Spine microdomains for postsynaptic signaling and plasticity
Abstract
Changes in the molecular composition and signaling properties of excitatory glutamatergic synapses onto dendritic spines mediate learning-related plasticity in the mammalian brain. This molecular adaptation serves as the most celebrated cell biological model for learning and memory. Within their micron-sized dimensions, dendritic spines restrict the diffusion of signaling molecules and spatially confine the activation of signal transduction pathways. Much of this local regulation occurs by spatial compartmentalization of glutamate receptors. Here, we review recently identified cell biological mechanisms regulating glutamate receptor mobility within individual dendritic spines. We discuss the emerging functions of glutamate receptors residing within sub-spine microdomains and propose a model for distinct signaling platforms with specialized functions in synaptic plasticity.
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Both membrane addition and membrane internalization are required for the growth and retraction of spines.
“both membrane addition and membrane internalization are required for the growth and retraction of spines (Holtmaat and Svoboda, 2009;Newpher and Ehlers, 2009;Kelly et al, 2011).”
From Ral mediates activity‐dependent growth of postsynaptic membranes via recruitment of the exocyst (2013) · cites this paper as Newpher and Ehlers, 2009
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- Authors
- Newpher, T. M., & Ehlers, M. D.
- Affiliations
- Duke Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Ehlers, Michael D.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 19
- Issue
- 5
- Pages
- 218-227
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2066774087
- Cited by
- 140
- References
- 20
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 8 · 2014: 12 · 2013: 17 · 2012: 16
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Federation of European Neuroscience Societies
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (F32NS061406)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dendritic spines, glutamate receptors, receptor mobility, synaptic plasticity, postsynaptic signaling, spatial compartmentalization, signal transduction, learning and memory
- MeSH terms
- Animals, Hippocampus, Humans, Synaptic Transmission, Neuronal Plasticity, Synapses, Receptors, Glutamate, Membrane Microdomains, Dendritic Spines
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