Magnetic resonance study of the transmembrane nitrite diffusion

Samouilov, A.; Woldman, Ya.Yu.; Zweier, J.L.; Khramtsov, V.V.

doi:10.1016/j.niox.2006.12.006

Cited by 46Nitric Oxide and Endothelin EffectsLipid Membrane Structure and BehaviorElectron Spin Resonance Studies

Magnetic resonance study of the transmembrane nitrite diffusion

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Samouilov, A., Woldman, Ya.Yu., Zweier, J.L., Khramtsov, V.V.·2007·Nitric Oxide

DOI 10.1016/j.niox.2006.12.006PMC PMC2709508

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Abstract

Nitrite (NO(2)-), being a product of metabolism of both nitric oxide (NO(*)) and nitrate (NO(3)-), can accumulate in tissues and regenerate NO() by several mechanisms. The effect of NO(2)- on ischemia/reperfusion injury was also reported. Nevertheless, the mechanisms of intracellular NO(2)- accumulation are poorly understood. We suggested significant role of nitrite penetration through biological membranes in the form of undissociated nitrous acid (HNO(2)). This hypothesis has been tested using large unilamellar phosphatidylcholine liposomes and several spectroscopic techniques. HNO(2) transport across the phospholipid bilayer of liposomes facilitates proton transfer resulting in intraliposomal acidification, which was measured using pH-sensitive probes. NO(2)(-)-mediated intraliposomal acidification was confirmed by EPR spectroscopy using membrane-impermeable pH-sensitive nitroxide, AMC (2,2,5,5-tetramethyl-1-yloxy-2,5-dihydro-1H-imidazol-3-ium-4-yl)-aminomethanesulfonic acid (pK 5.25), and by (31)P NMR spectroscopy using inorganic phosphate (pK 6.9). Nitrite accumulates inside liposomes in concentration exceeding its concentration in the bulk solution, when initial transmembrane pH gradient (alkaline inside) is applied. Intraliposomal accumulation of NO(2)- was observed by direct measurement using chemiluminescence technique. Perfusion of isolated rat hearts with buffer containing 4 microM NO(2)- was performed. The nitrite concentrations in the effluent and in the tissue, measured after 1 min perfusion, were close, supporting fast penetration of the nitrite through the tissue. Measurements of the nitrite/nitrate showed that total concentration of NO(x) in myocardium increased from initial 7.8 to 24.7 microM after nitrite perfusion. Physiological significance of passive transmembrane transport of NO(2)- and its coupling with intraliposomal acidification are discussed.

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Current perspectives postulate that nitrite diffuses across the plasma membrane by becoming protonated to nitrous acid and, in red cells from some species, by interacting with anion exchanger 1 (AE-1).
“Current perspectives postulate that nitrite diffuses across the plasma membrane by becoming protonated to nitrous acid [97] and, in the context of red cells from some species, by interacting with the anion exchanger 1 (AE-1) [98, 99].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [97]

Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807 · see citing works
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates
Ignarro, L. J., Lippton, H., Edwards, J. C., Baricos, W. H., Hyman, A. L., Kadowitz, P. J., & Gruetter, C. A. (1981) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32738-2 · Cited by 1,633 · cited 1× · see citing works
“Nitrite has been shown to exhibit vasodilatating activity in vitro at high concentrations [1-7].”
Background
Small-volume extrusion apparatus for preparation of large, unilamellar vesicles
MacDonald, R. C., MacDonald, R. I., Menco, B. P. M., Takeshita, K., Subbarao, N. K., & Hu, L. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90295-j · Cited by 1,494 · see citing works
Enzyme-independent formation of nitric oxide in biological tissues
Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788 · see citing works
Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia–reperfusion damage
Webb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608 · cited 1× · see citing works
“Indeed, in some in vitro and in vivo models of infarction, nitrite has been shown to protect against ischemia– reperfusion (I/R) damage [18-20].”
Background
Cardioprotective Function of Inducible Nitric Oxide Synthase and Role of Nitric Oxide in Myocardial Ischemia and Preconditioning: an Overview of a Decade of Research
Bolli, R. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1462 · Cited by 597 · see citing works
The Red Cell Membrane
Marchesi, V. T., Furthmayr, H., & Tomita, M. (1976) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.45.070176.003315 · Cited by 590 · see citing works
Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action
Lauer, T., Preik, M., Rassaf, T., Strauer, B. E., Deussen, A., Feelisch, M., & Kelm, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221381098 · Cited by 585 · see citing works
Spectrophotometric Determination of Serum Nitrite and Nitrate by Copper–Cadmium Alloy
Sastry, K. V. H., Moudgal, R. P., Mohan, J., Tyagi, J. S., & Rao, G. S. C. R. (2002) · Analytical Biochemistry · doi:10.1006/abio.2002.5676 · Cited by 557 · see citing works
Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.
Gruetter, C. A., Gruetter, D. Y., Lyon, J., Kadowitz, P. J., & Ignarro, L. J. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32778-3 · Cited by 533 · see citing works
Role of circulating nitrite and <i>S</i> -nitrosohemoglobin in the regulation of regional blood flow in humans
Gladwin, M. T., Shelhamer, J. H., Schechter, A. N., Pease-Fye, M. E., Waclawiw, M. A., Panza, J. A., Ognibene, F. P., & Cannon, R. O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11482 · Cited by 441 · see citing works
A chemiluminescent technique for the determination of nanomolar concentrations of nitrate and nitrite in seawater
Garside, C. (1982) · Marine Chemistry · doi:10.1016/0304-4203(82)90039-1 · Cited by 341 · see citing works
Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite possible involvement of S-nitrosothiols
Ignarro, L. J., & Gruetter, C. S. (1980) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(80)90297-4 · Cited by 317 · see citing works
Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite
Gruetter, C. A., Kadowitz, P. J., & Ignarro, L. J. (1981) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y81-025 · Cited by 316 · see citing works
Lipopolysaccharide-induced changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors
Tracey, W. R., Tse, J., & Carter, G. (1995) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24521-9 · Cited by 310 · cited 1× · see citing works
“In addition, pathological conditions associated with high levels of stress and inflammation such as sepsis that are accompanied by high levels of NOS induction are also markedly increased nitrite levels [33-35].”
Background
Dietary nitrate in man: friend or foe?
McKnight, G. M., Duncan, C. W., Leifert, C., & Golden, M. H. (1999) · British Journal of Nutrition · doi:10.1017/s000711459900063x · Cited by 300 · see citing works
Characterization of the Magnitude and Kinetics of Xanthine Oxidase-catalyzed Nitrite Reduction
Li, H., Samouilov, A., Liu, X., & Zweier, J. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011648200 · Cited by 280 · see citing works
Self-citation
Myocardial ischemia-reperfusion injury is exacerbated in absence of endothelial cell nitric oxide synthase
Jones, S. P., Girod, W. G., Palazzo, A. J., Granger, D. N., Grisham, M. B., Jourd’heuil, D., Huang, P. L., & Lefer, D. J. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.5.h1567 · Cited by 265 · see citing works
Cardioprotective effects of authentic nitric oxide in myocardial ischemia with reperfusion
Johnson, G., Tsao, P. S., & Lefer, A. M. (1991) · Critical Care Medicine · doi:10.1097/00003246-199102000-00021 · Cited by 217 · see citing works
Effect of Cholesterol on the Water Permeability of Thin Lipid Membranes
Finkelstein, A., & Cass, A. (1967) · Nature · doi:10.1038/216717a0 · Cited by 215 · see citing works
Chemical nature of nitric oxide storage forms in rat vascular tissue
Rodriguez, J., Maloney, R. E., Rassaf, T., Bryan, N. S., & Feelisch, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0234600100 · Cited by 210 · see citing works
Biochemistry and Function of the Plastid Envelope
Douce, R., & Joyard, J. (1990) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.06.110190.001133 · Cited by 207 · see citing works
Decreased nitric-oxide synthase activity causes impaired endothelium-dependent relaxation in the postischemic heart
Giraldez, R. R., Panda, A., Xia, Y., Sanders, S. P., & Zweier, J. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21420 · Cited by 180 · see citing works
Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues
Li, H., Samouilov, A., Liu, X., & Zweier, J. L. (2003) · Biochemistry · doi:10.1021/bi026385a · Cited by 180 · see citing works
Evaluation of the Magnitude and Rate of Nitric Oxide Production from Nitrite in Biological Systems
Samouilov, A., Kuppusamy, P., & Zweier, J. L. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0785 · Cited by 171 · see citing works
Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury
Ma, X. L., Gao, F., Gao-lin, L., Lopez, B. L., Christopher, T. A., Fukuto, J. M., Wink, D. A., & Feelisch, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14617 · Cited by 168 · see citing works
The Role of Nitric Oxide in Endotoxic Shock: Effects of NG-Monomethyl-L-Arginine
Nava, E., Palmer, R. M. J., & Moncada, S. (1992) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199204002-00037 · Cited by 156 · see citing works
NO adducts in mammalian red blood cells: too much or too little?
Rassaf, T., Bryan, N. S., Maloney, R. E., Specian, V., Kelm, M., Kalyanaraman, B., Rodriguez, J., & Feelisch, M. (2003) · Nature Medicine · doi:10.1038/nm0503-481 · Cited by 151 · see citing works
Direct measurement of nitric oxide generation from nitric oxide synthase
Xia, Y., & Zweier, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12705 · Cited by 136 · see citing works
Proton translocation and the respiratory nitrate reductase of Escherichia coli
Garland, P. B., Downie, J. A., & Haddock, B. A. (1975) · Biochemical Journal · doi:10.1042/bj1520547 · Cited by 117 · see citing works
Interactions of light and sodium nitrite in producing relaxation of rabbit aorta.
Matsunaga, K., & Furchgott, R. F. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23756-9 · Cited by 117 · see citing works
Infarct Size and Nitric Oxide Synthase in Murine Myocardium
Sumeray, M. S., Rees, D., & Yellon, D. M. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1999.1050 · Cited by 109 · see citing works
Cardioprotective effects of acidified sodium nitrite in myocardial ischemia with reperfusion
Johnson, G., Tsao, P. S., Mulloy, D., & Lefer, A. M. (1990) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13354-5 · Cited by 104 · cited 1× · see citing works
“Indeed, in some in vitro and in vivo models of infarction, nitrite has been shown to protect against ischemia– reperfusion (I/R) damage [18-20].”
Background
Inhibition of Nitric Oxide Synthase in Experimental Gram-Negative Sepsis
Evans, T. G., Carpenter, A., Silva, A., & Cohen, J. (1994) · The Journal of Infectious Diseases · doi:10.1093/infdis/169.2.343 · Cited by 93 · see citing works
Effect of Cold Acclimation on the Lipid Composition of the Inner and Outer Membrane of the Chloroplast Envelope Isolated from Rye Leaves
Uemura, M., & Steponkus, P. L. (1997) · PLANT PHYSIOLOGY · doi:10.1104/pp.114.4.1493 · Cited by 89 · see citing works
Nitrosyl-Heme Complexes Are Formed in the Ischemic Heart
Tiravanti, E., Samouilov, A., & Zweier, J. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311908200 · Cited by 67 · see citing works
Nitrite Transport in Chloroplast Inner Envelope Vesicles (I. Direct Measurement of Proton-Linked Transport)
Shingles, R., Roh, M. H., & McCarty, R. E. (1996) · PLANT PHYSIOLOGY · doi:10.1104/pp.112.3.1375 · Cited by 64 · see citing works
Photosynthesis of leaf cell protoplasts and permeability of the plasmalemma to some solutes
Kaiser, G., & Heber, U. (1983) · Planta · doi:10.1007/bf00397204 · Cited by 48 · see citing works
Role of endothelin, nitric oxide and L-arginine release in ischaemia/reperfusion injury of rat heart
Brünner, F. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00138-7 · Cited by 45 · see citing works
Direct Measurement of Nitrite Transport Across Erythrocyte Membrane Vesicles Using the Fluorescent Probe, 6-Methoxy-N-(3-sulfopropyl) quinolinium
Shingles, R., Roh, M. H., & McCarty, R. E. (1997) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1022491220299 · Cited by 43 · see citing works
Diffusion of Nitrite and Nitrate Salts in Pork Tissue in the Presence of Sodium Chloride
Pinotti, A. N., Graiver, N., Califano, A. N., & Zaritzky, N. (2002) · Journal of Food Science · doi:10.1111/j.1365-2621.2002.tb09521.x · Cited by 42 · see citing works
Exogenous GTP Enhances the Effects of Sodium Nitrite on Cyclic GMP Accumulation, Vascular Smooth Muscle Relaxation and Platelet Aggregation
Laustiola, K., Vuorinen, P., Pörsti, I. H., Metsä‐Ketelä, T., Manninen, V., & Vapaatalo, H. (1991) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1991.tb01209.x · Cited by 36 · see citing works
Conversion of metmyoglobin to NO myoglobin in the presence of nitrite and reductants
Nakamura, M., & Nakamura, S. (1996) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(95)00161-1 · Cited by 35 · see citing works
Relation of Cyclic Nucleotide Ratios to Ischemic and Reperfusion Injury in Nitric Oxide–Donor Treated Rat Hearts
Toit, E. F. D., Meiring, J., & Opie, L. H. (2001) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200110000-00005 · Cited by 30 · see citing works
Nitrite transport into pig erythrocytes and its potential biological role
Jensen, F. B. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2005.01448.x · Cited by 28 · see citing works
Lack of influence of dietary nitrate/nitrite on plasma nitrotyrosine levels measured using a competitive inhibition of binding ELISA assay
Oldreive, C., Bradley, N. J., Bruckdorfer, R. K., & Rice-Evans, C. A. (2001) · Free Radical Research · doi:10.1080/10715760100300891 · Cited by 23 · see citing works
A comparison of the effects of hydrallazine, diazoxide, sodium nitrite and sodium nitroprusside on human isolated arteries and veins.
Moulds, R., Jauernig, R. A., & Shaw, J. (1981) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1981.tb01102.x · Cited by 20 · see citing works
ESR study of proton transport across phospholipid vesicle membranes
Khramtsov, V. V., Panteleev, M. V., & Weiner, L. M. (1989) · Journal of Biochemical and Biophysical Methods · doi:10.1016/0165-022x(89)90008-0 · Cited by 20 · see citing works
New pH-sensitive aminoxyls: application to the study of biomembrane transport processes
Balakirev, M. Y., & Khramtsov, V. V. (1993) · Journal of the Chemical Society Perkin Transactions 2 · doi:10.1039/p29930002157 · Cited by 14 · see citing works
Does intragastric nitrite concentration reflect gastric carcinogenesis in Japanese Helicobacter pylori-infected patients?
Tari, A., Kodama, K., Sumii, M., Tani, H., Sumii, K., & Chayama, K. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1025438827070 · Cited by 13 · see citing works
Is apoptosis in antral mucosa correlated with serum nitrite concentration in Japanese Helicobacter pylori‐infected patients?
Tari, A., Kodama, K., Kitadai, Y., OHTA, M., Sumii, K., & Kajiyama, G. (2003) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2003.03013.x · Cited by 11 · see citing works
Does Serum Nitrite Concentration Reflect Gastric Carcinogenesis in Japanese Helicobacter pylori-Infected Patients?
Tari, A., Kodama, K., Kurihara, K., Fujihara, M., Sumii, K., & Kajiyama, G. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1013271605493 · Cited by 10 · see citing works
Left Ventricular Function After Extended Hypothermic Preservation of the Heart Is Dependent on Functional Coronary Capillarity
Manciet, L. H., Fox, K. A., Copeland, J. G., Wilson, D. S., Reimer, P. R., & McDonagh, P. F. (1995) · Circulation · doi:10.1161/01.cir.92.9.372 · Cited by 9 · see citing works
The reaction of myohaemiglobin and nitrite
Asendelft, O. W. V. (1965) · Clinica Chimica Acta · doi:10.1016/0009-8981(65)90170-1 · Cited by 6 · see citing works
Interaction of nitrite with haems and related compounds.
Bonnett, R., & Martin, R. A. (1976) · PubMed · Cited by 5 · see citing works

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1 of the 56 references couldn’t be matched to a known paper.

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van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435 · see citing works
How biology handles nitrite
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401 · see citing works
The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway
Kapil, V., Khambata, R. S., Jones, D. A., Rathod, K., Primus, C., Massimo, G., Fukuto, J. M., & Ahluwalia, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019240 · Cited by 248 · see citing works
Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health
Kapil, V., Weitzberg, E., Lundberg, J. O., & Ahluwalia, A. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.03.162 · Cited by 126 · see citing works
Platelet Inhibition by Nitrite Is Dependent on Erythrocytes and Deoxygenation
Srihirun, S., Sriwantana, T., Unchern, S., Kittikool, D., Noulsri, E., Pattanapanyasat, K., Fucharoen, S., Piknova, B., Schechter, A. N., & Sibmooh, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030380 · Cited by 109 · see citing works
The complex contribution of NOS interneurons in the physiology of cerebrovascular regulation
Duchemin, S., Boily, M., Sadekova, N., & Girouard, H. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00051 · Cited by 83 · see citing works
Nitric oxide metabolites in goldfish under normoxic and hypoxic conditions
Hansen, M. N., & Jensen, F. B. (2010) · Journal of Experimental Biology · doi:10.1242/jeb.048140 · Cited by 70 · see citing works
The potential role of the red blood cell in nitrite-dependent regulation of blood flow
Patel, R. P., Hogg, N., & Kim-Shapiro, D. B. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq323 · Cited by 70 · see citing works
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Hong, H., Sun, J., & Cai, W. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.06.011 · Cited by 68 · see citing works
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Hendgen-Cotta, U. B., Kelm, M., & Rassaf, T. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.005 · Cited by 67 · see citing works
Comparative analysis of nitrite uptake and hemoglobin–nitrite reactions in erythrocytes: sorting out uptake mechanisms and oxygenation dependencies
Jensen, F. B., & Rohde, S. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00813.2009 · Cited by 63 · see citing works
Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation
Vitturi, D. A., Teng, X., Toledo, J. C., Matalon, S., Lancaster, J. R., & Patel, R. P. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01303.2008 · Cited by 62 · see citing works
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Lim, N. Y. N., Frostegård, Å., & Bakken, L. R. (2018) · Soil Biology and Biochemistry · doi:10.1016/j.soilbio.2018.01.006 · Cited by 61 · see citing works
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Woldman, Y. Y., Semenov, S. V., Bobko, A. A., Kirilyuk, I. A., Polienko, Y. F., Voinov, M. A., Bagryanskaya, E. G., & Khramtsov, V. V. (2009) · The Analyst · doi:10.1039/b818184e · Cited by 29 · see citing works
Molecular Underpinnings of Nitrite Effect on CymA-Dependent Respiration in Shewanella oneidensis
Jin, M., Fu, H., Yin, J., Yuan, J., & Gao, H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01154 · Cited by 25 · see citing works
Nitric Oxide and Cerebrovascular Regulation
Tabatabaei, S. N., & Girouard, H. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800254-4.00014-3 · Cited by 18 · see citing works
Plasma-Activated Water (PAW) Decontamination of Foodborne Bacteria in Shucked Oyster Meats Using a Compact Flow-Through Generator
Thana, P., Boonyawan, D., Jaikua, M., Promsart, W., Rueangwong, A., Ungwiwatkul, S., Prasertboonyai, K., & Maitip, J. (2025) · Foods · doi:10.3390/foods14091502 · Cited by 17 · see citing works
Quantifying proton-induced membrane polarization in single biomimetic giant vesicles
Tivony, R., Fletcher, M. F., & Keyser, U. F. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.05.041 · Cited by 14 · see citing works
Achromobacter denitrificans Strain YD35 Pyruvate Dehydrogenase Controls NADH Production To Allow Tolerance to Extremely High Nitrite Levels
Doi, Y., Shimizu, M., Fujita, T., Nakamura, A., Takizawa, N., & Takaya, N. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.03316-13 · Cited by 14 · see citing works
A Common Target of Nitrite and Nitric Oxide for Respiration Inhibition in Bacteria
Wang, W., Wang, J., Feng, X., & Gao, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213841 · Cited by 12 · see citing works
Dietary Nitrate Supplementation Increases Nitrate and Nitrite Concentrations in Human Skin Interstitial Fluid
Fujii, N., Omori, S., Kataoka, Y., Maimaituxun, G., Bailey, S. J., Lloyd, A. B., Arnold, J. T., Amano, T., Tanabe, Y., Omi, N., et al. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.02.003 · Cited by 8 · see citing works
Nitric oxide affects immune cells bioenergetics
Hammami, I., Bertrand, M., Chen, J., Bronte, V., Crescenzo, G. D., & Jolicœur, M. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.05.005 · Cited by 5 · see citing works
The Quest to Quantify Selective and Synergistic Effects of Plasma for Cancer Treatment: Insights from Mathematical Modeling
Bengtson, C., & Bogaerts, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22095033 · Cited by 6 · see citing works
Acute hypoxia-induced depletion of striatal nitric oxide synthase pathway
Molina, F., Rus, A., Pedrosa, J. Á., & del Moral, M. L. (2012) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2012.12.003 · Cited by 5 · see citing works
Kinetic plasticity of nitrite-oxidizing bacteria containing cytoplasmic nitrite oxidoreductase
Lee, U.-J., Gwak, J.-H., Abiola, C., Lee, S., Yoo, J.-S., Si, O., Cho, H. J., Lu, Z., Kitzinger, K., Daims, H., et al. (2026) · The ISME Journal · doi:10.1093/ismejo/wrag040 · Cited by 4 · see citing works
Fetal-maternal nitrite exchange in sheep: Experimental data, a computational model and an estimate of placental nitrite permeability
Schroeder, H. J., Kanda, E., Power, G. G., & Blood, A. B. (2015) · Placenta · doi:10.1016/j.placenta.2015.12.009 · Cited by 3 · see citing works
Brine Enriched with Olive Wastewater Phenols: A Green Strategy to Reduce Nitrites in Cooked Ham
Mercatante, D., Balzan, S., Esposto, S., Barbieri, S., Fontana, F., Fasolato, L., Rosa, V. D., Servili, M., Taticchi, A., Novelli, E., et al. (2025) · Antioxidants · doi:10.3390/antiox14091124 · Cited by 2 · see citing works
Inhibition of Nitric Oxide Synthase Gene Expression: In vivo Imaging Approaches of Nitric Oxide with Multimodal Imaging
Sharma, R. D. (2012) · InTech eBooks · doi:10.5772/39137 · Cited by 2 · see citing works
Dual nitrogen species involved in foliar uptake of nitrogen dioxide in Arabidopsis thaliana
Takahashi, M., Arimura, G., & Morikawa, H. (2019) · Plant Signaling & Behavior · doi:10.1080/15592324.2019.1582263 · Cited by 2 · see citing works
Positron Emission Tomography of Nitric Oxide by a Specific Radical-Generating Dihydropyridine Tracer
Zhang, K., Li, H., Wu, X., Zhang, D., & Li, Z. (2024) · ACS Sensors · doi:10.1021/acssensors.4c00453 · Cited by 1 · see citing works
Methane bioactivity and interactions with other biological gases
Mészáros, A. (2017) · doi:10.14232/phd.3592
Avaliação do papel da xantina oxidoredutase gastroentérica no efeito hipotensor do nitrito de sódio
Medeiros, C. F. D. A. (2021) · doi:10.11606/d.17.2021.tde-04082021-124450
Nitrato de sódio atenua os efeitos anti-hipertensivos e vasorelaxantes exercidos pelo nitrito de sódio
de Angelis, C. D. (2018) · doi:10.47749/t/unicamp.2018.1082196
Amino Acid Profiles and Nitrogen-to-Protein Conversion Factors of Commercially Available Chlorellaceae Biomasses: Chlorella Vulgaris, Chlorella Sorokiniana and Auxenochlorella ProtothecoidesPreprint
Sägesser, C., Kallfelz, J. M., Boulos, S., Hammer, L., Böcker, L., Portmann, R., Nyström, L., & Mathys, A. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4569072
Étude métabolique des cellules myéloïdes suppressives dans le contexte du phénomène d'immunosuppression
Hammami, I. (2011) · PolyPublie (École Polytechnique de Montréal)
Investigating the role of nitric oxide clones in cardiovascular conditions
Arif, S. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)

Water permeability of bilipid membranes in presence of nitric acid and nitrogen dioxide
Jellinek, H. H. G., & Nadolski, P. (1976) · Colloid & Polymer Science · doi:10.1007/bf01775409
Permeability of Nitric Oxide through Lipid Bilayer Membranes
Subczynski, W. K., Łomnicka, M., & Hyde, J. S. (1996) · Free Radical Research · doi:10.3109/10715769609088032 · Cited by 129 · see citing works
Molecular dynamics investigation of nitric oxide (II) interaction with a model biological membrane
Mamonov, A. A., Стефанов, В. Е., & Щеголев, Б. Ф. (2009) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s1990747809020172 · Cited by 6 · see citing works
Membrane “Lens” Effect: Focusing the Formation of Reactive Nitrogen Oxides from the •NO/O2 Reaction
Möller, M. N., Li, Q., Vitturi, D. A., Robinson, J. M., Lancaster, J. R., & Denicola, A. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700010h · Cited by 98 · see citing works
Permeation of Phospholipid Membranes by Peroxynitrite
Khairutdinov, R. F., Coddington, J. W., & Hurst, J. K. (2000) · Biochemistry · doi:10.1021/bi001270x · Cited by 68 · see citing works

Authors: Samouilov, A., Woldman, Y. Y., Zweier, J. L., & Khramtsov, V. V.
Affiliations: The Ohio State University Wexner Medical Center (US)
Valdosta State University (US)
The Ohio State University (US)
Corresponding author: Samouilov, A.
ORCID: Samouilov, A.
Zweier, J.L.
Khramtsov, V.V.
Venue: Nitric Oxide
Publisher: Elsevier BV
Published: 2007-05
Volume: 16
Issue: 3
Pages: 362-370
ISSN: 1089-8603 (ISSN-L)
DOI: 10.1016/j.niox.2006.12.006
PMC: PMC2709508
OpenAlex: W2062788178
Cited by: 46
References: 56
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 7
FWCI: 1.79
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Nitric Oxide (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL063744, HL 65608, P01HL065608, HL 63744, HL38324-05, R01HL038324)
National Institute of Biomedical Imaging and Bioengineering (K01EB003519, K01 EB03519)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electron Spin Resonance Studies
Keywords: nitrite, membrane diffusion, proton transfer, phosphatidylcholine liposomes, nitrate, myocardium, ischemia-reperfusion injury, passive transport
MeSH terms: Animals, Cell Membrane, Diffusion, Electron Spin Resonance Spectroscopy, Female, Hydrogen-Ion Concentration, Liposomes, Myocardium, Nitrites, Phospholipids, Molecular Structure, Rats, Sprague-Dawley, Nuclear Magnetic Resonance, Biomolecular, Rats

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Magnetic resonance study of the transmembrane nitrite diffusion

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