Neurochemical and behavioral effects of corticotropin-releasing factor in the ventral tegmental area of the rat

Kalivas, P W; Duffy, P; Latimer, L G

doi:10.1016/s0022-3565(25)39170-6

Cited by 137Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Neurochemical and behavioral effects of corticotropin-releasing factor in the ventral tegmental area of the rat

Kalivas, P W, Duffy, P, Latimer, L G·1987·The Journal of Pharmacology and Experimental Therapeutics

DOI 10.1016/s0022-3565(25)39170-6

Open this paper in CoChat — free account

Abstract

Corticotropin-releasing factor (CRF) is thought to have a neurotransmitter function in the mammalian central nervous system. The release of CRF into the hypothalamic-hypophyseal portal system in response to stress is known, and it has been suggested that CRF may function elsewhere in the central nervous system to promote stress-induced physiological and behavioral changes. Acute stress has been shown to activate dopamine (DA) neurons in the ventral tegmental area (VTA) that project to the prefrontal cortex. To determine whether CRF may act in the VTA to activate the mesocortical or mesolimbic DA systems, it was injected into the VTA of rats, and changes in spontaneous motor behavior and DA metabolism were measured. Intra-VTA injection of CRF produced a dose-dependent increase in horizontal and vertical photocell counts with a minimal effective dose of 0.01 and 0.1 nmol, respectively. In contrast, the minimal effective dose for CRF-stimulated motor behavior after injection into the lateral ventricles was 0.3 nmol for horizontal activity. Furthermore, in the open field, the behavioral profile of CRF (0.3 nmol) given intra-VTA differed from that observed after intraventricular injection. The motor stimulant effect of intra-VTA CRF was not blocked by pretreatment with the DA receptor antagonist haloperidol. After intra-VTA injection, CRF produced a dose-dependent decrease in DA metabolism in the prefrontal cortex. The decrease in DA metabolism in the prefrontal cortex was present at 30 and 60 min but not at 120 min after injection, and in the nucleus accumbens DA metabolism was increased only at 60 min after injection.(ABSTRACT TRUNCATED AT 250 WORDS)

Integrity signals

Registry

Crossref · 10.1016/s0022-3565(25)39170-6

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

After birth, CRF and glucocorticoids can potentiate dopamine release.
“Postnatally, CRF and glucocorticoids can potentiate dopamine release (Bagosi et al., 2006; Kalivas et al., 1987; Piazza et al., 1996).”
From The effects of early life stress on reward processing (2018) · cites this paper as Kalivas et al., 1987

Sorted by citations

Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · see citing works
Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?
Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352 · see citing works
Psychobiologic mechanisms of posttraumatic stress disorder.
Charney, D., Deutch, A., Krystal, J., Southwick, S., & Davis, M. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820160064008 · Cited by 610 · see citing works
Stress-induced reinstatement of drug seeking: 20 years of progress
Mantsch, J. R., Baker, D. A., Funk, D., Lê, A. D., & Shaham, Y. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.142 · Cited by 438 · see citing works
Corticotropin-releasing factor produces fear-enhancing and behavioral activating effects following infusion into the locus coeruleus
Butler, P., Weiss, J., Stout, J., & Nemeroff, C. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-01-00176.1990 · Cited by 402 · see citing works
Corticotropin-releasing factor receptors: Physiology, pharmacology, biochemistry and role in central nervous system and immune disorders
Souza, E. B. D. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(95)00011-9 · Cited by 397 · see citing works
Cocaine Experience Establishes Control of Midbrain Glutamate and Dopamine by Corticotropin-Releasing Factor: A Role in Stress-Induced Relapse to Drug Seeking
Wang, B., Shaham, Y., Zitzman, D., Azari, S., Wise, R. A., & You, Z.-B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0955-05.2005 · Cited by 369 · see citing works
“, 2004), stimulate locomotion and the mesocorticolimbic dopamine system (Kalivas et al., 1987), a system that is also implicated in drug reward (Wise and Bozarth, 1987) and drug-seeking behavior (Stewart, 1984).”
BackgroundInfluential
Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action
Heinrichs, S. C., Pich, E. M., Miczek, K. A., Britton, K. T., & Koob, G. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)90708-h · Cited by 329 · see citing works
Corticotropin-releasing hormone receptor subtypes and emotion
Steckler, T., & Holsboer, F. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00170-5 · Cited by 323 · see citing works
Corticotropin-Releasing Factor, But Not Corticosterone, Is Involved in Stress-Induced Relapse to Heroin-Seeking in Rats
Shaham, Y., Funk, D., Erb, S., Brown, T. J., Walker, C.-D., & Stewart, J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02605.1997 · Cited by 308 · see citing works
“Previous studies have shown that CRF induces sensitization to the locomotor activating effects of d-amphetamine (Cador et al., 1993) and increases DA utilization in the prefrontal cortex and the nucleus accumbens (Dunn and Berridge, 1987; Lavicky and Dunn, 1993; but see Kalivas et al., 1987).”
Background
Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive
Lemos, J. C., Wanat, M. J., Smith, J. S., Reyes, B. A. S., Hollon, N. G., Bockstaele, E. J. V., Chavkin, C., & Phillips, P. E. M. (2012) · Nature · doi:10.1038/nature11436 · Cited by 304 · see citing works
The Corticotropin-Releasing Factor Family: Physiology of the Stress Response.
Deussing, J., & Chen, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2017 · Cited by 234 · see citing works
Corticotropin‐releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C‐dependent enhancement of<i>I</i><sub>h</sub>
Wanat, M. J., Hopf, F. W., Stuber, G. D., Phillips, P. E. M., & Bonci, A. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.150078 · Cited by 256 · see citing works
“2000) or directly into the VTA (Kalivas et al. 1987) increases locomotor activity, and the effect of ventricular infusions of CRF on motor activity is absent in CRF-R1−/– mice (Contarino et al.”
Accumbal dopamine and serotonin in anticipation of the next aggressive episode in rats
Ferrari, P. F., van Erp, A. M. M., Tornatzky, W., & Miczek, K. A. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02447.x · Cited by 256 · see citing works
Region-specific roles of the corticotropin-releasing factor–urocortin system in stress
Henckens, M. J. A. G., Deussing, J. M., & Chen, A. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.94 · Cited by 245 · see citing works
The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress**This research was supported by NIMH Grant MH-50479 and the Undergraduate Research Opportunities Program at the University of Colorado at Boulder.
Deak, T., Nguyen, K. T., Ehrlich, A. L., Watkins, L. R., Spencer, R. L., Maier, S. F., Licinio, J., Wong, M.-L., Chrousos, G. P., Webster, E., et al. (1999) · Endocrinology · doi:10.1210/endo.140.1.6415 · Cited by 242 · see citing works
Chapter 19 The determinants of stress-induced activation of the prefrontal cortical dopamine system
(1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62691-6 · Cited by 364 · see citing works
Influence of novel versus home environments on sensitization to the psychomotor stimulant effects of cocaine and amphetamine
Badiani, A., Browman, K. E., & Robinson, T. E. (1995) · Brain Research · doi:10.1016/0006-8993(95)00028-o · Cited by 204 · see citing works
The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192 · see citing works
“Postnatally, CRF and glucocorticoids can potentiate dopamine release (Bagosi et al., 2006; Kalivas et al., 1987; Piazza et al., 1996).”
Background
Attenuation of stress-induced behavior by antagonism of corticotropin-releasing factor receptors in the central amygdala in the rat
Swiergiel, A. H., Takahashi, L. K., & Kalin, N. H. (1993) · Brain Research · doi:10.1016/0006-8993(93)91432-r · Cited by 199 · see citing works
Corticotropin-releasing factor projections from limbic forebrain and paraventricular nucleus of the hypothalamus to the region of the ventral tegmental area
Rodaros, D., Caruana, D. A., Amir, S., & Stewart, J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.043 · Cited by 194 · see citing works
Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems
George, O., Le Moal, M., & Koob, G. F. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.11.004 · Cited by 184 · see citing works
The CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response
Dedic, N., Chen, A., & Deussing, J. M. (2017) · Current Molecular Pharmacology · doi:10.2174/1874467210666170302104053 · Cited by 181 · see citing works
“Accordingly, CRF was shown to increase dopamine neuron firing and dopamine release [106, 150-155], although opposite results were also observed depending on the study-design and the investigated release sites [150, 151].”
Result
Corticotropin‐Releasing Factor Stimulates Catecholamine Release in Hypothalamus and Prefrontal Cortex in Freely Moving Rats as Assessed by Microdialysis
Lavický, J., & Dunn, A. J. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03191.x · Cited by 176 · see citing works
Drug-induced neurobehavioral plasticity: the role of environmental context
Badiani, A., & Robinson, T. E. (2004) · Behavioural Pharmacology · doi:10.1097/00008877-200409000-00004 · Cited by 168 · see citing works
Effects of arousal‐ and feeding‐related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat
Korotkova, T. M., Brown, R. E., Sergeeva, O. A., Ponomarenko, A. A., & Haas, H. L. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04792.x · Cited by 162 · see citing works
“…(NMDA) receptor-mediated synaptic transmission in dopamine neurons in the VTA (Ungless et al., 2003); intraVTA injection of CRF produced an increase in spontaneous motor activity in rats (Kalivas et al., 1987) and foot-shock stress caused a release of CRF in the VTA (Wang et al., 2005).”
Background
The Role of CRF in Behavioral Aspects of Stress
Heinrichs, S. C., Menzaghi, F., Pich, E. M., Britton, K. T., & Koob, G. F. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44673.x · Cited by 160 · see citing works
Regulation of behavioral responses by corticotropin-releasing factor
Lowry, C. A., & Moore, F. L. (2006) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2005.12.006 · Cited by 156 · see citing works
Feelings about food: the ventral tegmental area in food reward and emotional eating
Meye, F. J., & Adan, R. A. H. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.11.003 · Cited by 156 · see citing works
VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation
Grieder, T. E., Herman, M. A., Contet, C., Tan, L. A., Vargas-Pérez, H., Cohen, A., Chwalek, M., Maal‐Bared, G., Freiling, J., Schlosburg, J. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3872 · Cited by 132 · see citing works
Corticotropin-Releasing Factor Receptors CRF1and CRF2Exert Both Additive and Opposing Influences on Defensive Startle Behavior
Risbrough, V. B., Hauger, R. L., Roberts, A. L., Vale, W., & Geyer, M. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5760-03.2004 · Cited by 123 · see citing works
“For example, CRF infusion into the ventral tegmentum significantly increased dopamine turnover in the nucleus accumbens (Kalivas et al., 1987), a brain region in which increased dopamine release disrupts PPI (Swerdlow et al.”
From Malthus to motive: How the HPA axis engineers the phenotype, yoking needs to wants
Pecoraro, N. C., Dallman, M. F., Warne, J. P., Ginsberg, A. B., Laugero, K. D., la Fleur, S. E., Houshyar, H., Gómez-Oliver, F., Bhargava, A., & Akana, S. F. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.07.004 · Cited by 120 · see citing works
CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors
Wanat, M. J., Bonci, A., & Phillips, P. E. M. (2013) · Nature Neuroscience · doi:10.1038/nn.3335 · Cited by 113 · see citing works
A ventral tegmental CRF–glutamate–dopamine interaction in addiction
Wise, R. A., & Morales, M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.101 · Cited by 111 · see citing works
“…signaling to dopamine neurons, implicated by the electrophysiological studies of Ungless et al. (2003) and first suggested by the histological studies of Swanson et al. (1983) and the intracranial injection studies of Kalivas et al. (1987), is confirmed by our microdialysis and anatomical studies.”
BackgroundResult
Synapses between corticotropin‐releasing factor‐containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic
Tagliaferro, P. A., & Morales, M. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21576 · Cited by 107 · see citing works
“…1999; Vale et al., 1981) by interacting with different neuronal pathways, such as the hypothalamic-pituitary-adrenal (HPA) circuit (Bale and Vale, 2004; Dunn and Berridge, 1990; Vale et al., 1981) and the mesocorticolimbic dopamine (DA) system (Deutch and Roth, 1990; Kalivas et al., 1987).”
Background
Psychological and neural mechanisms of relapse
Stewart, J. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0084 · Cited by 103 · see citing works
“…responses to stress including fear and anxiety (Schulkin et al. 2005; Davis 2006); in addition, CRF has been shown to facilitate locomotor activity (Kalivas et al. 1987; Cador et al. 1993) and responses to positive incentive stimuli (Pecina et al. 2006), responses involved in appetitive behaviour.”
Augmented Cocaine Seeking in Response to Stress or CRF Delivered into the Ventral Tegmental Area Following Long-Access Self-Administration Is Mediated by CRF Receptor Type 1 But Not CRF Receptor Type 2
Blacktop, J. M., Seubert, C., Baker, D. L., Ferda, N., Lee, G., Graf, E. N., & Mantsch, J. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1393-11.2011 · Cited by 102 · see citing works
“Accordingly, delivery of CRF into the VTA stimulates local and terminal field dopamine release (Kalivas et al., 1987; Wang et al., 2005).”
Perturbations in Effort-Related Decision-Making Driven by Acute Stress and Corticotropin-Releasing Factor
Bryce, C. A., & Floresco, S. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.15 · Cited by 102 · see citing works
“However, intra-VTA CRF infusions reduce dopamine metabolism in the PFC and increases DA metabolism in the NAc 60 min following infusion (Kalivas et al, 1987).”
Background
Neuroregulation of nonexercise activity thermogenesis and obesity resistance
Kotz, C. M., Teske, J. A., & Billington, C. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00095.2007 · Cited by 99 · see citing works
“Corticotropin-releasing hormone, increases spontaneous physical activity after intracerebroventricular (74–76, 101) and site-specific (38, 61, 69, 82, 100, 106, 140) administration, although corticotropin-releasing hormone has no effect on spontaneous physical activity after administration into some brain areas, inclu…”
Background
Stressor- and corticotropin releasing factor-induced reinstatement and active stress-related behavioral responses are augmented following long-access cocaine self-administration by rats
Mantsch, J. R., Baker, D. L., Francis, D. M., Katz, E. S., Hoks, M. A., & Serge, J. P. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0950-5 · Cited by 98 · see citing works
“CRFinduced increases in extracellular DA in the NAcc have also been found (Kalivas et al. 1987).”
Influential
Effects of the CRH Receptor Antagonist CP-154,526 on Intravenous Cocaine Self-administration in Rats
Goeders, N. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00148-2 · Cited by 94 · see citing works
“ICV CRH has little or no effect on dopamine in the nucleus accumbens (Kalivas et al. 1987; Dunn and Berridge 1990) and actually increases dopamine metabolism in the medial prefrontal cortex (Dunn and Berridge 1990).”
Background
Prevention of social stress-escalated cocaine self-administration by CRF-R1 antagonist in the rat VTA
Boyson, C. O., Miguel, T. T., Quadros, I. M., DeBold, J. F., & Miczek, K. A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2266-8 · Cited by 92 · see citing works
“These activational effects within the VTA most likely involve downstream elevation of DA and activation of DA receptors in the mPFC and Acb (Capriles et al. 2003; McFarland et al. 2004; Kalivas et al. 1987).”
Background
Nociceptin/orphanin FQ and drugs of abuse
Ciccocioppo, R., Angeletti, S., Panocka, I., & Massi, M. (2000) · Peptides · doi:10.1016/s0196-9781(00)00245-x · Cited by 92 · see citing works
Circulating adrenal hormones are not necessary for the development of sensitization to the psychomotor activating effects of amphetamine
Badiani, A., Morano, M. I., Akil, H., & Robinson, T. E. (1995) · Brain Research · doi:10.1016/0006-8993(94)01365-o · Cited by 89 · see citing works
Central administration of corticotropin releasing factor induces long-term sensitization to d-amphetamine
Cador, M., Cole, B. J., Koob, G. F., Stinus, L., & Moal, M. L. (1993) · Brain Research · doi:10.1016/0006-8993(93)90982-s · Cited by 87 · see citing works
The Role of Limbic and Hypothalamic Corticotropin‐Releasing Factor in Behavioral Responses to Stress
Menzaghi, F., Heinrichs, S. C., Pich, E. M., Weiss, F., & Koob, G. F. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb49929.x · Cited by 86 · see citing works
Chronic Cocaine Enhances Corticotropin-Releasing Factor-Dependent Potentiation of Excitatory Transmission in Ventral Tegmental Area Dopamine Neurons
Hahn, J., Hopf, F. W., & Bonci, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4773-08.2009 · Cited by 85 · see citing works
“Injection of CRF directly into the VTA increases locomotor activity (Kalivas et al., 1987) and drug taking (Wang et al., 2005), whereas injection of CRF antagonists inhibits stress-induced reinstatement of cocaine seeking (Wang et al., 2005, 2007).”
Background
A final common pathway for depression? Progress toward a general conceptual framework
Stone, E. A., Lin, Y., & Quartermain, D. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.08.007 · Cited by 82 · see citing works
“Also CRF stimulates motor behavior from the ventral tegmental area (Kalivas et al., 1987).”
Background
Central Administration of Corticotropin-Releasing Hormone Stimulates Locomotor Activity in Juvenile Chinook Salmon (Oncorhynchus tshawytscha)
Clements, S., Schreck, C. B., Larsen, D. A., & Dickhoff, W. W. (2002) · General and Comparative Endocrinology · doi:10.1006/gcen.2001.7707 · Cited by 82 · see citing works
CRF in the paraventricular nucleus of the hypothalamus induces dose-related behavioral profile in rats
Mönnikes, H., Heymann‐Mönnikes, I., & Taché, Y. (1992) · Brain Research · doi:10.1016/0006-8993(92)90801-f · Cited by 82 · see citing works
Neuropeptidergic Mediators of Spontaneous Physical Activity and Non-Exercise Activity Thermogenesis
Teske, J. A., Billington, C. J., & Kotz, C. M. (2007) · Neuroendocrinology · doi:10.1159/000110802 · Cited by 79 · see citing works
Corticotropin-releasing factor induces a place aversion independent of its neuroendocrine role
Cador, M., Ahmed, S. H., Koob, G. F., Le Moal, M., & Stinus, L. (1992) · Brain Research · doi:10.1016/0006-8993(92)91487-y · Cited by 74 · see citing works
Corticotropin releasing factor induces anxiogenic locomotion in trout and alters serotonergic and dopaminergic activity
Carpenter, R. E., Watt, M. J., Forster, G. L., Øverli, Ø., Bockholt, C., Renner, K. J., & Summers, C. H. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.07.012 · Cited by 74 · see citing works
“…including fish (Clements et al., 2002; Clements and Schreck, 2004a; Bernier and Craig, 2005; Bernier, 2006), amphibians (Lowry et al., 1990; Lowry and Moore, 1991; Lowry et al., 1996; Crespi and Denver, 2004), birds (Zhang et al., 2001a; Zhang et al., 2001b) and rodents (Kalivas et al., 1987).”
Background
Corticotropin‐releasing factor binding protein within the ventral tegmental area is expressed in a subset of dopaminergic neurons
Wang, H., & Morales, M. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21751 · Cited by 70 · see citing works
“PUBLISHED 2008 WILEY-LISS, INC. †This article is a US Government work and, as such, is in the public domain in the United States of America. injections of CRF into the VTA (Kalivas et al., 1987).”
Background
Urocortin-like immunoreactivity in the substantia nigra, ventral tegmental area and Edinger–Westphal nucleus of rat
Yamamoto, H., Maeda, T., Fujimura, M., & Fujimiya, M. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00071-8 · Cited by 68 · see citing works
Influence of corticotropin-releasing hormone on electrophysiological activity of locus coeruleus neurons
Borsody, M. K., & Weiss, J. M. (1996) · Brain Research · doi:10.1016/0006-8993(96)00199-0 · Cited by 66 · see citing works
Rapid Changes in Monoamine Levels Following Administration of Corticotropin-Releasing Factor or Corticosterone Are Localized in the Dorsomedial Hypothalamus
Lowry, C. A., Burke, K. A., Renner, K. J., Moore, F. L., & Orchinik, M. (2001) · Hormones and Behavior · doi:10.1006/hbeh.2001.1646 · Cited by 61 · see citing works
Microinfusion of corticotropin-releasing factor into the nucleus accumbens shell results in increased behavioral arousal and oral motor activity
Holahan, M. R., Kalin, N. H., & Kelley, A. E. (1997) · Psychopharmacology · doi:10.1007/s002130050228 · Cited by 60 · see citing works
Social stress-escalated intermittent alcohol drinking: modulation by CRF-R1 in the ventral tegmental area and accumbal dopamine in mice
Hwa, L. S., Holly, E. N., DeBold, J. F., & Miczek, K. A. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4144-2 · Cited by 59 · see citing works
“These current results appear to contrast with past studies demonstrating CRF increasing dopamine neuron firing and release (Kalivas et al. 1987; Wanat et al. 2008) while CRF receptor antagonists in the VTA reduce glutamate and dopamine release in the VTA (Wang et al. 2005).”
Effects of corticotropin-releasing factor on prepulse inhibition of the acoustic startle response in two rat strains
Conti, L. H., Murry, J., Ruiz, M., & Printz, M. P. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1025-2 · Cited by 59 · see citing works
Impact of Corticotropin‐Releasing Hormone on Extracellular Norepinephrine in Prefrontal Cortex After Chronic Cold Stress
Finlay, J. M., Jedema, H. P., Rabinovic, A. D., Mana, M. J., Zigmond, M. J., & Sved, A. F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69010144.x · Cited by 57 · see citing works
Social defeat protocol and relevant biomarkers, implications for stress response physiology, drug abuse, mood disorders and individual stress vulnerability: a systematic review of the last decade
Vasconcelos, M., Stein, D. J., & de Almeida, R. M. M. (2015) · Trends in Psychiatry and Psychotherapy · doi:10.1590/2237-6089-2014-0034 · Cited by 55 · see citing works
Repeated social defeat stress enhances glutamatergic synaptic plasticity in the VTA and cocaine place conditioning
Stelly, C. E., Pomrenze, M. B., Cook, J. B., & Morikawa, H. (2016) · eLife · doi:10.7554/elife.15448 · Cited by 49 · see citing works
“GR blockade may therefore attenuate CRF-induced excitation of dopamine neurons during stress (Kalivas et al., 1987; Ungless et al., 2003; Wanat et al., 2008; Holly et al., 2015).”
Background
Gender Difference in Cocaine-Induced HPA Axis Activation
Kuhn, C. M. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00278-3 · Cited by 50 · see citing works
CRHCeA→VTA inputs inhibit the positive ensembles to induce negative effect of opiate withdrawal
Jiang, C., Yang, X., He, G., Wang, Z., Wang, Z., Xu, W., Ma, L., Ma, L., & Wang, F. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01321-9 · Cited by 47 · see citing works
Effects of third intracerebroventricular injections of corticotropin- releasing factor (CRF) on ethanol drinking and food intake
Bell, S. M., Reynolds, J. G., Thiele, T. E., Gan, J., Figlewicz, D. P., & Woods, S. C. (1998) · Psychopharmacology · doi:10.1007/s002130050697 · Cited by 49 · see citing works
Corticotropin-releasing factor (CRF) antagonist suppresses stress-induced locomotor activity in an amphibian
Lowry, C. A. (1991) · Hormones and Behavior · doi:10.1016/0018-506x(91)90041-f · Cited by 47 · see citing works
Drug withdrawal conceptualized as a stressor
Chartoff, E. H., & Carlezon, W. A. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000080 · Cited by 43 · see citing works
“For example, corticosterone facilitates dopamine effects and potentiates drug reward (Piazza et al., 1993), and CRF injected into the VTA stimulates dopamine neurons (Kalivas et al., 1987).”
Background
Behavioral Diversity and Neurochemical Plasticity: Selection of Stress Coping Strategies That Define Social Status
Korzan, W. J., & Summers, C. H. (2007) · Brain Behavior and Evolution · doi:10.1159/000105489 · Cited by 45 · see citing works
“Stress coping is further connected to this output as the stress-related neuropeptide corticotropin releasing factor delivered to the ventral tegmental area has been demonstrated to increase stereotypical locomotory output [Kalivas et al., 1987].”
Background
Prior, repeated exposure to cocaine potentiates locomotor responsivity to central injections of corticotropin-releasing factor (CRF) in rats
Erb, S. M., Funk, D. R., & Lê, A. D. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1556-1 · Cited by 45 · see citing works
“Both areas contain CRF receptors, and CRF infusions into either area increase motoric activity (Holahan et al. 1997; Kalivas et al. 1987).”
Background
Injection of corticotropin‐releasing hormone into the amygdala aggravates visceral nociception and induces noradrenaline release in rats
Su, J., Tanaka, Y., Muratsubaki, T., Kano, M., Kanazawa, M., & Fukudo, S. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12462 · Cited by 44 · see citing works
Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption
Pucci, M., Bonaventura, M. V. M. D., Giusepponi, M. E., Romano, A., Filaferro, M., Maccarrone, M., Ciccocioppo, R., Cifani, C., & D’Addario, C. (2015) · Addiction Biology · doi:10.1111/adb.12303 · Cited by 42 · see citing works
“Of interest was the consistent increase between the gene expression changes and the levels of both CRF and CRF-1R in the VTA of rats showing binge-eating behavior, whereas no alterations where found in the hypothalamus (Figure S3).”
BackgroundInfluential
Evidence that corticotropin-releasing factor within the extended amygdala mediates the activation of tryptophan hydroxylase produced by sound stress in the rat
Boadle‐Biber, M. C., Singh, V. B., Corley, K. C., Phan, T.-H., & Dilts, R. P. (1993) · Brain Research · doi:10.1016/0006-8993(93)90944-i · Cited by 40 · see citing works
Corticotropin releasing factor and neuroplasticity in cocaine addiction
Corominas, M., Roncero, C., & Casas, M. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.11.005 · Cited by 39 · see citing works
“…effectors of stress, corticotropin releasing factor (CRF), facilitates addiction by increasing locomotion (Cador et al. 1992, 1993; Erb et al. 2003; Kalivas et al. 1987), mediating the response to conditioned stimuli (Lu et al. 2001), and facilitating relapse during abstinence (Erb et al. 1998;…”
Influential
The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat.
Harro, J., Tõnissaar, M., & Eller, M. (2001) · Neuropeptides · doi:10.1054/npep.2001.0851 · Cited by 42 · see citing works
Stress‐induced sensitization to cocaine: actin cytoskeleton remodeling within mesocorticolimbic nuclei
Esparza, M. A., Bollati, F. A., García‐Keller, C., Virgolini, M. B., Lopez, L. M., Brusco, A., Shen, H., Kalivas, P. W., & Cancela, L. M. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08239.x · Cited by 36 · see citing works
“…within the ventral tegmental area (VTA; Tagliaferro & Morales, 2008), and injection of CRF directly into the VTA increases locomotor activity (Kalivas et al., 1987), while injection of CRF antagonists inhibits stress-induced reinstatement of cocaine-seeking (Wang et al., 2005, 2007) as well…”
Background
Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats
Goeders, N. E., & Guerin, G. F. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.07.005 · Cited by 35 · see citing works
“Accordingly, the administration of CRF directly into the VTA results in a time-dependent decrease in prefrontal cortical dopamine metabolism with an increase in dopamine turnover in the nucleus accumbens (Kalivas et al., 1987).”
Cholecystokinin Modulation of Mesolimbic Dopamine Function: Regulation of Motivated Behaviour
Rotzinger, S., Bush, D. E. A., & Vaccarino, F. J. (2002) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2002.910620.x · Cited by 33 · see citing works
The neuroanatomic complexity of the CRF and DA systems and their interface: What we still don’t know
Kelly, E. A., & Fudge, J. L. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.014 · Cited by 31 · see citing works
Effects of a stressor and corticotrophin releasing factor on ethanol deprivation-induced ethanol intake and anxiety-like behavior in alcohol-preferring P rats
Knapp, D. J., Overstreet, D. H., Huang, M. M., Wills, T. A., Whitman, B. A., Angel, R. A., Sinnett, S. E., & Breese, G. R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2366-5 · Cited by 31 · see citing works
“Likewise, local injection of CRF into the Amyg, DRN, or VTA can also have an acute activating action (Hiroi and Neumaier 2009; Kalivas et al. 1987; Lack et al. 2008; Lee and Tsai 1989; Meloni et al. 2008; Wand 2005).”
Background
Peripheral but not intracerebroventricular corticotropin-releasing hormone (CRH) produces antinociception which is not opioid mediated
Ayesta, F. J. A., & Nikolarakis, K. E. (1989) · Brain Research · doi:10.1016/0006-8993(89)91667-3 · Cited by 31 · see citing works
Alterations in effort-related decision-making induced by stimulation of dopamine D1, D2, D3, and corticotropin-releasing factor receptors in nucleus accumbens subregions
Bryce, C. A., & Floresco, S. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05244-w · Cited by 29 · see citing works
Escalated cocaine “binges” in rats: enduring effects of social defeat stress or intra-VTA CRF
Leonard, M. Z., DeBold, J. F., & Miczek, K. A. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4677-7 · Cited by 28 · see citing works
“CRF doses were selected based on previous in vivo studies in rats (Kalivas et al. 1987; Blacktop et al. 2011; Wanat et al. 2013).”
Method
A study of the lasting effects of cocaine pre-exposure on anxiety-like behaviors under baseline conditions and in response to central injections of corticotropin-releasing factor
Erb, S. M., Kayyali, H., & Romero, K. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.08.002 · Cited by 28 · see citing works
PYY‐preferring receptor in the dorsal vagal complex and its involvement in PYY stimulation of gastric acid secretion in rats
Yang, H., Li, W. P., Reeve, J. R., Rivier, J., & Taché, Y. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701767 · Cited by 28 · see citing works
“…receptor proteins has been carried out (Bard et al., 1995; Nakamura et al., 1995; Gehlert et al., 1996a,b; Gerald et al., 1996; Gregor et al., 1996a,b; Hu et al., 1996; Weinberg et al., 1996) except for the Y3 and PYY-preferring receptor (Kalivas et al., 1987; Mannon et al., 1993; Gehlert, 1994).”
Background
CRF modulation of central monoaminergic function: Implications for sex differences in alcohol drinking and anxiety
Pleil, K. E., & Skelly, M. J. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.01.007 · Cited by 27 · see citing works
Differential Distribution of Corticotropin-Releasing Hormone Immunoreactive Axons in Monoaminergic Nuclei of the Human Brainstem
Austin, M. C. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00083-3 · Cited by 27 · see citing works
Social interaction reward in rats has anti‐stress effects
Lemos, C., Salti, A., Amaral, I. M., Fontebasso, V., Singewald, N., Dechant, G., Hofer, A., & Rawas, R. E. (2020) · Addiction Biology · doi:10.1111/adb.12878 · Cited by 26 · see citing works
“Human/rat CRF, alpha-helical CRF (9-41), and SB203580 were”
Low doses of corticotropin-releasing factor potentiate amphetamine-induced stereotyped behavior
Cole, B. J., & Koob, G. F. (1989) · Psychopharmacology · doi:10.1007/bf00634448 · Cited by 26 · see citing works
Shared genes influence sensitivity to the effects of ethanol on locomotor and anxiety-like behaviors, and the stress axis
Boehm, S. L., Reed, C. L., McKinnon, C. S., & Phillips, T. J. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1000-y · Cited by 26 · see citing works
Molecular Signaling and Translational Significance of the Corticotropin Releasing Factor System
Ronan, P. J., & Summers, C. H. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385506-0.00006-5 · Cited by 24 · see citing works
Effects of a Typical and an Atypical Antipsychotic on the Disruption of Prepulse Inhibition Caused by Corticotropin-Releasing Factor and by Rat Strain.
Conti, L. H., Costill, J. E., Flynn, S. P., & Tayler, J. E. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.4.1052 · Cited by 25 · see citing works
Fluoxetine inhibits corticotropin-releasing factor (CRF)-induced behavioural responses in rats
Lowry, C. A., Lowry, C. A., Hale, M. W., Lowry, C. A., Hale, M. W., Plant, A., Windle, R. J., Lowry, C. A., Hale, M. W., Plant, A., et al. (2008) · Stress · doi:10.1080/10253890802309861 · Cited by 24 · see citing works
“…and noradrenergic systems may contribute to CRF-induced behavioural arousal, elegant work has established that CRF-induced motor activation is not dependent upon activation of mesolimbic dopaminergic systems (Koob et al. 1984; Swerdlow and Koob 1985; Swerdlow et al. 1986; Kalivas et al. 1987).”
Background
Enhanced CRFR1-Dependent Regulation of a Ventral Tegmental Area to Prelimbic Cortex Projection Establishes Susceptibility to Stress-Induced Cocaine Seeking
Vranjkovic, O., Newenhizen, E. C. V., Nordness, M. E., Blacktop, J. M., Urbanik, L. A., Mathy, J. C., McReynolds, J. R., Miller, A. M., Doncheck, E. M., Kloehn, T. M., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2080-18.2018 · Cited by 24 · see citing works
“Although studies examining the regulation of mesocortical dopamine by VTA CRF have produced mixed results (Kalivas et al., 1987), reports that intracerebroventricular CRF increases dopaminergic neurotransmission in the prefrontal cortex (Dunn and Berridge, 1987; Lavicky and Dunn, 1993) and that CRF…”
Result
Studies on the interaction between ICV effects of CRF and CNS noradrenaline depletion
Bakke, H. K., Bogsnes, A., & Murison, R. C. C. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90379-i · Cited by 23 · see citing works
Corticotropin-releasing hormone receptor blockade fails to alter stress-evoked catecholamine release in prefrontal cortex of control or chronically stressed rats
Murphy, E., Sved, A. F., & Finlay, J. M. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00565-1 · Cited by 23 · see citing works
Area-specific analysis of the distribution of hypothalamic neurons projecting to the rat ventral tegmental area, with special reference to the GABAergic and glutamatergic efferents
Kalló, I., Molnár, C. S., Szöke, S., Fekete, C., Hrabovszky, E., & Liposits, Z. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00112 · Cited by 21 · see citing works
“, 1989), in the NAc shell (Kalivas et al., 1987) and in the basolateral amygdala (Inglis and Moghaddam, 1999).”
Background
Behavioral and hormonal regulation of expression of the clock protein, PER2, in the central extended amygdala
Amir, S., & Stewart, J. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.04.003 · Cited by 21 · see citing works
Alterations in local cerebral glucose utilization following central administration of corticotropin‐releaseing factor in rats
Sharkey, J., Appel, N. M., & Souza, E. B. D. (1989) · Synapse · doi:10.1002/syn.890040109 · Cited by 21 · see citing works
“In support of the latter hypothesis, CRF administration has been reported to alter dopamine turnover in nucleus accumbens and prefrontal cortex (Dunn and Berridge, 1985; Kalivas et al., 1987) and has been shown to increase the firing rate of noradrenergic neurons in locus coeruleus (Valentino et al.”
Background
A role for corticotropin-releasing factor in the long-term expression of behavioral sensitization to cocaine
Erb, S. M., & Brown, Z. J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.024 · Cited by 20 · see citing works

The effects of intracerebroventricularly injected corticotropin-releasing factor (CRF) on the central nervous system: Behavioural and biochemical studies
Matsuzaki, I., Takamatsu, Y., & Moroji, T. (1989) · Neuropeptides · doi:10.1016/0143-4179(89)90085-1 · Cited by 92 · see citing works
Effects of Corticotrophin Releasing Factor on Ventral Tegmental Area Neurons
Driscoll, J. R. (2017) · eScholarship (California Digital Library)
A novel mechanism linking corticotrophin‐releasing factor to ventral tegmental area dopamine neuron firing
Gao, L., & Wan, X. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.159079 · Cited by 2 · see citing works
The excitatory actions of corticotropin-releasing factor on ventral tegmental area dopamine neurons
Wanat, M. J. (2007) · eScholarship (California Digital Library)
Corticotropin-releasing factor projections from limbic forebrain and paraventricular nucleus of the hypothalamus to the region of the ventral tegmental area
Rodaros, D., Caruana, D. A., Amir, S., & Stewart, J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.043 · Cited by 194 · see citing works

Authors: Kalivas, P. W., Duffy, P., & Latimer, L. G.
Affiliations: Washington State University (US)
ORCID: Kalivas, P W
Venue: The Journal of Pharmacology and Experimental Therapeutics
Publisher: Elsevier BV
Published: 1987-09
Volume: 242
Issue: 3
Pages: 757-763
ISSN: 0022-3565 (ISSN-L)
DOI: 10.1016/s0022-3565(25)39170-6
OpenAlex: W2272340543
Cited by: 137
References: 0
Citations by year: 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 6
FWCI: 1.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed
Funders: National Institute of Mental Health (MH-40817)
National Institute on Drug Abuse (DA03906)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: corticotropin-releasing factor, ventral tegmental area, dopamine metabolism, mesolimbic dopamine system, mesocortical dopamine system, motor stimulation, prefrontal cortex, nucleus accumbens, stress, haloperidol, intraventricular injection
MeSH terms: Animals, Corticotropin-Releasing Hormone, Dopamine, Dose-Response Relationship, Drug, Frontal Lobe, Haloperidol, Male, Motor Activity, Naloxone, Rats, Inbred Strains, Tegmentum Mesencephali, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neurochemical and behavioral effects of corticotropin-releasing factor in the ventral tegmental area of the rat

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cited by

Related

Record

About these checks