The DOI matches its Crossref record; 132 of the 136 references it cites were found in a registry or an index.
Somatic mutations and aging: a re-evaluation
Abstract
Aging has been explained in terms of an accumulation of mutations in the genome of somatic cells, leading to tissue atrophy and neoplasms, as well as increased loss of function. Recent advances in transgenic mouse modeling and genomics technology have created, for the first time, the opportunity to begin testing this theory. In this paper the existing evidence for a possible role of somatic mutation accumulation in aging will be re-evaluated on the basis of the evolutionary logic of aging and recent insights in genome structure and function. New strategies for investigating the relationship between genome instability, mutation accumulation and aging will be discussed.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Cytogenetically visible lesions such as translocations, insertions, dicentrics, and acentric fragments also accumulate in aging mammalian cells.”
From DNA Repair, Genome Stability, and Aging (2005) · cites this paper as Vijg, 2000
In the citing paper
“DNA damage accumulates with age”
From DNA Repair, Genome Stability, and Aging (2005) · cites this paper as Vijg, 2000
Citations
Cites
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
The Metabolic and Molecular Bases of Inherited Disease
Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
Viable offspring derived from fetal and adult mammalian cells
Wilmut, I., Schnieke, A., McWhir, J., Kind, A., & Campbell, K. (1997) · Nature · doi:10.1038/385810a0 · Cited by 4,976
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Pleiotropy, natural selection, and the evolution of senescence.
Williams, G. C. (1957) · Evolution · doi:10.1111/j.1558-5646.1957.tb02911.x · Cited by 4,279
Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168
Research works printed but not linked: 2
- Aidoo, 1999, Effect of dietary restriction on lymphocyte HPRT mutant frequency in aging rats, Journal of Environ. Mole. Mutagen., 33, 5
- Wallace, 1995, Mitochondrial DNA variation in human evolution, degenerative disease, and aging, Am. J. Hum. Genet., 57, 201
Cited by
Sorted by citations
Items 201–241 of 241
Lynch, A. M. (2009) · Wiley eBooks · doi:10.1002/9780470744307.gat074 · Cited by 2
Oxidative Damage, Somatic Mutations and Cellular Aging
Busuttil, R. A., Rubio, M. Á., Dollé, M. E. T., Campisi, J., & Vijg, J. (2003) · Springer eBooks · doi:10.1007/978-94-017-0667-4_6 · Cited by 2
Self-citationMitochondria, Oxidative Damage and Longevity: What Can Comparative Biology Teach Us?
Shi, Y., Buffenstein, R., & Remmen, H. V. (2009) · Springer eBooks · doi:10.1007/978-90-481-3465-6_8 · Cited by 1
Skin photoprotection and nutraceuticals: an overview
Morganti, P. (2012) · Human health handbooks · doi:10.3920/978-90-8686-729-5_13 · Cited by 1
Ivanov, V. K., Kashcheev, V. V., Александровна, З. И., Saenko, A. S., Orlova, N. V., Smirnova, S. G., Корело, А. М., Gorsky, A. I., & Maksioutov, M. A. (2012) · Radiation Protection Dosimetry · doi:10.1093/rpd/ncs178 · Cited by 1
Woo, S.-W., Kim, M., Kang, D., Choe, Y., Oh, S.-J., You, A.-S., Lee, S., & Kim, J. (2024) · Genes · doi:10.3390/genes15060801 · Cited by 1
The Evolving Opportunistic Pathogen Communities on Host Individuals and the Evolution of Host Aging
Baig, U. I., Ojha, A., & Watve, M. (2017) · Journal of Evolutionary Medicine · doi:10.4303/jem/235975 · Cited by 1
Monckton, D. G. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.08.002 · Cited by 1
Small-pool PCR analysis of microsatellite instability in HNPCC
Coolbaugh-Murphy, M. I., Ramagli, L. S., & Siciliano, M. J. (2007) · Current Colorectal Cancer Reports · doi:10.1007/s11888-007-0029-z · Cited by 1
Vijg, J. (2007) · Elsevier eBooks · doi:10.1016/b0-12-370870-2/00055-x · Cited by 1
Self-citationMicrosatellite Instability in Cancer
Siciliano, M. J. (2006) · Elsevier eBooks · doi:10.1016/b978-012369462-1/50048-x · Cited by 1
Anti-Aging Medicine LiteratureWatch
Pawelec, G. (2000) · Rejuvenation Research · doi:10.1089/rej.1.2000.3.339 · Cited by 1
Amorós-Pérez, M., de Lara, Í. R.-P., & Andrés, V. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00245-5 · Cited by 2
Eickenberg, H.-U., Pientka, L., Eichhorn, M., Merbach, M., Beutel, M., & Brähler, E. (2004) · Springer eBooks · doi:10.1007/978-3-642-18705-6_1
Karakasilioti, I., Ιωαννίδου, Ά., & Garinis, G. A. (2014) · Wiley eBooks · doi:10.1002/9781118396292.ch2
Mutagenese und DNA-Reparaturmechanismen
Goedecke, W., & Pfeiffer, P. (2003) · Springer eBooks · doi:10.1007/978-3-662-07588-3_18
On key lesions and all that: a tribute to Paul Lohman
Vijg, J. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00302-5
Self-citationA Genetic Analysis of Genomic Stability in Caenorhabditis Elegans: A Dissertation
Auclair, M. M. (2007) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/et2k-5z51
Damage Segregation and Cellular Rejuvenation in Saccharomyces cerevisiae
Hill, S. M. (2015)
Constantinescu, D. (2008) · D-Scholarship@Pitt (University of Pittsburgh)
Basic Science of Lung Cancer in Older Patients
Fasano, M., Cantile, F., Morgillo, F., & Ciardiello, F. (2013) · Springer eBooks · doi:10.1007/978-0-85729-793-8_1
From the “RNAWorld” to Brain Complexity: Generation of Diversity
Muotri, A. R., Marchetto, M. C., & Gage, F. H. (2007) · Springer eBooks · doi:10.1007/978-3-540-74966-0_6
Anti-Aging Medicine LiteratureWatch
Pawelec, G. (1998) · Rejuvenation Research · doi:10.1089/rej.1.1998.1.275
Eshkoor, S. A., Jahanshiri, F., Ismail, P., Abd, S., Moin, S., & Adon, M. Y. (2012)
Aging: Is caloric restriction anti-aging?
Chatzidaki, E. E. (2010)
Mora, M. (2015) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
Neri, S., & Mariani, E. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_14
Neri, S., & Mariani, E. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_14-1
Estudo do papel de mTOR na regulação da atividade de reparo do DNA mitocondrial humano
Faria, C. M. P. B. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.46.2018.tde-08052018-151734
Ghosh, P., Goswami, S., Roy, S., Das, R., Chakraborty, T., & Ray, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.26.436274
Therapeutic approaches for the treatment of aging-induced stem cell dysfunction
Bizzaro, D., Russo, F. P., & Burra, P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820071-1.00018-9
Anti-Aging Medicine LiteratureWatch
(2000) · Rejuvenation Research · doi:10.1089/10945450050164808
Anti-Aging Medicine LiteratureWatch
Pawelec, G. (2000) · Rejuvenation Research · doi:10.1089/rej.1.2000.3.207
Neri, S., & Mariani, E. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_14
Pathomechanisms of Photoaged Skin
Krutmann, J. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_10-2
Detection of DNA Damage in Hematopoietic Stem Cells
Ayyar, S., & Beerman, I. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2679-5_2
Escala, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-82671-6
Fisher Information and the Dynamics of Multicellular AgingPreprint
Hale, Z. F., Cánez, G. A., & Michaels, T. C. T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.24.634675
Fisher Information and the Dynamics of Multicellular Ageing
Hale, Z. F., Cánez, G. A., & Michaels, T. C. T. (2025) · Entropy · doi:10.3390/e27060638
Vermeulen, O. (2021) · theses.fr (ABES) · doi:10.70675/277aa48cz7ec5z4c99z9fe9z34e8ea73f6b5
Metadata
- Authors
- Vijg, J.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Vijg, J
- ORCID
- Vijg, J
- Venue
- Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 447
- Issue
- 1
- Pages
- 117-135
- ISSN
- 0027-5107 (ISSN-L)
- 1386-1964
- OpenAlex
- W2063269133
- Cited by
- 243
- References
- 136
- Citations by year
- 2025: 5 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 12 · 2016: 4 · 2015: 6 · 2014: 9 · 2013: 4 · 2012: 11
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1 P30 AG13319-05, 1 RO1 ES/CA 08797-01, PO1 1801 AG10829-01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- somatic mutations, aging, mutation accumulation, genomic instability, transgenic mouse model, evolutionary theory of aging, tissue atrophy, neoplasms, loss of function
- MeSH terms
- Aging, Animals, Cell Transformation, Neoplastic, Cytogenetics, Disease Models, Animal, DNA Repair, DNA, Mitochondrial, Biological Evolution, Female, Humans, Male, Mice, Transgenic, Mutation, Cellular Senescence, Cell Death, Mice, Knockout, Telomerase, Aging, Premature, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
