The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
B cells in the aged: CD27, CD5, and CD40 expression
Abstract
Ageing is characterized by numerous changes in lymphocyte subpopulations. In the present paper we have focused on B cells carrying the surface markers CD27, CD5 and CD40. CD27 is considered a marker of primed (memory) cells and its engagement promotes the differentiation of memory B cells into plasma cells. CD5 is expressed on B1 cells, which are considered to be responsible for T cell-independent antibody production other than autoantibodies. The CD40 molecule binds CD40L (CD154) and is necessary for T-dependent antibody responses. Here we show that the absolute number of CD5+ and CD40+ B cells is decreased in the elderly, while CD27+ B lymphocytes only marginally decrease in centenarians. However, there is a decrease of the percentage of CD5+ B cells, an increase of CD27+ B cells, while CD40 does not change significantly. These data, together with the increased number of NK cells during aging, suggest different regulation of antibody production in the elderly which might be another example of immune remodeling with aging, based on interactions between human B and NK cells.
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“This defect might be linked to a reduced interaction with CD40L+ T helper cells, because, in older adults, the memory/effector T cells show a reduced expression of CD40L, necessary for B cells cooperation (74).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [74]
Citations
Cites
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
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CD40 AND CD154 IN CELL-MEDIATED IMMUNITY
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The immunology of exceptional individuals: the lesson of centenarians
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Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging
Fagnoni, F. F., Vescovini, R., Passeri, G., Bologna, G., Pedrazzoni, M., Lavagetto, G., Casti, A., Franceschi, C., Passeri, M., & Sansoni, P. (2000) · Blood · doi:10.1182/blood.v95.9.2860.009k35_2860_2868 · Cited by 515
Olsson, J., Wikby, A., Johansson, B., Löfgren, S., Nilsson, B.-O., & Ferguson, F. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00210-4 · Cited by 474
Agematsu, K., Hokibara, S., Nagumo, H., & Komiyama, A. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01605-4 · Cited by 411
Wikby, A., Maxson, P., Olsson, J., Johansson, B. E. A., & Ferguson, F. G. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00151-6 · Cited by 381
T cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 372
Ageing of lymphocytes and lymphocytes in the aged
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NK and NK/T cells in human senescence
Solana, R., & Mariani, E. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00495-8 · Cited by 279
Research works printed but not linked: 1
- Listı̀, F., Modica, M.A., Botindari, C., Balistreri, C.R., Lio, D., Colonna Romano, G., Di Lorenzo, G., Candore, G., Franceschi, C., Caruso, C., 2002. Third International Conference on Basic Biology and Clinical Impact of Immunosenescence, Palermo, April 10-14, 2002.
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The aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908
“Of particular importance, B cells from elderly individuals are stimulated 70% less efficiently by follicular dendritic cells than B cells from young subjects [53], suggesting loss of B cell function, as a result of the decreased expression of co-stimulatory molecules, such as CD40 or CD27 [54].”
BackgroundAiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693
“This defect might be linked to a reduced interaction with CD40L T helper cells, because, in older adults, the memory/effector T cells show a reduced expression of CD40L, necessary for B cells cooperation (74).”
BackgroundImmunosenescence and inflammaging in the aging process: age-related diseases or longevity?
Santoro, A., Bientinesi, E., & Monti, D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101422 · Cited by 603
Frasca, D., Landin, A. M., Lechner, S. C., Ryan, J. G., Schwartz, R., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5283 · Cited by 333
“Others have shown that the percentage of CD27 memory B cells increase with age but this increase is not significant (20).”
BackgroundAge-related Defects in CD4 T Cell Cognate Helper Function Lead to Reductions in Humoral Responses
Eaton, S. M., Burns, E. M., Kusser, K. L., Randall, T. D., & Haynes, L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041395 · Cited by 279
Metadata
- Authors
- Colonna-Romano, G., Bulati, M., Aquino, A., Scialabba, G., Candore, G., Lio, D., Motta, M., Malaguarnera, M., & Caruso, C.
- Affiliations
- University of Palermo (IT)
- University of Catania (IT)
- ORCID
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 124
- Issue
- 4
- Pages
- 389-393
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2033140693
- Cited by
- 137
- References
- 26
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 9 · 2013: 10 · 2012: 11
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- B cells, aging, CD27, CD5, CD40, memory B cells, B-1 cells, centenarians, immunosenescence, natural killer cells, antibody production, T cell-independent antibody response, T cell-dependent antibody response, B cell differentiation
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, B-Lymphocytes, Humans, Middle Aged, Biomarkers, Tumor Necrosis Factor Receptor Superfamily, Member 7, Lymphocyte Count, CD5 Antigens, CD40 Antigens
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