Cited by 173Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and MetabolismNicotinic Acetylcholine Receptors Study

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

N-methyl-D-aspartate receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents

Lynch, D R, Anegawa, N J, Verdoorn, T, Pritchett, D B·1994·Molecular Pharmacology

DOI 10.1016/s0026-895x(25)10028-x

Open this paper in CoChat — free account

Abstract

Expression of the NR-1 subunit in Xenopus oocytes produces channels that respond to glutamate and are blocked by competitive and noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptor. Ionic conductances through these channels are increased by coexpression with NR-2 receptor subunits. We have characterized the pharmacological properties of NMDA receptors assembled from combinations of subunits expressed in transfected cells, to determine the minimum subunit requirements for binding of competitive glutamate antagonists, glycine antagonists, and channel-blocking agents, as detected by ligand-binding experiments. Expression of NR-1a alone produced glycine antagonist binding, whereas the combination of NR-1a and NR-2A was needed to produce binding sites for glutamate antagonists and channel-blocking agents. These results suggest that functional NMDA receptors assemble from these subunits. However, differences in the pharmacological effects of NMDA and polyamines show that not all characteristics of native NMDA receptors are reproduced by this combination of subunits.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s0026-895x(25)10028-x

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
Yung-Chi, C., & Prusoff, W. H. (1973) · Biochemical Pharmacology · doi:10.1016/0006-2952(73)90196-2 · Cited by 12,922
High-Efficiency Transformation of Mammalian Cells by Plasmid DNA
Chen, C., & Okayama, H. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.8.2745 · Cited by 5,327
Molecular cloning and characterization of the rat NMDA receptor
Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1991) · Nature · doi:10.1038/354031a0 · Cited by 1,771
Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage
Choi, D. W. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90200-7 · Cited by 1,726
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS
Sommer, B., KEINÄNEN, K. P., Verdoorn, T. A., Wisden, W., Burnashev, N., Herb, A., Köhler, M. G., Takagi, T., Sakmann, B. J., & Seeburg, P. H. (1990) · Science · doi:10.1126/science.1699275 · Cited by 1,272
Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.
Williams, K. L. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13275-6 · Cited by 860
Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs
Meguro, H., Mori, H., Araki, K., Kushiya, E., Kutsuwada, T., Yamazaki, M., Kumanishi, T., Arakawa, M., Sakimura, K., & Mishina, M. (1992) · Nature · doi:10.1038/357070a0 · Cited by 799
Zinc potentiates agonist-lnduced currents at certain splice variants of the NMDA receptor
Hollmann, M., Boulter, J., Maron, C., Beasley, L., Sullivan, J., Pecht, G., & Heinemann, S. F. (1993) · Neuron · doi:10.1016/0896-6273(93)90209-a · Cited by 614
[3H]MK‐801 Labels a Site on the N‐Methyl‐D‐Aspartate Receptor Channel Complex in Rat Brain Membranes
Wong, E. H. F., Knight, A. R., & Woodruff, G. N. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb13260.x · Cited by 454

Show all 19 references

Research works printed but not linked: 1

Monaghan, D. T., H. J. Olverman, L. Nguyen, J. C. Watkins, and C. W. Cotman. Two classes of N-methyl-D-aapartate recognition sites: differential distribution and differential regulation by glycine. Proc. NatL Acad. Sci. USA 85:9836-9840 (1988).

Sorted by citations

Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies
Dalmau, J., Gleichman, A. J., Hughes, E. G., Rossi, J. E., Peng, X., Lai, M., Dessain, S. K., Rosenfeld, M. R., Balice-Gordon, R., & Lynch, D. R. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70224-2 · Cited by 3,488
Self-citation
Paraneoplastic anti– N ‐methyl‐ D ‐aspartate receptor encephalitis associated with ovarian teratoma
Dalmau, J., Tüzün, E., Wu, H., Masjuan, J., Rossi, J. E., Voloschin, A., Baehring, J. M., Shimazaki, H., Koide, R., King, D., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21050 · Cited by 2,492
The Role of Excitotoxicity in Neurodegenerative Disease
Doble, A. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00042-4 · Cited by 723
Glycine and N-Methyl-d-Aspartate Receptors: Physiological Significance and Possible Therapeutic Applications
Danysz, W., & Parsons, C. G. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01382-6 · Cited by 652
Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging
Michaelis, E. K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00055-5 · Cited by 578
Generation, Control, and Processing of Cellular Calcium Signals
Carafoli, E., Santella, L., Branca, D., & Brini, M. (2001) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/20014091074183 · Cited by 524
Molecular Determinants of Agonist Discrimination by NMDA Receptor Subunits: Analysis of the Glutamate Binding Site on the NR2B Subunit
Laube, B., Hirai, H., Sturgess, M., Betz, H., & Kuhse, J. (1997) · Neuron · doi:10.1016/s0896-6273(00)81249-0 · Cited by 476
NMDA Receptor Heterogeneity During Postnatal Development of the Rat Brain: Differential Expression of the NR2A, NR2B, and NR2C Subunit Proteins
Wenzel, A., Fritschy, J., Möhler, H., & Benke, D. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68020469.x · Cited by 442
Abnormal Glutamate Receptor Expression in the Medial Temporal Lobe in Schizophrenia and Mood Disorders
Beneyto, M., Kristiansen, L. V., Oni-Orisan, A., McCullumsmith, R. E., & Meador-Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301312 · Cited by 408
Glutamate receptor expression in schizophrenic brain
Meador‐Woodruff, J. H. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00044-2 · Cited by 416
d-Serine as a Neuromodulator: Regional and Developmental Localizations in Rat Brain Glia Resemble NMDA Receptors
Schell, M. J., Brady Jr., R. O., Molliver, M. E., & Snyder, S. H. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01604.1997 · Cited by 415
Dopamine D1 Receptor-Dependent Trafficking of Striatal NMDA Glutamate Receptors to the Postsynaptic Membrane
Dunah, A. W., & Standaert, D. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05546.2001 · Cited by 374
NMDA receptors: from genes to channels
Sucher, N. J., Awobuluyi, M., Choi, Y., & Lipton, S. A. (1996) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(96)80008-3 · Cited by 312
Effects of Ethanol on Ion Channels
Crews, F. T., Morrow, A. L., Criswell, H. E., & Breese, G. R. (1996) · International review of neurobiology · doi:10.1016/s0074-7742(08)60670-4 · Cited by 296
Targeting the N-Methyl-d-Aspartate Receptor for Chronic Pain Management
Fisher, K., Coderre, T. J., & Hagen, N. A. (2000) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(00)00213-x · Cited by 264
Alterations in Subunit Expression, Composition, and Phosphorylation of Striatal N-Methyl-d-Aspartate Glutamate Receptors in a Rat 6-Hydroxydopamine Model of Parkinson’s Disease
Dunah, A. W., Wang, Y., Yasuda, R. P., Kameyama, K., Huganir, R. L., Wolfe, B. B., & Standaert, D. G. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23206-5 · Cited by 262
Rationale for and use of NMDA receptor antagonists in Parkinson's disease
Hallett, P. J., & Standaert, D. G. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.04.001 · Cited by 238
Ionotropic Glutamate Receptor Binding and Subunit mRNA Expression in Thalamic Nuclei in Schizophrenia
Ibrahim, H. M., Hogg, A. J., Healy, D. J., Haroutunian, V. H., Davis, K. L., & Meador‐Woodruff, J. H. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.11.1811 · Cited by 233
Levodopa-induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease
Calon, F., Rajput, A. H., Hornykiewicz, O., Bédard, P. J., & Paolo, T. D. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.07.003 · Cited by 221
Ontogeny of the N-Methyl-D-Aspartate (NMDA) Receptor System and Susceptibility to Neurotoxicity
Haberny, K. A. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.1.9 · Cited by 218
Glutamate-mediated transmission, alcohol, and alcoholism
Dodd, P. R., Beckmann, A. M., Davidson, M. S., & Wilce, P. A. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(00)00061-9 · Cited by 216
Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule.
Chazot, P. L., Coleman, S. K., Cik, M., & Stephenson, F. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)51098-5 · Cited by 198
N-Methyl- d -Aspartic Acid Receptor Expression in the Dorsolateral Prefrontal Cortex of Elderly Patients With Schizophrenia
Dracheva, S. M., Marras, S. A. E., Elhakem, S. L., Kramer, F. R., Davis, K. L., & Haroutunian, V. H. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.9.1400 · Cited by 190
Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion
Snell, L. D., Nunley, K. R., Lickteig, R. L., Browning, M. D., Tabakoff, B., & Hoffman, P. L. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00038-1 · Cited by 178
Chronic ethanol treatment differentially regulates NMDA receptor subunit mRNA expression in rat brain
Follesa, P., & Ticku, M. K. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00235-7 · Cited by 174
Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia
Crino, P. B., Duhaime, A., Baltuch, G. H., & White, R. (2001) · Neurology · doi:10.1212/wnl.56.7.906 · Cited by 172
Polyamine Regulation of N-Methyl-D-Aspartate Receptor Channels
Rock, D. M., & Macdonald, R. L. (1995) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.002335 · Cited by 168
Quantitative neuropathological changes in presymptomatic Huntington's disease
Gómez‐Tortosa, E., MacDonald, M. E., Friend, J. C., Taylor, S. A., Weiler, L., Cupples, L. A., Srinidhi, J., Gusella, J. F., Bird, E. D., Vonsattel, J., et al. (2001) · Annals of Neurology · doi:10.1002/1531-8249(200101)49:1 · Cited by 174
Interactions between Ifenprodil and the NR2B Subunit of the N-Methyl-D-aspartate Receptor
Gallagher, M. J., Huang, H., Pritchett, D. B., & Lynch, D. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9603 · Cited by 159
Chronic ethanol treatment upregulates the NMDA receptor function and binding in mammalian cortical neurons
Hu, X.-J., & Ticku, M. K. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00019-o · Cited by 161
Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain
Boyer, P., Skolnick, P., & Fossom, L. H. (1998) · Journal of Molecular Neuroscience · doi:10.1007/bf02761776 · Cited by 158
Selective Activation Induced Cleavage of the NR2B Subunit by Calpain
Simpkins, K. L., Guttmann, R. P., Dong, Y., Chen, Z., Sokol, S. A., Neumar, R. W., & Lynch, D. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-36-11322.2003 · Cited by 146
Expression of NMDA glutamate receptor subunit mRNAs in neurochemically identified projection and interneurons in the striatum of the rat
Standaert, D. G., Friberg, I. K., Landwehrmeyer, G. B., Young, A. B., & Penney, J. B. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00293-9 · Cited by 143
Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons
Hu, X.-J., Follesa, P., & Ticku, M. K. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00223-f · Cited by 142
Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder
Meador‐Woodruff, J. H., Hogg, A. J., & Smith, R. E. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00523-8 · Cited by 141
Exitatory Amino Acids in Health and Disease
THOMAS, R. J. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb07407.x · Cited by 138
Regulation of NMDA receptors by ethanol
Kumari, M., & Ticku, M. K. (2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8391-7_5 · Cited by 135
Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder
Scarr, E., Pavey, G., Sundram, S., Mackinnon, A. J., & Dean, B. (2003) · Bipolar Disorders · doi:10.1034/j.1399-5618.2003.00024.x · Cited by 121
Specific proteolysis of the NR2 subunit at multiple sites by calpain
Guttmann, R. P., Baker, D. L., Seifert, K. M., Cohen, A. S., Coulter, D. A., & Lynch, D. R. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00493.x · Cited by 111
Ethanol-induced inhibition of NMDA receptor channels
Wirkner, K., Poelchen, W., Köles, L., Mühlberg, K. S., Scheibler, P., Allgaier, C., & Illés, P. (1999) · Neurochemistry International · doi:10.1016/s0197-0186(99)00057-1 · Cited by 107
Molecular Biology and Ontogeny of Glutamate Receptors in the Mammalian Central Nervous System
Simeone, T. A., Sanchez, R. M., & Rho, J. M. (2004) · Journal of Child Neurology · doi:10.1177/088307380401900507 · Cited by 110
Molecular Abnormalities of the Glutamate Synapse in the Thalamus in Schizophrenia
Meador‐Woodruff, J. H., Clinton, S. M., Beneyto, M., & McCullumsmith, R. E. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.005 · Cited by 104
Glycine-Independent NMDA Receptor Desensitization: Localization of Structural Determinants
Villarroel, Á., Regalado, M. P., & Lerma, J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80460-2 · Cited by 99
Improving the antibody-based evaluation of autoimmune encephalitis
McCracken, L., Zhang, J., Greene, M. I., Crivaro, A., González, J., Kamoun, M., & Lancaster, E. (2017) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000404 · Cited by 98
Alteration of glutamate receptors in the striatum of dyskinetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys following dopamine agonist treatment
Calon, F., Morissette, M., Ghribi, O., Goulet, M., Grondin, R., Blanchet, P. J., Bédard, P. J., & Paolo, T. D. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00237-8 · Cited by 93
Anti-NMDA-Receptor Encephalitis: Case Report and Literature Review of an Under-Recognized Condition
Day, G. S., High, S., Cot, B., & Tang‐Wai, D. F. (2011) · Journal of General Internal Medicine · doi:10.1007/s11606-011-1641-9 · Cited by 93
Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis
Liu, C., Zhu, J., Zheng, X., Ma, C., & Wang, X. (2017) · Mediators of Inflammation · doi:10.1155/2017/6361479 · Cited by 89
Subcellular segregation of distinct heteromeric NMDA glutamate receptors in the striatum
Dunah, A. W., & Standaert, D. G. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01744.x · Cited by 89
Export from the Endoplasmic Reticulum of Assembled N-Methyl-D-aspartic Acid Receptors Is Controlled by a Motif in the C Terminus of the NR2 Subunit
Hawkins, L. M., Prybylowski, K., Chang, K., Moussan, C., Stephenson, F. A., & Wenthold, R. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402599200 · Cited by 86
Interactions of Postsynaptic Density-95 and the NMDA Receptor 2 Subunit Control Calpain-Mediated Cleavage of the NMDA Receptor
Dong, Y., Waxman, E. A., & Lynch, D. R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3722-04.2004 · Cited by 85
Proteolysis of the N-Methyl-d-Aspartate Receptor by Calpain in Situ
Guttmann, R. P., Sokol, S. A., Baker, D. L., Simpkins, K. L., Dong, Y., & Lynch, D. R. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.036962 · Cited by 83
Estrogen-like Activity of Tamoxifen and Raloxifene on NMDA Receptor Binding and Expression of its Subunits in Rat Brain
Cyr, M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00233-0 · Cited by 80
N-methyl-d-aspartate 2b receptor subtype (NR2B) promoter methylation in patients during alcohol withdrawal
Biermann, T., Reulbach, U., Lenz, B., Frieling, H., Muschler, M. A. N., Hillemacher, T., Kornhuber, J., & Bleich, S. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0212-2 · Cited by 77
Coagonist Release Modulates NMDA Receptor Subtype Contributions at Synaptic Inputs to Retinal Ganglion Cells
Kalbaugh, T. L., Zhang, J., & Diamond, J. S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4240-08.2009 · Cited by 76
Effects of Acute and Chronic Ethanol Exposure on Heteromeric N‐Methyl‐ d ‐Aspartate Receptors Expressed in HEK 293 Cells
Blevins, T. L., Mirshahi, T., Chandler, L. J., & Woodward, J. J. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062345.x · Cited by 72
Appropriate NR1-NR1 Disulfide-linked Homodimer Formation Is Requisite for Efficient Expression of Functional, Cell Surface N-Methyl-D-aspartate NR1/NR2 Receptors
Papadakis, M., Hawkins, L. M., & Stephenson, F. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313446200 · Cited by 74
NMDA Receptor Binding in Adult Rat Brain after Several Chronic Ethanol Treatment Protocols
Rudolph, J. G., Walker, D. W., Limuro, Y., Thurman, R. G., & Crews, F. T. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb04483.x · Cited by 68
Intersubunit Cooperativity in the NMDA Receptor
Regalado, M. P., Villarroel, Á., & Lerma, J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00539-6 · Cited by 67
Anti-NR2A antibody as a predictor for neuropsychiatric systemic lupus erythematosus
Gono, T., Kawaguchi, Y., Kaneko, H., Nishimura, K., Hanaoka, M., Kataoka, S., Okamoto, Y., Katsumata, Y., & Yamanaka, H. (2011) · Rheumatology · doi:10.1093/rheumatology/keq408 · Cited by 63
The NR2B-specific Interactions of Polyamines and Protons with theN-Methyl-d-aspartate Receptor
Gallagher, M. J., Huang, H., Grant, E. R., & Lynch, D. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.24971 · Cited by 62
Expression of N-Methyl-D-Aspartate receptor subunit mRNAs in the human brain: Striatum and globus pallidus
Kosinski, C. M., Standaert, D. G., Counihan, T. J., Scherzer, C. R., Kerner, J. A., Daggett, L. P., Veli�elebi, G., Penney, J. B., Young, A. B., & Landwehrmeyer, G. B. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980105)390:1 · Cited by 62
A Site in the Fourth Membrane-associated Domain of the N-Methyl-d-aspartate Receptor Regulates Desensitization and Ion Channel Gating
Ren, H., Honse, Y., Karp, B. J., Lipsky, R. H., & Peoples, R. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209486200 · Cited by 60
Malignant catatonia due to anti-NMDA-receptor encephalitis in a 17-year-old girl: case report
Consoli, A., Ronen, K., Gourfinkel‐An, I., Barbeau, M., Marra, D., Costedoat-Chalumeau, N., Montefiore, D., Maksud, P., Bonnot, O., Didelot, A., et al. (2011) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-5-15 · Cited by 59
Effect of MK-801 at the human α7 nicotinic acetylcholine receptor
Briggs, C. A., & McKenna, D. G. (1996) · Neuropharmacology · doi:10.1016/0028-3908(96)00006-8 · Cited by 57
Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease
Jicha, G. A., Berenfeld, B., & Davies, P. J. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990315)55:6 · Cited by 119
Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery
Lin, Y. J., Bovetto, S., Carver, J. M., & Giordano, T. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00146-5 · Cited by 57
Structure of Ionotropic Glutamate Receptors
Hollmann, M. (1999) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-08022-1_1 · Cited by 56
N-Methyl-d-aspartate (NMDA) Receptor Subunit NR1 Forms the Substrate for Oligomeric Assembly of the NMDA Receptor
Atlason, P. T., Garside, M. L., Meddows, E., Whiting, P. J., & McIlhinney, R. A. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702778200 · Cited by 59
Immunohistochemical localization of N-methyl-d-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor subunits in the substantia nigra pars compacta of the rat
Albers, D. S., Weiss, S. W., Iadarola, M. J., & Standaert, D. G. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00328-5 · Cited by 53
Chronic ethanol attenuates circadian photic phase resetting and alters nocturnal activity patterns in the hamster
Ruby, C. L., Brager, A. J., DePaul, M. A., Prosser, R. A., & Glass, J. D. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00268.2009 · Cited by 53
Differentiation of Glycine Antagonist Sites ofN-Methyl-d-aspartate Receptor Subtypes
Honer, M., Benke, D., Laube, B., Kuhse, J., Heckendorn, R., Allgeier, H., Angst, C., Monyer, H., Seeburg, P. H., Betz, H., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.11158 · Cited by 53
Ethanol, Stroke, Brain Damage, and Excitotoxicity
Crews, F. T., Steck, J. C., Chandler, L. J., Yu, C. J., & Day, A. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00538-8 · Cited by 52
Decreased expression of N-methyl-d-aspartate receptor 1 messenger RNA in select regions of Alzheimer brain
Ułas, J., & Cotman, C. W. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00023-7 · Cited by 51
Ultrastructural localization of the serotonin transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to dopamine terminals
Miner, L. H., Schroeter, S., Blakely, R., & Sesack, S. R. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001113)427:2 · Cited by 148
Imaging the PCP site of the NMDA ion channel
Waterhouse, R. N. (2003) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(03)00127-6 · Cited by 47
Cave Canalem: How endogenous ion channels may interfere with heterologous expression in Xenopus oocytes
Terhag, J., Cavara, N. A., & Hollmann, M. (2010) · Methods · doi:10.1016/j.ymeth.2010.01.034 · Cited by 47
Ionotropic glutamate receptors: new types and new concepts
Barnard, E. A. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01053-5 · Cited by 46
Xenopus Oocytes express a unitary glutamate receptor endogenously
Soloviev, M., & Barnard, E. A. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1272 · Cited by 44
Ethanol sensitivity and subunit composition of NMDA receptors in cultured striatal neurons
Popp, R. L., Lickteig, R. L., Browning, M. D., & Lovinger, D. M. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(97)00186-x · Cited by 43
Sensitization Phenomena in Psychiatric Illness
Kraus, J. E. (2000) · Journal of Neuropsychiatry · doi:10.1176/jnp.12.3.328 · Cited by 44
Nucleus-specific expression of ionotropic glutamate receptor subunit mRNAs and binding sites in primate thalamus
Ibrahim, H. M., Healy, D. J., Hogg, A. J., & Meador‐Woodruff, J. H. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00072-3 · Cited by 41
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (ε2) subunit
Lynch, D. R., Shim, S. S., Seifert, K. M., Kurapathi, S., Mutel, V., Gallagher, M. J., & Guttmann, R. P. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00868-8 · Cited by 40
Chapter 12 Molecular determinants of NMDA receptor pharmacological diversity
Monaghan, D. T., Andaloro, V. J., & Skifter, D. A. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)60437-9 · Cited by 40
N-Methyl-d-aspartate receptor mediated toxicity in nonneuronal cell lines: characterization using fluorescent measures of cell viability and reactive oxygen species production
Anegawa, N. J., Guttmann, R. P., Grant, E. R., Anand, R., Lindstrom, J. M., & Lynch, D. R. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00050-4 · Cited by 38
Mutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency, ion channel gating and alcohol action
Ren, H., Salous, A. K., Paul, J. M., Lipsky, R. H., & Peoples, R. W. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707254 · Cited by 37
Prenatal Methamphetamine Exposure Induces Long-Lasting Alterations in Memory and Development of NMDA Receptors in the Hippocampus
Šlamberová, R., Vrajová, M., Schutová, B., Mertlova, M., Macuchova, E., Nohejlová, K., Hrubá, L., PUSKARČÍKOVÁ, J., Bubeníková‐Valešová, V., & Yamamotová, A. (2014) · Physiological Research · doi:10.33549/physiolres.932926 · Cited by 36
Changes in NMDA receptor subunit gene expression in the rat brain following withdrawal from forced long-term ethanol intake
Darstein, M., Landwehrmeyer, G. B., & Feuerstein, T. J. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002109900180 · Cited by 35
N-Methyl-d-aspartate Receptor-dependent Regulation of the Glutamate Transporter Excitatory Amino Acid Carrier 1
Waxman, E. A., Baconguis, I., Lynch, D. R., & Robinson, M. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702278200 · Cited by 33
The 71 kDa glutamate-binding protein is increased in cerebellar granule cells after chronic ethanol treatment
Hoffman, P. L., Bhave, S. V., Kumar, K. N., Iorio, K. R., Snell, L. D., Tabakoff, B., & Michaelis, E. K. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00021-6 · Cited by 31
Modulatory effects of d-serine and sarcosine on NMDA receptor-mediated neurotransmission are apparent after stress in the genetically inbred BALB/c mouse strain
Long, K. D., Mastropaolo, J. P., Rosse, R. B., Manaye, K. F., & Deutsch, S. I. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.03.007 · Cited by 30
Lead Inhibition of N-Methyl-d-aspartate Receptors Containing NR2A, NR2C and NR2D Subunits
Omelchenko, I., Nelson, C. S., & Allen, C. N. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36933-2 · Cited by 30
Functional Expression of a Recombinant Unitary Glutamate Receptor from Xenopus, Which Contains N-Methyl-D-aspartate (NMDA) and Non-NMDA Receptor Subunits
Soloviev, M., Brierley, M. J., Shao, Z., Mellor, I. R., Volkova, T. M., Kamboj, R. K., Ishimaru, H., Sudan, H. L., Harris, J. E., Foldes, R. L., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32572 · Cited by 30
NR2-reactive antibody decreases cell viability through augmentation of Ca2+ influx in systemic lupus erythematosus
Gono, T., Takarada, T., Fukumori, R., Kawaguchi, Y., Kaneko, H., Hanaoka, M., Katsumata, Y., Yoneda, Y., & Yamanaka, H. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30616 · Cited by 27
Subtype-selective antagonism of N-methyl-d-aspartate receptor ion channels by synthetic conantokin peptides
Sheng, Z., Dai, Q., Prorok, M., & Castellino, F. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.04.016 · Cited by 29
5-aminomethylquinoxaline-2,3-diones, Part III: Arylamide derivatives as highly potent and selective glycine-site NMDA receptor antagonists
Acklin, P., Allgeier, H., Auberson, Y. P., Bischoff, S. F., Ofner, S., Sauer, D., & Schmutz, M. (1998) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(98)00055-9 · Cited by 29
The influence of glycine and related compounds on spinal cord injury-induced spasticity
Simpson, R. K., Gondo, M., Robertson, C. S., & Goodman, J. C. (1995) · Neurochemical Research · doi:10.1007/bf00995384 · Cited by 27
Expression and characterization of the ζ1 subunit of the N-methyl-d-aspartate (NMDA) receptor channel in a baculovirus system
Kawamoto, S., Uchino, S., Hattori, S., Hamajima, K., Mishina, M., Nakajima‐Iijima, S., & Okuda, K. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00005-d · Cited by 28
Molecular Pathogenesis of Anti-NMDAR Encephalitis
Ding, H., Jian, Z., Stary, C. M., Yi, W., & Xiong, X. (2015) · BioMed Research International · doi:10.1155/2015/643409 · Cited by 28
Stimulus pattern dependence of the Alzheimer's disease amyloid-β 42 peptide's inhibition of long term potentiation in mouse hippocampal slices
Smith, J. P., Lal, V., Bowser, D. N., Cappai, R., Masters, C. L., & Ciccotosto, G. D. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.007 · Cited by 27
Anticonvulsant effect of reduced NMDA receptor expression in audiogenic DBA/2 mice
Chapman, A. G., Woodburn, V. L., Woodruff, G. N., & Meldrum, B. S. (1996) · Epilepsy Research · doi:10.1016/s0920-1211(96)00036-8 · Cited by 26

Authors: Lynch, D. R., Anegawa, N. J., Verdoorn, T., & Pritchett, D. B.
Affiliations: University of Pennsylvania (US)
ORCID: Lynch, D R
Verdoorn, T
Venue: Molecular Pharmacology
Publisher: Elsevier BV
Published: 1994-03
Volume: 45
Issue: 3
Pages: 540-545
ISSN: 0026-895X (ISSN-L)
DOI: 10.1016/s0026-895x(25)10028-x
OpenAlex: W1839333079
Cited by: 173
References: 19
Citations by year: 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 1
FWCI: 4.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Molecular Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed
Funders: National Institutes of Health (5r01da007130-08)
National Institute on Drug Abuse (DA 07130-02)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: NMDA receptor, NR1 subunit, NR2A subunit, subunit assembly, glutamate receptor antagonists, glycine antagonist, ligand binding, polyamines, competitive antagonism, non-competitive antagonism, ion channel pharmacology
MeSH terms: Binding Sites, Cells, Cultured, Glutamates, Glycine, Humans, Ion Channels, Kynurenic Acid, Transfection, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Excitatory Amino Acid Antagonists, Glutamic Acid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

N-methyl-D-aspartate receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks