The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Is social attachment an addictive disorder?
Abstract
There is a considerable literature on the neurobiology of reward, based largely on studies of addiction or substance abuse. This review considers the possibility that the neural circuits that mediate reward evolved for ethologically relevant cues, such as social attachment. Specifically, mesocorticolimbic dopamine appears important for maternal behavior in rats and pair bonding in monogamous voles. It is not yet clear that dopamine in this pathway mediates the hedonic properties of social bond formation or whether dopamine's role is more relevant to developing associative networks or assigning salience to social stimuli. The neuropeptides oxytocin (OT) and vasopressin (AVP) appear to be critical for linking social signals to the mesocorticolimbic circuit.
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“These parallels provide strong evidence for a link between attachment and addiction (MacLean 1990; Nelson and Panksepp 1998; Insel 2003; Fisher 2004; Reynaud et al 2010).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Insel 2003
In the citing paper
“it has been suggested that OT can positively influence prosocial behavior by linking approach behavior to the capacity to experience reward from social interaction (Insel, 2003;Campbell, 2008).”
From The effect of oxytocin on cooperation in a prisoner's dilemma depends on the social context and a person's social value orientation (2014) · cites this paper as Insel, 2003
Citations
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Social amnesia in mice lacking the oxytocin gene
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Research works printed but not linked: 1
- Insel, 1994, Patterns of vasopressin receptor distribution associated with social organization in monogamous and non-monogamous microtine rodents, J. Neurosci., 14, 5381, 10.1523/JNEUROSCI.14-09-05381.1994 · DOI · Paper page
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Sorted by citations
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523
Affective consciousness: core emotional feelings in animals and humans.
Panksepp, J. (2005) · Consciousness and Cognition · doi:10.1016/j.concog.2004.10.004 · Cited by 1,217
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
Dölen, G., Darvishzadeh, A., Huang, K. W., & Malenka, R. C. (2013) · Nature · doi:10.1038/nature12518 · Cited by 1,161
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Metadata
- Authors
- Insel, T. R.
- Affiliations
- Emory University (US)
- Corresponding author
- Insel, Thomas R
- ORCID
- Insel, Thomas R
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 79
- Issue
- 3
- Pages
- 351-357
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2067577447
- Cited by
- 430
- References
- 58
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 6 · 2023: 10 · 2022: 10 · 2021: 19 · 2020: 19 · 2019: 30 · 2018: 14 · 2017: 27 · 2016: 28 · 2015: 26 · 2014: 20 · 2013: 22 · 2012: 31
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- social attachment, addiction, maternal behavior, pair bonding, oxytocin, vasopressin, social bonding
- MeSH terms
- Animals, Brain, Dopamine, Female, Humans, Male, Neural Pathways, Object Attachment, Pair Bond, Parent-Child Relations, Social Behavior, Behavior, Addictive, Rats
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