The role of PPARα in lipid metabolism and obesity: Focusing on the effects of estrogen on PPARα actions
Abstract
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription factor that belongs to the steroid hormone receptor superfamily. PPARalpha is expressed predominantly in tissues that have a high level of fatty acid catabolism, such as liver, heart, and muscle. PPARalpha regulates the expression of a number of genes critical for lipid and lipoprotein metabolism. PPARalpha ligand fibrates have been used for the treatment of dyslipidemia due to their ability to lower plasma triglyceride levels and elevate HDL cholesterol levels. PPARalpha activators have been shown to regulate obesity in rodents by both increasing hepatic fatty acid oxidation and decreasing the levels of circulating triglycerides responsible for adipose cell hypertrophy and hyperplasia. However, these effects of PPARalpha on obesity and lipid metabolism may be exerted with sexual dimorphism and seem to be influenced by estrogen. Estrogen inhibits the actions of PPARalpha on obesity and lipid metabolism through its effects on PPARalpha-dependent regulation of target genes. Thus, the use of fibrates seems to be effective in men and postmenopausal women with obesity and lipid disorders, but not in premenopausal women with functioning ovaries.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PPARα activates fatty acid oxidation by inducing lipid oxidation genes in mitochondria and peroxisomes.
“For example, PPARα activates fatty acid oxidation by inducing lipid oxidation genes in mitochondria and peroxisomes (Yoon, 2009).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Yoon, 2009
Cites
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,442 · see citing works
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519 · see citing works
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism
Desvergne, B., & Wahli, W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0380 · Cited by 3,079 · see citing works
Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536636 · Cited by 2,217 · see citing works
Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164 · see citing works
Forman, B. M., Chen, J., & Evans, R. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4312 · Cited by 2,116 · see citing works
Roles of PPARs in health and disease
Kersten, S., Desvergne, B., & Wahli, W. (2000) · Nature · doi:10.1038/35013000 · Cited by 1,956 · see citing works
The PPARs: From Orphan Receptors to Drug Discovery
Willson, T. M., Brown, P. J., Sternbach, D. D., & Henke, B. R. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990554g · Cited by 1,816 · see citing works
Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism
Staels, B., Dallongeville, J., Auwerx, J., Schoonjans, K., Leitersdorf, E., & Fruchart, J.-C. (1998) · Circulation · doi:10.1161/01.cir.98.19.2088 · Cited by 1,786 · see citing works
Lee, S. S. T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernández‐Salguero, P. M., Westphal, H., & Gonzalez, F. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3012 · Cited by 1,655 · see citing works
PPARs and the complex journey to obesity
Evans, R. M., Barish, G. D., & Wang, Y.-X. (2004) · Nature Medicine · doi:10.1038/nm1025 · Cited by 1,621 · see citing works
Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors
Dreyer, C., Krey, G. D., Keller, H., Givel, F., Helftenbein, G., & Wahli, W. (1992) · Cell · doi:10.1016/0092-8674(92)90031-7 · Cited by 1,373 · see citing works
The PPARα–leukotriene B4 pathway to inflammation control
Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., & Wahli, W. (1996) · Nature · doi:10.1038/384039a0 · Cited by 1,345 · see citing works
Krey, G. D., Braissant, O., L’Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., & Wahli, W. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.6.0007 · Cited by 1,221 · see citing works
Schoonjans, K., Staels, B., & Auwerx, J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42003-6 · Cited by 1,216 · see citing works
Schoonjans, K., Peinado‐Onsurbe, J., Lefebvre, A. M., Heyman, R. A., Briggs, M., Deeb, S., Staels, B., & Auwerx, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00918.x · Cited by 1,173 · see citing works
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
Staels, B., Köenig, W., Habib, A., Merval, R., Lebret, M., Pineda‐Torra, I., Delerive, P., Fadel, A., Chinetti, G., Fruchart, J., et al. (1998) · Nature · doi:10.1038/31701 · Cited by 1,134 · see citing works
Fu, J., Gaetani, S., Oveisi, F., Verme, J., Serrano, A., de Fonseca, F. D., Rosengarth, A., Luecke, H., Giacomo, B. D., Tarzia, G., et al. (2003) · Nature · doi:10.1038/nature01921 · Cited by 1,113 · see citing works
Lehmann, J. M., Lenhard, J. M., Oliver, B. B., Ringold, G. M., & Kliewer, S. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3406 · Cited by 1,110 · see citing works
Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J.-C., Tedgui, A., Haegeman, G., & Staels, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32048 · Cited by 1,089 · see citing works
Nuclear receptors enhance our understanding of transcription regulation
Green, S., & Chambon, P. (1988) · Trends in Genetics · doi:10.1016/0168-9525(88)90108-4 · Cited by 1,042 · see citing works
Chinetti, G., Griglio, S., Antonucci, M., Pineda‐Torra, I., Delerive, P., Majd, Z., Fruchart, J., Chapman, J., Najïb, J., & Staels, B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25573 · Cited by 903 · see citing works
Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., & Green, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05072.x · Cited by 895 · see citing works
Orphan Nuclear Receptors: From Gene to Function
Giguère, V. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0378 · Cited by 848 · see citing works
Klein‐Hitpaß, L., Schorpp, M., Wagner, U. G., & Ryffel, G. U. (1986) · Cell · doi:10.1016/0092-8674(86)90705-1 · Cited by 720 · see citing works
Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids
Yu, K., Bayona, W., Kallen, C. B., Harding, H. P., Ravera, C., McMahon, G., Brown, M. A., & Lazar, M. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.23975 · Cited by 709 · see citing works
PPARs: therapeutic targets for metabolic disease
Berger, J. P., Akiyama, T. E., & Meinke, P. T. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.03.003 · Cited by 706 · see citing works
Guerre-Millo, M., Gervois, P., Raspé, E., Madsen, L., Poulain, P., Derudas, B., Herbert, J.-M., Winegar, D. A., Willson, T. M., Fruchart, J.-C., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.22.16638 · Cited by 605 · see citing works
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
Clapham, J. C., Arch, J. R. S., Chapman, H., Haynes, A., Lister, C., Moore, G. B. T., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., et al. (2000) · Nature · doi:10.1038/35019082 · Cited by 604 · see citing works
Gulick, T., Cresci, S., Caira, T., Moore, D. D., & Kelly, D. P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11012 · Cited by 560 · see citing works
Kopecky, J., Clarke, G., Enerbäck, S., Spiegelman, B., & Kozak, L. P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118363 · Cited by 553 · see citing works
Martin, G., Schoonjans, K., Lefebvre, A.-M., Staels, B., & Auwerx, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28210 · Cited by 551 · see citing works
Motojima, K., Passilly, P., Peters, J. M., Gonzalez, F. J., & Latruffe, N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.27.16710 · Cited by 524 · see citing works
Sher, T., Yi, H. F., McBride, O. W., & Gonzalez, F. J. (1993) · Biochemistry · doi:10.1021/bi00072a015 · Cited by 519 · see citing works
Marx, N., Duez, H., Fruchart, J.-C., & Staels, B. (2004) · Circulation Research · doi:10.1161/01.res.0000127122.22685.0a · Cited by 501 · see citing works
Orphan Nuclear Receptors: Shifting Endocrinology into Reverse
Kliewer, S. A., Lehmann, J. M., & Willson, T. M. (1999) · Science · doi:10.1126/science.284.5415.757 · Cited by 499 · see citing works
Gervois, P. P., Fruchart, J., Delerive, P., & Staels, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004045200 · Cited by 457 · see citing works
Brandt, J. M., Djouadi, F., & Kelly, D. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.23786 · Cited by 456 · see citing works
Fruchart, J.-C., Duriez, P., & Staels, B. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199906000-00007 · Cited by 425 · see citing works
Biochemical Mechanisms Of Induction Of Hepatic Peroxisome Proliferation
Lock, E. A., Mitchell, A. M., & Elcombe, C. R. (1989) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.29.040189.001045 · Cited by 424 · see citing works
AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARα and PGC-1
Lee, W. J., Kim, M., Park, H. S., Kim, H. S., Jeon, M. J., Oh, K. S., Koh, E. H., Won, J. C., Kim, M., Oh, G. T., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.011 · Cited by 420 · see citing works
Self-citationBarbier, O., Pineda‐Torra, I., Duguay, Y., Blanquart, C., Fruchart, J., Glineur, C., & Staels, B. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000015598.86369.04 · Cited by 412 · see citing works
Staels, B., Vu-Dac, N., Kosykh, V. A., Saladin, R., Fruchart, J. C., Dallongeville, J., & Auwerx, J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117717 · Cited by 410 · see citing works
Costet, P., Legendre, C., Moré, J., Edgar, A. D., Galtier, P., & Pineau, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29577 · Cited by 402 · see citing works
Vu‐Dac, N., Schoonjans, K., Kosykh, V., Dallongeville, J., Fruchart, J., Staels, B., & Auwerx, J. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118118 · Cited by 397 · see citing works
Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα
Moya-Camarena, S. Y., Heuvel, J. P. V., Blanchard, S. G., Leesnitzer, L. M., & Belury, M. A. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33384-8 · Cited by 396 · see citing works
Schoonjans, K., 渡辺, 光., Suzuki, H., Mahfoudi, A., Krey, G. D., Wahli, W., Grimaldi, P. A., Staels, B., Yamamoto, T. T., & Auwerx, J. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.33.19269 · Cited by 395 · see citing works
Weight Gain at the Time of Menopause
Wing, R. R. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.1991.00400010111016 · Cited by 394 · see citing works
Biochemical Mechanisms Of Induction Of Hepatic Peroxisome Proliferation
Lock, E. (1989) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.29.1.145 · Cited by 356 · see citing works
IJpenberg, A., Jeannin, E., Wahli, W., & Desvergne, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.20108 · Cited by 352 · see citing works
Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.
Hertz, R., Bishara-Shieban, J., & Bar‐Tana, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13470 · Cited by 339 · see citing works
Barberà, M. J., Schlüter, A., Pedraza, N., Iglesias, R., Villarroya, F., & Giralt, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006246200 · Cited by 337 · see citing works
Guzmán, M., Lo Verme, J., Fu, J., Oveisi, F., Blázquez, C., & Piomelli, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404087200 · Cited by 328 · see citing works
Mascaró, C., Acosta, E., Ortiz, J. A., Marrero, P. F., Hegardt, F. G., & Haro, D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8560 · Cited by 318 · see citing works
Muerhoff, A. S., Griffin, K. J., & Johnson, E. F. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41738-3 · Cited by 311 · see citing works
Some effects of ovarian hormones on food intake and body weight in female rats.
Wade, G. N. (1975) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0076186 · Cited by 308 · see citing works
Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
Li, B., Nolte, L. A., Ju, J.-S., Ho Han, D., Coleman, T., Holloszy, J. O., & Semenkovich, C. F. (2000) · Nature Medicine · doi:10.1038/80450 · Cited by 291 · see citing works
Gonzalez, F. J., Peters, J., & Cattley, R. C. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.22.1702 · Cited by 291 · see citing works
Metabolic Actions of Estrogen Receptor Beta (ERβ) are Mediated by a Negative Cross-Talk with PPARγ
Foryst‐Ludwig, A., Clemenz, M., Hohmann, S., Hartge, M., Sprang, C., Frost, N., Krikov, M., Bhanot, S., Barros, R. P. A., Morani, A., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000108 · Cited by 288 · see citing works
DiRenzo, J., Söderström, M., Kurokawa, R., Ogliastro, M.-H., Ricote, M., Ingrey, S., Hörlein, A., Rosenfeld, M. G., & Glass, C. K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2166 · Cited by 281 · see citing works
Protein composition determines the anti-atherogenic properties of HDL in transgenic mice
Schultz, J. R., Verstuyft, J. G., Gong, E. L., Nichols, A. V., & Rubin, E. M. (1993) · Nature · doi:10.1038/365762a0 · Cited by 275 · see citing works
Fu, J., Oveisi, F., Gaetani, S., Lin, E., & Piomelli, D. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.02.013 · Cited by 275 · see citing works
Kelly, L. J., Vicario, P. P., Thompson, G. M., Candelore, M. R., Doebber, T. W., Ventre, J. R., Wu, M. S., Meurer, R. D., Forrest, M. J., Conner, M. W., et al. (1998) · Endocrinology · doi:10.1210/endo.139.12.6384 · Cited by 268 · see citing works
Berthou, L., Duverger, N., Emmanuel, F., Langouët, S., Auwerx, J. H., Guillouzo, A., Fruchart, J., Rubin, E. M., Denèfle, P., Staels, B., et al. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118687 · Cited by 248 · see citing works
Harwood, H. J., Petras, S. F., Shelly, L. D., Zaccaro, L. M., Perry, D. A., Makowski, M. R., Hargrove, D. M., Martin, K. A., Tracey, W. R., Chapman, J. G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304481200 · Cited by 242 · see citing works
Vu‐Dac, N., Schoonjans, K., Laine, B., Fruchart, J., Auwerx, J. H., & Staels, B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47383-8 · Cited by 240 · see citing works
Zhang, B., Marcus, S. L., Sajjadi, F. G., Alvares, K., Reddy, J. K., Subramani, S. E., Rachubinski, R. A., & Capone, J. P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7541 · Cited by 232 · see citing works
Astrup, A., Buemann, B., Christensen, N. J., & Toubro, S. (1994) · American Journal of Physiology · doi:10.1152/ajpendo.1994.266.4.e592 · Cited by 231 · see citing works
Pineda‐Torra, I., Gervois, P. P., & Staels, B. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199904000-00009 · Cited by 231 · see citing works
Lazennec, G., Canaple, L., Saugy, D., & Wahli, W. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.12.0575 · Cited by 220 · see citing works
Keller, H., Givel, F., Perroud, M., & Wahli, W. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.7.7476963 · Cited by 220 · see citing works
Modulation of Estrogen Receptor-α Transcriptional Activity by the Coactivator PGC-1
Tcherepanova, I. Y., Puigserver, P., Norris, J. D., Spiegelman, B. M., & McDonnell, D. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001364200 · Cited by 218 · see citing works
Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice
Pineda‐Torra, I., Chinetti, G., Duval, C., Fruchart, J., & Staels, B. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200106000-00002 · Cited by 210 · see citing works
Suzuki, A., Okamoto, S., Lee, S. P., Saito, K., Shiuchi, T., & Minokoshi, Y. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02222-06 · Cited by 206 · see citing works
Oxidized phospholipids activate PPARα in a phospholipase A2‐dependent manner
Delerive, P., Furman, C., Teissier, E., Fruchart, J., Duriez, P., & Staels, B. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01364-8 · Cited by 200 · see citing works
Inoue, I., Shino, K., Noji, S., Awata, T., & Katayama, S. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8622 · Cited by 199 · see citing works
Fenofibrate and Rosiglitazone Lower Serum Triglycerides with Opposing Effects on Body Weight
Chaput, E., Saladin, R., Silvestre, M., & Edgar, A. D. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2647 · Cited by 199 · see citing works
Lambe, K. G., & Tugwood, J. D. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0001u.x · Cited by 198 · see citing works
Peroxisome Proliferator-Activated Receptor (PPAR) in Metabolic Syndrome and Type 2 Diabetes Mellitus
Jay, M., & Ren, J. T. (2007) · Current Diabetes Reviews · doi:10.2174/157339907779802067 · Cited by 196 · see citing works
A potent PPARα agonist stimulates mitochondrial fatty acid β-oxidation in liver and skeletal muscle
Minnich, A., Tian, N., Byan, L., & Bilder, G. E. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e270 · Cited by 192 · see citing works
Zhu, Y., Kan, L., Qi, C., Kanwar, Y. S., Yeldandi, A. V., Rao, M. S., & Reddy, J. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13510 · Cited by 187 · see citing works
The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin
Shalev, A., Siegrist-Kaiser, C. A., Yen, P. M., Wahli, W., Burger, A., Chin, W. W., & Meier, C. A. (1996) · Endocrinology · doi:10.1210/endo.137.10.8828512 · Cited by 187 · see citing works
Identification of Rev-erbα as a physiological repressor of apoC-III gene transcription
Raspé, E., Duez, H., Mansén, A., Fontaine, C., Fiévet, C., Fruchart, J.-C., Vennström, B., & Staels, B. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200386-jlr200 · Cited by 183 · see citing works
Peripheral metabolic actions of leptin
Muoio, D. M., & Lynis Dohm, G. (2002) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2002.0223 · Cited by 183 · see citing works
LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice
Schreyer, S. A., Vick, C. M., Lystig, T., Mystkowski, P., & LeBoeuf, R. C. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e207 · Cited by 182 · see citing works
Aldridge, T. C., Tugwood, J. D., & Green, S. (1995) · Biochemical Journal · doi:10.1042/bj3060473 · Cited by 182 · see citing works
Choi, C. S., Fillmore, J. J., Kim, J. K., Liu, Z., Kim, S., Collier, E. F., Kulkarni, A. S., Distefano, A. G., Hwang, Y.-J., Kahn, M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci13579 · Cited by 182 · see citing works
PPARα and PPARγ dual agonists for the treatment of type 2 diabetes and the metabolic syndrome
Fiévet, C., Fruchart, J., & Staels, B. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.06.009 · Cited by 182 · see citing works
Juge-Aubry, C. E., Hammar, E. B., Siegrist-Kaiser, C. A., Pernin, A., Takeshita, A., Chin, W. W., Burger, A., & Meier, C. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.15.10505 · Cited by 178 · see citing works
p300 Functions as a Coactivator for the Peroxisome Proliferator-activated Receptor α
Dowell, P., Ishmael, J. E., Avram, D., Peterson, V. J., Nevrivy, D. J., & Leid, M. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.33435 · Cited by 174 · see citing works
Mechanisms of Hepatocarcinogenicity of Peroxisome-Proliferating Drugs and Chemicals
Lake, B. G. (1995) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.002411 · Cited by 168 · see citing works
The brown adipocyte: update on its metabolic role
Sell, H., Deshaies, Y., & Richard, D. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.04.003 · Cited by 168 · see citing works
Influence of Gemfibrozil and Clofibrate on Metabolism of Cholesterol and Plasma Triglycerides in Man
Kesäniemi, Y. A. (1984) · JAMA · doi:10.1001/jama.1984.03340410049031 · Cited by 165 · see citing works
A role for fatty acids and liver fatty acid binding protein in peroxisome proliferation?
Issemann, I., Prince, R. A., Tugwood, J. D., & Green, S. (1992) · Biochemical Society Transactions · doi:10.1042/bst0200824 · Cited by 164 · see citing works
Zomer, A. W. M., van der Burg, B., Jansen, G. A., Wanders, R. J. A., Poll‐The, B. T., & van der Saag, P. T. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31973-8 · Cited by 160 · see citing works
Liang, C.-P., & Tall, A. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107250200 · Cited by 157 · see citing works
Brun, S., Carmona, M. C., Mampel, T., Viñas, O., Giralt, M., Iglesias, R., & Villarroya, F. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1217 · Cited by 156 · see citing works
Louet, J., Chatelain, F., Decaux, J., Park, E. A., Kohl, C., Pineau, T., Girard, J. R., & Pégorier, J. P. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3540189 · Cited by 154 · see citing works
Is There a Role for Fibrates in the Management of Dyslipidemia in the Metabolic Syndrome?
Barter, P. J., & Rye, K. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.148817 · Cited by 151 · see citing works
Lipoprotein Lipase: Recent Contributions from Molecular Biology
Auwerx, J. H., Leroy, P., & Schoonjans, K. (1992) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369209114602 · Cited by 148 · see citing works
Tsuboyama-Kasaoka, N., Takahashi, M. M., Kim, H., & Ezaki, O. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0555 · Cited by 138 · see citing works
Dowell, P., Ishmael, J. E., Avram, D., Peterson, V. J., Nevrivy, D. J., & Leid, M. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15901 · Cited by 135 · see citing works
Wang, X., & Kilgore, M. W. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00154-5 · Cited by 134 · see citing works
Nakatani, T., Tsuboyama-Kasaoka, N., Takahashi, M. M., Miura, S., & Ezaki, O. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110132200 · Cited by 132 · see citing works
Fenofibrate prevents and reduces body weight gain and adiposity in diet‐induced obese rats
Mancini, F. P., Lanni, A., Sabatino, L., Moreno, M., Giannino, A., Contaldo, F., Colantuoni, V., & Goglia, F. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02146-9 · Cited by 132 · see citing works
Peroxisome proliferator-activated receptor-α activation and high-density lipoprotein metabolism
Fruchart, J. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02149-x · Cited by 126 · see citing works
Cabrero, À., Alegret, M., Sánchez, R. M., Adzet, T., Laguna, J. C., & Vázquez‐Carrera, M. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1883 · Cited by 124 · see citing works
Fenofibrate and LDL metabolic heterogeneity in hypercholesterolemia.
CASLAKE, M. J., Packard, C. J., Gaw, A., Murray, E. F., Griffin, B. A., Vallance, B. D., & Shepherd, J. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.5.702 · Cited by 121 · see citing works
Hertz, R., Berman, I., KEPPLER, D. O. R., & Bar‐Tana, J. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00242.x · Cited by 105 · see citing works
Nuñez, S. B., Medin, J. A., Braissant, O., Kemp, L., Wahli, W., Ozato, K., & Segars, J. H. (1997) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(96)03980-9 · Cited by 104 · see citing works
The FIELD Study Investigators (2005) · Cardiovascular Diabetology · doi:10.1186/1475-2840-4-13 · Cited by 103 · see citing works
Kusunoki, J., Kanatani, A., & Moller, D. E. (2006) · Endocrine · doi:10.1385/endo:29:1:91 · Cited by 103 · see citing works
Cloning and Characterization of the 5′ Flanking Region of the Human Uncoupling Protein 3 (UCP3) Gene
Acı́n, A., Rodriguez, M., Rique, H., Canet, E., Boutin, J. A., & Galizzi, J. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0530 · Cited by 103 · see citing works
Dietary-induced obesity: effect of dietary fats on adipose tissue cellularity in mice
Bourgeois, F., Alexiu, A., & Lemonnter, D. (1983) · British Journal Of Nutrition · doi:10.1079/bjn19830006 · Cited by 99 · see citing works
Bouly, M., Masson, D., Gross, B. S., Jiang, X., Fiévet, C., Castro, G. R., Tall, A. R., Fruchart, J., Staels, B., Lagrost, L., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101160200 · Cited by 99 · see citing works
Gonadal steroids and energy homeostasis in the leptin era
Mystkowski, P., & Schwartz, M. W. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00458-5 · Cited by 98 · see citing works
Shinoda, M., Latour, M., & Lavoie, J.-M. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801900 · Cited by 97 · see citing works
Srivastava, R. A. K., Jahagirdar, R., Azhar, S., Sharma, S., & Bisgaier, C. L. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-9053-y · Cited by 94 · see citing works
Malmendier, C. L., Lontie, J., Delcroix, C., Dubois, D. Y., Magot, T., & Roy, L. D. (1989) · Atherosclerosis · doi:10.1016/0021-9150(89)90075-0 · Cited by 94 · see citing works
Human Uncoupling Protein‐3 and Obesity: An Update
Hesselink, M. K. C., Mensink, M., & Schrauwen, P. (2003) · Obesity Research · doi:10.1038/oby.2003.192 · Cited by 85 · see citing works
Pasternak, R. C., Brown, L. E., Stone, P. H., Silverman, D. I., Gibson, C. M., Sacks, F. M., & Harvard Atherosclerosis Reversibility Project (HARP) Study Group (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-125-7-199610010-00001 · Cited by 85 · see citing works
Boitier, E., Gautier, J., & Roberts, R. A. (2003) · Comparative Hepatology · doi:10.1186/1476-5926-2-3 · Cited by 85 · see citing works
Serrano, A., del Arco, I., Pavón, F. J., Macías, M., Perez‐Valero, V., & de Fonseca, F. R. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.03.007 · Cited by 80 · see citing works
On the Mode of Action of Lipid-lowering Agents
Maragoudakis, M. E., & Hankin, H. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62498-6 · Cited by 77 · see citing works
The ontogeny of peroxisome-proliferator-activated receptor gene expression in the mouse and rat
Beck, F., Plummer, S., Senior, P. V., Byrne, S., Green, S., & Brammar, W. J. (1992) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1992.0012 · Cited by 77 · see citing works
Increased fatty acid oxidation in transgenic mice overexpressing UCP3 in skeletal muscle
Wang, S., Subramaniam, A., Cawthorne, M. A., & Clapham, J. C. (2003) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2003.00273.x · Cited by 74 · see citing works
Ma, H., Sprecher, H. W., & Kolattukudy, P. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30131 · Cited by 72 · see citing works
Fenofibrate regulates obesity and lipid metabolism with sexual dimorphism
Yoon, M., Jeong, S., Nicol, C. J. B., Lee, H., Han, M., Kim, J.-J., Seo, Y.-J., Ryu, C., & Oh, G. T. (2002) · Experimental & Molecular Medicine · doi:10.1038/emm.2002.67 · Cited by 68 · see citing works
Self-citationJeong, S., Han, M., Lee, H., Kim, M. K., Kim, J. K., Nicol, C. J. B., Kim, B. H., Choi, J. H., Nam, K., Oh, G. T., et al. (2004) · Metabolism · doi:10.1016/j.metabol.2004.05.003 · Cited by 64 · see citing works
Self-citationThe respiratory quotient as a prognostic factor in weight-loss rebound
Valtueña, S., Salas‐Salvadó, J., & García‐Lorda, P. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800480 · Cited by 62 · see citing works
Thermogenic and metabolic antiobesity drugs: rationale and opportunities
Clapham, J. C., & Arch, J. R. S. (2007) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00608.x · Cited by 60 · see citing works
Bisgaier, C. L., Essenburg, A. D., Barnett, B. C., Auerbach, B. J., Haubenwallner, S., Leff, T., White, A. D., Creger, P. L., Pape, M. E., Rea, T. J., et al. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34199-7 · Cited by 58 · see citing works
Lentes, K., Tu, N., Chen, H., Winnikes, U., Reinert, I., Marmann, G., & Pirke, K. M. (1999) · Journal of Receptors and Signal Transduction · doi:10.3109/10799899909036648 · Cited by 57 · see citing works
Estradiol increases glucagon's satiating potency in ovariectomized rats.
Geary, N., & Asarian, L. (2001) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.4.r1290 · Cited by 56 · see citing works
PPAR Agonists and the Metabolic Syndrome
Staels, B. (2007) · Therapies · doi:10.2515/therapie:2007051 · Cited by 49 · see citing works
Modulation of lipoprotein production in hep G2 cells by fenofibrate and clofibrate
Hahn, S. E., & Goldberg, D. M. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90586-8 · Cited by 49 · see citing works
Tilly-Kiesi, M., & Tikkanen, M. J. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00370.x · Cited by 49 · see citing works
Inhibition of the Actions of Peroxisome Proliferator‐activated Receptor α on Obesity by Estrogen
Jeong, S., & Yoon, M. (2007) · Obesity · doi:10.1038/oby.2007.171 · Cited by 46 · see citing works
Self-citationFenofibrate prevents obesity and hypertriglyceridemia in low-density lipoprotein receptor-null mice
Jeong, S., Kim, M. K., Han, M., Lee, H., Ahn, J., Kim, M., Song, Y., Shin, C.-O., Nam, K., Kim, T. W., et al. (2004) · Metabolism · doi:10.1016/j.metabol.2003.12.010 · Cited by 45 · see citing works
Self-citationZeitler, H., Ulrich-Merzenich, G. S., Richter, D. F., Vetter, H., & Walger, P. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9491-1 · Cited by 42 · see citing works
Fibrate treatment does not modify the expression of acyl coenzyme A oxidase in human liver
Roglans, N. (2002) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2002.128605 · Cited by 41 · see citing works
Goldberg, R. B., Belle, P. L., Zupkis, R. V., & Ronca, P. D. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90436-5 · Cited by 40 · see citing works
Cabrero, À., Llaverı́as, G., Roglans, N., Alegret, M., Sánchez, R. M., Adzet, T., Laguna, J. C., & Vázquez‐Carrera, M. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0926 · Cited by 40 · see citing works
Vásquez, M., Roglans, N., Cabrero, À., Rodrı́guez, C., Adzet, T., Alegret, M., Sánchez, R. M., & Laguna, J. C. (2001) · Molecular and Cellular Biochemistry · doi:10.1023/a:1011060615234 · Cited by 33 · see citing works
Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice
Yoon, M., Jeong, S., Lee, H., Han, M., Kang, J. H., Kim, E. Y., Kim, M. K., & Oh, G. T. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00088-3 · Cited by 33 · see citing works
Self-citationBodkin, N. L., Pill, J., Meyer, K., & HANSEN, B. C. (2003) · Hormone and Metabolic Research · doi:10.1055/s-2003-43510 · Cited by 33 · see citing works
Peroxisome proliferator-activated receptors as attractive antiobesity targets
Zhang, F., Lavan, B. E., & Gregoire, F. M. (2004) · Drug News & Perspectives · doi:10.1358/dnp.2004.17.10.873918 · Cited by 31 · see citing works
Tailleux, A., Torpier, G., Mezdour, H., Fruchart, J., Staels, B., & Fiévet, C. (2003) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2003.08.001 · Cited by 28 · see citing works
Defects in substrate oxidation involved in the predisposition to obesity
Astrup, A. V., Buemann, B., Toubro, S., & Raben, A. (1996) · Proceedings of The Nutrition Society · doi:10.1079/pns19960081 · Cited by 27 · see citing works
Replacement Estrogen Use and Body Mass Index
Rodríguez, L. A., Pfaff, G., Schumacher, M. C., Walker, A. M., & Hoffineister, H. (1990) · Epidemiology · doi:10.1097/00001648-199005000-00007 · Cited by 26 · see citing works
Chen, X., Matthews, J. M., Zhou, L., Pelton, P. D., Liang, Y. T., Xu, J. Z., Yang, M., Cryan, E. V., Rybczynski, P. J., & Demarest, K. T. (2008) · Metabolism · doi:10.1016/j.metabol.2008.06.005 · Cited by 24 · see citing works
Estrogen effects on triglyceride metabolism in analbuminemic rats
Shearer, G. C., Joles, J. A., Jones, H. B., Walzem, R. L., & Kaysen, G. A. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00087.x · Cited by 21 · see citing works
Nuñez, S. B., WANG, K., Medin, J. A., Ozato, K., Wahli, W., & Segars, J. H. (1995) · Elsevier eBooks · doi:10.1016/b978-0-12-571150-0.50029-9 · Cited by 18 · see citing works
Mouthiers, A., Baillet, A., Deloménie, C., Porquet, D., & Mejdoubi‐Charef, N. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0188 · Cited by 17 · see citing works
Okamoto, Y., Higashiyama, H., Inoue, H., Kanematsu, M., Kinoshita, M., & Asano, S. (2007) · Pathology International · doi:10.1111/j.1440-1827.2007.02109.x · Cited by 15 · see citing works
Cabrero, À., Alegret, M., Sánchez, R. M., Adzet, T., Laguna, J. C., & Vázquez‐Carrera, M. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1927 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., Chu, S. H., Czajkowski, J., Esko, T., Fall, T., Kilpeläinen, T. O., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005378 · Cited by 664 · see citing works
Limonene: Aroma of innovation in health and disease
Vieira, A. J., Beserra, F. P., de Souza, M. C., Totti, B. M., & Rozza, A. L. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.02.007 · Cited by 388 · see citing works
Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity
Oka, T., Nishimura, Y., Zang, L., Hirano, M., Shimada, Y., Wang, Z., Umemoto, N., Kuroyanagi, J., Nishimura, N., & Tanaka, T. (2010) · BMC Physiology · doi:10.1186/1472-6793-10-21 · Cited by 386 · see citing works
Badmus, O. O., Hillhouse, S. A., Anderson, C. D., Hinds, T. D., & Stec, D. E. (2022) · Clinical Science · doi:10.1042/cs20220572 · Cited by 372 · see citing works
Phthalates: European regulation, chemistry, pharmacokinetic and related toxicity
Ventrice, P., Ventrice, D., Russo, E., & De Sarro, G. (2013) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2013.03.014 · Cited by 333 · see citing works
Harjumäki, R., Pridgeon, C. S., & Ingelman‐Sundberg, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158221 · Cited by 237 · see citing works
Tocmo, R., Peña-Fronteras, J. T., Calumba, K. F., Mendoza, M., & Johnson, J. J. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12561 · Cited by 221 · see citing works
Flavonoids as Antiobesity Agents: A Review
Rufino, A. T., Costa, V. M., Carvalho, F., & Fernandes, E. (2021) · Medicinal Research Reviews · doi:10.1002/med.21740 · Cited by 174 · see citing works
Lu, K., Xu, W., Wang, L., Zhang, D., Zhang, C., & Liu, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093135 · Cited by 175 · see citing works
Ji, H., Li, J., & Pin, L. (2011) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2011.01.009 · Cited by 167 · see citing works
The Role of PPAR α Activation in Liver and Muscle
Burri, L., Thoresen, G. H., & Berge, R. K. (2010) · PPAR Research · doi:10.1155/2010/542359 · Cited by 159 · see citing works
Lu, K., Xu, W., Li, X., Liu, W., Wang, L., & Zhang, C. (2013) · Aquaculture · doi:10.1016/j.aquaculture.2013.06.003 · Cited by 155 · see citing works
Mitochondrial response to nutrient availability and its role in metabolic disease
Gao, A. W., Cantó, C., & Houtkooper, R. H. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303782 · Cited by 148 · see citing works
Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet
Tan, C. K., Leuenberger, N., Tan, M., Yan, Y. W., Chen, Y., Kambadur, R., Wahli, W., & Tan, N. S. (2011) · Diabetes · doi:10.2337/db10-0801 · Cited by 147 · see citing works
Li, J., Zhang, Y., Fan, S., Gu, M., Guan, Y., Lu, X., Huang, C., & Zhou, Z. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.06.022 · Cited by 146 · see citing works
Liu, Q., Pan, R., Ding, L., Zhang, F., Hu, L., Ding, B., Zhu, L., Xia, Y., & Dou, X. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.05.026 · Cited by 144 · see citing works
AIP and its interacting partners
Trivellin, G., & Korbonits, M. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0054 · Cited by 144 · see citing works
Zhou, W., Rahimnejad, S., Lu, K., Wang, L., & Liu, W. (2018) · Fish Physiology and Biochemistry · doi:10.1007/s10695-018-0536-7 · Cited by 141 · see citing works
Tao, C., Sifuentes, A. J., & Holland, W. L. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.11.003 · Cited by 136 · see citing works
Anti-NASH Drug Development Hitches a Lift on PPAR Agonism
Boeckmans, J., Natale, A., Rombaut, M., Buyl, K., Rogiers, V., Kock, J. D., Vanhaecke, T., & Rodrigues, R. M. (2019) · Cells · doi:10.3390/cells9010037 · Cited by 123 · see citing works
Wu, C., Lin, M., Wang, H., Yang, M., Jou, M., & Wang, C. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.02033.x · Cited by 123 · see citing works
Interactions between metabolism and circadian clocks: reciprocal disturbances
Delezie, J., & Challet, É. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06246.x · Cited by 118 · see citing works
Artificial Sweeteners: History and New Concepts on Inflammation
Basson, A. R., Rodriguez‐Palacios, A., & Cominelli, F. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.746247 · Cited by 116 · see citing works
Chemello, F., Bean, C., Cancellara, P., Laveder, P., Reggiani, C., & Lanfranchi, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016807 · Cited by 114 · see citing works
AMPK-Dependent Metabolic Regulation by PPAR Agonists
Lee, W. H., & Kim, S. G. (2010) · PPAR Research · doi:10.1155/2010/549101 · Cited by 114 · see citing works
Kim, B., Farruggia, C., Ku, C. S., Pham, T. X., Yang, Y. J., Bae, M., Wegner, C., Farrell, N., Harness, E., Park, Y., et al. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.01.006 · Cited by 111 · see citing works
Maternal Overweight Programs Insulin and Adiponectin Signaling in the Offspring
Shankar, K., Kang, P., Harrell, A., Zhong, Y., Marecki, J. C., Ronis, M. J. J., & Badger, T. M. (2010) · Endocrinology · doi:10.1210/en.2010-0017 · Cited by 107 · see citing works
Inflammatory Mediators of Hepatic Steatosis
Hijona, E., Hijona, L., Arenas, J. I., & Bujanda, L. (2010) · Mediators of Inflammation · doi:10.1155/2010/837419 · Cited by 108 · see citing works
The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis
Xu, P., Zhai, Y., & Wang, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041260 · Cited by 109 · see citing works
Higuchi, N., Kato, M., Tanaka, M., MIYAZAKI, M., TAKAO, S., Kohjima, M., Kotoh, K., Enjoji, M., Nakamuta, M., & Takayanagi, R. (2011) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2011.328 · Cited by 106 · see citing works
Hu, W., Fitzgerald, M. A., Topp, B. L., Alam, M. M., & O’Hare, T. J. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103520 · Cited by 107 · see citing works
Ding, Q., Cao, F., Lai, S., Zhuge, H., Chang, K., Valencak, T. G., Liu, J., Li, S., & Ren, D. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111259 · Cited by 101 · see citing works
Youssef, D. A., El‐Fayoumi, H. M., & Mahmoud, M. F. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.10.010 · Cited by 97 · see citing works
Montrose, L. B., Padmanabhan, V., Goodrich, J. M., Domino, S. E., Treadwell, M. C., Meeker, J. D., Watkins, D. J., & Dolinoy, D. C. (2018) · Epigenetics · doi:10.1080/15592294.2018.1448680 · Cited by 92 · see citing works
Goyal, A., Tanwar, B., Sihag, M. K., & Sharma, V. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.131459 · Cited by 92 · see citing works
Giammanco, M., Liegro, C. M. D., Schiera, G., & Liegro, I. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114140 · Cited by 89 · see citing works
Emerging Role of Hepatic Ketogenesis in Fatty Liver Disease
Mooli, R. G. R., & Ramakrishnan, S. K. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.946474 · Cited by 84 · see citing works
Sex differences in nuclear receptor-regulated liver metabolic pathways
Rando, G., & Wahli, W. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.023 · Cited by 86 · see citing works
Berardo, C., Pasqua, L. G. D., Cagna, M., Richelmi, P., Vairetti, M., & Ferrigno, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249646 · Cited by 80 · see citing works
Takayanagi, K., Morimoto, S.-I., Shirakura, Y., Mukai, K., Sugiyama, T., Tokuji, Y., & Ohnishi, M. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf202821u · Cited by 78 · see citing works
Wang, W., Zhang, X., Wang, Z., Qin, J., Wang, W., Tian, H., & Ru, S. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.01.163 · Cited by 78 · see citing works
Huang, Q., Ma, C., Chen, L., Luo, D., Chen, R., & Liang, F. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00370 · Cited by 78 · see citing works
Han, S., Jiao, J., Zhang, W., Xu, J., Wan, Z., Zhang, W., Gao, X., & Qin, L. (2015) · Scientific Reports · doi:10.1038/srep15256 · Cited by 77 · see citing works
Linher‐Melville, K., Zantinge, S., Sanli, T., Gerstein, H. C., Tsakiridis, T. K., & Singh, G. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-56 · Cited by 75 · see citing works
Hinds, T. D., Kipp, Z. A., Xu, M., Yiannikouris, F. B., Morris, A. J., Stec, D. F., Wahli, W., & Stec, D. E. (2021) · Cells · doi:10.3390/cells11010004 · Cited by 71 · see citing works
PPAR α in Obesity: Sex Difference and Estrogen Involvement
Yoon, M. (2010) · PPAR Research · doi:10.1155/2010/584296 · Cited by 71 · see citing works
Self-citationLiu, X., Cui, J., Li, Z., Xu, J., Wang, J., Xue, C., & Wang, Y. (2013) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201300407 · Cited by 70 · see citing works
Insight into molecular pathways of retinal metabolism, associated with vitellogenesis in zebrafish
Levi, L., Ziv, T., Admon, A., Levavi‐Sivan, B., & Lubzens, E. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00310.2011 · Cited by 70 · see citing works
Lee, H., Ahn, J., Shin, S. S., & Yoon, M. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0212-0 · Cited by 69 · see citing works
Self-citationWang, C., Guo, Y., Zhou, M., Xue, C., Chang, Y., Zhang, T., & Wang, Y. (2019) · Food & Function · doi:10.1039/c8fo01822g · Cited by 69 · see citing works
Stearoyl-CoA Desaturase: A Vital Checkpoint in the Development and Progression of Obesity
Poudyal, H., & Brown, L. (2011) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153011796429826 · Cited by 64 · see citing works
Direct effects of iodothyronines on excess fat storage in rat hepatocytes
Grasselli, E., Voci, A., Canesi, L., Matteis, R. D., Goglia, F., Cioffi, F., Fugassa, E., Gallo, G., & Vergani, L. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.09.027 · Cited by 64 · see citing works
Template to improve glycemic control without reducing adiposity or dietary fat
Krishnapuram, R., Dhurandhar, E. J., Dubuisson, O. S., Kirk-Ballard, H., Bajpeyi, S., Butte, N. F., SOTHERN, M. S., Larsen-Meyer, E., Chalew, S. A., Bennett, B., et al. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00703.2010 · Cited by 64 · see citing works
A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum
Zhang, Y., Li, B., Cananzi, S. G., Han, C., Wang, L., Zou, Y., Fu, Y., Hon, G. C., & Zhang, C. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107339119 · Cited by 63 · see citing works
Ji, R., Xiang, X., Li, X., Mai, K., & Ai, Q. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520004171 · Cited by 62 · see citing works
Tian, J., Lu, R., Ji, H., Sun, J. H., Li, C., Pin, L., Lei, C., Chen, L., & Du, Z. (2015) · Gene · doi:10.1016/j.gene.2015.04.010 · Cited by 62 · see citing works
Khoo, N. K. H., Sachin Hebbar, C., Zhao, W., Moore, S. A., Domann, F. E., & Robbins, M. E. C. (2013) · Redox Biology · doi:10.1016/j.redox.2012.12.006 · Cited by 62 · see citing works
Wang, W., Zhang, X., Qin, J., Wei, P., Jia, Y., Wang, J., & Ru, S. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.01.020 · Cited by 62 · see citing works
Gao, M., Bu, L., Ma, Y., & Liu, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065641 · Cited by 61 · see citing works
Childs, C. E., Hoile, S. P., Burdge, G. C., & Calder, P. C. (2012) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2012.03.007 · Cited by 60 · see citing works
Multiparity leads to obesity and inflammation in mothers and obesity in male offspring.
Rebholz, S. L., Jones, T., Burke, K. T., Jaeschke, A., Tso, P., D'Alessio, D., & Woollett, L. (2012) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00487.2011 · Cited by 58 · see citing works
Tutunchi, H., Ostadrahimi, A., Saghafi‐Asl, M., Hosseinzadeh‐Attar, M. J., Shakeri, A., Jafarabadi, M. A., Roshanravan, N., Farrin, N., Naemi, M., & Hasankhani, M. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104770 · Cited by 60 · see citing works
Hypoxia via ERK Signaling Inhibits Hepatic PPARα to Promote Fatty Liver
Mooli, R. G. R., Rodriguez, J., Takahashi, S., Solanki, S. A., Gonzalez, F. J., Ramakrishnan, S. K., & Shah, Y. M. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.03.011 · Cited by 59 · see citing works
The Biological Clock: A Pivotal Hub in Non-alcoholic Fatty Liver Disease Pathogenesis
Mazzoccoli, G., Cosmo, S. D., & Mazza, T. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00193 · Cited by 59 · see citing works
Nervonic acid limits weight gain in a mouse model of diet‐induced obesity
Keppley, L. J. W., Walker, S. J., Gademsey, A. N., Smith, J. P., Keller, S. R., KESTER, M. A., & Fox, T. E. (2020) · The FASEB Journal · doi:10.1096/fj.202000525r · Cited by 58 · see citing works
Yeh, Y., Cho, Y.-Y., Hsieh, S., & Chiang, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-19553-1 · Cited by 58 · see citing works
Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states
Kang, H. S., Cho, H., Lee, J., Oh, G. T., Koo, S., Park, B., Lee, I., Choi, H., Song, D., & Im, S. (2016) · Scientific Reports · doi:10.1038/srep23665 · Cited by 56 · see citing works
Cao, X., Liu, W., Zheng, X., Yuan, X., Wang, C., & Jiang, G. (2018) · Aquaculture Nutrition · doi:10.1111/anu.12834 · Cited by 54 · see citing works
Yang, X., Wang, Q., Pang, Z.-R., Pan, M.-R., & Zhang, W. (2017) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1278454 · Cited by 53 · see citing works
Effect of cold stress on the MAPK pathway and lipidomics on muscle of Takifugu fasciatus
Chu, P., Wang, T., Sun, Y., Chu, M., Wang, H. Y., Zheng, X., & Yin, S. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.736691 · Cited by 54 · see citing works
Long, X., Zeng, X., Tan, F., Yi, R., Pan, Y., Zhou, X., Mu, J., & Zhao, X. (2020) · Food & Function · doi:10.1039/d0fo00519c · Cited by 50 · see citing works
Studies of the mechanism of fatty liver formation in Takifugu fasciatus following copper exposure
Wang, T., Wei, X., Chen, T., Wang, W., Xia, X., Jinhan, M., & Yin, S. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.06.013 · Cited by 50 · see citing works
Rebollo, A., Roglans, N., Baena, M., Sánchez, R. M., Merlos, M., Alegret, M., & Laguna, J. C. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.01.002 · Cited by 49 · see citing works
Beattie, J. H., Nicol, F., Gordon, M., Reid, M., Cantlay, L. L., Horgan, G. W., Kwun, I., Ahn, J., & Ha, T. Y. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100193 · Cited by 48 · see citing works
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I. L., Wenz, B. M., Clarke, S. L., Chesi, A., Wells, A. D., et al. (2022) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2022.06.012 · Cited by 47 · see citing works
Tan, S., Li, M., Ding, X., Fan, S., Guo, L., Gu, M., Zhang, Y., Li, F., Jiang, D., Li, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093510 · Cited by 47 · see citing works
AlSaleh, A. F. F., Sanders, T. A. B., & O’Dell, S. D. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665111003181 · Cited by 47 · see citing works
Lago-Fernandez, A., Zarzo-Arias, S., Jagerovic, N., & Morales, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031001 · Cited by 47 · see citing works
Maki, T., Maeda, Y., Sonoda, N., Makimura, H., Kimura, S., Maeno, S., Takayanagi, R., & Inoguchi, T. (2017) · Metabolism · doi:10.1016/j.metabol.2017.02.013 · Cited by 44 · see citing works
Wang, X., Huang, M. H., & Wang, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048069 · Cited by 45 · see citing works
Yin, F., Yu, H., Lepp, D., Shi, X., Yang, X., Hu, J., Leeson, S., Yang, C., Nie, S., Hou, Y., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160751 · Cited by 45 · see citing works
Ispada, J., de Lima, C. B., Sirard, M., Fontes, P. K., Nogueira, M. F. G., Annes, K., & Milazzotto, M. P. (2018) · Epigenetics & Chromatin · doi:10.1186/s13072-017-0171-z · Cited by 45 · see citing works
DNA Methylation Changes Are Associated With an Incremental Ascent to High Altitude
Childebayeva, A., Harman, T. S., Weinstein, J. B., Goodrich, J. M., Dolinoy, D. C., Day, T. A., Bigham, A. W., & Brutsaert, T. D. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01062 · Cited by 45 · see citing works
Sirotina, S., Ponomarenko, I., Харченко, А. В., Быканова, М. А., Бочарова, А. В., Вагайцева, К. В., Степанов, В. А., Churnosov, M. I., Solodilova, M. A., & Polonikov, A. (2018) · Disease Markers · doi:10.1155/2018/5812802 · Cited by 42 · see citing works
Anti-obesity potential of rare sugar d -psicose by regulating lipid metabolism in rats
Chen, J., Huang, W., Zhang, T., Lu, M. P., & Jiang, B. (2018) · Food & Function · doi:10.1039/c8fo01089g · Cited by 42 · see citing works
Impact of brominated flame retardants on lipid metabolism: An in vitro approach
Maia, M. L., Sousa, S., Pestana, D., Faria, A., Teixeira, D., Delerue-Matos, C. M., Domingues, V. F., & Calhau, C. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.118639 · Cited by 42 · see citing works
Kim, J., Lee, H., Lim, J., Oh, J.-H., Shin, S. C., & Yoon, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040846 · Cited by 41 · see citing works
Self-citationRetractedLee, H., Kim, M. K., Shin, S. S., & Yoon, M. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.07.034 · Cited by 40 · see citing works
Self-citationGou, N., Chang, Z., Deng, W. W., Ji, H., & Zhou, J. (2019) · Aquaculture Research · doi:10.1111/are.14295 · Cited by 40 · see citing works
Role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle
Sasaki, T., Nakata, R., Inoue, H., Shimizu, M., Inoue, J., & Sato, R. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2013 · Cited by 39 · see citing works
D-Limonene mitigate myocardial injury in rats through MAPK/ERK/NF-κB pathway inhibition
Younis, N. S. (2020) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2020.24.3.259 · Cited by 38 · see citing works
Pezeshki, H., Rajabi, S., Hashemi, M., Moradalizadeh, S., & Nasab, H. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42782 · Cited by 38 · see citing works
Reduction of Adipose Tissue Mass by the Angiogenesis Inhibitor ALS-L1023 from Melissa officinalis
Park, B. Y., Lee, H., Woo, S., Yoon, M.-S., Kim, J., Hong, Y., Lee, H. S., Park, E. K., Hahm, J. C., Kim, J. W., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141612 · Cited by 39 · see citing works
Self-citationYang, Y., Du, L., Hosokawa, M., & Miyashita, K. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103741 · Cited by 38 · see citing works
Ding, F., Ma, B., Nazary-Vannani, A., Kord‐Varkaneh, H., Fatahi, S., Papageorgiou, M., Rahmani, J., Poursoleiman, F., do Nascimento, I. J. B., Li, H., et al. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.10.002 · Cited by 37 · see citing works
Moraes, J. G. N., Behura, S. K., Geary, T. W., & Spencer, T. E. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz191 · Cited by 37 · see citing works
Zappaterra, M., Gioiosa, S., Chillemi, G., Zambonelli, P., & Davoli, R. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233372 · Cited by 38 · see citing works
Martínez, N., Kurtz, M., Capobianco, E., Higa, R., White, V., & Jawerbaum, A. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-10-0173 · Cited by 37 · see citing works
Benefits of Polyphenols and Methylxanthines from Cocoa Beans on Dietary Metabolic Disorders
Jean-Marie, É., Béreau, D., & Robinson, J.-C. (2021) · Foods · doi:10.3390/foods10092049 · Cited by 36 · see citing works
Wang, J., He, W., Yang, D., Cao, H., Bai, Y., Guo, J., & Su, Z. (2019) · Molecules · doi:10.3390/molecules24244455 · Cited by 36 · see citing works
- Authors
- Yoon, M.
- Affiliations
- Mokwon University (KR)
- Corresponding author
- Yoon, Michung
- ORCID
- Yoon, Michung
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 60
- Issue
- 3
- Pages
- 151-159
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2026756943
- Cited by
- 336
- References
- 155
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 13 · 2023: 23 · 2022: 33 · 2021: 20 · 2020: 27 · 2019: 27 · 2018: 25 · 2017: 15 · 2016: 16 · 2015: 15 · 2014: 18 · 2013: 14 · 2012: 17
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- PPARα, estrogen, obesity, lipid metabolism, fibrates, dyslipidemia, hepatic fatty acid oxidation, triglycerides, HDL cholesterol, sexual dimorphism, postmenopausal women, premenopausal women, lipoprotein metabolism
- MeSH terms
- Animals, Estrogens, Female, Humans, Male, Obesity, PPAR alpha, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review