The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides.
Open accessAbstract
Insulin-like growth factor I (IGF-I), a 70-amino acid basic polypeptide, plays a fundamental role in postnatal mammalian growth as a major mediator through which growth hormone exerts its biological effects. We have recently identified two human IGF-I cDNAs which predict distinct peptide precursors of 153 and 195 amino acids. In the present study, both cDNAs were used to isolate and characterize the human IGF-I gene from genomic libraries. The IGF-I gene extends over at least 45 kilobase pairs and contains five exons interrupted by four introns. The DNA sequence of exons 1 through 4 encodes the 195-amino acid precursor, while exons 1, 2, 3, and 5 code for the 153-residue peptide, confirming the hypothesis that at least two IGF-I mRNAs are generated by alternative RNA processing of the primary gene transcript. The structure of the IGF-I gene resembles that of its companion somatomedin, IGF-II, as judged by the analogous location of two introns and considerable nucleotide and amino acid sequence similarity, but appears more distantly related to other members of the insulin gene family. Restriction endonuclease polymorphisms in the IGF-I gene, which map near exon 5 as determined by Southern blot analysis, will be useful in defining the genetics of familial growth failure.
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Cites
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Cited by
Regulation of insulin-like growth factor I gene expression by growth hormone.
Mathews, L. S., Norstedt, G., & Palmiter, R. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9343 · Cited by 553
Growth Enhancement of Transgenic Mice Expressing Human Insulin-Like Growth Factor I*
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Evolution and distribution of (GT)n repetitive sequences in mammalian genomes
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Self-citation
Metadata
- Authors
- Rotwein, P., Pollock, K. M., Didier, D. K., & Krivi, G. G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1986-04
- Volume
- 261
- Issue
- 11
- Pages
- 4828-4832
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1545380907
- Cited by
- 368
- References
- 31
- FWCI
- 19.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Rotwein, P., Pollock, K. M., Didier, D. K., & Krivi, G. G. (1986). Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)89179-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
