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Social modulation of stress responses
Abstract
Social interactions can profoundly affect the hypothalamic-pituitary-adrenal (HPA) axis. Although most research on social modulation of glucocorticoid concentrations has focused on the consequences of exposure to stressful social stimuli, there is a growing body of literature which suggests that social support in humans and affiliative behaviors in some animals can provide a buffer against stress and have a positive impact on measures of health and well-being. This review will compare HPA axis activity among individuals for whom social relationships are maintained through aggressive displays, such as dominance hierarchies, vs. individuals engaging in high levels of prosocial behavior. We also will examine oxytocin, a neuropeptide that is well known for promoting social behavior, as the physiological link between positive social interactions and suppression of the HPA axis. Despite many examples of social interaction modulating the HPA axis and improving health outcomes, there is relatively little known regarding the underlying mechanisms through which social behavior can provide a buffer against stress-related disease.
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“In terms of stress-related oxytocin triggers, both non-social and social stressors are associated with oxytocin release (DeVries et al., 2003; Bartz and Hollander, 2006; Table 1).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as DeVries et al., 2003
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Metadata
- Authors
- DeVries, A. C., Glasper, E. R., & Detillion, C. E.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- DeVries, A.Courtney
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 79
- Issue
- 3
- Pages
- 399-407
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W1973259939
- Cited by
- 482
- References
- 103
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 25 · 2023: 15 · 2022: 25 · 2021: 30 · 2020: 26 · 2019: 20 · 2018: 22 · 2017: 31 · 2016: 28 · 2015: 26 · 2014: 21 · 2013: 17 · 2012: 19
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS040267, R01 NS40267-04)
- National Institute of Dental and Craniofacial Research (P50DE013749)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- hypothalamic-pituitary-adrenal axis, social support, affiliative behavior, dominance hierarchy, prosocial behavior, oxytocin, glucocorticoids, stress buffering, stress-related disorders
- MeSH terms
- Adaptation, Physiological, Adaptation, Psychological, Animals, Dominance-Subordination, Humans, Hypothalamo-Hypophyseal System, Interpersonal Relations, Pituitary-Adrenal System, Stress, Psychological
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