OSTEOSARCOMA
Abstract
Over the last several decades, significant advances have been made in our ability to understand and treat osteosarcoma. In this article we describe the diagnosis, evaluation, and treatment of patients with this disease. The surgical issues are discussed. We review the major clinical trials that have led to our current level of understanding. The current studies for the treatment of osteosarcoma are described.
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Osteosarcoma can occur in any bone, but the knee area and proximal humerus are the most frequent locations.
“Osteosarcoma can present in any bone in the body but the most common sites are around the knee and the proximal humerus 201 .”
From Osteosarcoma (2022) · cites this paper as [201]
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Meyers, P. A., Schwartz, C. L., Krailo, M. D., Healey, J. H., Bernstein, M. L., Betcher, D., Ferguson, W. S., Gebhardt, M. C., Goorin, A. M., Harris, M., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.14.0095 · Cited by 752 · see citing works
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MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells
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- Authors
- Meyers, P. A., & Gorlick, R.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- Pediatric Clinics of North America
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 44
- Issue
- 4
- Pages
- 973-989
- ISSN
- 0031-3955 (ISSN-L)
- OpenAlex
- W4245103890
- Cited by
- 299
- References
- 74
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 8 · 2023: 11 · 2022: 13 · 2021: 17 · 2020: 13 · 2019: 18 · 2018: 4 · 2017: 15 · 2016: 10 · 2015: 14 · 2014: 14 · 2013: 16 · 2012: 11
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
- Keywords
- osteosarcoma, diagnosis, treatment, surgical management, clinical trials, pediatric bone tumors
- MeSH terms
- Bone Neoplasms, Humans, Neoplasm Recurrence, Local, Prognosis, Osteosarcoma, Age Distribution, Sex Distribution
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