N-methyl-D-aspartate receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents
Abstract
Expression of the NR-1 subunit in Xenopus oocytes produces channels that respond to glutamate and are blocked by competitive and noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptor. Ionic conductances through these channels are increased by coexpression with NR-2 receptor subunits. We have characterized the pharmacological properties of NMDA receptors assembled from combinations of subunits expressed in transfected cells, to determine the minimum subunit requirements for binding of competitive glutamate antagonists, glycine antagonists, and channel-blocking agents, as detected by ligand-binding experiments. Expression of NR-1a alone produced glycine antagonist binding, whereas the combination of NR-1a and NR-2A was needed to produce binding sites for glutamate antagonists and channel-blocking agents. These results suggest that functional NMDA receptors assemble from these subunits. However, differences in the pharmacological effects of NMDA and polyamines show that not all characteristics of native NMDA receptors are reproduced by this combination of subunits.
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NMDA receptors are ligand-gated cation channels with crucial roles in synaptic transmission and plasticity.
“NMDA receptors are ligand-gated cation channels with crucial roles in synaptic transmission and plasticity.”
From Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies (2008) · cites this paper as [1]
NMDA receptors are heteromers of NR1 subunits that bind glycine and NR2 subunits that bind glutamate.
“The receptors are heteromers of NR1 subunits that bind glycine and NR2 (A, B, C, or D) subunits that bind glutamate.1”
From Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies (2008) · cites this paper as [1]
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Yung-Chi, C., & Prusoff, W. H. (1973) · Biochemical Pharmacology · doi:10.1016/0006-2952(73)90196-2 · Cited by 12,922 · see citing works
High-Efficiency Transformation of Mammalian Cells by Plasmid DNA
Chen, C., & Okayama, H. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.8.2745 · Cited by 5,374 · see citing works
Molecular cloning and characterization of the rat NMDA receptor
Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1991) · Nature · doi:10.1038/354031a0 · Cited by 1,771 · see citing works
Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage
Choi, D. W. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90200-7 · Cited by 1,726 · see citing works
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS
Sommer, B., KEINÄNEN, K. P., Verdoorn, T. A., Wisden, W., Burnashev, N., Herb, A., Köhler, M. G., Takagi, T., Sakmann, B. J., & Seeburg, P. H. (1990) · Science · doi:10.1126/science.1699275 · Cited by 1,259 · see citing works
Williams, K. L. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13275-6 · Cited by 860 · see citing works
Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs
Meguro, H., Mori, H., Araki, K., Kushiya, E., Kutsuwada, T., Yamazaki, M., Kumanishi, T., Arakawa, M., Sakimura, K., & Mishina, M. (1992) · Nature · doi:10.1038/357070a0 · Cited by 798 · see citing works
Zinc potentiates agonist-lnduced currents at certain splice variants of the NMDA receptor
Hollmann, M., Boulter, J., Maron, C., Beasley, L., Sullivan, J., Pecht, G., & Heinemann, S. F. (1993) · Neuron · doi:10.1016/0896-6273(93)90209-a · Cited by 611 · see citing works
[3H]MK‐801 Labels a Site on the N‐Methyl‐D‐Aspartate Receptor Channel Complex in Rat Brain Membranes
Wong, E. H. F., Knight, A. R., & Woodruff, G. N. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb13260.x · Cited by 454 · see citing works
Reynolds, I. J., Murphy, S. N., & Miller, R. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7744 · Cited by 336 · see citing works
Blount, P., & Merlie, J. P. (1989) · Neuron · doi:10.1016/0896-6273(89)90259-6 · Cited by 285 · see citing works
Stern, P., Béhé, P., Schoepfer, R., & Colquhoun, D. (1992) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1992.0159 · Cited by 262 · see citing works
Sills, M. A., Fagg, G. E., Pozza, M. F., Angst, C., Brundish, D. E., Hurt, S. D., Wilusz, E. J., & Williams, M. J. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90063-v · Cited by 211 · see citing works
Rock, D. M., & Macdonald, R. L. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08850-9 · Cited by 124 · see citing works
Polyamines regulate glycine interaction with the N‐methyl‐ D ‐aspartate receptor
Ransom, R. W., & Deschenes, N. L. (1990) · Synapse · doi:10.1002/syn.890050406 · Cited by 78 · see citing works
Chazot, P. L., Cik, M., & Stephenson, F. A. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08364.x · Cited by 71 · see citing works
Developmental Changes in the Sensitivity of the N-Methyl-d-Aspartate Receptor to Polyamines
Williams, K. L., Hanna, J. L., & Molinoff, P. B. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)15397-2 · Cited by 56 · see citing works
Molecular target size analyses of the NMDA-receptor complex in rat cortex
Honoré, T., Drejer, J., Nielsen, E. Ø., Watkins, J. C., Olverman, H. J., & Nielsen, M. (1989) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(89)90054-0 · Cited by 50 · see citing works
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Research works printed but not linked: 1
- Monaghan, D. T., H. J. Olverman, L. Nguyen, J. C. Watkins, and C. W. Cotman. Two classes of N-methyl-D-aapartate recognition sites: differential distribution and differential regulation by glycine. Proc. NatL Acad. Sci. USA 85:9836-9840 (1988).
Cited by
Sorted by citations
Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies
Dalmau, J., Gleichman, A. J., Hughes, E. G., Rossi, J. E., Peng, X., Lai, M., Dessain, S. K., Rosenfeld, M. R., Balice-Gordon, R., & Lynch, D. R. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70224-2 · Cited by 3,488 · see citing works
Self-citationDalmau, J., Tüzün, E., Wu, H., Masjuan, J., Rossi, J. E., Voloschin, A., Baehring, J. M., Shimazaki, H., Koide, R., King, D., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21050 · Cited by 2,492 · see citing works
The Role of Excitotoxicity in Neurodegenerative Disease
Doble, A. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00042-4 · Cited by 723 · see citing works
Danysz, W., & Parsons, C. G. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01382-6 · Cited by 649 · see citing works
Michaelis, E. K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00055-5 · Cited by 576 · see citing works
Generation, Control, and Processing of Cellular Calcium Signals
Carafoli, E., Santella, L., Branca, D., & Brini, M. (2001) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/20014091074183 · Cited by 529 · see citing works
Laube, B., Hirai, H., Sturgess, M., Betz, H., & Kuhse, J. (1997) · Neuron · doi:10.1016/s0896-6273(00)81249-0 · Cited by 467 · see citing works
Wenzel, A., Fritschy, J., Möhler, H., & Benke, D. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68020469.x · Cited by 442 · see citing works
Beneyto, M., Kristiansen, L. V., Oni-Orisan, A., McCullumsmith, R. E., & Meador-Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301312 · Cited by 408 · see citing works
Glutamate receptor expression in schizophrenic brain
Meador‐Woodruff, J. H. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00044-2 · Cited by 412 · see citing works
Schell, M. J., Brady Jr., R. O., Molliver, M. E., & Snyder, S. H. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01604.1997 · Cited by 415 · see citing works
Dunah, A. W., & Standaert, D. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05546.2001 · Cited by 374 · see citing works
NMDA receptors: from genes to channels
Sucher, N. J., Awobuluyi, M., Choi, Y., & Lipton, S. A. (1996) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(96)80008-3 · Cited by 316 · see citing works
Effects of Ethanol on Ion Channels
Crews, F. T., Morrow, A. L., Criswell, H. E., & Breese, G. R. (1996) · International review of neurobiology · doi:10.1016/s0074-7742(08)60670-4 · Cited by 296 · see citing works
Targeting the N-Methyl-d-Aspartate Receptor for Chronic Pain Management
Fisher, K., Coderre, T. J., & Hagen, N. A. (2000) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(00)00213-x · Cited by 264 · see citing works
Dunah, A. W., Wang, Y., Yasuda, R. P., Kameyama, K., Huganir, R. L., Wolfe, B. B., & Standaert, D. G. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23206-5 · Cited by 262 · see citing works
Rationale for and use of NMDA receptor antagonists in Parkinson's disease
Hallett, P. J., & Standaert, D. G. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.04.001 · Cited by 236 · see citing works
Ibrahim, H. M., Hogg, A. J., Healy, D. J., Haroutunian, V. H., Davis, K. L., & Meador‐Woodruff, J. H. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.11.1811 · Cited by 233 · see citing works
Calon, F., Rajput, A. H., Hornykiewicz, O., Bédard, P. J., & Paolo, T. D. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.07.003 · Cited by 221 · see citing works
Ontogeny of the N-Methyl-D-Aspartate (NMDA) Receptor System and Susceptibility to Neurotoxicity
Haberny, K. A. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.1.9 · Cited by 218 · see citing works
Glutamate-mediated transmission, alcohol, and alcoholism
Dodd, P. R., Beckmann, A. M., Davidson, M. S., & Wilce, P. A. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(00)00061-9 · Cited by 214 · see citing works
Chazot, P., Coleman, S., Cik, M., & Stephenson, F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)51098-5 · Cited by 205 · see citing works
Dracheva, S. M., Marras, S. A. E., Elhakem, S. L., Kramer, F. R., Davis, K. L., & Haroutunian, V. H. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.9.1400 · Cited by 190 · see citing works
Snell, L. D., Nunley, K. R., Lickteig, R. L., Browning, M. D., Tabakoff, B., & Hoffman, P. L. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00038-1 · Cited by 178 · see citing works
Follesa, P., & Ticku, M. K. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00235-7 · Cited by 172 · see citing works
Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia
Crino, P. B., Duhaime, A., Baltuch, G. H., & White, R. (2001) · Neurology · doi:10.1212/wnl.56.7.906 · Cited by 170 · see citing works
Polyamine Regulation of N-Methyl-D-Aspartate Receptor Channels
Rock, D. M., & Macdonald, R. L. (1995) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.002335 · Cited by 166 · see citing works
Quantitative neuropathological changes in presymptomatic Huntington's disease
Gómez‐Tortosa, E., MacDonald, M. E., Friend, J. C., Taylor, S. A., Weiler, L., Cupples, L. A., Srinidhi, J., Gusella, J. F., Bird, E. D., Vonsattel, J., et al. (2001) · Annals of Neurology · doi:10.1002/1531-8249(200101)49:1 · Cited by 170 · see citing works
Interactions between Ifenprodil and the NR2B Subunit of the N-Methyl-D-aspartate Receptor
Gallagher, M. J., Huang, H., Pritchett, D. B., & Lynch, D. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9603 · Cited by 160 · see citing works
Hu, X.-J., & Ticku, M. K. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00019-o · Cited by 159 · see citing works
Boyer, P., Skolnick, P., & Fossom, L. H. (1998) · Journal of Molecular Neuroscience · doi:10.1007/bf02761776 · Cited by 157 · see citing works
Selective Activation Induced Cleavage of the NR2B Subunit by Calpain
Simpkins, K. L., Guttmann, R. P., Dong, Y., Chen, Z., Sokol, S. A., Neumar, R. W., & Lynch, D. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-36-11322.2003 · Cited by 146 · see citing works
Standaert, D. G., Friberg, I. K., Landwehrmeyer, G. B., Young, A. B., & Penney, J. B. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00293-9 · Cited by 141 · see citing works
Hu, X.-J., Follesa, P., & Ticku, M. K. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00223-f · Cited by 140 · see citing works
Meador‐Woodruff, J. H., Hogg, A. J., & Smith, R. E. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00523-8 · Cited by 141 · see citing works
Exitatory Amino Acids in Health and Disease
THOMAS, R. J. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb07407.x · Cited by 138 · see citing works
Regulation of NMDA receptors by ethanol
Kumari, M., & Ticku, M. K. (2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8391-7_5 · Cited by 133 · see citing works
Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder
Scarr, E., Pavey, G., Sundram, S., Mackinnon, A. J., & Dean, B. (2003) · Bipolar Disorders · doi:10.1034/j.1399-5618.2003.00024.x · Cited by 121 · see citing works
Specific proteolysis of the NR2 subunit at multiple sites by calpain
Guttmann, R. P., Baker, D. L., Seifert, K. M., Cohen, A. S., Coulter, D. A., & Lynch, D. R. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00493.x · Cited by 111 · see citing works
Ethanol-induced inhibition of NMDA receptor channels
Wirkner, K., Poelchen, W., Köles, L., Mühlberg, K. S., Scheibler, P., Allgaier, C., & Illés, P. (1999) · Neurochemistry International · doi:10.1016/s0197-0186(99)00057-1 · Cited by 107 · see citing works
Molecular Biology and Ontogeny of Glutamate Receptors in the Mammalian Central Nervous System
Simeone, T. A., Sanchez, R. M., & Rho, J. M. (2004) · Journal of Child Neurology · doi:10.1177/088307380401900507 · Cited by 107 · see citing works
Molecular Abnormalities of the Glutamate Synapse in the Thalamus in Schizophrenia
Meador‐Woodruff, J. H., Clinton, S. M., Beneyto, M., & McCullumsmith, R. E. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.005 · Cited by 101 · see citing works
Glycine-Independent NMDA Receptor Desensitization: Localization of Structural Determinants
Villarroel, Á., Regalado, M. P., & Lerma, J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80460-2 · Cited by 99 · see citing works
Improving the antibody-based evaluation of autoimmune encephalitis
McCracken, L., Zhang, J., Greene, M. I., Crivaro, A., González, J., Kamoun, M., & Lancaster, E. (2017) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000404 · Cited by 98 · see citing works
Calon, F., Morissette, M., Ghribi, O., Goulet, M., Grondin, R., Blanchet, P. J., Bédard, P. J., & Paolo, T. D. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00237-8 · Cited by 93 · see citing works
Anti-NMDA-Receptor Encephalitis: Case Report and Literature Review of an Under-Recognized Condition
Day, G. S., High, S., Cot, B., & Tang‐Wai, D. F. (2011) · Journal of General Internal Medicine · doi:10.1007/s11606-011-1641-9 · Cited by 93 · see citing works
Liu, C., Zhu, J., Zheng, X., Ma, C., & Wang, X. (2017) · Mediators of Inflammation · doi:10.1155/2017/6361479 · Cited by 89 · see citing works
Subcellular segregation of distinct heteromeric NMDA glutamate receptors in the striatum
Dunah, A. W., & Standaert, D. G. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01744.x · Cited by 89 · see citing works
Hawkins, L. M., Prybylowski, K., Chang, K., Moussan, C., Stephenson, F. A., & Wenthold, R. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402599200 · Cited by 86 · see citing works
Dong, Y., Waxman, E. A., & Lynch, D. R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3722-04.2004 · Cited by 85 · see citing works
Proteolysis of the N-Methyl-d-Aspartate Receptor by Calpain in Situ
Guttmann, R. P., Sokol, S. A., Baker, D. L., Simpkins, K. L., Dong, Y., & Lynch, D. R. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.036962 · Cited by 83 · see citing works
Cyr, M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00233-0 · Cited by 78 · see citing works
Biermann, T., Reulbach, U., Lenz, B., Frieling, H., Muschler, M. A. N., Hillemacher, T., Kornhuber, J., & Bleich, S. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0212-2 · Cited by 77 · see citing works
Kalbaugh, T. L., Zhang, J., & Diamond, J. S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4240-08.2009 · Cited by 76 · see citing works
Blevins, T. L., Mirshahi, T., Chandler, L. J., & Woodward, J. J. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062345.x · Cited by 72 · see citing works
Papadakis, M., Hawkins, L. M., & Stephenson, F. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313446200 · Cited by 70 · see citing works
NMDA Receptor Binding in Adult Rat Brain after Several Chronic Ethanol Treatment Protocols
Rudolph, J. G., Walker, D. W., Limuro, Y., Thurman, R. G., & Crews, F. T. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb04483.x · Cited by 68 · see citing works
Intersubunit Cooperativity in the NMDA Receptor
Regalado, M. P., Villarroel, Á., & Lerma, J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00539-6 · Cited by 67 · see citing works
Anti-NR2A antibody as a predictor for neuropsychiatric systemic lupus erythematosus
Gono, T., Kawaguchi, Y., Kaneko, H., Nishimura, K., Hanaoka, M., Kataoka, S., Okamoto, Y., Katsumata, Y., & Yamanaka, H. (2011) · Rheumatology · doi:10.1093/rheumatology/keq408 · Cited by 63 · see citing works
The NR2B-specific Interactions of Polyamines and Protons with theN-Methyl-d-aspartate Receptor
Gallagher, M. J., Huang, H., Grant, E. R., & Lynch, D. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.24971 · Cited by 64 · see citing works
Testa, C. M., Friberg, I. K., Weiss, S. W., & Standaert, D. G. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980105)390:1 · Cited by 237 · see citing works
Ren, H., Honse, Y., Karp, B. J., Lipsky, R. H., & Peoples, R. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209486200 · Cited by 60 · see citing works
Malignant catatonia due to anti-NMDA-receptor encephalitis in a 17-year-old girl: case report
Consoli, A., Ronen, K., Gourfinkel‐An, I., Barbeau, M., Marra, D., Costedoat-Chalumeau, N., Montefiore, D., Maksud, P., Bonnot, O., Didelot, A., et al. (2011) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-5-15 · Cited by 59 · see citing works
Effect of MK-801 at the human α7 nicotinic acetylcholine receptor
Briggs, C. A., & McKenna, D. G. (1996) · Neuropharmacology · doi:10.1016/0028-3908(96)00006-8 · Cited by 59 · see citing works
Jicha, G. A., Berenfeld, B., & Davies, P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990315)55:6 · Cited by 123 · see citing works
Lin, Y. J., Bovetto, S., Carver, J. M., & Giordano, T. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00146-5 · Cited by 55 · see citing works
Structure of Ionotropic Glutamate Receptors
Hollmann, M. (1999) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-08022-1_1 · Cited by 55 · see citing works
Atlason, P. T., Garside, M. L., Meddows, E., Whiting, P. J., & McIlhinney, R. A. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702778200 · Cited by 54 · see citing works
Albers, D. S., Weiss, S. W., Iadarola, M. J., & Standaert, D. G. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00328-5 · Cited by 54 · see citing works
Ruby, C. L., Brager, A. J., DePaul, M. A., Prosser, R. A., & Glass, J. D. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00268.2009 · Cited by 53 · see citing works
Differentiation of Glycine Antagonist Sites ofN-Methyl-d-aspartate Receptor Subtypes
Honer, M., Benke, D., Laube, B., Kuhse, J., Heckendorn, R., Allgeier, H., Angst, C., Monyer, H., Seeburg, P. H., Betz, H., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.11158 · Cited by 53 · see citing works
Ethanol, Stroke, Brain Damage, and Excitotoxicity
Crews, F. T., Steck, J. C., Chandler, L. J., Yu, C. J., & Day, A. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00538-8 · Cited by 52 · see citing works
Ułas, J., & Cotman, C. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00023-7 · Cited by 54 · see citing works
SCHMOLESKY, M. T., Wang, Y., Creel, D. J., & Leventhal, A. G. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001113)427:2 · Cited by 13 · see citing works
Imaging the PCP site of the NMDA ion channel
Waterhouse, R. N. (2003) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(03)00127-6 · Cited by 47 · see citing works
Terhag, J., Cavara, N. A., & Hollmann, M. (2010) · Methods · doi:10.1016/j.ymeth.2010.01.034 · Cited by 47 · see citing works
Ionotropic glutamate receptors: new types and new concepts
Barnard, E. A. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01053-5 · Cited by 46 · see citing works
Xenopus Oocytes express a unitary glutamate receptor endogenously
Soloviev, M., & Barnard, E. A. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1272 · Cited by 45 · see citing works
Ethanol sensitivity and subunit composition of NMDA receptors in cultured striatal neurons
Popp, R. L., Lickteig, R. L., Browning, M. D., & Lovinger, D. M. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(97)00186-x · Cited by 43 · see citing works
Sensitization Phenomena in Psychiatric Illness
Kraus, J. E. (2000) · Journal of Neuropsychiatry · doi:10.1176/jnp.12.3.328 · Cited by 44 · see citing works
Ibrahim, H. M., Healy, D. J., Hogg, A. J., & Meador‐Woodruff, J. H. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00072-3 · Cited by 41 · see citing works
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (ε2) subunit
Lynch, D. R., Shim, S. S., Seifert, K. M., Kurapathi, S., Mutel, V., Gallagher, M. J., & Guttmann, R. P. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00868-8 · Cited by 40 · see citing works
Chapter 12 Molecular determinants of NMDA receptor pharmacological diversity
Monaghan, D. T., Andaloro, V. J., & Skifter, D. A. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)60437-9 · Cited by 39 · see citing works
Anegawa, N. J., Guttmann, R. P., Grant, E. R., Anand, R., Lindstrom, J. M., & Lynch, D. R. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00050-4 · Cited by 38 · see citing works
Ren, H., Salous, A. K., Paul, J. M., Lipsky, R. H., & Peoples, R. W. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707254 · Cited by 37 · see citing works
Šlamberová, R., Vrajová, M., Schutová, B., Mertlova, M., Macuchova, E., Nohejlová, K., Hrubá, L., PUSKARČÍKOVÁ, J., Bubeníková‐Valešová, V., & Yamamotová, A. (2014) · Physiological Research · doi:10.33549/physiolres.932926 · Cited by 36 · see citing works
Darstein, M., Landwehrmeyer, G. B., & Feuerstein, T. J. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002109900180 · Cited by 35 · see citing works
Waxman, E. A., Baconguis, I., Lynch, D. R., & Robinson, M. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702278200 · Cited by 32 · see citing works
Hoffman, P. L., Bhave, S. V., Kumar, K. N., Iorio, K. R., Snell, L. D., Tabakoff, B., & Michaelis, E. K. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00021-6 · Cited by 31 · see citing works
Long, K. D., Mastropaolo, J. P., Rosse, R. B., Manaye, K. F., & Deutsch, S. I. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.03.007 · Cited by 30 · see citing works
Lead Inhibition of N-Methyl-d-aspartate Receptors Containing NR2A, NR2C and NR2D Subunits
Omelchenko, I., Nelson, C. S., & Allen, C. N. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36933-2 · Cited by 30 · see citing works
Soloviev, M., Brierley, M. J., Shao, Z., Mellor, I. R., Volkova, T. M., Kamboj, R. K., Ishimaru, H., Sudan, H. L., Harris, J. E., Foldes, R. L., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32572 · Cited by 30 · see citing works
Gono, T., Takarada, T., Fukumori, R., Kawaguchi, Y., Kaneko, H., Hanaoka, M., Katsumata, Y., Yoneda, Y., & Yamanaka, H. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30616 · Cited by 27 · see citing works
Sheng, Z., Dai, Q., Prorok, M., & Castellino, F. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.04.016 · Cited by 29 · see citing works
Acklin, P., Allgeier, H., Auberson, Y. P., Bischoff, S. F., Ofner, S., Sauer, D., & Schmutz, M. (1998) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(98)00055-9 · Cited by 29 · see citing works
The influence of glycine and related compounds on spinal cord injury-induced spasticity
Simpson, R. K., Gondo, M., Robertson, C. S., & Goodman, J. C. (1995) · Neurochemical Research · doi:10.1007/bf00995384 · Cited by 27 · see citing works
Kawamoto, S., Uchino, S., Hattori, S., Hamajima, K., Mishina, M., Nakajima‐Iijima, S., & Okuda, K. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00005-d · Cited by 28 · see citing works
Molecular Pathogenesis of Anti-NMDAR Encephalitis
Ding, H., Jian, Z., Stary, C. M., Yi, W., & Xiong, X. (2015) · BioMed Research International · doi:10.1155/2015/643409 · Cited by 26 · see citing works
Smith, J. P., Lal, V., Bowser, D. N., Cappai, R., Masters, C. L., & Ciccotosto, G. D. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.007 · Cited by 27 · see citing works
Anticonvulsant effect of reduced NMDA receptor expression in audiogenic DBA/2 mice
Chapman, A. G., Woodburn, V. L., Woodruff, G. N., & Meldrum, B. S. (1996) · Epilepsy Research · doi:10.1016/s0920-1211(96)00036-8 · Cited by 26 · see citing works
- Authors
- Lynch, D. R., Anegawa, N. J., Verdoorn, T., & Pritchett, D. B.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 1994-03
- Volume
- 45
- Issue
- 3
- Pages
- 540-545
- ISSN
- 0026-895X (ISSN-L)
- OpenAlex
- W1839333079
- Cited by
- 173
- References
- 19
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Funders
- National Institutes of Health (5r01da007130-08)
- National Institute on Drug Abuse (DA 07130-02)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- NMDA receptor, NR1 subunit, NR2A subunit, subunit assembly, glutamate receptor antagonists, glycine antagonist, ligand binding, polyamines, competitive antagonism, non-competitive antagonism, ion channel pharmacology
- MeSH terms
- Binding Sites, Cells, Cultured, Glutamates, Glycine, Humans, Ion Channels, Kynurenic Acid, Transfection, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Excitatory Amino Acid Antagonists, Glutamic Acid
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