Cited by 37Stress Responses and CortisolMaternal Mental Health During Pregnancy and PostpartumNeonatal and fetal brain pathology

Brain N-acetyl aspartate concentrations measured by 1H MRS are reduced in adult male rats subjected to perinatal stress: preliminary observations and hypothetical implications for neurodevelopmental disorders

Poland, Russell E, Cloak, Christine, Lutchmansingh, Preetam J, McCracken, James T, Chang, Linda, Ernst, Thomas·1999·Journal of Psychiatric Research

Abstract

The present study was undertaken to determine if the concentration of brain N-acetyl-aspartate (NAA), a putative neuronal marker, is reduced in adult rats subjected to stress during the perinatal period. As the prenatal stressor, pregnant rats were subjected to restraint stress for one hour twice daily from days 14-21 of gestation; stressed offspring were reared by normal dams and studied as adults. As the postnatal stressor, normal pups were reared by prenatally 'stressed' dams and studied as adults. As compared to non-stressed controls (n=6), NAA concentrations were significantly reduced 21 and 25% in left frontal cortex from the prenatal (n=4) and postnatal (n=6) stress groups. respectively. The data suggest that in perinatally stressed adult offspring permanent neuronal damage or loss has occurred. While no direct causal associations between perinatal stress and the developmental of particular disorders can be inferred from these limited data, the effects of perinatal stress on subsequent brain neuropathology are reviewed. particularly in relation to NAA. For hypothesis-generating purposes, the possible relevance of stress and NAA to the neurodevelopmental hypothesis of schizophrenia is discussed in greater detail.

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Crossref · 10.1016/s0022-3956(98)00043-0

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Authors
Poland, R. E., Cloak, C., Lutchmansingh, P. J., McCracken, J. T., Chang, L., & Ernst, T.
Affiliations
  • Harbor–UCLA Medical Center (US)
  • University of California, Los Angeles (US)
Corresponding author
Poland, Russell E
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
1999-01
Volume
33
Issue
1
Pages
41-51
ISSN
0022-3956 (ISSN-L)
OpenAlex
W1988384114
Cited by
37
References
132
Citations by year
2024: 1 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2012: 4
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (MH-00534, K02MH000534)
  • National Institute on Drug Abuse (DA 00280, K20DA000280)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Keywords
N-acetylaspartate, perinatal stress, prenatal restraint stress, postpartum stress, brain neurochemistry, frontal cortex, neuronal injury, neurodevelopmental disorders, schizophrenia
MeSH terms
Age Factors, Analysis of Variance, Animals, Aspartic Acid, Mental Disorders, Disease Models, Animal, Female, Frontal Lobe, Hippocampus, Male, Magnetic Resonance Spectroscopy, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Stress, Psychological, Rats, Sprague-Dawley, Observation, Postpartum Period, Rats

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