Cited by 253Immunotoxicology and immune responsesToxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicals

Prenatal Exposures to Persistent and Non‐Persistent Organic Compounds and Effects on Immune System Development

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Hertz‐Picciotto, Irva, Park, Hye‐Youn, Dostal, Miroslav, Kocan, Anton, Trnovec, Tomas, Sram, Radim·2008·Basic & Clinical Pharmacology & Toxicology

Abstract

Abstract: Immune system development, particularly in the prenatal period, has far‐reaching consequences for health during early childhood, as well as throughout life. Environmental disturbance of the complex balances of Th1 and Th2 response mechanisms can alter that normal development. Dysregulation of this process or an aberrant trajectory or timing of events can result in atopy, asthma, a compromised ability to ward off infection, or other auto‐immune disease. A wide range of chemical, physical and biological agents appear to be capable of disrupting immune development. This MiniReview briefly reviews developmental milestones of the immune system in the prenatal period and early life, and then presents examples of environmentally induced alterations in immune markers. The first example involves a birth cohort study linked to an extensive programme of air pollution monitoring; the analysis shows prenatal ambient polycyclic aromatic hydrocarbons (PAH) and fine particle (PM2.5) exposures to be associated with altered lymphocyte immunophenotypic distributions in cord blood and possible changes in cord serum immunoglobulin E levels. The second example is a study of prenatal‐polychlorinated biphenyl (PCB) exposures and the foetal development of the thymus, the organ responsible for lymphocyte maturation. Mothers with higher serum concentrations of PCBs gave birth to neonates having smaller indices of thymus size. Finally, this report underscores the tight connection between development of the immune system and that of the central nervous system, and the plausibility that disruption of critical events in immune development may play a role in neurobehavioural disorders.

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Crossref · 10.1111/j.1742-7843.2007.00190.x

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Research works printed but not linked: 4

  1. Herr CE, Hertz-Picciotto I, Yap PS et al. Exposure to air pollution in critical time windows and IgE levels in newborns. Occup Environ Med; in press.
  2. Tryphonas H, Feeley M. Polychlorinated bipenyl-induced immunomodulation and human health effects. In: Robertson L, Hansen L (eds). PCBs. University Press of Kentucky, Lexing- ton, KY, 2001;193 -209.
  3. Hertz-Picciotto I, Trnovec T, Kocan A et al. PCB's and early childhood development in Slovakia: study design and back- ground. Fresenius Environ Bull 2003;12:208 -14.
  4. Sonneborn D, Park H-Y, Petrik J et al. Prenatal PCB exposures in Eastern Slovakia modify effects of social factors on birth- weight. Paediatr Perinat Epidemiol; in press.

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Authors
Hertz‐Picciotto, I., Park, H., Dostal, M., Kocan, A., Trnovec, T., & Sram, R.
Affiliations
  • University of California, Davis (US)
  • Slovak Medical University (SK)
Corresponding author
Hertz‐Picciotto, Irva
Venue
Basic & Clinical Pharmacology & Toxicology
Publisher
Wiley
Published
2008-01-22
Volume
102
Issue
2
Pages
146-154
ISSN
  • 1742-7835 (ISSN-L)
  • 1742-7843
OpenAlex
W2146912985
Cited by
253
References
88
Citations by year
2026: 9 · 2025: 8 · 2024: 12 · 2023: 7 · 2022: 7 · 2021: 17 · 2020: 9 · 2019: 11 · 2018: 17 · 2017: 16 · 2016: 9 · 2015: 16 · 2014: 10 · 2013: 21 · 2012: 18
FWCI
1.59
Type
journal article
Language
en
Open access
Locations
  • Basic & Clinical Pharmacology & Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Environmental Protection Agency (R-829388)
  • United States Agency for International Development
  • Health Effects Institute
  • Ministry of Environment
  • National Institutes of Health (ES11269, R01-CA96525)
  • National Cancer Institute (R01 CA96525, R01CA096525)
  • National Institute of Environmental Health Sciences (1 P01-ES11269, P01ES011269, R829388, ES11269)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords
prenatal exposure, persistent organic pollutants, immune system development, Th1/Th2 balance, polycyclic aromatic hydrocarbons, PM2.5, air pollution, polychlorinated biphenyls, thymus development, cord blood lymphocytes, immunoglobulin E, atopy, asthma, neurobehavioral disorders
MeSH terms
Air Pollution, Animals, Autistic Disorder, Environmental Pollutants, Female, Humans, Hypersensitivity, Immune System, Maternal-Fetal Exchange, Polychlorinated Biphenyls, Polycyclic Aromatic Hydrocarbons, Pregnancy, Prenatal Exposure Delayed Effects, Maternal Exposure

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