Cited by 336Peroxisome Proliferator-Activated ReceptorsParaoxonase enzyme and polymorphismsLipid metabolism and disorders

The role of PPARα in lipid metabolism and obesity: Focusing on the effects of estrogen on PPARα actions

Yoon, Michung·2009·Pharmacological Research

Abstract

Peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription factor that belongs to the steroid hormone receptor superfamily. PPARalpha is expressed predominantly in tissues that have a high level of fatty acid catabolism, such as liver, heart, and muscle. PPARalpha regulates the expression of a number of genes critical for lipid and lipoprotein metabolism. PPARalpha ligand fibrates have been used for the treatment of dyslipidemia due to their ability to lower plasma triglyceride levels and elevate HDL cholesterol levels. PPARalpha activators have been shown to regulate obesity in rodents by both increasing hepatic fatty acid oxidation and decreasing the levels of circulating triglycerides responsible for adipose cell hypertrophy and hyperplasia. However, these effects of PPARalpha on obesity and lipid metabolism may be exerted with sexual dimorphism and seem to be influenced by estrogen. Estrogen inhibits the actions of PPARalpha on obesity and lipid metabolism through its effects on PPARalpha-dependent regulation of target genes. Thus, the use of fibrates seems to be effective in men and postmenopausal women with obesity and lipid disorders, but not in premenopausal women with functioning ovaries.

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Crossref · 10.1016/j.phrs.2009.02.004

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Authors
Yoon, M.
Affiliations
Mokwon University (KR)
Corresponding author
Yoon, Michung
Venue
Pharmacological Research
Publisher
Elsevier BV
Published
2009-09
Volume
60
Issue
3
Pages
151-159
ISSN
1043-6618 (ISSN-L)
OpenAlex
W2026756943
Cited by
336
References
155
Citations by year
2026: 12 · 2025: 25 · 2024: 13 · 2023: 23 · 2022: 33 · 2021: 20 · 2020: 27 · 2019: 27 · 2018: 25 · 2017: 15 · 2016: 16 · 2015: 15 · 2014: 18 · 2013: 14 · 2012: 17
FWCI
7.11
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacological Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
PPARα, estrogen, obesity, lipid metabolism, fibrates, dyslipidemia, hepatic fatty acid oxidation, triglycerides, HDL cholesterol, sexual dimorphism, postmenopausal women, premenopausal women, lipoprotein metabolism
MeSH terms
Animals, Estrogens, Female, Humans, Male, Obesity, PPAR alpha, Lipid Metabolism

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