24(241)[Z]-dehydroamarasterone B, a phytoecdysteroid from seeds of Leuzea carthamoides
Abstract
A new phytoecdysteroid, 24(24(1))[Z]-dehydroamarasterone B, has been isolated from seeds of Leuzea (Rhaponticum) carthamoides. It has been unambiguously identified by CIMS, 13C NMR and 1H NMR spectroscopy. The biological activity of the ecdysteroid has been determined in the Drosophila melanogaster BII bioassay. The ED50 (5.2 x 10(-7) M) is 70-fold higher than that for 20-hydroxyecdysone (7.5 x 10(-9) M).
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Z-24(28)-dehydroamarasterone B, isolated from the seeds of L. carthamoides, showed potent growth-inhibitory activity against Drosophila melanogaster B11 cells with ED50 0.52 μmol/L.
“A known PE Z-24(28)-dehydroamarasterone B, isolated from the seeds of L. carthamoides, has show potent growth-inhibitory activity against Drosophila melanogaster B11 cells with median effective dose (ED50) of 0.52 μmol/L169.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [169]
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- Authors
- Baltayev, U. A., Dinan, L., Girault, J.-P., & Lafont, R.
- Affiliations
- Institute of Catalysis and Petrochemistry (RU)
- University of Exeter (GB)
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Venue
- Phytochemistry
- Publisher
- Elsevier BV
- Published
- 1997-09
- Volume
- 46
- Issue
- 1
- Pages
- 103-105
- ISSN
- 0031-9422 (ISSN-L)
- OpenAlex
- W2054626367
- Cited by
- 21
- References
- 12
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2015: 1 · 2012: 3
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Royal Society
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- phytoecdysteroids, Leuzea carthamoides, Rhaponticum carthamoides, seeds, natural product isolation, structure elucidation, 20-hydroxyecdysone
- MeSH terms
- Animals, Cell Line, Drosophila melanogaster, Insect Hormones, Magnetic Resonance Spectroscopy, Plants, Spectrophotometry, Ultraviolet, Steroids, Stigmasterol, Ecdysteroids
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