Fatigue symptoms relate to systemic inflammation in patients with type 2 diabetes
Open accessAbstract
Fatigue is frequent in patients with diabetes and this symptom appears to be more prominent in type 2 rather than type 1 diabetic subjects. Chronic inflammation represents one characteristic of type 2 diabetes that may contribute to fatigue symptoms. This possibility was assessed in a sample of 20 type 2 diabetic patients relatively to a group of 20 type 1 diabetic subjects. Specific dimensions of fatigue, including general fatigue, physical fatigue, reduced activity, mental fatigue and reduced motivation, were assessed using the Multidimensional-Fatigue-Inventory (MFI). Biological assays comprised the measurement of serum inflammatory markers [high-sensitive C-reactive-protein (hsCRP), high-sensitive interleukin-6 (hsIL-6), high-sensitive tumor-necrosis-factor-α (hsTNF-α) and neopterin]. Clinical parameters including indexes of adiposity were collected. In comparison to type 1 diabetic subjects, patients with type 2 diabetes exhibited higher fatigue scores, notably in the dimensions of general fatigue, physical fatigue and reduced activity, together with greater levels of inflammatory markers that correlated with indexes of adiposity. Regression analyses controlling for diabetes duration, insulin treatment status, glycemic control and fasting status, indicated that levels of inflammatory markers, in particular hsIL-6, hsCRP and neopterin, were associated with MFI fatigue dimensions in type 2 diabetic patients. Mediation analyses revealed that adiposity did not significantly account for the relationship of inflammatory markers with fatigue scores albeit coefficient regressions decreased somewhat when this variable was controlled for in regression models. These findings indicate that systemic low-grade inflammation relates to fatigue symptoms in patients with type 2 diabetes and suggest the involvement of inflammatory processes in the pathophysiology of diabetes-related fatigue.
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Inflammatory status is probably best defined by a combination of several cytokine concentrations rather than one cytokine only.
“Given that the inflammatory status is probably best defined by a combination of several cytokine concentrations rather than one cytokine only, composite scores of inflammation were calculated using a standard method for identifying latent factors, i.e. Principal Component Analysis, which has been used in several previous studies (Hsu et al. 2009; Lasselin et al. 2012; Lasselin et al. 2014).”
From Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults (2016) · cites this paper as Lasselin et al. 2012
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- Authors
- Lasselin, J., Layé, S., Dexpert, S., Aubert, A., Gonzalez, C., Gin, H., & Capuron, L.
- Affiliations
- Université de Bordeaux (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Corresponding author
- Capuron, Lucile
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 26
- Issue
- 8
- Pages
- 1211-1219
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W1967341354
- Cited by
- 77
- References
- 60
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 6 · 2013: 5 · 2012: 1
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
- Funders
- Institut National de la Recherche Agronomique
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- fatigue, type 2 diabetes, type 1 diabetes, systemic inflammation, low-grade inflammation, interleukin-6, C-reactive protein, TNF-α, neopterin, adiposity, Multidimensional Fatigue Inventory
- MeSH terms
- Adult, Aged, Diabetes Mellitus, Type 2, Fatigue, Female, Humans, Inflammation, Male, Middle Aged, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Adiposity
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