Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692

An endotoxin-induced serum factor that causes necrosis of tumors

Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532

Current Protocols in Immunology

(2018) · Current Protocols in Immunology · doi:10.1002/(issn)1934-368x · Cited by 3,574

Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages

Hsieh, C.-S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., & Murphy, K. M. (1993) · Science · doi:10.1126/science.8097338 · Cited by 3,134

Biology of Natural Killer Cells

Trinchieri, G. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60664-1 · Cited by 2,902

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

Fiorentino, D. F., Bond, M. W., & Mosmann, T. R. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.6.2081 · Cited by 2,733

Cloning of a new cytokine that induces IFN-γ production by T cells

Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., et al. (1995) · Nature · doi:10.1038/378088a0 · Cited by 2,602

Interleukin 12: A Proinflammatory Cytokine with Immunoregulatory Functions That Bridge Innate Resistance and Antisen-Specific Adaptive Immunity

Trinchieri, G. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.001343 · Cited by 2,379

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P. J. L., Lanzavecchia, A., & Alber, G. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.747 · Cited by 1,982

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

Nathan, C. F., Murray, H. W., Wiebe, M. E., & Rubin, B. Y. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.3.670 · Cited by 1,962

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

Kobayashi, M., Fitz, L. J., Ryan, M., Hewick, R. M., Clark, S., Chan, S. H., Loudon, R. P., Sherman, F., PERUSSIA, B., & Trinchieri, G. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.3.827 · Cited by 1,953

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

Manetti, R., Parronchi, P., Giudizi, M. G., Piccinni, M., Maggi, E., Trinchieri, G., & Romagnani, S. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.4.1199 · Cited by 1,666

Acquisition of lymphokine-producing phenotype by CD4+ T cells

Seder, R. A., & Paul, W. E. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.003223 · Cited by 1,557

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

Klinman, D., Yi, A., Beaucage, S., Conover, J., & Krieg, A. (1996) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.93.7.2879 · Cited by 1,543

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

Macatonia, S. E., Hosken, N. A., Litton, M. J., Vieira, P., Hsieh, C., Culpepper, J., Wysocka, M., Trinchieri, G., MURPHY, K. M. M., & O’Garra, A. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.10.5071 · Cited by 1,524

gp 130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

Taga, T., & Kishimoto, T. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.797 · Cited by 1,468

A TH1→TH2 switch is a critical step in the etiology of HIV infection

Clerici, M. S., & Shearer, G. M. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90208-3 · Cited by 1,399

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell · doi:10.1016/0092-8674(89)90438-8 · Cited by 1,396

Differentiation and proliferation of hematopoietic stem cells

Ogawa, M. (1993) · Blood · doi:10.1182/blood.v81.11.2844.2844 · Cited by 1,383

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

D’Andrea, A., Aste-Amézaga, M., Valiante, N. M., Ma, X., Kubin, M. Z., & Trinchieri, G. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.3.1041 · Cited by 1,367

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

Neurath, M., Fuss, I. J., Kelsall, B. L., Stuber, E. R., & Strober, W. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.5.1281 · Cited by 1,334

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

Bendelac, A. S., Rivera, M. N., Park, S., & Roark, J. H. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.535 · Cited by 1,314

IL‐4 directs the development of Th2‐like helper effectors

Swain, S. L., Weinberg, A. D., English, M., & Huston, G. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.11.3796 · Cited by 1,254

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

Kaplan, M. H., Sun, Y.-L., Hoey, T., & Grusby, M. J. (1996) · Nature · doi:10.1038/382174a0 · Cited by 1,240

Macrophage deactivation by interleukin 10.

Bogdan, C., Yoram Vodovotz, B., & Nathan, C. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.6.1549 · Cited by 1,236

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A. B., Quintal, L. J., Sekut, L., Talanian, R. V., Paskind, M. P., et al. (1997) · Nature · doi:10.1038/386619a0 · Cited by 1,204

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

Brunda, M. J., Luistro, L. L., Warrier, R. R., Wright, R. B., Hubbard, B. R., Murphy, M. E., Wolf, S. F., & Gately, M. K. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.4.1223 · Cited by 1,197

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

Thierfelder, W. E., van Deursen, J. M., Yamamoto, K., Tripp, R. A., Sarawar, S. R., Carson, R. T., Sangster, M. Y., Vignali, D. A. A., Doherty, P. C., Grosveld, G. C., et al. (1996) · Nature · doi:10.1038/382171a0 · Cited by 1,183

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

Gu, Y., Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M. A., Hayashi, N., Higashino, K., Okamura, H., Nakanishi, K., et al. (1997) · Science · doi:10.1126/science.275.5297.206 · Cited by 1,159

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

D’Andrea, A., Rengaraju, M., Valiante, N. M., Chehimi, J., Kubin, M. Z., Aste-Amézaga, M., Chan, S. H., Kobayashi, M., Young, D., & Nickbarg, E. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.5.1387 · Cited by 1,143

An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

Meuer, S. C., Hussey, R. E., Fabbi, M., Fox, D. A., Acuto, O., Fitzgerald, K. A., Hodgdon, J. C., Protentis, J. P., Schlossman, S. F., & Reinherz, E. L. (1984) · Cell · doi:10.1016/0092-8674(84)90039-4 · Cited by 1,113

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

Sato, Y., Roman, M., Tighe, H., Lee, D. J., Corr, M., Nguyen, M., Silverman, G. J., Lotz, M., Carson, D. A., & Raz, E. (1996) · Science · doi:10.1126/science.273.5273.352 · Cited by 1,052

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

Trinchieri, G. (1994) · Blood · doi:10.1182/blood.v84.12.4008.bloodjournal84124008 · Cited by 1,045

THE TREATMENT OF MALIGNAT TUMORS BY REPEATED INOCULATIONS OF ERYSIPELAS

COLEY, W. B. (1893) · The American Journal of the Medical Sciences · doi:10.1097/00000441-189305000-00001 · Cited by 1,004

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

Seder, R. A., Paul, W. E., Davis, M. M., & Groth, B. F. D. S. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.4.1091 · Cited by 994

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

Magram, J., Connaughton, S. E., Warrier, R. R., Carvajal, D. M., Wu, C. Y., Ferrante, J., Stewart, C. L., Sarmiento, U. M., Faherty, D. A., & Gately, M. K. (1996) · Immunity · doi:10.1016/s1074-7613(00)80413-6 · Cited by 989

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

Szabo, S. J., Dighe, A. S., Gubler, U., & MURPHY, K. M. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.5.817 · Cited by 982

Recognition of a lipid antigen by CD1-restricted αβ+ T cells

Beckman, E. M., Porcelli, S. A., Morita, C. T., Behar, S. M., Furlong, S. T., & Brenner, M. B. (1994) · Nature · doi:10.1038/372691a0 · Cited by 977

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

Seder, R. A., Gazzinelli, R. T., Sher, A., & Paul, W. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10188 · Cited by 976

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

Chan, S. H., PERUSSIA, B., Gupta, J. W., Kobayashi, M., Pospísil, M., Young, H. A., Wolf, S. F., Young, D., Clark, S., & Trinchieri, G. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.4.869 · Cited by 962

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

Le Gros, G., Ben-Sasson, S. Z., Seder, R., Finkelman, F. D., & Paul, W. E. (1990) · The Journal of experimental medicine · doi:10.1084/jem.172.3.921 · Cited by 954

Interleukin-12 and its role in the generation of TH1 cells.

Trinchieri, G. (1993) · Immunology today (Amsterdam. Regular ed.) · doi:10.1016/0167-5699(93)90230-i · Cited by 931

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α

Gazzinelli, R. T., Wysocka, M., Hieny, S. E., Scharton‐Kersten, T., Cheever, A. W., Kühn, R., Müller, W., Trinchieri, G., & Sher, A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.2.798 · Cited by 928

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

Koch, F., Stanzl, U., Jennewein, P., Janke, K., Heufler, C., Kämpgen, E., Romani, N., & Schuler, G. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.741 · Cited by 928

Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

Winzler, C., Rovere, P. Q., Rescigno, M., Granucci, F., Penna, G., Adorini, L., Zimmermann, V. S., Davoust, J. M., & Ricciardi‐Castagnoli, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.2.317 · Cited by 848

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells

Wolf, S. F., Temple, P. A., Kobayashi, M., Young, D. V., Dicig, M., Lowe, L. D., Dzialo, R., Fitz, L. J., Ferenz, C. R., & Hewick, R. M. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.9.3074 · Cited by 845

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

Gazzinelli, R. T., Hieny, S. E., Wynn, T. A., Wolf, S., & Sher, A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6115 · Cited by 835

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

Allen, R. C., Armitage, R. J., Conley, M. E., Rosenblatt, H. M., Jenkins, N. A., Copeland, N. G., Bedell, M. A., Edelhoff, S., Distèche, C. M., Simoneaux, D. K., et al. (1993) · Science · doi:10.1126/science.7679801 · Cited by 829

Recombinant IL-12 administration induces tumor regression in association with IFN- gamma production.

Nastala, C. L., Edington, H. D., McKinney, T. G., Tahara, H., Nalesnik, M. A., Brunda, M. J., Gately, M. K., Wolf, S. F., Schreiber, R. D., Storkus, W. J., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.4.1697 · Cited by 780

Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?

Romagnani, S. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90083-j · Cited by 780

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

Tripp, C. S., Wolf, S. F., & Unanue, E. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3725 · Cited by 768

Recombinant interleukin 12 cures mice infected with Leishmania major.

Heinzel, F. P., Schoenhaut, D. S., Rerko, R. M., Rosser, L. E., & Gately, M. K. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.5.1505 · Cited by 761

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

Rogge, L., Barberis-Maino, L., Biffi, M., Passini, N., Presky, D. H., Gubler, U., & Sinigaglia, F. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.5.825 · Cited by 746

Parasite-induced IL-12 stimulates early IFN- gamma synthesis and resistance during acute infection with Toxoplasma gondii .

Gazzinelli, R. T., Wysocka, M., Hayashi, S., Denkers, E., Hieny, S. E., Caspar, P., Trinchieri, G., & Sher, A. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.6.2533 · Cited by 729

Inhibition of Angiogenesis In Vivo by Interleukin 12

Voest, E. E., Kenyon, B. M., OʼReilly, M., Truitt, G. A., D’Amato, R. J., & Folkman, J. (1995) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/87.8.581 · Cited by 722

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

Sypek, J. P., Chung, C. L., Mayor, S. E., Subramanyam, J. M., Goldman, S. J., Sieburth, D., Wolf, S. F., & Schaub, R. G. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.6.1797 · Cited by 721

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

Robinson, D. S., Shibuya, K., Mui, A., Zonin, F., Murphy, E., Sana, T., Hartley, S. B., Menon, S., KASTELEIN, R. A., Bazán, F., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80378-7 · Cited by 717

Interleukin 12 (IL-12) Is Crucial to the Development of Protective Immunity in Mice Intravenously Infected with Mycobacterium tuberculosis

Cooper, A. M., Magram, J., Ferrante, J., & Orme, I. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.1.39 · Cited by 715

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

Santo, J. P. D., Bonnefoy, J., Gauchatt, J. F., Fischer, A., & Basile, G. D. S. (1993) · Nature · doi:10.1038/361541a0 · Cited by 702

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

Heufler, C., Koch, F., Stanzl, U., Topar, G., Wysocka, M., Trinchieri, G., Enk, A., Steinman, R. M., Romani, N., & Schuler, G. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260323 · Cited by 700

Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.

Prete, G., Carli, M., Mastromauro, C., Biagiotti, R., Macchia, D., Falagiani, P., Ricci, M., & Romagnani, S. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115300 · Cited by 694

The Th1–Th2 hypothesis of HIV infection: new insights

Clerici, M. S., & Shearer, G. M. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90220-8 · Cited by 693

A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits

Presky, D. H., Yang, H., Minetti, L. J., Chua, A. O., Nabavi, N., Wu, C. Y., Gately, M. K., & Gubler, U. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14002 · Cited by 689

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

Sad, S., Marcotte, R., & Mosmann, T. R. (1995) · Immunity · doi:10.1016/1074-7613(95)90051-9 · Cited by 685

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

Jacobson, N. G., Szabo, S. J., Weber-Nordt, R., Zhong, Z.-H., Schreiber, R. D., Darnell, J. E., Jr., & MURPHY, K. M. M. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.5.1755 · Cited by 675

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

STERN, A. S., Podlaski, F., Hulmes, J. D., Pan, Y.-C. E., Quinn, P. M., Wolitzky, A. G., Familletti, P. C., Stremlo, D. L., Truitt, T., & Chizzonite, R. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6808 · Cited by 670

Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.

Kraan, T. C. T. M. V. D. P., Boeije, L. C. M., Smeenk, R. J. T., Wijdenes, J., & Aarden, L. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.775 · Cited by 665

Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFNγ receptors

Dighe, A. S., Richards, E., Old, L. J., & Schreiber, R. D. (1994) · Immunity · doi:10.1016/1074-7613(94)90087-6 · Cited by 663

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

Ferrick, D. A., Schrenzel, M. D., Mulvania, T., Hsieh, B., Ferlin, W. G., & Lepper, H. (1995) · Nature · doi:10.1038/373255a0 · Cited by 662

Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10

de Waal Malefyt, R., Figdor, C. G., Huijbens, R., Mohan-Peterson, S., Bennett, B., Culpepper, J., Dang, W., Zurawski, G., & de Vries, J. E. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.11.6370 · Cited by 648

The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.

Ma, X., Chow, J. M., Gri, G., Carra, G., Gerosa, F., Wolf, S. F., Dzialo, R., & Trinchieri, G. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.1.147 · Cited by 648

Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene

Holtschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.-P., Gabriele, L., Waring, J. F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81348-3 · Cited by 644

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

Davis, S. H., Aldrich, T. H., Stahl, N., Li, P., Taga, T., Kishimoto, T., Ip, N. Y., & Yancopoulos, G. D. (1993) · Science · doi:10.1126/science.8390097 · Cited by 634

Crystal Structure of Mouse CD1: An MHC-Like Fold with a Large Hydrophobic Binding Groove

Zeng, Z.-H., Castaño, A. R., Segelke, B. W., Stura, E. A., Peterson, P. A., & Wilson, I. A. (1997) · Science · doi:10.1126/science.277.5324.339 · Cited by 631

Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein

Ushio, S., Namba, M., Okura, T., Hattori, K., Nukada, Y., Akita, K., Tanabe, F., Konishi, K., Micallef, M. J., Fujii, M., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.11.4274 · Cited by 624

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.

Gavett, S. H., O’Hearn, D. J., Li, X., Huang, S. K., Finkelman, F. D., & Wills-Karp, M. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.5.1527 · Cited by 618

Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.

Scharton, T. M., & Scott, P. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.567 · Cited by 613

Response of resting human peripheral blood natural killer cells to interleukin 2.

Trinchieri, G., Matsumoto-Kobayashi, M., Clark, S., Seehra, J. S., London, L., & PERUSSIA, B. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.160.4.1147 · Cited by 603

IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells

Kaliński, P., Hilkens, C. M. U., Snijders, A. J., Snijdewint, F. G. M., & Kapsenberg, M. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.1.28 · Cited by 602

Interferon‐γ‐inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin‐12 for interferon‐γ production

Micallef, M. J., Ohtsuki, T., Kohno, K., Tanabe, F., Ushio, S., Namba, M., Tanimoto, T., Torigoe, K., Fujii, M., Ikeda, M., et al. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260736 · Cited by 597

Options for the control of influenza III

Ada, G., Tannock, G. A., & Hampson, A. W. (1997) · Vaccine · doi:10.1016/s0264-410x(96)00191-0 · Cited by 587

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

Gubler, U., Chua, A. O., Schoenhaut, D. S., Dwyer, C. M., McComas, W. W., Motyka, R., Nabavi, N., Wolitzky, A. G., Quinn, P. M., & Familletti, P. C. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4143 · Cited by 576

Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells

Monteleone, G., Biancone, L., Marasco, R., Morrone, G., Marasco, O., Luzza, F., & Pallone, F. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70128-8 · Cited by 571

Effect of interleukin‐10 on dendritic cell maturation and function

Smedt, T. D., van Mechelen, M., Becker, G. D., Urbain, J., Léo, O., & Moser, M. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270526 · Cited by 564

Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus

Karp, C. L., Wysocka, M., Wahl, L. M., Ahearn, J. M., Cuomo, P. J., Sherry, B. A., Trinchieri, G., & Griffin, D. E. (1996) · Science · doi:10.1126/science.273.5272.228 · Cited by 548

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

Leonard, J. P., Waldburger, K. E., & Goldman, S. J. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.1.381 · Cited by 541

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

Openshaw, P., Murphy, E. E., Hosken, N. A., Maino, V. C., Davis, K. A., MURPHY, K. M. M., & O’Garra, A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.5.1357 · Cited by 538

Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1

Hsu, D., Malefyt, R. D. W., Fiorentino, D. F., Dang, M. N., Vieira, P., Devriès, J., Spits, H., Mosmann, T. R., & Moore, K. W. (1990) · Science · doi:10.1126/science.2173142 · Cited by 535

Immunosuppressive Actions of 1,25-Dihydroxyvitamin D3: Preferential Inhibition of Th1 Functions

Lemire, J. M., Archer, D. C., Beck, L., & Spiegelberg, H. L. (1995) · Journal of Nutrition · doi:10.1093/jn/125.suppl_6.1704s · Cited by 526

IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12

Kohno, K., Kataoka, J., Ohtsuki, T., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.4.1541 · Cited by 521

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

Croft, M., Carter, L., Swain, S. L., & Dutton, R. W. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.5.1715 · Cited by 514

Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10

Bogdan, C., Paik, J., Yoram Vodovotz, B., & Nathan, C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50091-0 · Cited by 502

Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease.

Parronchi, P., Romagnani, P., Annunziato, F., et al. (1997) · PubMed · Cited by 497

Major Injury Leads to Predominance of the T Helper-2 Lymphocyte Phenotype and Diminished Interleukin-12 Production Associated with Decreased Resistance to Infection

O’Sullivan, S. T., Lederer, J. A., Horgan, A. F., Chin, D. H. L., Mannick, J. A., & Rodrick, M. L. (1995) · Annals of Surgery · doi:10.1097/00000658-199522240-00006 · Cited by 494

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

Xu, X. M., Sun, Y., & Hoey, T. (1996) · Science · doi:10.1126/science.273.5276.794 · Cited by 484

Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site

Murphy, T. L., Cleveland, M., Kulesza, P., Magram, J., & MURPHY, K. M. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5258 · Cited by 482

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

Sgadari, C., Angiolillo, A., & Tosato, G. (1996) · Blood · doi:10.1182/blood.v87.9.3877.bloodjournal8793877 · Cited by 476

Cloning and expression of murine IL-12

Schoenhaut, D. S., Chua, A. O., Wolitzky, A. G., Quinn, P. M., Dwyer, C. M., McComas, W. W., Familletti, P. C., Gately, M. K., & Gubler, U. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.11.3433 · Cited by 470

Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.

Clerici, M., Hakim, F. T., Venzon, D. J., Blatt, S., Hendrix, C. W., Wynn, T. A., & Shearer, G. M. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116294 · Cited by 469

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

Mattner, F., Magram, J., Ferrante, J., Launois, P., Padova, K. D., Behin, R., Gately, M. K., Louis, J. A., & Alber, G. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260722 · Cited by 469

T cell genetic background determines default T helper phenotype development in vitro.

Hsieh, C., Macatonia, S. E., O’Garra, A., & MURPHY, K. M. M. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.713 · Cited by 462

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)

Gately, M. K., Desai, B. B., Wolitzky, A. G., et al. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.3.874 · Cited by 461

Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration.

Orange, J. S., Wang, B., Terhorst, C., & Biron, C. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.4.1045 · Cited by 455

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

Windhagen, A., Newcombe, J., Dangond, F., Strand, C., Woodroofe, M. N., Cuzner, M. L., & Hafler, D. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.6.1985 · Cited by 454

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

Wysocka, M., Kubin, M. Z., Vieira, L. Q., Ozmen, L., Garotta, G., Scott, P., & Trinchieri, G. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250307 · Cited by 452

Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice

Pulendran, B., Lingappa, J., Kennedy, M., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.5.2222 · Cited by 449

Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma.

Billiau, A., Heremans, H., Vandekerckhove, F., Dijkmans, R., Sobis, H., Meulepas, E., & Carton, H. (1988) · Journal of Immunology · doi:10.4049/jimmunol.140.5.1506 · Cited by 447

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

Bacon, C. M., Petricoin, E. F., Ortaldo, J. R., Rees, R. C., Larner, A. C., Johnston, J. A., & O’Shea, J. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7307 · Cited by 440

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.

Manetti, R., Gerosa, F., Giudizi, M. G., Biagiotti, R., Parronchi, P., Piccinni, M., Sampognaro, S., Maggi, E., Romagnani, S., & Trinchieri, G. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1273 · Cited by 437

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

Murphy, E., Shibuya, K., Hosken, N. A., Openshaw, P., Maino, V. C., Davis, K. A., MURPHY, K. M. M., & O’Garra, A. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.3.901 · Cited by 435

Activation of human dendritic cells following infection with Mycobacterium tuberculosis

Henderson, R. A., Watkins, S. C., & Flynn, J. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.2.635 · Cited by 432

Lack of Evidence for the Dichotomy of T H 1 and T H 2 Predominance in HIV-Infected Individuals

Graziosi, C., Pantaleo, G., Gantt, K. R., et al. (1994) · Science · doi:10.1126/science.8023143 · Cited by 430

IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones

Parronchi, P., Carli, M., Manetti, R., et al. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.9.2977 · Cited by 427

Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis.

Uyemura, K., Demer, L. L., Castle, S. C., Jullien, D., Berliner, J. A., Gately, M. K., Warrier, R. R., Pham, N., Fogelman, A. M., & Modlin, R. L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118650 · Cited by 427

Impaired interleukin 12 production in human immunodeficiency virus-infected patients.

Chehimi, J., Starr, S. E., Frank, I., et al. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1361 · Cited by 425

Measles Virus Suppresses Cell-mediated Immunity by Interfering with the Survival and Functions of Dendritic and T Cells

Vivier, I., Delprat, C., Rivailler, P., Rissoan, M., Liu, Y.-J., & Rabourdin‐Combe, C. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.6.813 · Cited by 424

Inducible Nitric Oxide Is Essential for Host Control of Persistent but Not Acute Infection with the Intracellular Pathogen Toxoplasma gondii

Scharton‐Kersten, T., Yap, G. S., Magram, J., & Sher, A. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.7.1261 · Cited by 423

Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway

Verhasselt, V., Buelens, C., Willems, F., Groote, D. D., Haeffner‐Cavaillon, N., & Goldman, M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.6.2919 · Cited by 421

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

Trembleau, S., Penna, G., Bosi, E., Mortara, A., Gately, M. K., & Adorini, L. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.817 · Cited by 421

Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications.

Elenkov, I. J., Papanicolaou, D. A., Wilder, R. L., & Chrousos, G. P. (1996) · PubMed · Cited by 419

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.

Scharton‐Kersten, T., Afonso, L., Wysocka, M., Trinchieri, G., & Scott, P. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.10.5320 · Cited by 414

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

Shu, U., Kiniwa, M., Wu, C. Y., Maliszewski, C. R., Vezzio, N., Hakimi, J., Gately, M. K., & Delespesse, G. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250442 · Cited by 414

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice

Screpanti, I., Romani, L., Musiani, P., Modesti, A., Fattori, E., Lazzaro, D., Sellitto, C., Scarpa, S., Bellavia, D., & Lattanzio, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07185.x · Cited by 407

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

Szabo, S. J., Jacobson, N. G., Dighe, A. S., Gubler, U., & MURPHY, K. M. M. (1995) · Immunity · doi:10.1016/1074-7613(95)90011-x · Cited by 406

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

Wynn, T. A., Cheever, A. W., Jankovic, D. L., Poindexter, R. W., Caspar, P., Lewis, F. A., & Sher, A. (1995) · Nature · doi:10.1038/376594a0 · Cited by 403

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.

Ling, P., Gately, M. K., Gubler, U., STERN, A. S., Lin, P., Hollfelder, K., Su, C., Pan, Y.-C. E., & Hakimi, J. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.1.116 · Cited by 399

In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection

Scharton‐Kersten, T., Wynn, T. A., Denkers, E., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.9.4045 · Cited by 396

Bacterial DNA Induces Murine Interferon-γ Production by Stimulation of Interleukin-12 and Tumor Necrosis Factor-α

Halpern, M. D., Kurlander, R. J., & Pisetsky, D. S. (1996) · Cellular Immunology · doi:10.1006/cimm.1996.0009 · Cited by 395

Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

Strober, W., Kelsall, B. L., Fuss, I. J., Marth, T., Ludviksson, B. R., Ehrhardt, R. O., & Neurath, M. F. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01000-1 · Cited by 392

Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes

Damle, N. K., Klussman, K., Linsley, P. S., & Aruffo, A. A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.1985 · Cited by 386

Molecular Mechanisms of the Induction of IL-12 and Its Inhibition by IL-10

Aste-Amézaga, M., Ma, X., Sartori, A., & Trinchieri, G. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.12.5936 · Cited by 385

Restoration of HIV-Specific Cell-Mediated Immune Responses by Interleukin-12 in Vitro

Clerici, M., Lucey, D. R., Berzofsky, J. A., Pinto, L. A., Wynn, T. A., Blatt, S. P., Dolan, M. J., Hendrix, C. W., Wolf, S. F., & Shearer, G. M. (1993) · Science · doi:10.1126/science.7903123 · Cited by 384

An absolute and restricted requirement for IL-12 in natural killer cell IFN-γ production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections

Orange, J. S., & Biron, C. A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.3.1138 · Cited by 381

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

Street, N. E., Schumacher, J. H., Fong, T. A. T., Bass, H. Z., Fiorentino, D. F., Leverah, J. A., & Mosmann, T. R. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.5.1629 · Cited by 378

The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells.

Roy, M., Waldschmidt, T. J., Aruffo, A. A., et al. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.5.2497 · Cited by 371

Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production

D'Andrea, A., Ma, X., Aste-Amezaga, M., Paganin, C., & Trinchieri, G. (1995) · The Journal of experimental medicine · doi:10.1084/jem.181.2.537 · Cited by 365

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

Reiner, S. L., Zheng, S., Wang, Z., Stowring, L., & Locksley, R. M. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.2.447 · Cited by 363

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

Gately, M. K., Warrier, R. R., Honasoge, S., Carvajal, D. M., Faherty, D. A., Connaughton, S. E., Anderson, T. D., Sarmiento, U. M., Hubbard, B. R., & Murphy, M. (1994) · International Immunology · doi:10.1093/intimm/6.1.157 · Cited by 363

Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways

Perry, L. L., Feilzer, K., & Caldwell, H. D. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3344 · Cited by 359

Vaccination with DNA Encoding the Immunodominant LACK Parasite Antigen Confers Protective Immunity to Mice Infected with Leishmania major

Gurunathan, S., Sacks, D. L., Brown, D. R., Reiner, S. L., Charest, H., Glaichenhaus, N., & Seder, R. A. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.7.1137 · Cited by 357

Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha

Hunter, C. A., Subauste, C. S., Cleave, V. H. V., & Remington, J. S. (1994) · Infection and Immunity · doi:10.1128/iai.62.7.2818-2824.1994 · Cited by 355

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.

Bacon, C. M., McVicar, D. W., Ortaldo, J. R., et al. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.1.399 · Cited by 355

Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1

Taki, S., Sato, T., Ogasawara, K., Fukuda, T., Sato, M., Hida, S., Suzuki, G., Mitsuyama, M., Shin, E.-H., Kojima, S., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80443-4 · Cited by 353

Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF.

Robertson, M. J., Soiffer, R. J., Wolf, S. F., Manley, T. J., Donahue, C., Young, D., Herrmann, S. H., & Ritz, J. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.3.779 · Cited by 353

IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi

Hunter, C. A., Neyer, L., Slifer, T. R., Kanaly, S. T., Grünig, G., Fort, M., Rennick, D. M., & Araujo, F. G. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3311 · Cited by 352

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.

Kubin, M. Z., Kamoun, M., & Trinchieri, G. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.211 · Cited by 351

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.

Murphy, E. E., Terres, G., Macatonia, S. E., Hsieh, C., Mattson, J. D., Lanier, L. L., Wysocka, M., Trinchieri, G., MURPHY, K. M. M., & O’Garra, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.223 · Cited by 351

Dendritic cells and macrophages are required for Th1 development of CD4 + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN- γ production is IFN- γ -dependent

Macatonia, S. E., Hsleh, C.-S., MURPHY, K. M. M., & O’Garra, A. (1993) · International Immunology · doi:10.1093/intimm/5.9.1119 · Cited by 349

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

Gajewski, T. F., Joyce, J., & Fitch, F. W. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.1.15 · Cited by 348

Selective Suppression of Interleukin-12 Induction after Macrophage Receptor Ligation

Sutterwala, F. S., Noel, G. J., Clynes, R., & Mosser, D. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.11.1977 · Cited by 348

Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes

Blotta, M. H. S. L., DeKruyff, R. H., & Umetsu, D. T. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.12.5589 · Cited by 346

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha.

Flesch, I. E. A., Hess, J., Huang, S., Aguet, M., Rothe, J., Bluethmann, H., & Kaufmann, S. H. E. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.5.1615 · Cited by 346

A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock

Okamura, H., Nagata, K., Komatsu, T., Tanimoto, T., Nukata, Y., Tanabe, F., Akita, K., Torigoe, K., Okura, T., & Fukuda, S. (1995) · Infection and Immunity · doi:10.1128/iai.63.10.3966-3972.1995 · Cited by 345

Expression Cloning of a Protective Leishmania Antigen

Mougneau, E., Altare, F., Wakil, A. E., Zheng, S., Coppola, T., Wang, Z., Waldmann, R., Locksley, R. M., & Glaichenhaus, N. (1995) · Science · doi:10.1126/science.7725103 · Cited by 345

Regulation of neutrophil-derived chemokine expression by IL-10.

Kasama, T., Strieter, R. M., Lukacs, N. W., Burdick, M., & Kunkel, S. L. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.7.3559 · Cited by 343

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.

Stuber, E. R., Strober, W., & Neurath, M. F. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.2.693 · Cited by 341

In vivo engineering of a cellular immune response by co-administration of IL-12 expression vector with a DNA immunogen

Kim, J. (1997) · Immunology Letters · doi:10.1016/s0165-2478(97)86917-9 · Cited by 340

A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes

Devergne, O., Hummel, M., Koeppen, H., Beau, M. M. L., Nathanson, E., Kieff, E. D., & Birkenbach, M. P. (1996) · Journal of Virology · doi:10.1128/jvi.70.2.1143-1153.1996 · Cited by 338

Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin‐10 or antibodies to interleukin‐12

Duchmann, R., Schmitt, E., Knolle, P. A., Büschenfelde, K. M. Z., & Neurath, M. F. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260432 · Cited by 338

Clinical Trials: IL-12 Deaths: Explanation and a Puzzle

Cohen, J. (1995) · Science · doi:10.1126/science.270.5238.908a · Cited by 332

Switch of CD8 T Cells to Noncytolytic CD8 - CD4 - Cells that Make T H 2 Cytokines and Help B Cells

Erard, F., Wild, M.-T., García‐Sanz, J. A., & Gros, G. S. L. (1993) · Science · doi:10.1126/science.8511588 · Cited by 331

Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes

Hayes, M. M., Wang, J., & Norcross, M. (1995) · Blood · doi:10.1182/blood.v86.2.646.bloodjournal862646 · Cited by 330

IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells.

Wang, P., Wu, P., Siegel, M. I., Egan, R. W., & Billah, M. M. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.2.811 · Cited by 329

Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis

Möller, D. R., Forman, J. D., Liu, M. C., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.12.4952 · Cited by 329

Epstein–Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

Devergne, O., Birkenbach, M. P., & Kieff, E. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.12041 · Cited by 329

Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis

Quelle, F. W., Shimoda, K., Thierfelder, W. E., Fischer, C. D., Kim, A. C., Ruben, S. M., Cleveland, J. L., Pierce, J. H., Keegan, A. D., Nelms, K. A., et al. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3336 · Cited by 327

Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.

Tahara, H., Zeh, H. J., Storkus, W. J., Pappo, I., Watkins, S. C., Gubler, U., Wolf, S. F., Robbins, P., & Lotze, M. T. (1994) · PubMed · Cited by 326

IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection

Flynn, J. L., Goldstein, M. M., Triebold, K. J., Sypek, J. P., Wolf, S., & Bloom, B. R. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.5.2515 · Cited by 324

Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells

PERUSSIA, B., Chan, S. H., D’Andrea, A., Tsuji, K., Santoli, D., Pospísil, M., Young, D., Wolf, S. F., & Trinchieri, G. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.11.3495 · Cited by 324

Interleukin‐12 profoundly up‐regulates the synthesis of antigen‐specific complement‐fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo

Germann, T., Bongartz, M., Długońska, H., Hess, H., Schmitt, E., Kolbe, L., Kölsch, E., Podlaski, F., Gately, M. K., & Rüde, E. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250329 · Cited by 324

A direct role for IFN-γ in regulation of Th1 cell development

Bradley, L. M., Dalton, D. K., & Croft, M. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.4.1350 · Cited by 322

CD40 Ligand Is Required for Protective Cell-Mediated Immunity to Leishmania major

Campbell, K. A., Ovendale, P. J., Kennedy, M. K., Fanslow, W. C., Reed, S. G., & Maliszewski, C. R. (1996) · Immunity · doi:10.1016/s1074-7613(00)80436-7 · Cited by 321

Regulation of human cytolytic lymphocyte responses by interleukin-12

Gately, M. K., Wolitzky, A. G., Quinn, P. M., & Chizzonite, R. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90011-d · Cited by 321

Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway

Cleveland, M. G., Gorham, J. D., Murphy, T. L., TUOMANEN, E. I., & MURPHY, K. M. M. (1996) · Infection and Immunity · doi:10.1128/iai.64.6.1906-1912.1996 · Cited by 319

A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma

Ahn, H., Maruo, S., Tomura, M., Mu, J., Hamaoka, T., Nakanishi, K., Clark, S., Kurimoto, M., Okamura, H., & Fujiwara, H. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.5.2125 · Cited by 318

IL-12-induced protection against blood-stage Plasmodium chabaudi AS requires IFN-γ and TNF-α and occurs via a nitric oxide-dependent mechanism

Stevenson, M. M., Tam, M. F., Wolf, S. F., & Sher, A. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.5.2545 · Cited by 316

Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4 + T cells via CD40 ligand

Balashov, K. E., Smith, D. R., Khoury, S. J., Hafler, D. A., & Weiner, H. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.599 · Cited by 316

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

Carrera, L., Gazzinelli, R. T., Badolato, R., Hieny, S. E., Müller, W., Kühn, R., & Sacks, D. L. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.2.515 · Cited by 312

Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production.

Leung, D. Y. M., Gately, M. K., Trumble, A. E., et al. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.747 · Cited by 309

The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection.

Cooper, A. M., Roberts, A. D., Rhoades, E. R., Callahan, J. E., Getzy, D. M., & Orme, I. M. (1995) · PubMed Central · Cited by 308

Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

Gerosa, F., Paganin, C., Peritt, D., Paiola, F., Scupoli, M. T., Aste-Amézaga, M., Frank, I., & Trinchieri, G. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2559 · Cited by 306

Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.

Chua, A. O., Chizzonite, R., Desai, B. B., Truitt, T., Nunes, P., Minetti, L. J., Warrier, R. R., Presky, D. H., Levine, J. F., Gately, M. K., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.1.128 · Cited by 305

Roles of IFN-γ and IFN-α in IL-12-induced T helper cell-1 development

Wenner, C. A., Guler, M. L., Macatonia, S. E., O’Garra, A., & MURPHY, K. M. M. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.4.1442 · Cited by 304

Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins

Plevy, S. E., Gemberling, J. H. M., Hsu, S., Dorner, A. J., & Smale, S. T. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4572 · Cited by 302

Endotoxin-induced serum factor that stimulates gamma interferon production

Nakamura, K., Okamura, H., Wada, M., Nagata, K., & Tamura, T. (1989) · Infection and Immunity · doi:10.1128/iai.57.2.590-595.1989 · Cited by 300

Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection

Cousens, L. P., Orange, J. S., Su, H. C., & Biron, C. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.634 · Cited by 299

Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines

Iwasaki, A., Stiernholm, B. J., Chan, A. K., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.10.4591 · Cited by 298

Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.

Tripp, C. S., Gately, M. K., Hakimi, J., Ling, P., & Unanue, E. R. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.4.1883 · Cited by 296

In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen

Kim, J. J., Ayyavoo, V., Bagarazzi, M. L., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.2.816 · Cited by 295

Protective Role of CD40 in Leishmania major Infection at Two Distinct Phases of Cell-Mediated Immunity

Kamanaka, M., Yu, P., Yasui, T., Yoshida, K., Kawabe, T., Horii, T., Kishimoto, T., & Kikutani, H. (1996) · Immunity · doi:10.1016/s1074-7613(00)80435-5 · Cited by 294

IL-12 receptor. II. Distribution and regulation of receptor expression

Desai, B. B., Quinn, P. M., Wolitzky, A. G., et al. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.10.3125 · Cited by 289

Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit

Snijders, A. J., Hilkens, C. M. U., Kraan, T. C. T. M. V. D. P., Engel, M., Aarden, L. A., & Kapsenberg, M. L. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.3.1207 · Cited by 288

Effects of IL-12 on helper T cell-dependent immune responses in vivo.

McKnight, A. J., Zimmer, G. J., Fogelman, I., Wolf, S. F., & Abbas, A. K. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.5.2172 · Cited by 287

T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin‐12 and interferon‐γ and is inhibited by transforming growth factor‐β

Schmitt, E., Hoehn, P., Hüls, C., Goedert, S., Palm, N., Rüde, E., & Germann, T. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240403 · Cited by 287

Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1

Chen, H., & Paul, W. E. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.5.2240 · Cited by 286

Interferon Regulatory Factor-1 Is Required for a T Helper 1 Immune Response In Vivo

Lohoff, M. D., Ferrick, D. A., Mittrücker, H., Duncan, G. S., Bischof, S., Röllinghoff, M., & Mak, T. W. (1997) · Immunity · doi:10.1016/s1074-7613(00)80444-6 · Cited by 286

Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes

Aliberti, J., Cardoso, M. A., Martins, G. A., Gazzinelli, R. T., Vieira, L. Q., & Silva, J. S. (1996) · Infection and Immunity · doi:10.1128/iai.64.6.1961-1967.1996 · Cited by 286

Coley's toxins in perspective

Starnes, C. O. (1992) · Nature · doi:10.1038/357011a0 · Cited by 284

The interleukin‐12 subunit p40 specifically inhibits effects of the interleukin‐12 heterodimer

Mattner, F., Fischer, S., Guckes, S., et al. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230923 · Cited by 283

A newly defined interleukin-1?

Bazán, J. F., Timans, J. C., & Kastelein, R. A. (1996) · Nature · doi:10.1038/379591a0 · Cited by 283

NK cell-based immunotherapy for malignant diseases

Cheng, M., Chen, Y., Xiao, W., Sun, R., & Tian, Z. (2013) · Cellular & Molecular Immunology · doi:10.1038/cmi.2013.10 · Cited by 631

Chemokines: agents for the immunotherapy of cancer?

Homey, B., Müller, A., & Zlotnik, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri748 · Cited by 398

IL-12 and IFN-γ in host defense against mycobacteria and salmonella in mice and men

Jouanguy, E., Döffinger, R., Dupuis, S., Pallier, A., Altare, F., & Casanova, J.-L. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80055-7 · Cited by 331

The thalidomide saga

Melchert, M., & List, A. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.01.022 · Cited by 246

An IFN-γ-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages

Wang, I.-M., Contursi, C., Masumi, A., Ma, X., Trinchieri, G., & Ozato, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.271 · Cited by 187

The Innate Immune System

Heeg, K. M. (2007) · Neuroimmune biology · doi:10.1016/s1567-7443(07)00205-0

Aspects of the innate and adaptive immune responses to acute infections with BVDV

Brackenbury, L. S., Carr, B. V., & Charleston, B. (2003) · Veterinary Microbiology · doi:10.1016/j.vetmic.2003.09.004 · Cited by 58

Do adaptive immune cells suppress or activate innate immunity?

Zhao, J., Yang, X., Auh, S. L., Kim, K. D., Tang, H., & Fu, Y. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.10.003 · Cited by 40

Earthworm and innate immunity

Liu, Z., & Niu, B. (2008) · Int J Immunol · doi:10.3760/cma.j.issn.1673-4394.2008.04.005

Innate and adaptive immunity

Noakes, P. S., & Michaelis, L. J. (2013) · Elsevier eBooks · doi:10.1533/9780857095749.1.3 · Cited by 12