Cited by 223Virology and Viral DiseasesInfectious Encephalopathies and EncephalitisGenetics and Neurodevelopmental Disorders

Behavioral consequences of congenital rubella

Chess, Stella, Fernandez, Paulina, Korn, Sam·1978·The Journal of Pediatrics

Abstract

Psychiatric and behavioral consequences of congenital rubella are reported for 243 children studies during the preschool period, and for 205 of these who were re-examined at ages 8 to 9. At preschool 37% were retarded, with the skew toward severe and profound; 15% had reactive behavior disorder and 7% had autism. At school age retardation diminished to 25%, but neurotic problems and behavioral pathology due to neurologic damage both increased. There were two remissions and three new instances of autism.

Integrity signals

Registry

Crossref · 10.1016/s0022-3476(78)80921-4

Cites

22 of 22 references verified0 citation errors · 0 not checkable

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  • Congenital rubella syndrome is associated with a markedly increased incidence of autism, reported as 741 per 10,000 in Chess's preschool sample and later 905 per 10,000.

    “The study reported 18 children with some degree of autism, implying an incidence of 741 cases per 10 000 among the population of CRS children”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Chess, 1978

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Authors
Chess, S., Fernandez, P., & Korn, S.
Corresponding author
Chess, Stella
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
1978-10
Volume
93
Issue
4
Pages
699-703
ISSN
0022-3476 (ISSN-L)
OpenAlex
W2011496335
Cited by
223
References
22
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 8 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 12 · 2014: 11 · 2013: 13 · 2012: 12
FWCI
3.38
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
congenital rubella syndrome, behavioral effects, intellectual disability, autism spectrum disorder, neurobehavioral sequelae, neurologic damage, preschool children, elementary school students, neuropsychiatric outcomes
MeSH terms
Autistic Disorder, Child, Child Behavior Disorders, Child Reactive Disorders, Child, Preschool, Humans, Intellectual Disability, Rubella

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