Cited by 639Gut microbiota and healthInfant Nutrition and HealthProbiotics and Fermented Foods

Development of the gut microbiota in infancy and its impact on health in later life

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Tanaka, Masaru, Nakayama, Jiro·2017·Allergology International

Abstract

Gut microbial ecology and function are dynamic in infancy, but are stabilized in childhood. The 'new friends' have a great impact on the development of the digestive tract and host immune system. In the first year of life, especially, the gut microbiota dramatically changes through interactions with the developing immune system in the gut. The process of establishing the gut microbiota is affected by various environmental factors, with the potential to be a main determinant of life-long health. In this review, we summarize recent findings regarding gut microbiota establishment, including the importance of various factors related to the development of the immune system and allergic diseases later in life.

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Crossref · 10.1016/j.alit.2017.07.010

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  • Diet, together with other factors, appears to have the greatest impact on microbial ecology during the first three years of life.

    “As described in the introduction it is the first three years of life that diet, together with other factors, appears to have the greatest impact on microbial ecology [11].”

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  1. Matsui H, Takahashi T, Øverby A, Murayama SY, Yoshida H, Yamamoto Y, et al. Mouse models for assessing the protective efficacy of Lactobacillus gasseri SBT2055 against Helicobacter suis infection associated with the development of gastric mucosa-associated lymphoid tissue lymphoma. Helicobacter 2015;20:291e8.

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Authors
Tanaka, M., & Nakayama, J.
Affiliations
Kyushu University (JP)
Corresponding author
Nakayama, Jiro
Venue
Allergology International
Publisher
Elsevier BV
Published
2017-10
Volume
66
Issue
4
Pages
515-522
ISSN
1323-8930 (ISSN-L)
OpenAlex
W2746392566
Cited by
639
References
130
Citations by year
2026: 41 · 2025: 69 · 2024: 72 · 2023: 75 · 2022: 99 · 2021: 101 · 2020: 92 · 2019: 62 · 2018: 25 · 2017: 3
FWCI
4.62
Type
journal article
Language
en
Open access
Locations
  • Allergology International (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Japan Society for the Promotion of Science (17H04620, 25304006)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
gut microbiota, infancy, microbial colonization, immune system development, allergic diseases, environmental factors, long-term health, digestive tract development, host-microbe interactions
MeSH terms
Gastrointestinal Microbiome, Age Factors, Animals, Anti-Bacterial Agents, Disease Susceptibility, Food, Health Status, Humans, Hypersensitivity, Immune System, Infant, Infant, Newborn, Milk, Human, Delivery, Obstetric, Biodiversity, Host-Pathogen Interactions, Microbiota

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