The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
A rapid micromethod for apolipoprotein E phenotyping directly in serum
Open accessAbstract
A new method for the apolipoprotein E phenotyping has been developed. The method is based on isoelectric focusing of either delipidated or guanidine-HC1-treated serum or plasma in a horizontal slab gel system followed by immunoblotting using either polyclonal or monoclonal anti-apolipoprotein E antibodies as first antibody. Apolipoprotein E phenotyping with this method in 200 serum samples that had been stored at -20 degrees C for more than one year gave exactly the same results as obtained with the conventional method based on isoelectric focusing of delipidated very low density lipoproteins isolated from fresh serum followed by protein staining. Compared with the conventional method, the present method is less laborious because ultracentrifugation to isolate VLDL is not needed; it is suitable for large scale screening purposes; it needs only a few microliters of serum or plasma, and can easily be performed with samples with low concentrations of apolipoprotein E.
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Cites
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Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34954-8 · Cited by 673
Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man
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Polymorphism of apolipoprotein E: Genetics of hyperlipoproteinemia type III
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Cited by
Apolipoprotein E: an important gene and protein to follow in laboratory medicine
Siest, G., Pillot, T., Régis-Bailly, A., Leininger-Muller, B., Steinmetz, J., Galteau, M. M., & Visvikis, S. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.8.1068 · Cited by 347
Matikainen, N., Mänttäri, S., Schweizer, A., Ulvestad, A., Mills, D., Dunning, B. E., Foley, J. E., & Taskinen, M.-R. (2006) · Diabetologia · doi:10.1007/s00125-006-0340-2 · Cited by 336
Defective regulation of triglyceride metabolism by insulin in the liver in NIDDM.
Malmström, R., Packard, C. J., Caslake, M., Bedford, D., Stewart, P., Yki-Järvinen, H., Shepherd, J., & Taskinen, M.-R. (1997) · Diabetologia · doi:10.1007/s001250050700 · Cited by 319
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Characterization of four lipoprotein classes in human cerebrospinal fluid
Koch, S., Donarski, N., Goetze, K., Kreckel, M., Stuerenburg, H.-J., Buhmann, C., & Beisiegel, U. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31605-9 · Cited by 298
Self-citation
Metadata
- Authors
- Havekes, L. M., de Knijff, P., Beisiegel, U., Havinga, J., Smit, M., & Klasen, E.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1987-04
- Volume
- 28
- Issue
- 4
- Pages
- 455-463
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2399967633
- Cited by
- 265
- References
- 23
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Havekes, L. M., de Knijff, P., Beisiegel, U., Havinga, J., Smit, M., & Klasen, E. (1987). A rapid micromethod for apolipoprotein E phenotyping directly in serum. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)38697-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
