Differences in the concentration and composition of low-density lipoprotein subfraction particles between sedentary and trained hypercholesterolemic men

Halle, Martin; Berg, Aloys; König, Daniel; Keul, Joseph; Baumstark, Manfred W.

doi:10.1016/s0026-0495(97)90300-0

Cited by 41Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsCholesterol and Lipid Metabolism

Differences in the concentration and composition of low-density lipoprotein subfraction particles between sedentary and trained hypercholesterolemic men

Halle, Martin, Berg, Aloys, König, Daniel, Keul, Joseph, Baumstark, Manfred W.·1997·Metabolism

DOI 10.1016/s0026-0495(97)90300-0

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Abstract

There is evidence that a low-density lipoprotein (LDL) subfraction profile of increased concentrations of small, dense LDL particles is less common among trained than among sedentary normocholesterolemic men, but it is still uncertain whether there is a similar association in hypercholesterolemia also. Therefore, we determined the lipid and apolipoprotein concentration and composition of six LDL subfractions (density gradient ultracentrifugation) in 20 physically fit, regularly exercising (>three times per week) hypercholesterolemic men and 20 sedentary hypercholesterolemic controls. Trained (maximal oxygen consumption [VO2max], 57.3 +/- 7.4 mL/kg/min) and sedentary (VO2max, 37.5 +/- 8.8 mL/kg/min) individuals (aged 35 +/- 11 years; body mass index [BMI], 23.9 +/- 2.7 kg/m2) were matched for LDL apolipoprotein (apo) B levels (108 +/- 23 and 112 +/- 36 mg/dL, respectively). Trained subjects had significantly lower serum triglyceride (P < .05) and very-low-density lipoprotein (VLDL) cholesterol levels (P < .05) and higher high-density lipoprotein 2 (HDL2) cholesterol levels (P < .01) than sedentary controls. LDL particle distribution showed that trained individuals had significantly less small, dense LDL (d = 1.040 to 1.063 g/mL) and more large LDL (d = 1.019 to 1.037 g/mL) subfraction particles than sedentary controls, despite equal total LDL particle number. Analysis of LDL composition showed that LDL particles of hypercholesterolemic trained men had a higher free cholesterol content than LDL of untrained hypercholesterolemic men. Small, dense LDL in hypercholesterolemic trained men were richer in phospholipids than those in sedentary controls. These data demonstrate the significant influence of aerobic fitness on lipoprotein subfraction concentration and composition, thereby emphasizing the role of exercise in the treatment and risk reduction of hypercholesterolemia.

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It has been suggested that regular physical activity may change the LDL cholesterol particle size, even when total LDL concentrations remain constant.
“However, it has been suggested that regular physical activity may change the LDL cholesterol particle size, even when total LDL concentrations remain constant [82, 83].”
From Can consumer wearable activity tracker-based interventions improve physical activity and cardiometabolic health in patients with chronic diseases? A systematic review and meta-analysis of randomised controlled trials (2020) · cites this paper as [82]

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Authors: Halle, M., Berg, A., König, D., Keul, J., & Baumstark, M. W.
Affiliations: University Medical Center Freiburg (DE)
ORCID: Halle, Martin
Berg, Aloys
König, Daniel
Baumstark, Manfred W.
Venue: Metabolism
Publisher: Elsevier BV
Published: 1997-02
Volume: 46
Issue: 2
Pages: 186-191
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/s0026-0495(97)90300-0
OpenAlex: W2019043171
Cited by: 41
References: 59
Citations by year: 2026: 3 · 2024: 1 · 2022: 1 · 2020: 6 · 2018: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 4
FWCI: 1.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords: low-density lipoprotein subfractions, small dense LDL, hypercholesterolemia, cardiorespiratory fitness, physical activity, sedentary lifestyle, lipoprotein composition, free cholesterol, phospholipids, HDL2, VLDL cholesterol, triglycerides, apolipoprotein B, cardiovascular risk
MeSH terms: Centrifugation, Density Gradient, Humans, Hypercholesterolemia, Lipoproteins, LDL, Cholesterol, LDL, Male, Physical Fitness, Triglycerides, Ultracentrifugation, Cholesterol, VLDL, Exercise

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Differences in the concentration and composition of low-density lipoprotein subfraction particles between sedentary and trained hypercholesterolemic men

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