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Cited by 119Sepsis Diagnosis and TreatmentClinical Nutrition and GastroenterologyLiver Disease and Transplantation

Hepatic metabolic response to injury and sepsis

Dahn, Michael S., Mitchell, Robert A., Lange, M. Patricia, Smith, Stuart, Jacobs, Lloyd A.·1995·Surgery
DOI 10.1016/s0039-6060(05)80251-x
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Abstract

Background Experimental reports have indicated that hepatic oxidative and synthetic metabolism may become depressed in sepsis. Because the mechanism of infection-related liver dysfunction has not been established, further study of these functional alterations could contribute to the therapeutic management of septic organ failure syndromes. However, recently controversy has arisen over the existence of these derangements that must be reconciled before further progress in this field can be made. Methods Splanchnic balance studies for the measurement of glucose output and oxygen consumption were used to assess hepatic function in fasted normal volunteers (n = 18), injured patients (n = 10), and patients with sepsis (n = 18). The liver's contribution to splanchnic metabolism was estimated from a comparison of splanchnic oxygen utilization in response to increases in the liver-specific process of glucogenesis. In addition, in vivo liver albumin production was determined by using the [14C] carbonate technique. Results Glucose output after injury and sepsis was increased by 12.8% and 76.6%, respectively, compared with controls. On the basis of substrate balance studies, gluconeogenesis was estimated to account for 46%, 87%, and 93%, respectively, of splanchnic glucose output in each of the three groups. In patients with sepsis glucose output was also noted to be linearly related to regional oxygen consumption, indicating that these processes were coupled and increases in the respiratory activity of the splanchnic cellular mass could be accounted for by increases in new glucose output and gluconeogenic substrate clearance. The mean albumin synthetic rate increased during injury and sepsis by 22% and 29%, respectively, compared with normal volunteers. Conclusions These studies cast doubt on the commonly held notion that tissue respiratory dysfunction may occur during sepsis. On the contrary, hepatic function is accelerated during hyperdynamic sepsis, and evidence indicating oxidative or synthetic functional depression is lacking.

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  • In most disease states in which synthesis rates have been measured, fractional synthesis rate in plasma is normal or mildly increased.

    “However, in most disease states in which synthesis rates have been measured, fractional synthesis rate (FSR) in plasma has been reported to be normal or mildly increased (Table 1).63, 64, 65, 66, 67, 68, 69, 70, 71”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [71]

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Authors
Dahn, M. S., Mitchell, R. A., Lange, M. P., Smith, S., & Jacobs, L. A.
Affiliations
United States Department of Veterans Affairs (US)
Corresponding author
Dahn, Michael S.
ORCID
Smith, Stuart
Venue
Surgery
Publisher
Elsevier BV
Published
1995-05
Volume
117
Issue
5
Pages
520-530
ISSN
0039-6060 (ISSN-L)
DOI
10.1016/s0039-6060(05)80251-x
OpenAlex
W2005655866
Cited by
119
References
78
Citations by year
2025: 1 · 2023: 2 · 2021: 9 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 4
FWCI
5.43
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords
sepsis, hepatic metabolism, liver injury, gluconeogenesis, glucose production, splanchnic oxygen consumption, albumin synthesis, hyperdynamic sepsis, splanchnic metabolism
MeSH terms
Adult, Aged, Gluconeogenesis, Glucose, Humans, Infections, Liver, Middle Aged, Oxygen Consumption, Reference Values, Serum Albumin, Viscera, Wounds and Injuries

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