Behavioral consequences of congenital rubella
Abstract
Psychiatric and behavioral consequences of congenital rubella are reported for 243 children studies during the preschool period, and for 205 of these who were re-examined at ages 8 to 9. At preschool 37% were retarded, with the skew toward severe and profound; 15% had reactive behavior disorder and 7% had autism. At school age retardation diminished to 25%, but neurotic problems and behavioral pathology due to neurologic damage both increased. There were two remissions and three new instances of autism.
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Congenital rubella syndrome is associated with a markedly increased incidence of autism, reported as 741 per 10,000 in Chess's preschool sample and later 905 per 10,000.
“The study reported 18 children with some degree of autism, implying an incidence of 741 cases per 10 000 among the population of CRS children”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Chess, 1978
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VIRAL INFECTIONS OF THE FETUS AND NEONATE
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Psychiatric manifestations of congenital rubella syndrome: A case report and review of literature
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DIAGNOSTIC ISSUES IN THE PERVASIVE DEVELOPMENTAL DISORDERS
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- Authors
- Chess, S., Fernandez, P., & Korn, S.
- Corresponding author
- Chess, Stella
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 1978-10
- Volume
- 93
- Issue
- 4
- Pages
- 699-703
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2011496335
- Cited by
- 223
- References
- 22
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 8 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 12 · 2014: 11 · 2013: 13 · 2012: 12
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- congenital rubella syndrome, behavioral effects, intellectual disability, autism spectrum disorder, neurobehavioral sequelae, neurologic damage, preschool children, elementary school students, neuropsychiatric outcomes
- MeSH terms
- Autistic Disorder, Child, Child Behavior Disorders, Child Reactive Disorders, Child, Preschool, Humans, Intellectual Disability, Rubella
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