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Cited by 263Diet, Metabolism, and DiseaseDietary Effects on HealthGlycogen Storage Diseases and Myoclonus

Liver Glycogen in Man –- the Effect of Total Starvation or a Carbohydrate-Poor Diet Followed by Carbohydrate Refeeding

Nilsson, L. Hson, Hultman, E.·1973·Scandinavian Journal of Clinical and Laboratory Investigation
DOI 10.3109/00365517309084355
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Abstract

Liver glycogen content was determined in specimens obtained by repeated percutaneous biopsies during starvation and under various dietary conditions in 19 human subjects. During rest and following an overnight fast, there was a decrease in liver glycogen content by a mean of 0.30 mmol glucosyl units per kg wet liver tissue per min during a further 4 hours' starvation. Prolonged starvation or carbohydrate-poor normocaloric diet decreased the liver glycogen from a mean of 232 to 24–55 mmol glucosyl units per kg within 24 hours. During an additional period of up to 9 days on the carbohydrate-poor diet the liver glycogen remained at a low level. Refeeding with a carbohydrate-rich diet gave a rapid increase of the liver glycogen to supernormal values, 424–624 mmol glucosyl units per kg wet liver tissue.

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Crossref · 10.3109/00365517309084355

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30 of 30 references verified0 citation errors · 0 not checkable

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  • Under a resting postprandial state, the production of blood glucose relies primarily on glycogenolysis.

    “Under a resting postprandial state, the production of blood glucose relies primarily on glycogenolysis [105].”

    From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [105]

  • When training fasted, muscle glycogen should be unaffected by the overnight fast, but liver glycogen will be very low.

    “When training fasted, muscle glycogen should be unaffected by the overnight fast, but liver glycogen will be very low [33].”

    From Periodized Nutrition for Athletes (2017) · cites this paper as [33]

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Authors
Nilsson, L. H., & Hultman, E.
Venue
Scandinavian Journal of Clinical and Laboratory Investigation
Publisher
Informa UK Limited
Published
1973-01
Volume
32
Issue
4
Pages
325-330
ISSN
  • 0036-5513 (ISSN-L)
  • 1502-7686
DOI
10.3109/00365517309084355
OpenAlex
W2008406557
Cited by
263
References
30
Citations by year
2026: 6 · 2025: 11 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 7
FWCI
1.93
Type
journal article
Language
en
Open access
closed
Locations
  • Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
Keywords
liver glycogen, starvation, carbohydrate refeeding, glycogen depletion, glycogen synthesis, overnight fasting, percutaneous liver biopsy, research participants
MeSH terms
Adult, Biopsy, Needle, Blood Glucose, Blood Pressure, Body Weight, Depression, Chemical, Dietary Carbohydrates, Female, Glycogen, Humans, Liver, Male, Middle Aged, Pulse, Starvation, Stimulation, Chemical, Time Factors

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