Protective effect of melanocortin peptides in rat myocardial ischemia
Open accessAbstract
The influence of the melanocortin peptide ACTH-(1-24) (adrenocorticotropin) on the consequences of short-term coronary ischemia (5 min) followed by reperfusion, and the effect of the long-acting melanocortin [Nle(4),D-Phe(7)]alpha-melanocyte-stimulating hormone (NDP-MSH) on the damage induced by a permanent coronary occlusion, were investigated in anesthetized rats. Ischemia was produced by ligature of the left anterior descending coronary artery. Reperfusion-induced arrhythmias [ventricular tachycardia (VT), ventricular fibrillation (VF)] and survival rate within the 5 min following reperfusion, blood levels of free radicals detected 2 min after reperfusion by electron spin resonance spectrometry, and amount of healthy myocardial tissue, measured 72 h after permanent coronary occlusion on immunohistologically stained serial sections, were evaluated. Postischemic reperfusion induced VT in all saline-treated rats, and VF and death in a high percentage of animals (87%). In rats treated i.v. (2.5 min after coronary occlusion) with ACTH-(1-24) (0.16-0.48 mg/kg) there was a significantly dose-dependent reduction in the incidence of arrhythmias and lethality. Ischemia/reperfusion caused a large increase in free radical blood levels; treatment with ACTH-(1-24) (0.48 mg/kg i.v.) almost completely prevented this increase. In rats subjected to permanent coronary occlusion, the amount of healthy myocardial tissue was much reduced in saline-treated rats, while in rats treated s.c. with NDP-MSH (0.27 mg/kg every 12 h) it was significantly higher. The present data demonstrate, for the first time, an unforeseen property of melanocortin peptides, i.e., their ability to significantly reduce both heart ischemia/reperfusion injury and size of the ischemic area induced by permanent coronary occlusion.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
Theory and Practice of Histological Techniques
Bancroft, J. D., & Gamble, M. (1990) · Cited by 6,986 · see citing works
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399 · see citing works
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211 · see citing works
Apoptosis in the Failing Human Heart
Olivetti, G., Abbi, R., Quaini, F., Kajstura, J., Cheng, W., Nitahara, J. A., Quaini, E., Di Loreto, C., Beltrami, C. A., Krajewski, S., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361603 · Cited by 1,673 · see citing works
Walker, M. J., Curtis, M. J., Hearse, D. J., CAMPBELL, R. W. F., Janse, M. J., Yellon, D. M., Cobbe, S. M., Coker, S. J., Harness, J. B., Harron, D. W. G., et al. (1988) · Cardiovascular Research · doi:10.1093/cvr/22.7.447 · Cited by 1,107 · see citing works
Róna, G. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80130-9 · Cited by 726 · see citing works
Reperfusion-induced arrhythmias: Mechanisms and prevention
MANNING, A. S., & HEARSE, D. (1984) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(84)80638-0 · Cited by 573 · see citing works
Simple Techniques for the Surgical Occlusion of Coronary Vessels in the Rat
Selye, H., Bajusz, E., Grasso, S., et al. (1960) · Angiology · doi:10.1177/000331976001100505 · Cited by 543 · see citing works
Role of leukocytes in response to acute myocardial ischemia and reflow in dogs
Engler, R. L., Dahlgren, M. D., Morris, D., Peterson, M. A., & Schmid‐Schönbein, G. W. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.251.2.h314 · Cited by 507 · see citing works
Schömig, A., Dart, A. M., Dietz, R., et al. (1984) · Circulation Research · doi:10.1161/01.res.55.5.689 · Cited by 368 · see citing works
Anti-inflammatory actions of the neuroimmunomodulator α-MSH
Lipton, J. M., & Catania, A. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01009-8 · Cited by 356 · see citing works
Effect of some free radical scavengers on reperfusion induced arrhythmias in the isolated rat heart
Woodward, B. D., & ZAKARIA, M. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80053-5 · Cited by 239 · see citing works
Modulation of Leukocyte-Mediated Myocardial Reperfusion Injury
Lucchesi, B. R. (1990) · Annual Review of Physiology · doi:10.1146/annurev.ph.52.030190.003021 · Cited by 204 · see citing works
Melanocortin receptors: perspectives for novel drugs
Wikberg, J. E. S. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00298-8 · Cited by 189 · see citing works
Schömig, A., Fischer, S., Kurz, T., Richardt, G., & Schömig, E. (1987) · Circulation Research · doi:10.1161/01.res.60.2.194 · Cited by 178 · see citing works
The Role of α-Melanocyte-Stimulating Hormone in Cutaneous Biology
Luger, T. A., Scholzen, T. E., & Grabbe, S. (1997) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.1997.17 · Cited by 132 · see citing works
Kihara, Y., & Morgan, J. P. (1991) · Circulation Research · doi:10.1161/01.res.68.5.1378 · Cited by 102 · see citing works
Tortólani, A. J., Powell, S. R., Mišı́k, V., et al. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90091-8 · Cited by 100 · see citing works
Bertolini, A., Guarini, S., Rompianesi, E., & Ferrari, W. (1986) · European Journal of Pharmacology · doi:10.1016/0014-2999(86)90179-2 · Cited by 96 · see citing works
Self-citationIn vivo monitoring of myocardial interstitial norepinephrine by dialysis technique
Akiyama, T., Yamazaki, T., & Ninomiya, I. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.261.5.h1643 · Cited by 78 · see citing works
Obata, T., Hosokawa, H., & Yamanaka, Y. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.3.h903 · Cited by 70 · see citing works
The opioid/anti-opioid balance in shock: a new target for therapy in resuscitation
Bertolini, A. (1995) · Resuscitation · doi:10.1016/0300-9572(94)00863-b · Cited by 55 · see citing works
Self-citationReperfusion-induced arrhythmias. A role for washout of extracellular protons?
Avkiran, M., & Ibuki, C. (1992) · Circulation Research · doi:10.1161/01.res.71.6.1429 · Cited by 50 · see citing works
Guarini, S., Bazzani, C., Cainazzo, M. M., Mioni, C., Ferrazza, G., Vergoni, A. V., Schiöth, H. B., Wikberg, J. E. S., & Bertolini, A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35205-x · Cited by 44 · see citing works
Self-citationIschemia And Reperfusion Induced Alterations In Membrane Phospholipids: An Overview a
Vusse, G. J., van Bilsen, M., & Reneman, R. S. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb36712.x · Cited by 42 · see citing works
ACTH-(1–24) restores blood pressure in acute hypovolaemia and haemorrhagic shock in humans
Bertolini, A., Guarini, S., Ferrari, W., et al. (1987) · European Journal of Clinical Pharmacology · doi:10.1007/bf00637684 · Cited by 40 · see citing works
Self-citationResuscitating effect of melanocortin peptides after prolonged respiratory arrest
Guarini, S., Bazzani, C., & Bertolini, A. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701264 · Cited by 39 · see citing works
Self-citationGuarini, S., Bazzani, C., Ricigliano, G. M., Bini, A., Tomasi, A., & Bertolini, A. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15673.x · Cited by 36 · see citing works
Self-citationSquadrito, F., Guarini, S., Altavilla, D., Squadrito, G., Campo, G. M., Arlotta, M., Quartarone, C., Saitta, A., Cucinotta, D., Bazzani, C., et al. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702848 · Cited by 34 · see citing works
Self-citationPeptide Modulation of Inflammatory Processes within the Brain
Lipton, J. M., Catania, A., & Delgado, R. (1998) · NeuroImmunoModulation · doi:10.1159/000026335 · Cited by 33 · see citing works
Adrenocorticotropin normalizes the blood levels of nitric oxide in hemorrhage-shocked rats
Guarini, S., Bini, A., Bazzani, C., Ricigliano, G. M., Cainazzo, M. M., Tomasi, A., & Alfio, B. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01210-7 · Cited by 31 · see citing works
Self-citationLudbrook, J., & Ventura, S. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00003-4 · Cited by 28 · see citing works
[Reperfusion induced arrhythmias].
Chen, Z. (1990) · PubMed · Cited by 27 · see citing works
Haemorrhagic shock in cardiac surgery. Pharmacological treatment with ACTH (1–24)
Noera, G., Angiello, L., Biagi, B., et al. (1991) · Resuscitation · doi:10.1016/0300-9572(91)90002-g · Cited by 26 · see citing works
ACTH-(1-24) and hemorrhagic shock: Preliminary clinical results
Noera, G., Pensa, P., Guelfi, P., et al. (1989) · Resuscitation · doi:10.1016/0300-9572(89)90010-5 · Cited by 26 · see citing works
Preliminary data on the use of ACTH-(1-24) in human shock conditions
Pinelli, G., Chesi, G., Donato, C. D., et al. (1989) · Resuscitation · doi:10.1016/0300-9572(89)90011-7 · Cited by 25 · see citing works
Reperfusion-induced arrhythmias and lethality are reduced by a 2KDa heparin fragment
Guarini, S., Martini, M. C., & Bertolini, A. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02031-d · Cited by 9 · see citing works
Self-citationMANNING, A. S., CROME, R., Klein, N. J., et al. (1989) · Cardiovascular Research · doi:10.1093/cvr/23.10.852 · Cited by 9 · see citing works
Adrenocorticotropin inhibits nitric oxide synthase II mRNA expression in rat macrophages
Altavilla, D., Bazzani, C., Squadrito, F., et al. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00553-1 · Cited by 7 · see citing works
Self-citationGuarini, S., Bazzani, C., Bini, A., Cainazzo, M. M., Tomasi, A., & Bertolini, A. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00244-6 · Cited by 7 · see citing works
Self-citationChenzhong, F., Yixuan, S., & Jiazhen, Z. (1993) · Forensic Science International · doi:10.1016/0379-0738(93)90309-x · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Targeting melanocortin receptors as a novel strategy to control inflammation
Catania, A., Gatti, S., Colombo, G., & Lipton, J. M. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.1.1 · Cited by 438 · see citing works
Mioni, C., Bazzani, C., Giuliani, D., Altavilla, D., Leone, S., Ferrari, A., Minutoli, L., Bitto, A., Marini, H., Zaffe, D., et al. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000186762.05301.13 · Cited by 148 · see citing works
Self-citationRetractedGUARINI, S. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.03.029 · Cited by 131 · see citing works
Self-citationNeuroprotection in focal cerebral ischemia owing to delayed treatment with melanocortins
Giuliani, D., Ottani, A., Mioni, C., Bazzani, C., Galantucci, M., Minutoli, L., Bitto, A., Zaffe, D., Botticelli, A. R., Squadrito, F., et al. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.05.025 · Cited by 44 · see citing works
Self-citationRole of the brain melanocortins in blood pressure regulation
do Carmo, J. M., da Silva, A. A., Wang, Z., Fang, T., Aberdein, N., Perez de Lara, C. E., & Hall, J. E. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.03.003 · Cited by 38 · see citing works
Corander, M. P., Fenech, M., & Coll, A. P. (2009) · Circulation · doi:10.1161/circulationaha.109.854612 · Cited by 31 · see citing works
- Authors
- Bazzani, C., Guarini, S., Botticelli, A. R., Zaffe, D., Tomasi, A., Bini, A., Cainazzo, M. M., Ferrazza, G., Mioni, C., & Bertolini, A.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- Corresponding author
- Guarini, Salvatore
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 297
- Issue
- 3
- Pages
- 1082-1087
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2163741237
- Cited by
- 59
- References
- 41
- Citations by year
- 2025: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- PubMed
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- melanocortin peptides, ACTH1-24, NDP-MSH, myocardial ischemia, ischemia-reperfusion injury, coronary artery occlusion, ventricular arrhythmias, ventricular fibrillation, free radicals, cardioprotection, myocardial infarct size
- MeSH terms
- alpha-MSH, Animals, Arrhythmias, Cardiac, Coronary Disease, Cosyntropin, Dose-Response Relationship, Drug, Drug Administration Schedule, Electrocardiography, Electron Spin Resonance Spectroscopy, Female, Free Radicals, Injections, Intravenous, Injections, Subcutaneous, Male, Neuropeptides, Myocardial Reperfusion, Reperfusion Injury, Survival Rate, Myocardial Ischemia, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
