Nelson, James F.

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 3,766

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 896

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T.-T., et al. (2003) · Physiological Genomics

Genetics, Aging, and Longevity in Model OrganismsRedox biology and oxidative stress

Cited by 734

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

Liao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F. (2010) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 501

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Harrison, D. E., Strong, R., Allison, D. B., Ames, B. N., Astle, C. M., Atamna, H., Fernandez, E., Flurkey, K., Javors, M. A., Nadon, N. L., et al. (2014) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 445

Longer Lifespan in Male Mice Treated With a Weakly Estrogenic Agonist, an Antioxidant, an α-Glucosidase Inhibitor or a Nrf2-Inducer

Strong, R., Miller, R. A., Antebi, A., Astle, C. M., Bogue, M., Denzel, M. S., Fernandez, E., Flurkey, K., Hamilton, K. L., Lamming, D. W., et al. (2016) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 362

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

Strong, R., Miller, R. A., Astle, C. M., Floyd, R. A., Flurkey, K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., et al. (2008) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 349

Altered Profiles of Estradiol and Progesterone Associated with Prolonged Estrous Cycles and Persistent Vaginal Cornification in Aging C578L/6J Mice1

Nelson, J. F., Felicio, L. S., Osterburg, H. H., & Finch, C. E. (1981) · Biology of Reproduction

Reproductive Biology and FertilityEstrogen and related hormone effects

Cited by 223

Genetic Influences on the Timing of Puberty in Mice1

Nelson, J. F., Karelus, K., Felicio, L. S., & Johnson, T. E. (1990) · Biology of Reproduction

Hypothalamic control of reproductive hormonesReproductive Biology and Fertility

Cited by 165

Dietary Restriction Reduces Atherosclerosis and Oxidative Stress in the Aorta of Apolipoprotein E-Deficient Mice

Guo, Z., Mitchell-Raymundo, F., Yang, H., Ikeno, Y., Nelson, J., Diaz, V., Richardson, A., & Reddick, R. (2002) · Mechanisms of Ageing and Development

Atherosclerosis and Cardiovascular DiseasesGenetics, Aging, and Longevity in Model Organisms

Cited by 121

Fat maintenance is a predictor of the murine lifespan response to dietary restriction

Liao, C., Rikke, B. A., Johnson, T. E., Gelfond, J. A. L., Diaz, V., & Nelson, J. F. (2011) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 120

Genetic dissection of dietary restriction in mice supports the metabolic efficiency model of life extension

Rikke, B. A., Liao, C.-Y., McQueen, M. B., Nelson, J. F., & Johnson, T. E. (2010) · Experimental Gerontology

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 84

Housing Density Does Not Influence the Longevity Effect of Calorie Restriction

Ikeno, Y., Hubbard, G. B., Lee, S., Richardson, A., Strong, R., Diaz, V., & Nelson, J. F. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 83

The role of insulin and insulin-like growth factor-I in mammalian ageing

Richardson, A., Liu, F., Adamo, M. L., Remmen, H. V., & Nelson, J. F. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism

Genetics, Aging, and Longevity in Model OrganismsGrowth Hormone and Insulin-like Growth Factors

Cited by 64

Food restriction delays the age-related increase in GFAP mRNA in rat hypothalamus

Nichols, N. R., Finch, C. E., & Nelson, J. F. (1995) · Neurobiology of Aging

Genetics, Aging, and Longevity in Model OrganismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 46