The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.
Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice
Abstract
Dietary restriction (DR) has been shown to inhibit almost all the age-related diseases, e.g. cardiomyopathy and cancers, in rodents. However, there is little information for the effect of DR on atherosclerosis. In the present study, we examined the effect of DR on the development of atherosclerosis in mice homozygous knockout for apolipoprotein E gene (ApoE(-/-)). The ApoE(-/-) mice were fed either ad libitum (AL) or 60% of the diet consumed by the mice fed AL. Atherosclerotic lesions in the proximal aorta of these mice were measured. Our results showed that ApoE(-/-) mice fed the calorie-restricted diet had smaller and relatively early stages of atherosclerotic lesions (e.g. foam cells and free lipids) when compared to ApoE(-/-) mice fed AL, who developed more advanced lesions (e.g. fibrous caps and acellular areas). In addition, ApoE(-/-) mice fed the calorie-restricted diet showed a significant decrease in the level of lipid hydroperoxides and the production of superoxide and hydrogen peroxide in the aorta as compared to ApoE(-/-) mice fed AL. These observations suggest that reduction of oxidative stress in the arterial wall may contribute to the anti-atherogenic effect of DR in ApoE(-/-) mice.
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“Apart from lifespan extension, caloric restriction also reduces the risk factors for major diseases including diabetes and cardiovascular disease in rodents (209, 210).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [209]
Citations
Cites
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765
Tissue-specific functions of individual glutathione peroxidases
Brigelius-Flohé, R. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00173-2 · Cited by 1,114
Piedrahita, J. A., Zhang, S. H., Hagaman, J. R., Oliver, P. M., & Maeda, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4471 · Cited by 944
Minimally modified low density lipoprotein stimulates monocyte endothelial interactions.
Berliner, J. A., Territo, M., Sevanian, A., Ramin, S., Kim, J. A., Bamshad, B., Esterson, M., & Fogelman, A. M. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114562 · Cited by 924
Oxidative Stress as a Regulator of Gene Expression in the Vasculature
KUNSCH, C. A., & Medford, R. M. (1999) · Circulation Research · doi:10.1161/01.res.85.8.753 · Cited by 801
Plasma triglyceride and coronary heart disease
Austin, M. A. (1991) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.11.1.2 · Cited by 697
Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression
Reddick, R. L., Zhang, S. H., & Maeda, N. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.141 · Cited by 633
Yu, B., Masoro, E. J., & McMahan, C. A. (1985) · Journal of Gerontology · doi:10.1093/geronj/40.6.657 · Cited by 591
Hessler, J. R., Robertson, A. L., & Chisolm, G. M. (1979) · Atherosclerosis · doi:10.1016/0021-9150(79)90166-7 · Cited by 505
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Yu, Q., Liu, R., Han, L., Zhang, G., Guan, H., Pan, Q., Wang, S., & Liu, E. (2018) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2017-0876 · Cited by 3
Sazali, M. F. I. B., Hilmy, M. A., Shari, N. B., Herawati, L., Nordin, N. I., & Othman, Z. (2021) · Nutrition & Food Science · doi:10.1108/nfs-01-2021-0029 · Cited by 3
The Effects of Caloric Restriction on Health and Longevity
Green, J. L., Sawaya, F., & Dollar, A. L. (2011) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-011-0127-8 · Cited by 2
“Essentially, every marker of risk for the development of atherosclerosis responds in a favorable fashion to CR. In one animal study, Guo et al. [ 17 ] investigated the effect of CR on atherosclerosis in ApoE gene knockout mice.”
BackgroundWang, S., Chen, Y., Qin, L., Wang, R., Dong, F., Wang, Y., ZHANG, F., Wu, Z., Zhong, Z., & Cui, G. (2026) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70776 · Cited by 1
Mclk1+/- mice are not resistant to the development of atherosclerosis
Hughes, B. G., & Hekimi, S. (2009) · Lipids in Health and Disease · doi:10.1186/1476-511x-8-16 · Cited by 1
Molecular Mechanisms of Cardiovascular Aging
Meiliana, A., & Wijaya, A. (2013) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v5i3.64 · Cited by 1
“Endothelial function is enhanced and both atherosclerosis and arterial stiffness are reduced by CR in rodents.(174,175) With regard to cardiac function, CR delays the age-related decline in diastolic filling accompanied by reductions in inflammation, cardiomyopathy, cardiac fibrosis, and myocardial degeneration.”
BackgroundKamel, M., Barkia, A., Nasri, M., Rebaï, T., Sahnoun, Z., Kassis, M., & Aouidet, A. (2011) · Pathologie Biologie · doi:10.1016/j.patbio.2011.08.001 · Cited by 1
Kalori kısıtlaması uygulanan farelerde biyokimyasal değerler
Çakıcı, Ö., & Kurtoğlu, F. (2017) · Eurasian journal of veterinary sciences · doi:10.15312/eurasianjvetsci.2017.150 · Cited by 1
Pretorius, J. (2012) · SUNScholar (Stellenbosch University)
OXIDATIVE STRESS-INDUCED VASCULAR DYSFUNCTION: MECHANISTIC PERSPECTIVES AND PREVENTIVE STRATEGIES
Vasamsetti, S. B., & Kotamraju, S. (2011)
Food Restriction and Atherosclerotic Plaque Stabilization
Munck, D. G. D., Meyer, G. R. Y. D., & Martinet, W. (2018) · InTech eBooks · doi:10.5772/intechopen.76560
“Consistent with this finding, animal studies showed that dietary restriction attenuates atherosclerotic plaque development and decreases endothelial dysfunction [6, 7].”
BackgroundResultBrás‐Silva, C., & Neves, D. (2015) · Wiley eBooks · doi:10.1002/9781118823408.ch6
Saeed, M., & Tian, X. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_1070
Intense Caloric Restriction from Birth Prevents Cardiovascular Aging in RatsPreprint
Melo, D. D. S., Melo, D. D. S., Pereira, L. C., SANTOS, C. D. S., Mendes, B. F., Konig, I. F. M., Queiroz, I. P., Moreno, L. G., Cassilhas, R. C., Esteves, E. A., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3980325
Saeed, M., & Tian, X. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_1070-1 · Cited by 1
(2007) · Elsevier eBooks · doi:10.1016/b978-012373657-4/50008-8
Leal, D. P. (2023) · doi:10.11606/t.5.2023.tde-04052023-160941
Friend or Foe: Dietary Restriction and Its Protective Effects on Responses to Ionizing Radiation
Shang, Y., Katsube, T., Dechsupa, N., Morioka, T., KAKINUMA, S., Wang, B., & Kantapan, J. (2026) · Dose-Response · doi:10.1177/15593258261469165
Metadata
- Authors
- Guo, Z., Mitchell-Raymundo, F., Yang, H., Ikeno, Y., Nelson, J., Diaz, V., Richardson, A., & Reddick, R.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Guo, ZhongMao
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 123
- Issue
- 8
- Pages
- 1121-1131
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2034827383
- Cited by
- 121
- References
- 60
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 7 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 8
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- National Institute on Aging (AG16998, P01 AG-13319, R01AG016998)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- dietary restriction, caloric restriction, atherosclerosis, ApoE-deficient mice, oxidative stress, lipid peroxidation, superoxide, hydrogen peroxide, aortic lesions, foam cells, antiatherogenic effects, aging
- MeSH terms
- Animals, Aorta, Apolipoproteins E, Arteriosclerosis, Energy Intake, Cholesterol, Diet, Disease Models, Animal, Hydrogen Peroxide, Lipoproteins, LDL, Male, Superoxides, Lipid Peroxidation, Mice, Knockout, Oxidative Stress, Mice
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