CoChat
Sign Up
Cited by 143Endometriosis Research and TreatmentMedical Imaging and Pathology StudiesPleural and Pulmonary Diseases

Pleuro-pulmonary endometriosis and pulmonary ectopic deciduosis: A clinicopathologic and immunohistochemical study of 10 cases with emphasis on diagnostic pitfalls

Flieder, Douglas B, Moran, Cesar A, Travis, William D, Koss, Michael N, Mark, Eugene J·1998·Human Pathology
DOI 10.1016/s0046-8177(98)90021-1
Open this paper in CoChat — free account

Abstract

The clinical and pathological features of nine cases of pleuro-pulmonary endometriosis and the first case of pulmonary ectopic deciduosis are presented. The patients were all women between the ages of 27 and 74 years (median, 36 years) who presented with symptoms of catamenial pleural pain, shortness of breath, hemoptysis, or radiographically detected lung masses. Clinically, six patients were multiparous, one patient had pelvic endometriosis, and four patients had undergone prior pelvic surgical procedures, including dilatation and curettage. Radiographically, eight patients had pulmonary infiltrates or nodules, and four patients had pneumothorax. Three cases involved the visceral pleura and one case the parietal pleura. The other six cases, including the single case of ectopic deciduosis, involved the lung parenchyma. Histologically, the single or multifocal lesions were well circumscribed or infiltrative, nodular, cystic, or nodulo-cystic, and showed the characteristic features of proliferative or secretory endometrium with numerous mullerian metaplastic changes. Mucin stains were negative in five cases of endometriosis and in the single case of ectopic deciduosis. Immunohistochemical studies were performed in these same six cases using antibodies to epithelial, mesenchymal, vascular, and neuroendocrine markers. The glandular epithelium was decorated with antibodies to pan-cytokeratin, CK7, BER-EP4, ER, and PR, whereas the stromal cells showed positive staining for vimentin, actin, smooth muscle actin, desmin, ER, and PR. Follow-up information obtained in seven patients showed all women without recurrences after 1 to 20 years. The current study highlights the importance of recognizing intrathoracic endometriosis and ectopic deciduosis and properly assessing small biopsy specimens to avoid a misdiagnosis of malignancy.

Integrity signals

Registry

Crossref · 10.1016/s0046-8177(98)90021-1

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The histological diagnosis of thoracic endometriosis is performed via the identification of endometrial-like glands, stroma and hemosiderin-laden macrophages on hematoxylin and eosin stains (H&E).

    “The histological diagnosis of thoracic endometriosis is performed via the identification of endometrial-like glands, stroma and hemosiderin-laden macrophages on hematoxylin and eosin stains (H&E) [ 73 ].”

    From Thoracic Endometriosis Syndrome: A Comprehensive Review and Multidisciplinary Approach to Management (2024) · cites this paper as [73]

Cites

Flagged first, then by citations

2 of the 54 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Flieder, D. B., Moran, C. A., Travis, W. D., Koss, M. N., & Mark, E. J.
Affiliations
Massachusetts General Hospital (US)
Corresponding author
  • Flieder, Douglas B
  • Travis, William D
ORCID
Venue
Human Pathology
Publisher
Elsevier BV
Published
1998-12
Volume
29
Issue
12
Pages
1495-1503
ISSN
0046-8177 (ISSN-L)
DOI
10.1016/s0046-8177(98)90021-1
OpenAlex
W2112666605
Cited by
143
References
54
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 11 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 2 · 2016: 9 · 2015: 7 · 2014: 6 · 2013: 11 · 2012: 6
FWCI
1.07
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Human Pathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Medical Imaging and Pathology Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pleural and Pulmonary Diseases
Keywords
diagnostic pitfalls, immunohistochemical markers, endometrial differentiation, misdiagnosis of malignancy, pneumothorax, pulmonary nodules, endometriosis recurrence
MeSH terms
Adult, Aged, Choristoma, Decidua, Diagnosis, Differential, Endometriosis, Female, Humans, Immunoenzyme Techniques, Lung Diseases, Pleural Diseases, Pneumothorax, Pregnancy, Radiography, Thoracic, Tomography, X-Ray Computed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review