Brain N-acetyl aspartate concentrations measured by 1H MRS are reduced in adult male rats subjected to perinatal stress: preliminary observations and hypothetical implications for neurodevelopmental disorders
Abstract
The present study was undertaken to determine if the concentration of brain N-acetyl-aspartate (NAA), a putative neuronal marker, is reduced in adult rats subjected to stress during the perinatal period. As the prenatal stressor, pregnant rats were subjected to restraint stress for one hour twice daily from days 14-21 of gestation; stressed offspring were reared by normal dams and studied as adults. As the postnatal stressor, normal pups were reared by prenatally 'stressed' dams and studied as adults. As compared to non-stressed controls (n=6), NAA concentrations were significantly reduced 21 and 25% in left frontal cortex from the prenatal (n=4) and postnatal (n=6) stress groups. respectively. The data suggest that in perinatally stressed adult offspring permanent neuronal damage or loss has occurred. While no direct causal associations between perinatal stress and the developmental of particular disorders can be inferred from these limited data, the effects of perinatal stress on subsequent brain neuropathology are reviewed. particularly in relation to NAA. For hypothesis-generating purposes, the possible relevance of stress and NAA to the neurodevelopmental hypothesis of schizophrenia is discussed in greater detail.
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Early-life stress-exposed mice show reductions in N-acetylaspartate in the frontal cortex and hypothalamus.
“These include reductions in N-acetylaspartate (a marker of neuronal integrity) in the frontal cortex and hypothalamus in early-life stress-exposed mice [97–99]”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [98]
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Murmu, M. S., Salomon, S., Biala, Y., Weinstock, M., Braun, K., & Bock, J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05024.x · Cited by 278 · see citing works
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- Authors
- Poland, R. E., Cloak, C., Lutchmansingh, P. J., McCracken, J. T., Chang, L., & Ernst, T.
- Affiliations
- Harbor–UCLA Medical Center (US)
- University of California, Los Angeles (US)
- Corresponding author
- Poland, Russell E
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 33
- Issue
- 1
- Pages
- 41-51
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W1988384114
- Cited by
- 37
- References
- 132
- Citations by year
- 2024: 1 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2012: 4
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-00534, K02MH000534)
- National Institute on Drug Abuse (DA 00280, K20DA000280)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- N-acetylaspartate, perinatal stress, prenatal restraint stress, postpartum stress, brain neurochemistry, frontal cortex, neuronal injury, neurodevelopmental disorders, schizophrenia
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Aspartic Acid, Mental Disorders, Disease Models, Animal, Female, Frontal Lobe, Hippocampus, Male, Magnetic Resonance Spectroscopy, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Stress, Psychological, Rats, Sprague-Dawley, Observation, Postpartum Period, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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