Studies in prebiotic synthesis

Fuller, William D.; Sanchez, Robert A.; Orgel, Leslie E.

doi:10.1016/0022-2836(72)90383-x

Cited by 280Origins and Evolution of LifeRNA and protein synthesis mechanismsDNA and Nucleic Acid Chemistry

Studies in prebiotic synthesis

Fuller, William D., Sanchez, Robert A., Orgel, Leslie E.·1972·Journal of Molecular Biology

DOI 10.1016/0022-2836(72)90383-x

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For the purines, but not the pyrimidines, simply heating the nucleobase with ribose or ribose-phosphate results in the synthesis of the corresponding ribonucleoside or ribonucleotide, but in low yield.
“It has long been known for the purines, but not the pyrimidines, that simply heating the nucleobase with ribose or ribose-phosphate results in the synthesis of the corresponding ribonucleoside or ribonucleotide, but in low yield (Fuller et al. 1972).”
From Protocells and RNA Self-Replication (2018) · cites this paper as Fuller et al. 1972

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Authors: Fuller, W. D., Sanchez, R. A., & Orgel, L. E.
Affiliations: Salk Institute for Biological Studies (US)
ORCID: Sanchez, Robert A.
Venue: Journal of Molecular Biology
Publisher: Elsevier BV
Published: 1972-06
Volume: 67
Issue: 1
Pages: 25-33
ISSN: 0022-2836 (ISSN-L)
DOI: 10.1016/0022-2836(72)90383-x
OpenAlex: W219287239
Cited by: 280
References: 36
Citations by year: 2026: 4 · 2025: 12 · 2024: 5 · 2023: 5 · 2022: 11 · 2021: 12 · 2020: 7 · 2019: 12 · 2018: 9 · 2017: 12 · 2016: 8 · 2015: 10 · 2014: 9 · 2013: 12 · 2012: 9
FWCI: 5.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: prebiotic synthesis, adenine, ribose, magnesium catalysis, polyphosphate, inosine, adenosine, guanosine, guanine, hypoxanthine
MeSH terms: Adenine, Adenosine, Chemistry, Chromatography, Paper, Electrophoresis, Paper, Guanine, Guanosine, Hot Temperature, Hypoxanthines, Inosine, Kinetics, Magnesium, Nucleosides, Phosphates, Diphosphates, Ribonucleosides, Ribose, Chemical Phenomena

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