Autocatalytic synthesis of a tetranucleotide analogue

Zielinski, Wojciech S.; Orgel, Leslie E.

doi:10.1038/327346a0

Cited by 311Origins and Evolution of LifeRNA and protein synthesis mechanismsDNA and Nucleic Acid Chemistry

Autocatalytic synthesis of a tetranucleotide analogue

Zielinski, Wojciech S., Orgel, Leslie E.·1987·Nature

DOI 10.1038/327346a0

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Abstract

As an approach to the study of the kind of chemical process that might have contributed to the origin of life, attempts have been made to develop purely chemical systems in which oligonucleotides self-replicate. Although performed oligonucleotides have been shown to facilitate the formation of their complements from activated mononucleotides, only a restricted range of oligomers are efficient templates and it will clearly be difficult to find a pair of complementary oligomers each of which will facilitate the formation of the other. Many of the difficulties facing the development of a self-replicating system could be overcome by using a pair of complementary substrate molecules that condense together more easily than ribonucleotides. It would also be helpful if each substrate molecule contained equal numbers of purine and pyrimidine bases as, otherwise, there is a tendency for purines to be overrepresented in the products. We have therefore explored the chemistry of 3'-amino-3'-deoxynucleotides and their dimers. We report here that the tetranucleoside triphosphoramidate GNHpCNHpGNHpCN3 acts as a template to catalyse the condensation of GNHpCNH2 and pGNHpCN3, forming further molecules of the template. The system is therefore autocatalytic, and in accordance with elementary theory the amount of product made increases with the square root of the template concentration.

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Authors: Zielinski, W. S., & Orgel, L. E.
Affiliations: Salk Institute for Biological Studies (US)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1987-05
Volume: 327
Issue: 6120
Pages: 346-347
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/327346a0
OpenAlex: W1967935039
Cited by: 310
References: 1
Citations by year: 2026: 3 · 2025: 7 · 2024: 14 · 2023: 9 · 2022: 14 · 2021: 11 · 2020: 8 · 2019: 9 · 2018: 8 · 2017: 3 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 12 · 2012: 5
FWCI: 7.29
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: origin of life, chemical evolution
MeSH terms: Catalysis, Chemistry, Oligodeoxyribonucleotides, Templates, Genetic, Macromolecular Substances, Chemical Phenomena

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