Brain-derived neurotrophic factor serum and plasma levels in the treatment of acute schizophrenia with olanzapine or risperidone: 6-week prospective study
Abstract
Antipsychotics have been the mainstay of the treatment of schizophrenia, and their potential role in neuroprotection could be related to brain-derived neurotrophic factor (BDNF). So far different effects on both serum and plasma levels of BDNF were reported related to the various antipsychotic treatments. Aim of this study was to investigate the influence of olanzapine or risperidone on both plasma and serum levels of BDNF in patients with acute schizophrenia. For 50 participants with acute episode of schizophrenia both plasma and serum BDNF, along with the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression scale, were assessed pretreatment and post treatment - after 6 weeks of either risperidone or olanzapine. Results show that a weak correlation between pretreatment plasma and serum levels of BNDF was found no longer significant after 6 weeks of treatment. Antipsychotics, olanzapine and risperidone showed no significant effect on post treatment plasma and serum levels of BDNF. Pretreatment plasma level of BDNF and PANSS positive subscale were positively correlated. Post treatment serum level of BDNF and Clinical Global Impression were negatively correlated. In conclusion, plasma and serum BDNF levels could be different markers to some extent with regard to clinical symptoms, response to therapy and outcome. The interrelation between serum and plasma BDNF should be established in further studies.
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Drug treatment that is effective in controlling disease progression in schizophrenic patients can have diverse effects on peripheral BDNF protein levels.
“Remarkably, drug treatment that is effective in controlling disease progression in schizophrenic patients can have diverse effects on peripheral BDNF protein levels [126–128].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [126]
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Zavod za kliničku psihijatriju: jučer, danas i sutra
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Klinika za psihijatriju i psihološku medicinu, K. B. C. Z., Božičević, M., Medicinski fakultet Sveučilišta u Zagrebu, Z., Bradaš, Z., Klinika za psihijatriju i psihološku medicinu, K. B. C. Z., Medicinski fakultet Sveučilišta u Zagrebu, Z., Dragija, L., Klinika za psihijatriju i psihološku medicinu, K. B. C. Z., Medicinski fakultet Sveučilišta u Zagrebu, Z., Aurer, Z., et al. (2022) · Socijalna psihijatrija · doi:10.24869/spsih.2022.187
Self-citationMedved, S., Mihaljević-Peleš, A., Bulum, J., Sović, S., Ganoci, L., Božina, N., Janović, M. B., Šagud, M., & Jurak, I. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111442
Self-citationSedky, A. A., Raafat, M. H., Hamam, G. G., Sedky, K. A., & Magdy, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19731788
- Authors
- Kudlek Mikulic, S., Mihaljevic-Peles, A., Sagud, M., Bajs Janovic, M., Ganoci, L., Grubisin, J., Kuzman Rojnic, M., Vuksan Cusa, B., Bradaš, Z., & Božina, N.
- Affiliations
- Department of Psychiatry, Clinical Hospital Center Zagreb, Zagreb, Croatia;
- Department of Psychiatry, School of Medicine, Clinical Hospital Center Zagreb, University of Zagreb, Zagreb, Croatia;
- University Hospital Centre Zagreb (HR)
- Venue
- Nordic Journal of Psychiatry
- Publisher
- Informa UK Limited
- Published
- 2017-07-02
- Volume
- 71
- Issue
- 7
- Pages
- 513-520
- ISSN
- 0029-1455 (ISSN-L)
- 0803-9488
- 1502-4725
- OpenAlex
- W2725815489
- Cited by
- 25
- References
- 60
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 4
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nordic Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- brain-derived neurotrophic factor, serum BDNF, plasma BDNF, acute schizophrenia, olanzapine, risperidone, antipsychotic drugs, neuroprotection, treatment response, Clinical Global Impression Scale
- MeSH terms
- Olanzapine, Acute Disease, Adult, Age Factors, Benzodiazepines, Female, Humans, Male, Middle Aged, Prospective Studies, Schizophrenia, Sex Factors, Antipsychotic Agents, Risperidone, Brain-Derived Neurotrophic Factor, Young Adult
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