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B cells in the aged: CD27, CD5, and CD40 expression
Abstract
Ageing is characterized by numerous changes in lymphocyte subpopulations. In the present paper we have focused on B cells carrying the surface markers CD27, CD5 and CD40. CD27 is considered a marker of primed (memory) cells and its engagement promotes the differentiation of memory B cells into plasma cells. CD5 is expressed on B1 cells, which are considered to be responsible for T cell-independent antibody production other than autoantibodies. The CD40 molecule binds CD40L (CD154) and is necessary for T-dependent antibody responses. Here we show that the absolute number of CD5+ and CD40+ B cells is decreased in the elderly, while CD27+ B lymphocytes only marginally decrease in centenarians. However, there is a decrease of the percentage of CD5+ B cells, an increase of CD27+ B cells, while CD40 does not change significantly. These data, together with the increased number of NK cells during aging, suggest different regulation of antibody production in the elderly which might be another example of immune remodeling with aging, based on interactions between human B and NK cells.
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“This defect might be linked to a reduced interaction with CD40L+ T helper cells, because, in older adults, the memory/effector T cells show a reduced expression of CD40L, necessary for B cells cooperation (74).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [74]
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Research works printed but not linked: 1
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The aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908
“Of particular importance, B cells from elderly individuals are stimulated 70% less efficiently by follicular dendritic cells than B cells from young subjects [53], suggesting loss of B cell function, as a result of the decreased expression of co-stimulatory molecules, such as CD40 or CD27 [54].”
BackgroundAiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693
“This defect might be linked to a reduced interaction with CD40L T helper cells, because, in older adults, the memory/effector T cells show a reduced expression of CD40L, necessary for B cells cooperation (74).”
BackgroundImmunosenescence and inflammaging in the aging process: age-related diseases or longevity?
Santoro, A., Bientinesi, E., & Monti, D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101422 · Cited by 603
Frasca, D., Landin, A. M., Lechner, S. C., Ryan, J. G., Schwartz, R., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5283 · Cited by 333
“Others have shown that the percentage of CD27 memory B cells increase with age but this increase is not significant (20).”
BackgroundAge-related Defects in CD4 T Cell Cognate Helper Function Lead to Reductions in Humoral Responses
Eaton, S. M., Burns, E. M., Kusser, K. L., Randall, T. D., & Haynes, L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041395 · Cited by 279
Hakim, F. T., Flomerfelt, F. A., Boyiadzis, M. M., & Gress, R. E. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.01.009 · Cited by 275
“Indeed, the frequency of circulating CD27þ memory B cells is reduced in the infirm elderly, although the deficit is minor in healthy centenarians [23,24]; reductions in CD27þ memory B cell numbers in nursing home residents not only correlate with low T-cell numbers but also with reduced T-cell functions [24].”
Age effects on B cells and humoral immunity in humans
Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.004 · Cited by 271
Colonna-Romano, G., Bulati, M., Aquino, A., Pellicanò, M., Vitello, S., Lio, D., Candore, G., & Caruso, C. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.08.003 · Cited by 270
“We and others (Colonna-Romano et al., 2003; Gupta et al., 2005) have also shown that in the elderly there is a significant decrease in naı̈ve CD27 B lymphocytes and no significant reciprocal increase in CD27+ memory B cells (Klein et al., 1998; Agematsu et al., 2000).”
Self-citationChidrawar, S. M., Khan, N., Wei, W., McLarnon, A., Smith, N., Nayak, L., & Moss, P. A. H. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03785.x · Cited by 244
Melatonin, immune function and aging
Srinivasan, V. J., Gj, M., Cardinali, D. P., Esquifino, A. I., Pandi-Perumal, S. R., & Miller, S. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-17 · Cited by 239
“A decrease in CD5+ B cells independent of T cell decline was also reported in aging [48].”
BackgroundRegulation of Aged Humoral Immune Defense against Pneumococcal Bacteria by IgM Memory B Cell
Shi, Y., Yamazaki, T., Okubo, Y., Uehara, Y., Sugane, K., & Agematsu, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.3262 · Cited by 229
“(23) reported that the percentage of CD27 B cells increase in the elderly.”
BackgroundFrasca, D., Diaz, A., Romero, M., Garcia, D., & Blomberg, B. B. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-011620-034148 · Cited by 232
Immunosenescence: deficits in adaptive immunity in the elderly
Hakim, F. T., & Gress, R. E. (2007) · Tissue Antigens · doi:10.1111/j.1399-0039.2007.00891.x · Cited by 218
Metcalf, T. U., Cubas, R. A., Ghneim, K., Cartwright, M. J., Grevenynghe, J. V., Richner, J. M., Olagnier, D. P., Wilkinson, P. A., Cameron, M. J., Park, B. S., et al. (2015) · Aging Cell · doi:10.1111/acel.12320 · Cited by 189
“Previously, the percentage of CD40+ B cells was shown to be unaltered with aging (Colonna-Romano et al., 2003).”
BackgroundEffects of aging on B cell function
Frasca, D., & Blomberg, B. B. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.06.001 · Cited by 161
“Peripheral blood total memory B cells (CD19+CD27+) nd increased % (not significantly) [30]”
BackgroundResultAging Affects Human B Cell Responses
Frasca, D., & Blomberg, B. B. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9501-7 · Cited by 181
“However, in one report [41], this was not significant whereas in the other report, it was significant, but the analysis was carried out on a limited number, five, of elderly subjects [42].”
Ferrara, R., Mezquita, L., Auclin, E., Chaput, N., & Besse, B. (2017) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2017.08.003 · Cited by 163
The Dynamics of B Cell Aging in Health and Disease
de Mol, J., Kuiper, J., Tsiantoulas, D., & Foks, A. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.733566 · Cited by 159
Melatonin and the Immune System in Aging
Cardinali, D. P., Esquifino, A. I., Srinivasan, V., & Pandi-Perumal, S. R. (2008) · NeuroImmunoModulation · doi:10.1159/000156470 · Cited by 152
“A decrease in CD5+ B cells independent of T cell decline was also reported in aging [”
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“increase in the blood of elderly humans [82].”
The ageing B cell population: Composition and function
Ademokun, A., Wu, Y.-C. B., & Dunn‐Walters, D. K. (2009) · Biogerontology · doi:10.1007/s10522-009-9256-9 · Cited by 146
“There are reports suggesting that the proportion and numbers of CD27 ? (memory) B cells increase ( Colonna-Romano et al. 2003; Veneri et al. 2009) and other reports show a decrease (Breitbart et al. 2002; Chong et al. 2005; Frasca et al. 2008; Shi et al. 2005) with age.”
Leukocyte function in the aging immune system
Desai, A., Grolleau‐Julius, A., & Yung, R. L. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809542 · Cited by 147
“[124] observed that the percentage of CD27 cells was slightly elevated in the elderly and that serum concentrations of IgD correlate negatively with CD27 B cells.”
BackgroundListı̀, F., Candore, G., Modica, M. A., Russo, M., Lorenzo, G. D., Esposito-Pellitteri, M., Colonna‐Romano, G., Aquino, A., Bulati, M., Lio, D., et al. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1386.013 · Cited by 140
Mechanisms of immunosenescence
Caruso, C., Buffa, S., Candore, G., Colonna‐Romano, G., Dunn‐Walters, D. K., Kipling, D., & Pawelec, G. (2009) · Immunity & Ageing · doi:10.1186/1742-4933-6-10 · Cited by 136
“However, these data are controversial since not all studies have shown this [12-14].”
ResultAging induces B cell defects and decreased antibody responses to influenza infection and vaccination
Frasca, D., & Blomberg, B. B. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00210-z · Cited by 130
Lin, Y., Kim, J., Metter, E. J., Huy, N. V., Truong, T., Lustig, A., Ferrucci, L., & Weng, N. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0079-7 · Cited by 126
B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans
Bulati, M., Buffa, S., Candore, G., Caruso, C., Dunn‐Walters, D. K., Pellicanò, M., Wu, Y.-C. B., & Romano, G. C. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.12.002 · Cited by 121
Kverneland, A. H., Streitz, M., Geissler, E., Hutchinson, J., Vogt, K., Boës, D., Niemann, N., Pedersen, A. E., Schlickeiser, S., & Sawitzki, B. (2016) · Cytometry Part A · doi:10.1002/cyto.a.22855 · Cited by 99
“This finding is consistent with some reported findings (22,72), while others described significant age-dependent relationships (14,15).”
ResultA comparative review of aging and B cell function in mice and humans
Scholz, J. L., Diaz, A., Riley, R. L., Cancro, M. P., & Frasca, D. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.07.006 · Cited by 103
“This was not statistically significant in the first report [42], whereas in the second it was significant for an analysis carried out on a limited number of elderly subjects [43].”
ResultThe role of immunity in elderly cancer
Malaguarnera, L., Cristaldi, E., & Malaguarnera, M. (2009) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2009.06.002 · Cited by 103
Plasma cell numbers decrease in bone marrow of old patients
Pritz, T., Lair, J., Ban, M., Keller, M., Weinberger, B., Krismer, M., & Grubeck‐Loebenstein, B. (2015) · European Journal of Immunology · doi:10.1002/eji.201444878 · Cited by 98
Mechanisms for Decreased Function of B Cells in Aged Mice and Humans
Frasca, D., Landin, A. M., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.2741 · Cited by 97
“Others have shown that the percentage of total CD27 memory B cells increase with age, but not significantly (41), and we have further results (see below).”
ResultmTOR and Aging: An Old Fashioned Dress
Stallone, G., Infante, B., Prisciandaro, C., & Grandaliano, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112774 · Cited by 97
Moderate exercise may attenuate some aspects of immunosenescence
Drela, N., Kozdroń, E., & Szczypiorski, P. (2004) · BMC Geriatrics · doi:10.1186/1471-2318-4-8 · Cited by 89
“peripheral tissues), increased level of NK cells, and decreased level of CD8+ and B cells [1-4].”
BackgroundMacrophAging: A cellular and molecular review
Sebastián, C., Espia, M., Serra, M., Celada, A., & Lloberas, J. (2005) · Immunobiology · doi:10.1016/j.imbio.2005.05.006 · Cited by 88
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Fernández-Morera, J. L., Calvanese, V., Rodríguez‐Rodero, S., Torre, E. L. M., & Fraga, M. F. (2010) · Tissue Antigens · doi:10.1111/j.1399-0039.2010.01587.x · Cited by 78
“B cell subsets, and thus the antibody repertoire, are altered in specificity, isotype, and idiotype (113, 114).”
Immunosenescence, inflammation and Alzheimer’s disease
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“The humoral compartment is also affected in the aged [15-20]; indeed, B-cell numbers are decreased and the B-cell repertoire is influenced by ageing through the quality of antibody response [21-25], and this decreased B-cell diversity is associated with poor health status [26-28].”
BackgroundIs Regular Exercise a Friend or Foe of the Aging Immune System? A Systematic Review
Haaland, D. A., Sabljic, T. F., Baribeau, D. A., Mukovozov, I., & Hart, L. E. (2008) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e3181865eec · Cited by 71
Memory B Cell Subpopulations in the Aged
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“11 These data are seemingly important, because CD27 is a marker of primed memory cells and its engagement promotes the differentiation differentiation of memory B cells into plasma cells.”
Abedin, S. M., Michel, J. J., Lemster, B. H., & Vallejo, A. N. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.04.012 · Cited by 70
Lee, N.-S., Barber, L. C., Akula, S. M., Sigounas, G., Kataria, Y. P., & Arce, S. (2011) · Clinical and Vaccine Immunology · doi:10.1128/cvi.05118-11 · Cited by 68
“In healthy individuals, the percentage of memory B cells increases gradually with age (15).”
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“However, data are controversial since not all studies have shown, in elderly, a significant decrease of naïve CD27- B cells and an increase of CD27+ memory B cells (30-35).”
ResultKolibab, K., Smithson, S. L., Rabquer, B. J., Khuder, S., & Westerink, M. A. J. (2005) · Infection and Immunity · doi:10.1128/iai.73.11.7465-7476.2005 · Cited by 64
“Several studies in humans have described a similar shift toward a memory B-cell phenotype with aging (4, 9).”
Immunosenescence and organ transplantation
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“In addition to a reduced output of naïve B cells and intrinsic repertoire differences in B cells generated from old HSCs, some truncation of the repertoiremight reflect expanded clones of memory B cells [112].”
Variation Rhythms of Lymphocyte Subsets during Healthy Aging
Faria, A. M. C., de Moraes, S. M., de Freitas, L. H. F., Speziali, E., Soares, T. F., Neves, S. P. F., Vitelli-Avelar, D. M., Martins, M. Â., Barbosa, K. V. B. D., Soares, E. B., et al. (2008) · NeuroImmunoModulation · doi:10.1159/000156478 · Cited by 59
“Previous data hypothesized that the increased number of NK cells, accompanied by a decreased number of B cells is an another example of remodeling, because the antibodies produced do not seem to be markedly reduced, as might be expected from the decreased frequencies of B and T lymphocytes [”
Abraham, R. S., Ballman, K. V., Dispenzieri, A. A., Grill, D. E., Manske, M. K., Price-Troska, T. L., Gonzalez-Paz, N. C., Gertz, M. A., & Fonseca, R. (2004) · Blood · doi:10.1182/blood-2004-04-1424 · Cited by 60
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Santos‐Lozano, A., Valenzuela, P. L., Llavero, F., Lista, S., Carrera‐Bastos, P., Hampel, H. J., Pareja-Galeano, H., Gálvez, B. G., López, J. A., Vázquez, J., et al. (2020) · Aging · doi:10.18632/aging.102826 · Cited by 56
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Frasca, D., & Blomberg, B. B. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.05.008 · Cited by 60
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BackgroundB Cell Immunosenescence in the Elderly and in Centenarians
Colonna‐Romano, G., Bulati, M., Aquino, A., Vitello, S., Lio, D., Candore, G., & Caruso, C. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0664 · Cited by 59
“…of B1 cells has been reported, 12 although we have shown a reduction of CD5 (cid:2) B cells (B1 cells) and a decreased expression of CD40 on B cells obtained from old and the old-est subjects, 19 which points out the problem of the source of the antibodies found in the serum of old subjects.”
Genetics of longevity. Data from the studies on Sicilian centenarians
Balistreri, C. R., Candore, G., Accardi, G., Bova, M., Buffa, S., Bulati, M., Forte, G. I., Listı̀, F., Martorana, A., Palmeri, M., et al. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-8 · Cited by 56
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BackgroundImmunosenescence and Anti-Immunosenescence Therapies: The Case of Probiotics
Candore, G., Balistreri, C. R., Colonna‐Romano, G., Grimaldi, M. P., Lio, D., Listı̀, F., Scola, L., Vasto, S., & Caruso, C. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0662 · Cited by 55
“29 As a consequence T and B immunosenes-cence and, likely, mortality and morbidity will occur earlier in people who have been exposed to an antigenic overload (due to chronic infections).”
B Cell Production of Both OPG and RANKL is Significantly Increased in Aged Mice
Weitzmann, M. N., Li, Y., Terauchi, M., Vikulina, T., & Roser‐Page, S. (2015) · The Open Bone Journal · doi:10.2174/1876525401406010008 · Cited by 54
“It is generally agreed that B cell precursors are diminished with age as are memory B cells in the periphery [27, 39].”
BackgroundThe immune system in the aging human
Rymkiewicz, P. D., Heng, Y. X., Vasudev, A., & Larbi, A. (2012) · Immunologic Research · doi:10.1007/s12026-012-8289-3 · Cited by 50
“CD27? B cells (primed/memory) are maintained in elderly [70].”
BackgroundGaraud, S., Dantec, C. L., Berthou, C., Lydyard, P. M., Youinou, P., & Renaudineau, Y. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.2010 · Cited by 50
“Furthermore, there is evidence that the proportion of CD5expressing B cells declines with age (27), and that the density of CD5 molecules on B cells is reduced by IL-4 which is important for their differentiation (28), but increased by PMA stimulation (29).”
BackgroundImpact of immunosenescence on transplant outcome
Heinbokel, T., Hock, K., Liu, G., Edtinger, K., Elkhal, A., & Tullius, S. G. (2012) · Transplant International · doi:10.1111/tri.12013 · Cited by 49
“In addition to a reduced output of naive B cells and intrinsic repertoire differences of old HSCs, some truncation of the repertoire might reflect expanded clones of memory B cells [100].”
BackgroundB cell subset distribution is altered in patients with severe periodontitis
Demoersman, J., Pochard, P., Framery, C., Simon, Q., Boisramé, S., Soueidan, A., & Pers, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192986 · Cited by 50
Contact sensitization in the elderly
Balato, A., Balato, N., Costanzo, L. D., & Ayala, F. (2010) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2010.07.003 · Cited by 48
Nipper, A. J., Smithey, M. J., Shah, R. C., Canaday, D. H., & LANDAY, A. L. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.02.003 · Cited by 48
Frasca, D., Diaz, A., Romero, M., & Blomberg, B. B. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.715981 · Cited by 45
Vlková, M., Thon, V., Šárfyová, M., Bláha, L., Svobodník, A., Lokaj, J., & Litzman, J. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.02999.x · Cited by 44
Immunosenescence and Immune Response in Organ Transplantation
Martins, P. N. A., Tullius, S. G., & Markmann, J. F. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2013.829469 · Cited by 44
“[27] Colonna-Romano G, Bulati M, Aquino A, et al.”
BackgroundLeggat, D. J., Thompson, R. S., Khaskhely, N. M., Iyer, A. S., & Westerink, M. A. J. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit139 · Cited by 43
“In concordance with our findings, Colonna-Romano et al and others reported no change in the IgMCD27 B-cell percentage with increased age [32, 33].”
ResultCYTOKINE SERUM PROFILE IN A GROUP OF SICILIAN NONAGENARIANS
Palmeri, M., Misiano, G., Malaguarnera, M., Forte, G. I., Vaccarino, L., Milano, S., Scola, L., Caruso, C., Motta, M., Maugeri, D., et al. (2011) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2011.601781 · Cited by 41
“[ 19 , 20 ] In this view our data might be related to different the role played by IL-4 and IL-13 in Th2 switch and B cell response maintenance in aging.”
MethodThe diseased kidney: aging and senescent immunology
Chi, M., Tian, Z., Ma, K., Li, Y., Wang, L., Nasser, M. I., & Liu, C. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00313-9 · Cited by 43
“The memory/ effector T cells show reduced expression of CD40L and reduced B cell synthesis [49].”
BackgroundBrunelli, D. T., Boldrini, V. D. O., Bonfante, I. L. P., Duft, R. G., Mateus, K., Costa, L., Chacon-Mikahil, M. P. T., Teixeira, A. M., Farias, A. S., & Cavaglieri, C. R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.806400 · Cited by 39
Terekhova, M., Boháčová, P., & Artyomov, M. N. (2025) · Immunity · doi:10.1016/j.immuni.2025.10.009 · Cited by 43
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“Naïve and memory B cells have similar levels in young and elderly individuals There are several conflicting reports concerning the effects of aging on the composition of CD19+ B cells (Colonna-Romano et al. 2003, 2009; Chong et al. 2005; Shi et al. 2005).”
BackgroundLee, J. L., Fra-Bidó, S., Burton, A. R., Innocentin, S., Hill, D. L., & Linterman, M. A. (2022) · Aging Cell · doi:10.1111/acel.13692 · Cited by 34
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“Since the B cell compartment is heavily remodelled during aging (Colonna-Romano et al., 2003) it may be hypothesized that a B-cell subtype prevailing in people of far advanced age is more resistant to apoptosis.”
BackgroundAging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues.
Frasca, D., & Blomberg, B. B. (2011) · Europe PMC (PubMed Central) · Cited by 31
Premature B-cell senescence as a consequence of chronic immune activation
Palma, P., Rinaldi, S., Cotugno, N., Santilli, V., Pahwa, S. G., Rossi, P., & Cagigi, A. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.28698 · Cited by 29
“On the contrary, a reduction of CD27naïve B-cells, with no reciprocal increase of CD27+ memory B-cells, had previously been reported in older individuals and centenarians.(30) A possible explanation for these conflicting data has later been suggested to be the substantial age difference between the cohorts analyzed.”
ResultZheng, H., Zhang, M., Pang, W., & Zheng, Y. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.04.004 · Cited by 27
Molecular and Cellular Aspects of Macrophage Aging
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Immunotherapy in Elderly Patients Affected by Non-Small Cell Lung Cancer: A Narrative Review
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Melatonin and Melatonergic Drugs in Clinical Practice
Srinivasan, V. J., Shillcutt, S. D., Öter, Ş., & Brzezinski, A. (2014) · Springer eBooks · doi:10.1007/978-81-322-0825-9 · Cited by 23
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“But contradictory evidence shows that with aging there is generally an alteration in the B cell repertoirewith an increased serum concentra-S tion of autoantibodies (reviewed in [79,80]).”
Immunizations in the elderly: do they live up to their promise?
Herndler‐Brandstetter, D., Cioca, D., & Grubeck‐Loebenstein, B. (2006) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-006-0267-8 · Cited by 20
Role of mesenteric lymph nodes and aging in secretory IgA production in mice
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Immune Cells and Immunosenescence
Bischof, J., Gärtner, F., Zeiser, K., Kunz, R., Schreiner, C., Hoffer, E., Burster, T., Knippschild, U., & Zimecki, M. (2019) · Folia Biologica · doi:10.14712/fb2019065020053 · Cited by 18
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“The ratio between naïve and memory B cells varies in human subjects and is influenced by age [9,10].”
BackgroundCompartmentalization of immunosenescence: a deeper look at the mucosa
Martelli, S., Pender, S. L. F., & Larbi, A. (2015) · Biogerontology · doi:10.1007/s10522-015-9628-2 · Cited by 13
Numerical alterations of ageing B lymphocyte subsets (Review)
Ongrádi, J., & Kövesdi, V. (2011) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.98.2011.2.1 · Cited by 13
“Recent studies have started to focus on the human B cell subpopulations (12).”
BackgroundWu, H.-P., Shieh, W.-B., Hsien, F.-K., & Hua, C. (2004) · PubMed · Cited by 11
Hakim, F. T., & Gress, R. E. (2005) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.1.3.443 · Cited by 11
Acquired immunity: immunosenescence and physical activity
Malaguarnera, L., Cristaldi, E., Lipari, H. M. A., & Malaguarnera, M. (2008) · European Review of Aging and Physical Activity · doi:10.1007/s11556-008-0039-0 · Cited by 10
“The B-cell repertoire changes with age and determines an altered ability to recognize antigen [12].”
BackgroundZhang, W., Zhang, X., Cheng, C., Jia, S., Liu, L., & Wang, W. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.09.022 · Cited by 9
“For instance, CD27 was the marker of the priming memory B cells, and the CD27 memory B cells decreased slightly (Colonna-Romano et al., 2003) or significantly (Shi et al.”
Cytomegalovirus and the immune system in old age
Herndler‐Brandstetter, D., Almanzar, G., & Grubeck‐Loebenstein, B. (2006) · Clinical and Applied Immunology Reviews · doi:10.1016/j.cair.2006.06.002 · Cited by 9
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Characterization of the adaptive immune response of donors receiving live anthrax vaccine
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Integration of immunity with physical and cognitive function in definitions of successful aging.
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Introduction to Ageing of the Adaptive Immune System
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Age- and Race-Related Changes in Subpopulations of Peripheral Blood Lymphocytes in Humans
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The immune system during ageing
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Immunosenescence, Oxidative Stress, and Cancers
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“CD27 is a marker of primed memory cells and its engagement promotes the differentiation of memory B cells into plasma cells [29].”
BackgroundCaruso, C., Accardi, G., Aiello, A., & Candore, G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00029-6 · Cited by 3
Aging of the adaptive immune system affects the gut microbiome and systemic levels of vitamin B6
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“But there is a research [23] and a review article [24] indicating that memory B cell counts increase with age.”
BackgroundImmune Mechanism, Aging, Season and Diseases: Modulatory Role of Melatonin
Srinivasan, V., Maestroni, G., Rosenstein, R. E., & Mohamed, M. (2012) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152212803520995 · Cited by 2
Metadata
- Authors
- Colonna-Romano, G., Bulati, M., Aquino, A., Scialabba, G., Candore, G., Lio, D., Motta, M., Malaguarnera, M., & Caruso, C.
- Affiliations
- University of Palermo (IT)
- University of Catania (IT)
- ORCID
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 124
- Issue
- 4
- Pages
- 389-393
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2033140693
- Cited by
- 137
- References
- 26
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 9 · 2013: 10 · 2012: 11
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- B cells, aging, CD27, CD5, CD40, memory B cells, B-1 cells, centenarians, immunosenescence, natural killer cells, antibody production, T cell-independent antibody response, T cell-dependent antibody response, B cell differentiation
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, B-Lymphocytes, Humans, Middle Aged, Biomarkers, Tumor Necrosis Factor Receptor Superfamily, Member 7, Lymphocyte Count, CD5 Antigens, CD40 Antigens
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