleep
Stenberg, D. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6530-3 · Cited by 151
Breaching the great wall: peptidoglycan and microbial interactions
Cloud-Hansen, K. A., Peterson, S. B., Stabb, E. V., Goldman, W. E., McFall‐Ngai, M., & Handelsman, J. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1486 · Cited by 134
Krueger, J. M., & Opp, M. R. (2016) · International Review of Neurobiology · doi:10.1016/bs.irn.2016.07.003 · Cited by 120
Self-citationBacterial Peptidoglycans from Microbiota in Neurodevelopment and Behavior
Gonzalez-Santana, A., & Diaz Heijtz, R. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.05.003 · Cited by 118
Martin, S. A., Karnovsky, M. L., Krueger, J. M., Pappenheimer, J. R., & BIEMANN, K. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90795-7 · Cited by 114
Self-citationKrueger, J. M., Karnovsky, M. L., Martin, S. A., Pappenheimer, J. R., Walter, J., & Biemann, K. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90796-9 · Cited by 111
Self-citationNotch signaling in vascular morphogenesis
Alva, J. A., & Iruela‐Arispe, M. L. (2004) · Current Opinion in Hematology · doi:10.1097/01.moh.0000130309.44976.ad · Cited by 109
Primary structure of the peptidoglycan-derived tracheal cytotoxin of Bordetella pertussis
Cookson, B. T., Tyler, A. N., & Goldman, W. E. (1989) · Biochemistry · doi:10.1021/bi00430a048 · Cited by 110
Invited review: MDP and other muropeptides — direct and synergistic effects on the immune system
Traub, S., von Aulock, S., Härtung, T., & Hermann, C. (2006) · Journal of Endotoxin Research · doi:10.1179/096805106x89044 · Cited by 127
Inoué, S., Honda, K., Komoda, Y., Uchizono, K., Ueno, R., & Hayaishi, O. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.6240 · Cited by 100
Krueger, J. M., Takahashi, S., Kapás, L., Bredow, S., Roky, R., Fang, J., Floyd, R. A., Renegar, K. B., Guha‐Thakurta, N., Novitsky, S. V., et al. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(95)00007-o · Cited by 98
Self-citationMuramyl peptides. Variation of somnogenic activity with structure.
Krueger, J. M., Walter, J., Karnovsky, M. L., CHEDID, L. A., Choay, J., Lefrancier, P., & LEDERER, E. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.159.1.68 · Cited by 98
Self-citationMuramylpeptides and lipopeptides: Studies towards immunostimulants
Baschang, G. (1989) · Tetrahedron · doi:10.1016/s0040-4020(01)89512-0 · Cited by 95
Delta-sleep-inducing peptide (DSIP): A review
Graf, M., & Kastin, A. J. (1984) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(84)90022-8 · Cited by 86
Fleming, T. J., Wallsmith, D. E., & Rosenthal, R. S. (1986) · Infection and Immunity · doi:10.1128/iai.52.2.600-608.1986 · Cited by 85
Interferon and the central nervous system
Dafny, N., & Yang, P. B. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.08.029 · Cited by 83
Ursin, R. (1984) · Experimental brain research. Supplementum · doi:10.1007/978-3-642-69554-4_9 · Cited by 77
Somnogenic cytokines and models concerning their effects on sleep.
Jm, K., Obál, F., Opp, M., Toth, L. A., Johannsen, L., & Cady, A. B. (1990) · PubMed Central · Cited by 75
The biology of bacterial peptidoglycans and their impact on host immunity and physiology
Wheeler, R., Chevalier, G., Eberl, G., & Boneca, I. G. (2014) · Cellular Microbiology · doi:10.1111/cmi.12304 · Cited by 75
Luker, K. E., Collier, J. L., Kolodziej, E. W., Marshall, G. R., & Goldman, W. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2365 · Cited by 70
The organization and regulation of sleep
Koella, W. P. (1984) · Cellular and Molecular Life Sciences · doi:10.1007/bf01952538 · Cited by 69
Sleep as a host defense: Its regulation by microbial products and cytokines
Krueger, J. M., & Majde, J. A. (1990) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(90)90033-m · Cited by 66
Self-citationDokter, W. H. A., Dijkstra, A. J., Koopmans, S., Stulp, B. K., Keck, W., Halie, M. R., & Vellenga, E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41763-7 · Cited by 65
Processing of Bacillus subtilis peptidoglycan by a mouse macrophage cell line
Vermeulen, M. W., & Gray, G. R. (1984) · Infection and Immunity · doi:10.1128/iai.46.2.476-483.1984 · Cited by 65
Dantzer, R., Bluthé, R.-M., Aubert, A., Goodall, G., Bret-Dibat, J. L., Kent, S., Goujon, E., Layé, S., Parnet, P., & Kelley, K. W. (1996) · Neuroscience intelligence unit · doi:10.1007/978-1-4615-9695-0_7 · Cited by 60
Krueger, J. M., & Karnovsky, M. L. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb35808.x · Cited by 59
Self-citationEffects of Muramyl Peptides on Macrophages, Monokines, and Sleep
Pabst, M. J., Beranová-Giorgianni, Š., & Krueger, J. M. (1999) · NeuroImmunoModulation · doi:10.1159/000026384 · Cited by 58
Self-citationUridine Receptor: Discovery and Its Involvement in Sleep Mechanism
Kimura, T., Ho, I. K., & Yamamoto, I. (2001) · SLEEP · doi:10.1093/sleep/24.3.251 · Cited by 58
Bush, K., Henry, P. R., & SLUSARCHYK, D. S. (1984) · The Journal of Antibiotics · doi:10.7164/antibiotics.37.330 · Cited by 57
Qualitative detection of muramic acid in normal mammalian tissues
Sen, Z., & Karnovsky, M. L. (1984) · Infection and Immunity · doi:10.1128/iai.43.3.937-941.1984 · Cited by 57
Self-citationSleep, cytokines and immune function
Dickstein, J. B. (1999) · Sleep Medicine Reviews · doi:10.1016/s1087-0792(99)90003-5 · Cited by 57
Is interferon-α a neuromodulator?
Dafny, N. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00029-5 · Cited by 55
Martin, S. A., Rosenthal, R. S., & BIEMANN, K. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47596-5 · Cited by 53
Krueger, J. M., Fang, J., Hansen, M. K., Zhang, J., & Obál, F. (1998) · Physiology · doi:10.1152/physiologyonline.1998.13.4.189 · Cited by 51
Self-citationBacterial peptidoglycans as novel signaling molecules from microbiota to brain
Tosoni, G., Conti, M., & Heijtz, R. D. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.08.003 · Cited by 54
Influence of host defense activation on sleep in humans
Pollmächer, T., Mullington, J. M., Korth, C., & Hinze‐Selch, D. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(95)00006-n · Cited by 48
Sleep and Psychoneuroimmunology
Opp, M. R. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.009 · Cited by 47
Central nervous system and peripheral immune functions and the sleep-wake system.
Moldofsky, H. (1994) · PubMed Central · Cited by 47
Muramyl Peptides as Possible Endogenous Immunopharmacological Mediators
CHEDID, L. A. (1983) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1983.tb00636.x · Cited by 46
Biological properties of bacterial peptidoglycan
Johannsen, L. (1993) · Apmis · doi:10.1111/j.1699-0463.1993.tb00119.x · Cited by 44
A modern neurobiological concept of vigilance
Koella, W. P. (1982) · Cellular and Molecular Life Sciences · doi:10.1007/bf01955754 · Cited by 44
Structure and immunochemistry of meningococcal lipopolysaccharides
Jennings, H. J., Beurret, M., Gamian, A., & Michon, F. (1987) · Antonie van Leeuwenhoek · doi:10.1007/bf00415511 · Cited by 45
Schmidt, E.-M., Linz, B., Diekelmann, S., Besedovsky, L., Lange, T., & Born, J. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.11.012 · Cited by 41
Stress hormonal response to exercise after sleep loss
Martin, B., Bender, P. R., & Chen, H.-I. (2004) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/bf00715007 · Cited by 37
Bausteine von Oligosacchariden, LXIX. Synthese von 1,6‐Anhydromuramylpeptiden
Paulsen, H. M., Himpkamp, P., & Peters, T. (1986) · Liebigs Annalen der Chemie · doi:10.1002/jlac.198619860408 · Cited by 41
Meltzer, L. T., Serpa, K. A., & Moos, W. H. (1989) · Psychopharmacology · doi:10.1007/bf00634462 · Cited by 41
CHEDID, L. A. (1985) · Annales de l Institut Pasteur Immunologie · doi:10.1016/s0769-2625(85)80113-6 · Cited by 39
Fever alters characteristics of sleep in rats
Kent, S., Price, M., & Satinoff, E. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90051-0 · Cited by 39
Root-Bernstein, R. S., & Westall, F. C. (1990) · Brain Research Bulletin · doi:10.1016/0361-9230(90)90178-3 · Cited by 37
Bacteria and MAMP-induced morphogenesis of the immune system
Eberl, G., & Boneca, I. G. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.06.002 · Cited by 37
Kapás, L., Obál, F., & Krueger, J. M. (1993) · International review of neurobiology · doi:10.1016/s0074-7742(08)60570-x · Cited by 36
Self-citationKrueger, J. M., Rosenthal, R. S., Martin, S. A., Walter, J., Davenne, D., Shoham, S., Kubillus, S. L., & BIEMANN, K. (1987) · Brain Research · doi:10.1016/0006-8993(87)90062-x · Cited by 35
Self-citationSleep and Psychoneuroimmunology
Opp, M. R. (2006) · Neurologic Clinics · doi:10.1016/j.ncl.2006.03.002 · Cited by 32
Hoijer, M. A., Melief, M., Keck, W., & Hazenberg, M. P. (1996) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(95)00136-0 · Cited by 32
Krueger, J. M., Davenne, D., Walter, J., Shoham, S., Kubillus, S. L., Rosenthal, R. S., Martin, S. A., & BIEMANN, K. (1987) · Brain Research · doi:10.1016/0006-8993(87)90063-1 · Cited by 32
Self-citationAndrews, R. C. R. (1990) · Medical Hypotheses · doi:10.1016/0306-9877(90)90010-c · Cited by 31
Root-Bernstein, R. S., & Westall, F. C. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90115-1 · Cited by 31
Imeri, L., Bianchi, S., & Mancia, M. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.5.r1663 · Cited by 31
Opp, M. R., Jan Born, A., & Irwin, M. R. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50034-4 · Cited by 29
Somnogenic activity of O-acetylated and dimeric muramyl peptides
Johannsen, L., Rosenthal, R. S., Martin, S. A., Cady, A. B., Obál, F., Guinand, M., & Krueger, J. M. (1989) · Infection and Immunity · doi:10.1128/iai.57.9.2726-2732.1989 · Cited by 28
Self-citationSleep as a neuroimmune phenomenon: A brief historical perspective
Krueger, J. M., & Karnovsky, M. L. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(94)00047-r · Cited by 29
Self-citationCytokines and sleep: the first hundred years
Opp, M. R. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.12.008 · Cited by 28
Endogenous sleep-promoting factors
Inoué, S., Uchizono, K., & Nagasaki, H. (1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90127-8 · Cited by 28
Kozar, M. P., Krahmer, M. T., Fox, A., & Gray, B. M. (2000) · Infection and Immunity · doi:10.1128/iai.68.8.4688-4698.2000 · Cited by 27
Biosynthesis of the Aspartate Family of Amino Acids
Paulus, H. (2014) · ASM Press eBooks · doi:10.1128/9781555818388.ch18 · Cited by 27
Valisena, S., Varaldo, P. E., & Satta, G. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115224 · Cited by 26
Degradation of muramyl dipeptide by mammalian serum
Harrison, J., & Fox, A. (1985) · Infection and Immunity · doi:10.1128/iai.50.1.320-321.1985 · Cited by 26
Tomašić, J., Sesartić, L., Martin, S. A., Valinger, Z., & Ladešić, B. (1988) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)94544-8 · Cited by 26
Properties of the Cell Surfaces of Pathogenic Bacteria
Doyle, R. J., & Sonnenfeld, E. M. (1989) · International review of cytology · doi:10.1016/s0074-7696(08)60872-4 · Cited by 25
Bayliss‐Starling Memorial Lecture (1982). Induction of sleep by muramyl peptides.
Pappenheimer, J. R. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014561 · Cited by 25
Self-citationEndogeneous morphine and codeine in mice — effect of muramyl dipeptide
Horàk, P., Haberman, F., & Spector, S. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90011-q · Cited by 25
Watanabe, K., Tanaka, R., Sakurai, H., Iguchi, K., Yamada, Y., Hsu, C., Sakuma, C., Kikuchi, H., Shibayama, H., & Kawai, T. (2007) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.55.780 · Cited by 24
Tenu, J., Adam, A., Souvannavong, V., Yapo, A., Petit, J. F., & Douglas, K. T. (1989) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(89)90151-3 · Cited by 24
Recent developments in the field of biologically active peptides
Schmidt, G. (1986) · Topics in current chemistry · doi:10.1007/3-540-16724-2_8 · Cited by 23
Somnogenic activities of synthetic lipid A
Cady, A. B., Kotani, S., Shiba, T., Kusumoto, S., & Krueger, J. M. (1989) · Infection and Immunity · doi:10.1128/iai.57.2.396-403.1989 · Cited by 22
Self-citationSLEEP FACTORS: DO MURAMYL PEPTIDES ACTIVATE SEROTONIN BINDING SITES?
Root-Bernstein, R. S., & Westall, F. C. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91827-5 · Cited by 22
Dokter, W. H. A., Dijkstra, A. J., Koopmans, S., Mulder, A., Stulp, B. K., Halie, M. R., Keck, W., & Vellenga, E. (1994) · Infection and Immunity · doi:10.1128/iai.62.7.2953-2957.1994 · Cited by 20
SINGH, P. D., & JOHNSON, J. H. (1984) · The Journal of Antibiotics · doi:10.7164/antibiotics.37.336 · Cited by 20
Somnogenic activity of muramyl peptides
Krueger, J. M. (1985) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(85)90099-9 · Cited by 19
Self-citationPurification and characterization of amidase from human serum
Vanderwinkel, E., de Vlieghere, M., Pauw, P. E. M. D., Cattalini, N., Ledoux, V., Gigot, D., & Have, J.-P. T. (1990) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(90)90267-j · Cited by 19
Metadata
- Authors
- Krueger, J. M., Pappenheimer, J. R., & Karnovsky, M. L.
- Affiliations
- Harvard University (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1982-02
- Volume
- 257
- Issue
- 4
- Pages
- 1664-1669
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1559956276
- Cited by
- 192
- References
- 19
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 2 · 2021: 4 · 2020: 5 · 2019: 5 · 2017: 3 · 2016: 2 · 2014: 3
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- glycopeptides, amino acid composition, diaminopimelic acid, muramic acid, bacterial peptidoglycan, slow-wave sleep, sleep deprivation, intraventricular infusion, rabbits
- MeSH terms
- Acetylmuramyl-Alanyl-Isoglutamine, Amino Acids, Animals, Biological Assay, Glucosamine, Glycopeptides, Humans, Male, Rabbits, Sleep
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
