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Homeostatic Imbalance between Apoptosis and Cell Renewal in the Liver of Premature Aging XpdTTD Mice

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Understanding the Blood-Brain Barrier: From Physiology to Pathology

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Effect of Every-Other-Day Fasting on Spontaneous Chromosomal Damage in Rat's Bone-Marrow Cells

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Machine learning based classification of cells into chronological stages using single-cell transcriptomics

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Spontaneous Mutations in Digestive Tract of Old Mice Show Tissue-Specific Patterns of Genomic Instability

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Senescence and apoptosis in yeast mother cell-specific aging and in higher cells: A short review

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Age-related alteration in hepatic acyl-CoA: cholesterol acyltransferase and its relation to LDL receptor and MAPK

Bose, C., Bhuvaneswaran, C., & Udupa, K. B. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.02.003 · Cited by 27

Detection and Analysis of Somatic Mutations at a lacZ Reporter Locus in Higher Organisms

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DNA Enrichment by Allele-Specific Hybridization (DEASH): A Novel Method for Haplotyping and for Detecting Low-Frequency Base Substitutional Variants and Recombinant DNA MoleculesPreprint

Jeffreys, A. J., & May, C. A. (2003) · Genome Research · doi:10.1101/gr.1214603 · Cited by 26

Mitochondrial DNA deletions and differential mitochondrial DNA content in Rhesus monkeys: Implications for aging

Mao, P., Gallagher, P., Nedungadi, S., Mańczak, M., Shirendeb, U. P., Kohama, S. G., Ferguson, B. M., Park, B. S., & Reddy, P. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.014 · Cited by 26

DNA Damage and the Aging Epigenome

Siametis, A., Niotis, G., & Garinis, G. A. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.10.006 · Cited by 24

Maintaining Genetic Integrity in Aging: A Zero Sum Game

Suh, Y., & Vijg, J. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.559 · Cited by 24

Microsatellite instability in in vitro ageing of T lymphocyte clones

Neri, S., Cattini, L., Facchini, A., Pawelec, G., & Mariani, E. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.11.017 · Cited by 23

Effect of DNA Repair on Aging of Transgenic Drosophila melanogaster: I. mei-41 Locus

Symphorien, S., & Woodruff, R. C. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.9.b782 · Cited by 22

Genomic instability and genetic heterogeneity in aging: insights from clonal hematopoiesis (CHIP), monoclonal gammopathy (MGUS), and monoclonal B-cell lymphocytosis (MBL)

Kállai, A., Ungvari, Z. I., Fekete, M., Maier, A. B., Mikala, G., Andrikovics, H., & Lehoczki, A. (2024) · GeroScience · doi:10.1007/s11357-024-01374-y · Cited by 25

Age-related Cardiac Deterioration: insights from Drosophila

Wessells, R. J. (2006) · Frontiers in bioscience · doi:10.2741/2047 · Cited by 23

Moderate G6PD deficiency increases mutation rates in the brain of mice

Felix, K., Rockwood, L. D., Pretsch, W., Nair, J., Bartsch, H., Bornkamm, G.-W., & Janz, S. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00756-6 · Cited by 22

Serum Oxidative Stress Markers and Genotoxic Profile Induced by Chemotherapy in Patients with Breast Cancer: A Pilot Study

Júnior, A. L. G., Paz, M. F. C. J., da Silva, L. I. S., Carvalho, S. D. C. E. S., Sobral, A. L. P., Machado, K. D. C., Ferreira, P. M. P., Satyal, P., de Freitas, R. M., & Cavalcante, A. A. D. C. M. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/212964 · Cited by 21

Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice

Popovich, I. G., Voĭtenkov, B. O., Anisimov, V. N., Ivanov, V. T., Mikhaleva, I. I., Zabezhinski, M. A., Alimova, I. N., Baturin, D. A., Zavarzina, N. Y., Rosenfeld, S. V., et al. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00082-4 · Cited by 21

Yeast Aging and Apoptosis

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Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability

Chen, M., Huang, J., Deng, H. K., Dong, S.-S., Deng, W., Tsang, S. L., Huen, M. S. Y., Chen, L., Tong, Z., Zhu, G., et al. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-199 · Cited by 20

Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice

Anisimov, V. N., Khavinson, V. K., Popovich, I. G., Zabezhinski, M. A., Alimova, I. N., Rosenfeld, S. V., Zavarzina, N. Y., Semenchenko, A. V., & Yashin, A. I. (2003) · Biogerontology · doi:10.1023/a:1025114230714 · Cited by 20

Senescence-Dependent MutSα Dysfunction Attenuates Mismatch Repair

Chang, I. Y., Jin, M., Yoon, S. P., Youn, C.-K., Yoon, Y. A., Moon, S.-P., Hyun, J. W., Jun, J. Y., & You, H. J. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0380 · Cited by 20

Cancer: evolutionary, genetic and epigenetic aspects

Lichtenstein, A. V. (2010) · Clinical Epigenetics · doi:10.1007/s13148-010-0010-6 · Cited by 20

Which is the Most Reasonable Anti-aging Strategy: Meta-analysis

Liang, Y., & Wang, Z. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1117-8_17 · Cited by 23

Myelodysplastic syndromes, aging, and age: Correlations, common mechanisms, and clinical implications

Pfeilstöcker, M., Karlic, H., Nösslinger, T., Sperr, W. R., Stauder, R., Krieger, O., & Valent, P. (2007) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190701534382 · Cited by 21

Germline burden of rare damaging variants negatively affects human healthspan and lifespan

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Evolution of Aging and Death: What Insights Bacteria Can Provide

Baig, U. I., Bhadbhade, B. J., & Watve, M. (2014) · The Quarterly Review of Biology · doi:10.1086/677572 · Cited by 19

Microsatellite Instability and Compromized Mismatch Repair Gene Expression During In Vitro Passaging of Monoclonal Human T Lymphocytes

Neri, S., Pawelec, G., Facchini, A., & Mariani, E. (2007) · Rejuvenation Research · doi:10.1089/rej.2006.0510 · Cited by 19

Aging and cancer in transgenic and mutant mice

Anisimov, V. N. (2003) · Frontiers in bioscience · doi:10.2741/1122 · Cited by 19

Age-related changes in the response of intestinal cells to 1α,25(OH)2-vitamin D3

Pardo, V. G., & de Boland, A. R. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.06.001 · Cited by 18

Effects of multivitamin supplementation on DNA damage in lymphocytes from elderly volunteers

Ribeiro, M. L., Arçari, D. P., Squassoni, A. C., & Pedrazzoli, J. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.08.002 · Cited by 18

BRCA1 Gene Sequence Variation in Centenarians

Vijg, J., Perls, T. T., Franceschi, C., & van Orsouw, N. J. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05639.x · Cited by 17

ADAR1 Protein Induces Adenosine-targeted DNA Mutations in Senescent Bcl6 Gene-deficient Cells

Tsuruoka, N., Arima, M., Yoshida, N., Okada, S., Sakamoto, A., Hatano, M., Satake, H., Arguni, E., Wang, J. O., Yang, J.-H., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.365718 · Cited by 16

Somatic mutations – Evolution within the individual

Oota, S. (2019) · Methods · doi:10.1016/j.ymeth.2019.11.002 · Cited by 19

Cancer as a Programmed Death of an Organism

Lichtenstein, A. V. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0224-y · Cited by 15

Research and perspectives in neurosciences

Reul, J., & Linthorst, A. C. E. (2000) · Cited by 15

Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging

Chao, C., Shen, P.-W., Tzeng, T., Kung, H., Tsai, T., & Wong, Y. (2021) · Biomedicines · doi:10.3390/biomedicines9111635 · Cited by 13

Circadian tempo: A paradigm for genome stability?

Shadan, F. F. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.08.020 · Cited by 14

DNA repair in human fibroblasts, as reflected by host-cell reactivation of a transfected UV-irradiated luciferase gene, is not related to donor age

Merkle, T. J., O’Brien, K., Brooks, P. J., Tarone, R. E., & Robbins, J. H. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.02.013 · Cited by 14

Age-associated alterations in the somatic mutation level in Arabidopsis thaliana

Kiselev, K. V., Tyunin, A. P., Ogneva, Z. V., & Dubrovina, A. S. (2014) · Plant Growth Regulation · doi:10.1007/s10725-014-0012-z · Cited by 13

Biological Interactions of Aging and Carcinogenesis

Anisimov, V. N. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-387-23962-6_2 · Cited by 13

The protein poly(ADP-ribosyl)ation system: Its role in genome stability and lifespan determination

Shilovsky, G. A., Khokhlov, A. N., & Shram, S. I. (2013) · Biochemistry (Moscow) · doi:10.1134/s0006297913050015 · Cited by 13

A reduction in DNA damage in neural tissue and peripheral blood of old mice treated with caffeine

Damiani, A. P., Garcez, M. L., de Abreu, L. L., Tavares, T. H., Boeck, C. R., & de Andrade, V. M. (2017) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2017.1286901 · Cited by 12

Differential activation of mitogen-activated protein kinases by methyl methanesulfonate in the kidney of young and old rats

Suh, Y., & Park, S. C. (2001) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(01)00207-8 · Cited by 13

Hematopoietic Stem Cells: Self-Renewing or Aging?

de Haan, G. (2002) · Cells Tissues Organs · doi:10.1159/000057689 · Cited by 13

Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect

Anglada, T., Repullés, J., Espinal, A., LaBarge, M. A., Stampfer, M. R., Genescà, A., & Martı́n, M. (2019) · Aging · doi:10.18632/aging.101849 · Cited by 11

Analysis of chemotherapy effect on the second primary malignancy for head and neck cancer patients by a nomogram based on SEER database

Li, X., Guo, K., Feng, Y., & Guo, Y. (2020) · Cancer Medicine · doi:10.1002/cam4.3442 · Cited by 12

Multiple primary malignancies in elderly patients with high-grade soft tissue sarcoma

Kozawa, E., Sugiura, H., Tsukushi, S., Urakawa, H., Arai, E., Futamura, N., Nakashima, H., Yamada, Y., Ishiguro, N., & Nishida, Y. (2013) · International Journal of Clinical Oncology · doi:10.1007/s10147-013-0543-8 · Cited by 12

DNA repair, insulin signaling and sirtuins: at the crossroads between cancer and aging

Mostoslavsky, R. (2008) · Frontiers in bioscience · doi:10.2741/3203 · Cited by 11

Sex, senescence, sources and sinks

Galipaud, M., & Kokko, H. (2019) · Functional Ecology · doi:10.1111/1365-2435.13462 · Cited by 13

Carcinogenesis: Evolution of concepts

Lichtenstein, A. V. (2009) · Biochemistry (Moscow) · doi:10.1134/s0006297909040014 · Cited by 10

Association Between Telomere Shortening and Ageing During Occupational Exposure

Eshkoor, S. A., Jahanshiri, F., Ismail, P., Rahman, S. A., Moin, S., & Adon, M. Y. (2012) · Journal of Medical Biochemistry · doi:10.2478/v10011-012-0005-2 · Cited by 10

mtLOH (mitochondrial loss of heteroplasmy), aging, and ‘surrogate self’

Nekhaeva, E., Kraytsberg, Y., & Khrapko, K. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00026-x · Cited by 10

Effect of Epithalon on the Incidence of Chromosome Aberrations in Senescence-Accelerated Mice

Rosenfeld, S. V., Togo, E. F., Mikheev, V. S., Popovich, I. G., Zabezhinskiĭ, M. A., Khavinson, V. K., & Anisimov, V. N. (2002) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1015899003974 · Cited by 10

PTH regulation of c-Jun terminal kinase and p38 MAPK cascades in intestinal cells from young and aged rats

Buzzi, N. S., Boland, R., & de Boland, A. R. (2006) · Biogerontology · doi:10.1007/s10522-006-9068-0 · Cited by 9

The Role of Somatic and Germline Mutations in Aging and a Mutation Interaction Model of Aging

Woodruff, R. C., & Thompson, J. N. (2003) · Rejuvenation Research · doi:10.1089/109454503765361560 · Cited by 9

Pharmacologic manipulation of the ataxia–telangiectasia mutated gene product as an intervention in age-related disease

Shackelford, R. E. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.02.015 · Cited by 9

Mitochondrial mutation detection using enhanced multiplex denaturing high‐performance liquid chromatography

Bayat, A., Walter, J., Lamb, H., Marino, M. J., Ferguson, M. W. J., & Ollier, W. (2005) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2005.00508.x · Cited by 9

Polymorphism of CAG repeats in androgen receptor of carnivores

Wang, Q., Zhang, X., Wang, X., Zeng, B., Jia, X., Hou, R., & Yue, B. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-0979-8 · Cited by 8

The Szilard Hypothesis on the Nature of Aging Revisited

Zetterberg, H., Båth, M., Zetterberg, M., Bernhardt, P., & Hammarsten, O. (2009) · Genetics · doi:10.1534/genetics.109.103341 · Cited by 9

Theory of the age dependence of mortality from congenital defects

Dolejs, J. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00325-6 · Cited by 8

A life course approach to biological ageing

Sayer, A. A., & Cooper, C. C. (2004) · doi:10.1093/acprof:oso/9780198578154.003.0013 · Cited by 8

Differential response of mature TrkA/p75NTR expressing human and pig oligodendrocytes: Aging, does it matter?

Althaus, H. H., Mursch, K., & Klöppner, S. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1053 · Cited by 8

Pathomechanisms of Photoaged Skin

Krutmann, J. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_10 · Cited by 7

ROLE OF THE CYP1A2 GENE POLYMORPHISM ON EARLY AGEING FROM OCCUPATIONAL EXPOSURE

Eshkoor, S. A., Ismail, P., Rahman, S., Moin, S., & Adon, M. (2013) · Balkan Journal of Medical Genetics · doi:10.2478/bjmg-2013-0031 · Cited by 7

DNA Repair: Corrections in the Golden Years

Gottschling, D. E. (2006) · Current Biology · doi:10.1016/j.cub.2006.10.016 · Cited by 7

Genetically Engineered Mice and Their Use in Aging Research

Andersen, J. K. (2001) · Molecular Biotechnology · doi:10.1385/mb:19:1:045 · Cited by 7

Changing complexity in aging: a metric not an hypothesis

Kirkwood, T. B. L. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00260-3 · Cited by 7

An Old Question Revisited: Current Understanding of Aging Theories

Wong, T. P. (2020) · McGill Journal of Medicine · doi:10.26443/mjm.v6i1.693 · Cited by 7

Dynamics of Chromosomal Aberrations in Male Mice of Various Strains during Aging

Sv, R., Togo, E. F., Михеев, Popovich, I. G., Zabezhinskiĭ, & Anisimov, V. N. (2001) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1017940418751 · Cited by 7

Non-neutral role of replicative senescence in tissue homeostasis and tumorigenesis

Poyatos, J. F., & Carnero, A. (2004) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2004.05.011 · Cited by 6

Genotype Profiles of Loci Encoding DNA Repair Enzymes in Newborn and Elderly Populations: No Evidence of Association with Longevity

Wilding, C. S., Rees, G. S., Relton, C. L., & Tawn, E. J. (2006) · Biogerontology · doi:10.1007/s10522-005-6042-1 · Cited by 6

Improved Mutation Detection in Duplex Sequencing Data with Sample-Specific Error ProfilesPreprint

Cheng, Y., Nandi, S. P., Culibrk, L., Kristin, A., Stuewe, I., Al-Azzam, S., Petljak, M., & Alexandrov, L. B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.13.664565 · Cited by 7

Molecular and Environmental Modulators of Aging: Interplay Between Inflammation, Epigenetics, and RNA Stability

Dragoumani, K., Kletsas, D., Chrousos, G. P., Vlachakis, D., & Balatsos, N. A. A. (2025) · Genes · doi:10.3390/genes16070796 · Cited by 5

The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age

Šetinc, M., Celinšćak, Ž., Bočkor, L., Petranović, M. Z., Marković, A. S., Salihović, M. P., Deelen, J., & Škarić‐Jurić, T. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111926 · Cited by 5

Aging and Cancer Biology

Anisimov, V. N. (2017) · Springer eBooks · doi:10.1007/978-3-319-44870-1_72-1 · Cited by 5

Optimal intercellular competition in senescence and cancer

Michaels, T. C. T., & Mahadevan, L. (2023) · Proceedings of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rspa.2023.0204 · Cited by 4

Alzheimer's Disease, Mild Cognitive Impairment, and the Biology of Intrinsic Aging

Kirkwood, T. B. L. (2006) · Philosophy, psychiatry & psychology · doi:10.1353/ppp.2006.0043 · Cited by 5

Cytogenetic Aberrations in the Cells of Liver and Spermatogenic Epithelium in Senescence Accelerated SAMP1 and SAMR1 Mice

Zakhidov, S. T., Маршак, Т. Л., Uryvaeva, I. V., Gopko, A. V., Semenova, М. L., Delone, G. V., Mikhaleva, Y. Y., & Makarov, A. A. (2002) · Russian Journal of Developmental Biology · doi:10.1023/a:1021158727040 · Cited by 5

Low-Fidelity Alternative Dna Repair Carcinogenesis Theory May Interpret Many Cancer Features and Anticancer Strategies

Jiang, C., Starr, S., Chen, F., & Wu, J. (2016) · Future Oncology · doi:10.2217/fon-2016-0066 · Cited by 4

The impact of the cardiovascular component and somatic mutations on ageing

Garger, D., Meinel, M., Dietl, T., Hillig, C., Garzorz‐Stark, N., Eyerich, K., de Angelis, M. H., Eyerich, S., & Menden, M. P. (2023) · Aging Cell · doi:10.1111/acel.13957 · Cited by 3

Contribution of CYP2E1 polymorphism to aging in the mechanical workshop workers

Eshkoor, S. A., Ismail, P., Rahman, S. A., Adon, M. Y., & Devan, R. V. (2012) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2012.743637 · Cited by 4

Sleep-wake cycle, aging and cancer

Shadan, F. F. (2008) · Journal of Applied Biomedicine · doi:10.32725/jab.2008.016 · Cited by 4

Skin Aging

Krutmann, J. (2010) · Springer eBooks · doi:10.1007/978-3-642-12264-4_2 · Cited by 4

Aging and Cancer Biology

Anisimov, V. N. (2020) · Springer eBooks · doi:10.1007/978-3-319-57415-8_72 · Cited by 4

Pathomechanisms of Photoaged Skin

Krutmann, J. (2009) · Springer eBooks · doi:10.1007/978-3-540-89656-2_10 · Cited by 4

Therapy-selected clonal hematopoiesis and its role in myeloid neoplasms

Jahn, J., Diamond, B. T., Hsu, J., Montoya, S., Totiger, T. M., Landgren, O., Maura, F., & Taylor, J. (2023) · Leukemia Research · doi:10.1016/j.leukres.2023.107020 · Cited by 3

Orthologs of Human-Disease-Associated Genes in Plants Are Involved in Regulating Leaf Senescence

Wang, H., Yin, W., Xia, X., & Li, Z. (2023) · Life · doi:10.3390/life13020559 · Cited by 3

Retrotransposition and Neuronal Diversity

Marchetto, M. C., Gage, F. H., & Muotri, A. R. (2009) · Springer eBooks · doi:10.1007/978-90-481-3375-8_7 · Cited by 3

Molekulare Mechanismen des Alterns Über das Altern der Zellen und den Einfluss von oxidativem Stress auf den Alternsprozess

Behl, C., & Moosmann, B. (2008) · Springer eBooks · doi:10.1007/978-3-540-76711-4_2 · Cited by 3

Chapter 8 Calcium dysregulation, insulin release and the pathogenesis of diabetes

Bergsten, P. (2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)10020-4 · Cited by 3

Does CYP1A1 gene polymorphism affect cell damage biomarkers and ageing?

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