Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy
Abstract
Both chronic stress in adulthood and episodes of stress in the early postnatal period have been shown to interfere with neuronal development in limbic prefrontal cortical regions. The present study in rats showed for the first time that the development of layer II/III pyramidal neurons in the dorsal anterior cingulate (ACd) and orbitofrontal cortex (OFC) is significantly affected in offspring of mothers exposed to stress during pregnancy. In prenatally stressed (PS) male rat pups the ACd and OFC showed significantly lower spine densities on the apical dendrite (ACd, −20%; OFC, −25%), on basal dendrites reduced spine densities where found only in the OFC (−20% in PS males). Moreover, in both cortical areas a significant reduction of dendritic length was observed in PS males compared to control offspring, which was confined to the apical dendrites (ACd, −30%, OFC, −26%). Sholl analysis revealed that these alterations were accompanied by a significantly reduced complexity of the dendritic trees in both cortical regions. PS females displayed reductions of dendritic spine densities in the ACd and OFC on both the basal (ACd, −21%; OFC, −20%) and apical dendrites (ACd, −21%; OFC, −21%), however, in contrast to the findings in PS males, no dendritic atrophy was detected in the PS females. These findings demonstrate that gestational stress leads to significant alterations of prefrontal neuronal structure in the offspring of the stressed mothers in a sex‐specific manner.
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Dendritic changes can occur in utero when the mother is exposed to stress.
“Dendritic changes can occur in utero when the mother is exposed to stress121.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [121]
Prenatal stress is linked to lower spine density and shorter dendritic length of pyramidal neurons in dorsal anterior cingulate and orbitofrontal cortex.
“Also, reduced spine densities and significant reduction of dendritic length of pyramidal neurons in the dorsal anterior cingulate and orbitofrontal cortex have been reported in offspring of mothers exposed to stress during pregnancy (Murmu et al., 2006).”
From High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. (2010) · cites this paper as Murmu et al., 2006
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- Authors
- Murmu, M. S., Salomon, S., Biala, Y., Weinstock, M., Braun, K., & Bock, J.
- Affiliations
- Otto-von-Guericke-Universität Magdeburg (DE)
- Hebrew University of Jerusalem (IL)
- Weizmann Institute of Science (IL)
- Corresponding author
- Bock, Jörg
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2006-09
- Volume
- 24
- Issue
- 5
- Pages
- 1477-1487
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2076507942
- Cited by
- 278
- References
- 78
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 18 · 2020: 13 · 2019: 7 · 2018: 11 · 2017: 17 · 2016: 21 · 2015: 23 · 2014: 23 · 2013: 25 · 2012: 17
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Israel Science Foundation
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- prenatal stress, dendritic spine density, dendritic complexity, prefrontal cortex, dorsal anterior cingulate cortex, orbitofrontal cortex, layer II/III pyramidal neurons, sex differences, neuronal development, Sholl analysis, dendritic atrophy
- MeSH terms
- Animals, Animals, Newborn, Corticosterone, Dendrites, Female, Functional Laterality, Male, Pregnancy, Prenatal Exposure Delayed Effects, Radioimmunoassay, Sex Factors, Stress, Psychological, Rats, Sprague-Dawley, Prefrontal Cortex, Dendritic Spines, Rats
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