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Cited by 53Circadian rhythm and melatoninSleep and Work-Related FatigueAlcohol Consumption and Health Effects

Chronic ethanol attenuates circadian photic phase resetting and alters nocturnal activity patterns in the hamster

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Ruby, Christina L., Brager, Allison J., DePaul, Marc A., Prosser, Rebecca A., Glass, J. David·2009·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.00268.2009PMC PMC2739793
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Abstract

Acute ethanol (EtOH) administration impairs circadian clock phase resetting, suggesting a mode for the disruptive effect of alcohol abuse on human circadian rhythms. Here, we extend this research by characterizing the chronobiological effects of chronic alcohol consumption. First, daily profiles of EtOH were measured in the suprachiasmatic nucleus (SCN) and subcutaneously using microdialysis in hamsters drinking EtOH. In both cases, EtOH peaked near lights-off and declined throughout the dark-phase to low day-time levels. Drinking bouts preceded EtOH peaks by approximately 20 min. Second, hamsters chronically drinking EtOH received a light pulse during the late dark phase [Zeitgeber time (ZT) 18.5] to induce photic phase advances. Water controls had shifts of 1.2 +/- 0.2 h, whereas those drinking 10% and 20% EtOH had much reduced shifts (0.5 +/- 0.1 and 0.3 +/- 0.1 h, respectively; P < 0.001 vs. controls). Third, incremental decreases in light intensity (270 lux to 0.5 lux) were used to explore chronic EtOH effects on photic entrainment and rhythm stability. Activity onset was unaffected by 20% EtOH at all light intensities. Conversely, the 24-h pattern of activity bouts was disrupted by EtOH under all light intensities. Finally, replacement of chronic EtOH with water was used to examine withdrawal effects. Water controls had photic phase advances of 1.1 +/- 0.3 h, while hamsters deprived of EtOH for 2-3 days showed enhanced shifts (2.1 +/- 0.3 h; P < 0.05 vs. controls). Thus, in chronically drinking hamsters, brain EtOH levels are sufficient to inhibit photic phase resetting and disrupt circadian activity. Chronic EtOH did not impair photic entrainment; however, its replacement with water potentiated photic phase resetting.

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  • Animal studies provide strong evidence that both acute and chronic alcohol use disrupts circadian timing through direct effects on the central clock.

    “These limited data are generally cohesive with animal studies, which have provided strong evidence that both acute and chronic alcohol use disrupts circadian timing through direct effects on the central clock (Brager, Ruby, Prosser, & Glass, 2010; Ruby, Brager, DePaul, Prosser, & Glass, 2009).”

    From Sleep and circadian contributions to adolescent alcohol use disorder (2015) · cites this paper as Ruby et al., 2009

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Research works printed but not linked: 2

  1. [27]Hendrikson AE, Wagoner N, Cowan WM. An autoradiographic and electron microscope study of retinohypothalamic connections. Z Zellforsch Mikrosk Anat 135: 1–26, 1972. [DOI] [PubMed] [Google Scholar]
  2. [64]Trinkoff AM, Storr CL. Work schedule characteristic and substance abuse. Am J Ind Med 34: 266–271, 1998. [DOI] [PubMed] [Google Scholar]

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Authors
Ruby, C. L., Brager, A. J., DePaul, M. A., Prosser, R. A., & Glass, J. D.
Affiliations
Kent State University (US)
ORCID
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2009-09
Volume
297
Issue
3
Pages
R729-R737
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.00268.2009
PMC
PMC2739793
OpenAlex
W2129411407
Cited by
53
References
73
Citations by year
2023: 2 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 9 · 2013: 6 · 2012: 5
FWCI
2.09
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Alcohol Abuse and Alcoholism (AA-015948, R21AA015948, R01AA017898)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
chronic ethanol exposure, alcohol consumption, light entrainment, suprachiasmatic nucleus, nocturnal activity patterns, alcohol withdrawal, alcohol abuse, circadian rhythm, hamster
MeSH terms
Alcohol Drinking, Ethanol, Animals, Behavior, Animal, Circadian Rhythm, Cricetinae, Male, Mesocricetus, Photic Stimulation, Substance Withdrawal Syndrome, Suprachiasmatic Nucleus, Photoperiod, Microdialysis

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