Functions of DNA Polymerases

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

WATSON, J. D., & CRICK, F. H. C. (1953) · Nature · doi:10.1038/171737a0 · Cited by 13,584

DNA Repair and Mutagenesis

Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683

DNA repair and mutagenesis

Bootsma, D., & Hoeijmakers, J. H. J. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81408-9 · Cited by 2,285

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

Hoege, C., Pfander, B., Moldovan, G., Pyrowolakis, G., & Jentsch, S. (2002) · Nature · doi:10.1038/nature00991 · Cited by 2,202

Quality Control by DNA Repair

Lindahl, T. L., & Wood, R. D. (1999) · Science · doi:10.1126/science.286.5446.1897 · Cited by 1,521

Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., & Rajewsky, K. (1994) · Science · doi:10.1126/science.8016642 · Cited by 1,397

The Y-Family of DNA Polymerases

Ohmori, H., Friedberg, E. C., Fuchs, R. P., Goodman, M. F., Hanaoka, F., Hinkle, D. C., Kunkel, T. A., Lawrence, C. W., Livneh, Z., Nohmi, T., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00278-7 · Cited by 882

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

Ollis, D. L., Brick, P., Hamlin, R. C., Xuong, N., & Steitz, T. A. (1985) · Nature · doi:10.1038/313762a0 · Cited by 848

V(D)J Recombination: RAG Proteins, Repair Factors, and Regulation

Gellert, M. F. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.150203 · Cited by 771

DNA Replication Fidelity

Kunkel, T. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400006200 · Cited by 754

Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase η and reduces DNA synthesis fidelity

Chang, C., Luo, C. L., Eleraky, S., Lin, A., Zhou, G., & Gao, Y. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.102938 · Cited by 5

DNA Polymerases for PCR Applications

Drouin, R., Dridi, W., & Samassékou, O. (2007) · Springer eBooks · doi:10.1007/1-4020-5377-0_22 · Cited by 5

Mechanisms for High Fidelity DNA Replication

McElhinny, S. A. N., Pursell, Z. F., & Kunkel, T. A. (2009) · Royal Society of Chemistry eBooks · doi:10.1039/9781847559852-00086 · Cited by 5

Effect of pH on the Misincorporation Rate of DNA Polymerase η

Nishimoto, N., Suzuki, M., & Izuta, S. (2016) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00900 · Cited by 4

ϕ29 DNA Polymerase Active Site: Role of Residue Val250 as Metal–dNTP Complex Ligand and in Protein-Primed Initiation

Pérez-Arnaiz, P., Lázaro, J. M., Salas, M., & de Vega, M. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.10.061 · Cited by 4

A method to accurately quantitate intensities of 32P-DNA bands when multiple bands appear in a single lane of a gel is used to study dNTP insertion opposite a benzo[a]pyrene-dG adduct by Sulfolobus DNA polymerases Dpo4 and Dbh

Sholder, G., & Loechler, E. L. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.10.001 · Cited by 4

L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells

Stovbun, S. V., Vedenkin, A. S., Bukhvostov, A. A., Королева, Л. С., Silnikov, V. N., & Kuznetsov, D. A. (2020) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2020.100835 · Cited by 4

Survival choices

Kunkel, T. A., & Houten, B. V. (2006) · Nature Cell Biology · doi:10.1038/ncb0606-547 · Cited by 4

Furfural and Hydroxymethylfurfural

Solayman, M., Shapla, U. M., & Khalil, I. (2023) · Wiley eBooks · doi:10.1002/9781119113324.ch11 · Cited by 5

Bst DNA Polymerase: Structure, Properties and Engineering Strategies in LAMP

Tikhonova, E. E., Popinako, A., & Sazonov, A. E. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104261 · Cited by 3

Overview of neuroimaging in primary mitochondrial disorders

Kandemirli, S. G., Al‐Dasuqi, K., Aslan, B., Goldstein, A. C., & Alves, C. (2025) · Pediatric Radiology · doi:10.1007/s00247-025-06172-y · Cited by 3

Evolving DNA Repair Polymerases: From Double—Strand Break Repair to Base Excision Repair and VDJ Recombination

José, M., & Blanco, L. (2013) · InTech eBooks · doi:10.5772/53908 · Cited by 3

Generation of Active Bovine Terminal Deoxynucleotidyl Transferase (TdT) in E.coli

Kuan, W. L., Joy, J. K., Mee, N. F., Kwek, P. Z., Wen, T. S., Nguen, T., James, J., Chai, E., Flotow, H., Crasta, S. C., et al. (2010) · Biochemistry Insights · doi:10.4137/bci.s5123 · Cited by 3

RNA Sequencing and Bioinformatics Analysis Reveals the Downregulation of DNA Replication Genes by Morindone in Colorectal Cancer Cells

Chee, C. W., Hashim, N. M., Abdullah, I., & Rashid, N. N. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04690-9 · Cited by 3

Inhibition of DNA polymerase λ by glucosyl compounds from soybean (Glycine max L.) and their associated inflammatory activity

Mizushina, Y., Takahashi, Y., Satō, Y., Yamaguchi, Y., Takeuchi, T., Kuriyama, I., Sugawara, F., & Yoshida, H. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.12.046 · Cited by 3

Mitochondrial Genomics and Targeted Toxicities

Copeland, W. C., & Wallace, K. B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64219-8 · Cited by 3

Impact of DNA polymerase ζ mutations on genotoxic thresholds of oxidative mutagens

Suzuki, T., Matsumoto, K., Honma, M., & Nohmi, T. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.02.001 · Cited by 3

Pan-genomic insights into resistance, virulence, and stress adaptation in Clostridium perfringens from the Tibetan Plateau

Luo, R., Wan, Y., Chen, W., Wei, H., Wang, J., Bai, Z., Li, K., Zhong, Y., Ma, B., Jin, H., et al. (2026) · mSphere · doi:10.1128/msphere.00792-25 · Cited by 2

Targeting DNA Repair Pathways for Cancer Therapy

Vens, C., & Sobol, R. W. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5847-0_6 · Cited by 2

DNA Repair Polymerases

Sobol, R. W. (2013) · Nucleic acids and molecular biology · doi:10.1007/978-3-642-39796-7_3 · Cited by 3

Evidence that DNA polymerase δ proofreads errors made by DNA polymerase α across the Saccharomyces cerevisiae nuclear genome

Marks, S. A., Zhou, Z.-X., Lujan, S. A., Burkholder, A., & Kunkel, T. A. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103768 · Cited by 2

DNA Replication in Time and Space: The Archaeal Dimension

Serdyuk, A., & Allers, T. (2025) · DNA · doi:10.3390/dna5020024 · Cited by 2

Inhibition of DNA polymerase λ and associated inflammatory activities of extracts from steamed germinated soybeans

Mizushina, Y., Kuriyama, I., & Yoshida, H. (2014) · Food & Function · doi:10.1039/c3fo60650c · Cited by 2

Enhanced Reusability of Immobilized T7 DNA Polymerase in Multi-Cycle Exonuclease Reactions on Gold-Coated SAM Biosensor Platforms

Sarvutienė, J., Plaušinaitis, D., Bučinskas, V., Ramanavičius, S., Ručinskienė, A., Ramanavičius, A., & Prentice, U. (2026) · Biosensors · doi:10.3390/bios16010037 · Cited by 1

Mitochondrial DNA Replication in Health and Disease

Apostolova, N., & Juan, V. (2011) · InTech eBooks · doi:10.5772/19162 · Cited by 1

Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate

Perera, L., Beard, W. A., Pedersen, L. G., Shock, D. D., & Wilson, S. H. (2020) · ACS Omega · doi:10.1021/acsomega.0c01345 · Cited by 1

Base Excision DNA Repair: The House Keeping Guardian for Genomic Stability in the Brain

Swain, U., & Rao, K. S. (2012) · Springer eBooks · doi:10.1007/978-94-007-5237-5_2 · Cited by 1

Template Principle in Biology

Inge-Vechtomov, S. G. (2016) · Springer eBooks · doi:10.1007/978-3-319-48838-7_5 · Cited by 1

Making Mutations is an Active Process: Methods to Examine DNA Polymerase Errors

Eckert, K. A., & Gestl, E. E. (2010) · Wiley eBooks · doi:10.1002/9783527629398.ch4 · Cited by 1

Evolution of the Mutation Rate in Sexual Species

Romero‐Mujalli, D., & Tiedemann, R. (2021) · Wiley eBooks · doi:10.1002/9780470015902.a0029080 · Cited by 1

Construcción QSAR de redes complejas de compuestos de interés en Química Farmacéutica, Microbiología y Parasitología

Pintos, I. G. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Oligonucleotide-modified Nuclotides

Steck, A. (2013) · KOPS (University of Konstanz)

Translesion Synthesis and Mutagenic Pathways inEscherichia coliCells

Chandani, S., & Loechler, E. L. (2010) · Wiley eBooks · doi:10.1002/9783527630110.ch15

The characterisation of polymicrobial bacterial communities in the lower respiratory tract of individuals with chronic pulmonary disease

Purcell, P. (2013) · Northumbria Research Link (Northumbria University)

The influence of aging on oocyte quality and the importance of mitochondria

Trull, K. (2014) · Digital Repository Service (Northeastern University) · doi:10.17760/d20005089

DNA Polymerase Inhibition

Mizushina, Y., Yoshida, H., & Miyazawa, T. (2008) · CRC Press eBooks · doi:10.1201/9781420080391.ch11

The relationships among biological membranes and signaling mediators. II. How do the receptors find and identify their targets

Kurchii, B. A. (2010)

RADIATION RESPONSES OF CHEMORESISTANT ADENOCARCINOMA CELLS: FROM MOLECULAR MECHANISMS TO NEW REVERSAL STRATEGIES

Luzhna, L. (2009) · Open ULeth Scholarship (OPUS) (University of Lethbridge)

DNA structural selectivity of binding by the Pol I DNA polymerases from Escherichia coli and Thermus aquaticus

Wowor, A. J. (2009) · doi:10.31390/gradschool_dissertations.179

Thermodynamics of DNA binding and break repair by the Pol I DNA polymerases from Escherichia coli and Thermus aquaticus

Yang, Y. (2011) · doi:10.31390/gradschool_dissertations.3092

Eukaryotic DNA Replicases

Zaher, M. S., Oke, M., & Hamdan, S. M. (2014) · Springer eBooks · doi:10.1007/978-1-4614-6436-5_55-4

A DNS-hibaelkerülő útvonalak szabályozásának genetikai vizsgálata

Gervai, J. Z. (2018) · Eötvös Loránd Tudományegyetem · doi:10.15476/elte.2017.136

DNA Dependent DNA Polymerases as Targets for Low-Weight Molecular Inhibitors: State of Art and Prospects of Rational Design

Nyporko, A. Y. (2014) · Challenges and advances in computational chemistry and physics · doi:10.1007/978-94-017-9257-8_4

Archetypical and Specialized DNA Replication Proteins in Entamoeba histolytica

Pastor-Palacios, G., López-Ramírez, V., Cardona-Félix, C. S., Azuara-Liceaga, E. I., Lara‐González, S., & Brieba, L. G. (2014) · Springer eBooks · doi:10.1007/978-4-431-55200-0_22

Eukaryotic DNA Replicases

Zaher, M. S., Oke, M., & Hamdan, S. M. (2018) · Springer eBooks · doi:10.1007/978-1-4614-1531-2_55

Kinetic and Structural Analysis of Ribonucleotide Extension by DNA Polymerase ηPreprint

Chang, C., Luo, C. L., Eleraky, S., Lin, A., Zhou, G., & Gao, Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.12.507597

The Molecular Architects of Life: Unraveling the Marvels of DNA Polymerases

Kankanamge, L. S. P. (2023) · Advances in Clinical Toxicology · doi:10.23880/act-16000287

An Insight into the Approach Taken to Appurtenances Disorders Linked to Mitochondria

Hmar, E. B. L., Paul, S., Islam, R., & Sharma, H. K. (2024) · Biology Bulletin · doi:10.1134/s1062359023604962

Three-metal ion mechanism of cross-linked and uncross-linked DNA polymerase β: A theoretical study

Chu, W., Suo, Z., & Wang, J. (2024) · The Journal of Chemical Physics · doi:10.1063/5.0200109

Causes and Consequences of Perturbations of the Mitochondrial Genome

King, D. E., Copeland, W. C., Wallace, K. B., & Meyer, J. N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00128-5

Functional and structural properties of eukaryotic DNA polymerase epsilon

Chilkova, O. (2006) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Influence de la variation de la concentration intracellulaire des désoxyribonucléotides et rubbonucléotides sur la stabilité génomique chez Pyrococcus abyssi

Lemor, M. (2017) · theses.fr (ABES) · doi:10.70675/c008e746z3c84z45e6zb8f1z9f96609cbe22

Characterizing Resistance Mechanisms to Immune Checkpoint Blockades in Mismatch Repair-Deficient Tumors

Nebot-Bral, L. (2021) · theses.fr (ABES) · doi:10.70675/e1797b79z28d4z4e65zbd29zdc771b604d21

The adduct models of aflatoxins with DNA and effects on DNA polymerase Ⅳ

Hu, D., Chen, S., Liu, H., Cheng, Y., Song, Y., Wang, X., Yu, W., Hu, K., Cao, Y., Zhang, M., et al. (2026) · Journal of Molecular Modeling · doi:10.1007/s00894-026-06673-z

Isolation, Characterization, and Anti-Cancer Properties of Microalgal Monogalactosyldiacylglycerol (MGDG)

Harutyunyan, B., Zakoyana, A. A., Aghabekyan, A., Sayadyan, A., Kalita, E., Babayan, N., Shahazizyan, I. V., & Goginyan, V. B. (2026) · IGI Global eBooks · doi:10.4018/979-8-3373-1524-9.ch009

The Role of the POLB Gene Alternative Splicing in the Fetal Growth Retardation Pathogenesis

Gavrilenko, M. M., Trifonova, E. A., Babovskaya, A. A., Izhoikina, E. V., Swarovskaya, M. G., & Степанов, В. А. (2026) · Russian Journal of Genetics · doi:10.1134/s1022795426700250

Elevated mutation in haploid yeast driven by error-prone Rev1 polymerase

Fredette-Roman, J., Smith, D. R., Omari, S. B., & Sharp, N. P. (2026) · Genetics · doi:10.1093/genetics/iyag184

Recombinant Thermostable DNA Polymerases: Current Approaches to Production, Molecular Engineering, and Applications in Biotechnology and Diagnostics

Mussakhmetov, A., & Khassenov, B. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167188

BindingDB Entry 50043939: Formosusin A, a novel specific inhibitor of mammalian DNA polymeraseß from the fungus Paecilomyces formosus.

BindingDB (2014) · UC San Diego · doi:10.7270/q22v2hmw

BindingDB Entry 50039514: Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.

BindingDB (2013) · UC San Diego · doi:10.7270/q2t154ng

Assembly and Mechanism of Action of Sulfolobus solfataricus DNA Replication Complexes

Bauer, R. J. (2014) · D-Scholarship@Pitt (University of Pittsburgh)

An Evolutionary Perspective: DNA Polymerases Have a Very Conserved

Maga, G., Spadari, S., & Abbiategrasso, V. (2014)

The role of human replicative DNA polymerases in DNA repair and replication

Rytkönen, A. K. (2006) · Cited by 11

Functions of Eukaryotic DNA Polymerases

Shcherbakova, P. V., Bębenek, K., & Kunkel, T. A. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.8.re3 · Cited by 69

Eukaryotic DNA Polymerases

Hübscher, U., Maga, G., & Spadari, S. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.150041 · Cited by 691

The critical roles of DNA polymerases in genome stability and related human diseases

You, Z. (2014) · Shengming kexue