Science of self-preservation: how melanocortin action in the brain modulates body weight, blood pressure, and ischemic damage
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The melanocortin system also plays an important role in regulating sympathetic nervous system activity and blood pressure besides its effects on food intake and body weight regulation.
“Besides its effects on food intake and body weight regulation, the melanocortin system also plays an important role in regulating SNS activity and BP.”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [2]
Melanocortins play an important role in regulating blood pressure and sympathetic nervous system activity as well as energy balance, glucose and other metabolic functions in humans and experimental animals.
“Melanocortins play an important role in regulating blood pressure (BP) and sympathetic nervous system (SNS) activity as well as energy balance, glucose and other metabolic functions in humans and experimental animals.”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [2]
Administration of melanocortin peptides prevented oxygen release of free radicals in a model of myocardial ischemia/reperfusion.
“Administration of melanocortin peptides prevented oxygen release of free radicals, inflammatory responses, development of severe ventricular arrhythmia, and increased survival in a model of myocardial ischemia/reperfusion [2, 67].”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [2]
Administration of melanocortin peptides prevented inflammatory responses in a model of myocardial ischemia/reperfusion.
“Administration of melanocortin peptides prevented oxygen release of free radicals, inflammatory responses, development of severe ventricular arrhythmia, and increased survival in a model of myocardial ischemia/reperfusion [2, 67].”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [2]
Administration of melanocortin peptides increased survival in a model of myocardial ischemia/reperfusion.
“Administration of melanocortin peptides prevented oxygen release of free radicals, inflammatory responses, development of severe ventricular arrhythmia, and increased survival in a model of myocardial ischemia/reperfusion [2, 67].”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [2]
ACTH, α-MSH and other fragments lacking the C-terminal Arg-Phe sequence may have a life-saving effect in humans and experimental animals in conditions associated with severe tissue hypoxia.
“However, ACTH, α-MSH and other fragments lacking the C-terminal Arg-Phe sequence may also have a life-saving effect in humans and experimental animals in conditions associated with severe tissue hypoxia [2, 67–69].”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [2]
Administration of melanocortin peptides prevented development of severe ventricular arrhythmia in a model of myocardial ischemia/reperfusion.
“Administration of melanocortin peptides prevented oxygen release of free radicals, inflammatory responses, development of severe ventricular arrhythmia, and increased survival in a model of myocardial ischemia/reperfusion [2, 67].”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [2]
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Ottani, A., Galantucci, M., Ardimento, E., Neri, L., Canalini, F., Calevro, A., Zaffe, D., Novellino, E., Grieco, P., Giuliani, D., et al. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.03.005 · Cited by 32 · see citing works
Protective effects of melanocortins on short-term changes in a rat model of traumatic brain injury*
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RetractedMelanocortins protect against multiple organ dysfunction syndrome in mice
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Protective effects of the melanocortin analog NDP-α-MSH in rats undergoing cardiac arrest
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Obesity Drug Update: The Lost Decade?
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Molecular Changes Induced in Rat Liver by Hemorrhage and Effects of Melanocortin Treatment
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Disease Models in Safety Pharmacology
Wallis, R. M. (2022) · Springer eBooks · doi:10.1007/978-3-030-73317-9_88-1
Disease Models in Safety Pharmacology
Wallis, R. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-35529-5_88
- Authors
- Corander, M. P., Fenech, M., & Coll, A. P.
- Affiliations
- University of Cambridge (GB)
- Venue
- Circulation
- Published
- 2009-12
- Volume
- 120
- Issue
- 22
- Pages
- 2260-2268
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC2880450
- OpenAlex
- W2115860315
- Cited by
- 31
- References
- 72
- Citations by year
- 2024: 1 · 2022: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- Wellcome Trust (08478/Z/08/Z, 084748, 73637)
- Medical Research Council (G108/617)
- Topics
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- self-preservation, self-preservation instinct, survival instinct
- MeSH terms
- Blood Pressure, Body Weight, Brain, Humans, Hypertension, Obesity, Reperfusion Injury, Receptors, Melanocortin, Melanocortins
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