Cited by 243Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceEvolution and Genetic Dynamics

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Somatic mutations and aging: a re-evaluation

Vijg, J·2000·Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

DOI 10.1016/s0027-5107(99)00202-x

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Abstract

Aging has been explained in terms of an accumulation of mutations in the genome of somatic cells, leading to tissue atrophy and neoplasms, as well as increased loss of function. Recent advances in transgenic mouse modeling and genomics technology have created, for the first time, the opportunity to begin testing this theory. In this paper the existing evidence for a possible role of somatic mutation accumulation in aging will be re-evaluated on the basis of the evolutionary logic of aging and recent insights in genome structure and function. New strategies for investigating the relationship between genome instability, mutation accumulation and aging will be discussed.

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Authors: Vijg, J.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
Corresponding author: Vijg, J
ORCID: Vijg, J
Venue: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Publisher: Elsevier BV
Published: 2000-01
Volume: 447
Issue: 1
Pages: 117-135
ISSN: 0027-5107 (ISSN-L)
1386-1964
DOI: 10.1016/s0027-5107(99)00202-x
OpenAlex: W2063269133
Cited by: 243
References: 136
Citations by year: 2025: 5 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 12 · 2016: 4 · 2015: 6 · 2014: 9 · 2013: 4 · 2012: 11
FWCI: 1.34
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1 P30 AG13319-05, 1 RO1 ES/CA 08797-01, PO1 1801 AG10829-01)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: somatic mutations, aging, mutation accumulation, genomic instability, transgenic mouse model, evolutionary theory of aging, tissue atrophy, neoplasms, loss of function
MeSH terms: Aging, Animals, Cell Transformation, Neoplastic, Cytogenetics, Disease Models, Animal, DNA Repair, DNA, Mitochondrial, Biological Evolution, Female, Humans, Male, Mice, Transgenic, Mutation, Cellular Senescence, Cell Death, Mice, Knockout, Telomerase, Aging, Premature, Mice

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Somatic mutations and aging: a re-evaluation

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