The DOI matches its Crossref record; 748 of the 748 references it cites were found in a registry or an index.
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“IL-12 is composed of the p35 and p40 subunits, forming a heterodimer p70. (42)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [42]
Citations
Cites
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Current Protocols in Immunology
(2018) · Current Protocols in Immunology · doi:10.1002/(issn)1934-368x · Cited by 3,574
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
Hsieh, C.-S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., & Murphy, K. M. (1993) · Science · doi:10.1126/science.8097338 · Cited by 3,134
Biology of Natural Killer Cells
Trinchieri, G. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60664-1 · Cited by 2,902
Self-citationFiorentino, D. F., Bond, M. W., & Mosmann, T. R. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.6.2081 · Cited by 2,733
Cloning of a new cytokine that induces IFN-γ production by T cells
Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., et al. (1995) · Nature · doi:10.1038/378088a0 · Cited by 2,602
Trinchieri, G. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.001343 · Cited by 2,379
Self-citationCella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P. J. L., Lanzavecchia, A., & Alber, G. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.747 · Cited by 1,982
Nathan, C. F., Murray, H. W., Wiebe, M. E., & Rubin, B. Y. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.3.670 · Cited by 1,962
Research works printed but not linked: 10
- Nadeau, 1995, Pharmacokinetics and pharmacodynamics of recombinant human IL-12 in male rhesus monkeys, J. Pharmacol. Exp. Therapeut., 274, 78
- Sarmiento, 1994, Biologic effects of recombinant human interleukin-12 in squirrel monkeys, Sciureus saimiri). Lab. Invest., 71, 862
- Wolf, 1992, Cell sources of natural killer cell stimulatory factor (NKSF/IL-12) transcripts and subunit expression, FASEB J., 6, A1335
- Moller, D.R. Wysocka, M. Greenlee, B.M. Ma, X. Wahl, L. Flockhart, D.A. Trinchieri, G. Karp, C.L., (1997) Inhibition of interleukin 12 production by thalidomide. Submitted for publication · DOI
- Wang, 1997, A critical role of interferon consensus sequence binding protein (ICSBP) in the activation of IL-12 p40 gene promoter, J. Interf. Cykokine Res., 17, 576
- Not In, 1994, Parasite induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with. Toxoplasma gondii, J. Immunol., 153, 2533, 10.4049/jimmunol.153.6.2533 · DOI
- Afonso, 1994, The adjuvant effect of interleukin-12 in a vaccine against, Leishmania major. Science, 263, 235
- Kripte, 1990, Photoimmunology, Photochem. Photobiol., 52, 919
- Waldburger, 1996, Am. J. Pathol., 148, 375
- Constantinescu, 1997, Interleukin-12 is involved in spontaneous and superantigen-induced relapses in experimental allergic encephalomyelitis, Neurology, 48, 2070
Cited by
Sorted by citations
NK cell-based immunotherapy for malignant diseases
Cheng, M., Chen, Y., Xiao, W., Sun, R., & Tian, Z. (2013) · Cellular & Molecular Immunology · doi:10.1038/cmi.2013.10 · Cited by 631
Chemokines: agents for the immunotherapy of cancer?
Homey, B., Müller, A., & Zlotnik, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri748 · Cited by 398
IL-12 and IFN-γ in host defense against mycobacteria and salmonella in mice and men
Jouanguy, E., Döffinger, R., Dupuis, S., Pallier, A., Altare, F., & Casanova, J.-L. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80055-7 · Cited by 331
Melchert, M., & List, A. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.01.022 · Cited by 246
Wang, I.-M., Contursi, C., Masumi, A., Ma, X., Trinchieri, G., & Ozato, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.271 · Cited by 187
Self-citation
Metadata
- Authors
- Trinchieri, G.
- Affiliations
- The Wistar Institute (US)
- Corresponding author
- Trinchieri, Giorgio
- ORCID
- Trinchieri, Giorgio
- Venue
- Advances in Immunology
- Publisher
- Elsevier
- Published
- 1998
- Volume
- 70
- Pages
- 83-243
- ISSN
- 0065-2776 (ISSN-L)
- OpenAlex
- W1598996496
- Cited by
- 760
- References
- 748
- Citations by year
- 2025: 6 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 11 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 14 · 2016: 10 · 2015: 15 · 2014: 16 · 2013: 23 · 2012: 18
- FWCI
- 102.24
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca032898-13)
- National Cancer Institute (CA 32898, CA-20833, CA-10815, P30CA010815)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- IL-12, inflammatory cytokines, immunomodulation, interferon-gamma, macrophage activation, innate immunity, adaptive immunity, infection, antitumor immunity, autoimmunity, allergy, cytokine adjuvants, immunotherapy
- MeSH terms
- Animals, Communicable Diseases, Gene Expression Regulation, Graft Rejection, Humans, Hypersensitivity, Immunity, Inflammation, Autoimmunity, Receptors, Interleukin, Interleukin-12, Receptors, Interleukin-12
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review