The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα
Open accessAbstract
We have previously shown that a mixture of dietary conjugated derivatives of linoleic acid (conjugated linoleic acid, CLA) induces peroxisome proliferator-responsive enzymes and modulates hepatic lipid metabolism in vivo. The present studies demonstrate that CLA is a high affinity ligand and activator of peroxisome proliferator-activated receptor alpha (PPARalpha) and induces accumulation of PPAR-responsive mRNAs in a rat hepatoma cell line. Using a scintillation proximity assay (SPA), CLA isomers were shown to be ligands for human PPARalpha with a rank order of potency of (9Z,11E)>(10E,12Z)>(9E,11E)> furan-CLA (IC(50) values from 140 nm to 400 nm). Levels of acyl-CoA oxidase (ACO), liver fatty acid-binding protein (L-FABP), and cytochrome P450IVA1 (CYP4A1) mRNA were induced by CLA in FaO hepatoma cells. Even though linoleate and CLA were incorporated into lipids of hepatoma cells to the same extent, linoleate had little or no effect on ACO, CYP4A1, or L-FABP mRNA. In agreement with its binding potency, (9Z,11E)-CLA was the most efficacious PPARalpha activator in the mouse PPARalpha-GAL4(UAS)(5)-CAT reporter system. These data indicate that CLA is a ligand and activator of PPARalpha and its effects on lipid metabolism may be attributed to transcriptional events associated with this nuclear receptor. Also, (9Z,11E)-CLA is one of the most avid fatty acids yet described as a PPARalpha ligand.
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Cited by
Roles of PPARs in health and disease
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Action of epoxyeicosatrienoic acids on cellular function
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Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition
Kishino, S., Takeuchi, M., Park, S.-B., Hirata, A., Kitamura, N., Kunisawa, J., Kiyono, H., Iwamoto, R., Isobe, Y., Arita, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312937110 · Cited by 395
Implication of Conjugated Linoleic Acid (CLA) in Human Health
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Metadata
- Authors
- Moya-Camarena, S. Y., Heuvel, J. P. V., Blanchard, S. G., Leesnitzer, L. A., & Belury, M. A.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 40
- Issue
- 8
- Pages
- 1426-1433
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2105140628
- Cited by
- 396
- References
- 35
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Moya-Camarena, S. Y., Heuvel, J. P. V., Blanchard, S. G., Leesnitzer, L. A., & Belury, M. A. (1999). Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)33384-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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