Cited by 430Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorOlfactory and Sensory Function Studies

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Is social attachment an addictive disorder?

Insel, Thomas R·2003·Physiology & Behavior

DOI 10.1016/s0031-9384(03)00148-3

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Abstract

There is a considerable literature on the neurobiology of reward, based largely on studies of addiction or substance abuse. This review considers the possibility that the neural circuits that mediate reward evolved for ethologically relevant cues, such as social attachment. Specifically, mesocorticolimbic dopamine appears important for maternal behavior in rats and pair bonding in monogamous voles. It is not yet clear that dopamine in this pathway mediates the hedonic properties of social bond formation or whether dopamine's role is more relevant to developing associative networks or assigning salience to social stimuli. The neuropeptides oxytocin (OT) and vasopressin (AVP) appear to be critical for linking social signals to the mesocorticolimbic circuit.

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The Physiology of Reproduction
Legendre, M., & Jalabert, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-2-176_1 · Cited by 7,876
Affective Neuroscience: The Foundations of Human and Animal Emotions
Panksepp, J. (1998) · doi:10.1093/oso/9780195096736.001.0001 · Cited by 4,428
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
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Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
Physiology of Reproduction
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Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
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Legg, C. R. (1990) · Biological Psychology · doi:10.1016/0301-0511(90)90083-9 · Cited by 976

Show all 58 references

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Insel, 1994, Patterns of vasopressin receptor distribution associated with social organization in monogamous and non-monogamous microtine rodents, J. Neurosci., 14, 5381, 10.1523/JNEUROSCI.14-09-05381.1994 · DOI · Paper page

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Authors: Insel, T. R.
Affiliations: Emory University (US)
Corresponding author: Insel, Thomas R
ORCID: Insel, Thomas R
Venue: Physiology & Behavior
Publisher: Elsevier BV
Published: 2003-08
Volume: 79
Issue: 3
Pages: 351-357
ISSN: 0031-9384 (ISSN-L)
DOI: 10.1016/s0031-9384(03)00148-3
OpenAlex: W2067577447
Cited by: 430
References: 58
Citations by year: 2026: 5 · 2025: 6 · 2024: 6 · 2023: 10 · 2022: 10 · 2021: 19 · 2020: 19 · 2019: 30 · 2018: 14 · 2017: 27 · 2016: 28 · 2015: 26 · 2014: 20 · 2013: 22 · 2012: 31
FWCI: 2.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Physiology & Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords: social attachment, addiction, maternal behavior, pair bonding, oxytocin, vasopressin, social bonding
MeSH terms: Animals, Brain, Dopamine, Female, Humans, Male, Neural Pathways, Object Attachment, Pair Bond, Parent-Child Relations, Social Behavior, Behavior, Addictive, Rats

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