Functions of DNA Polymerases

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

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DNA Repair and Mutagenesis

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DNA repair and mutagenesis

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RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

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Quality Control by DNA Repair

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Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

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The Y-Family of DNA Polymerases

Ohmori, H., Friedberg, E. C., Fuchs, R. P., Goodman, M. F., Hanaoka, F., Hinkle, D. C., Kunkel, T. A., Lawrence, C. W., Livneh, Z., Nohmi, T., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00278-7 · Cited by 882

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

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V(D)J Recombination: RAG Proteins, Repair Factors, and Regulation

Gellert, M. F. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.150203 · Cited by 771

DNA Replication Fidelity

Kunkel, T. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400006200 · Cited by 754

DNA MISMATCH REPAIR

Kunkel, T. A., & Erie, D. A. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133243 · Cited by 1,372

5-Hydroxymethylfurfural (HMF) levels in honey and other food products: effects on bees and human health

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DNA mismatch repair in cancer

Baretti, M., & Le, D. T. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.04.004 · Cited by 574

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

McCulloch, S. D., & Kunkel, T. A. (2008) · Cell Research · doi:10.1038/cr.2008.4 · Cited by 569

POLG-related disorders and their neurological manifestations

Rahman, S., & Copeland, W. C. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0101-0 · Cited by 437

What a difference a decade makes: Insights into translesion DNA synthesis

Yang, W., & Woodgate, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704219104 · Cited by 380

Trading Places: How Do DNA Polymerases Switch during Translesion DNA Synthesis?

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A Gradient of Template Dependence Defines Distinct Biological Roles for Family X Polymerases in Nonhomologous End Joining

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Translesion DNA Polymerases

Goodman, M. F., & Woodgate, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a010363 · Cited by 317

Base excision DNA repair

Zharkov, D. O. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7543-2 · Cited by 314

DNA Polymerase γ in Mitochondrial DNA Replication and Repair

Graziewicz, M. A., Longley, M. J., & Copeland, W. C. (2006) · Chemical Reviews · doi:10.1021/cr040463d · Cited by 301

Dividing the workload at a eukaryotic replication fork

Kunkel, T., & Burgers, P. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.08.005 · Cited by 294

DNA Damage and Repair: From Molecular Mechanisms to Health Implications

Fabio Altieri, F., Grillo, C., Maceroni, M., & Chichiarelli, S. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1830 · Cited by 222

Evolving Views of DNA Replication (In)FidelityPreprint

Kunkel, T. A. (2009) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2009.74.027 · Cited by 206

Ubiquitin-Binding Motifs in REV1 Protein Are Required for Its Role in the Tolerance of DNA Damage

Guo, C., Tang, T.-S., Bienko, M., Parker, J. L., Bielen, A. B., Sonoda, E., Takeda, S., Ulrich, H. D., Đikić, I., & Friedberg, E. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01118-06 · Cited by 204

The X family portrait: Structural insights into biological functions of X family polymerases

Moon, A. F., García–Díaz, M., Batra, V. K., Beard, W. A., Bębenek, K., Kunkel, T. A., Wilson, S. H., & Pedersen, L. C. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.05.009 · Cited by 193

Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis

Vaisman, A., Ling, H., Woodgate, R., & Yang, W. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600786 · Cited by 182

Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

DeBalsi, K. L., Hoff, K. E., & Copeland, W. C. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.006 · Cited by 180

DNA polymerase gamma and mitochondrial disease: Understanding the consequence of POLG mutations

Chan, S. S. L., & Copeland, W. C. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.10.007 · Cited by 183

Evidence that Errors Made by DNA Polymerase α are Corrected by DNA Polymerase δ

Pavlov, Y. I., Frahm, C., McElhinny, S. A. N., Niimi, A., Suzuki, M., & Kunkel, T. A. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.002 · Cited by 177

Chemistry and Biology of DNA Containing 1,N2-Deoxyguanosine Adducts of the α,β-Unsaturated Aldehydes Acrolein, Crotonaldehyde, and 4-Hydroxynonenal

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Fidelity of DNA replication—a matter of proofreading

Bębenek, A., & Ziuzia-Graczyk, I. (2018) · Current Genetics · doi:10.1007/s00294-018-0820-1 · Cited by 168

Low-fidelity DNA synthesis by human DNA polymerase theta

Arana, M. E., Seki, M., Wood, R. D., Rogozin, I. B., & Kunkel, T. A. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn310 · Cited by 160

Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion

Rechkoblit, O., Malinina, L. V., Cheng, Y., Kuryavyi, V., Broyde, S. B., Geacintov, N. E., & Patel, D. J. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0040011 · Cited by 146

Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine

Nebot-Bral, L., Brandão, D., Verlingue, L., Rouleau, É., Caron, O., Despras, E., Dakdouki, Y. E., Champiat, S., Aoufouchi, S., Leary, A. F., et al. (2017) · European Journal of Cancer · doi:10.1016/j.ejca.2017.07.026 · Cited by 144

A closed conformation for the Pol λ catalytic cycle

García–Díaz, M., Bębenek, K., Krahn, J. M., Kunkel, T. A., & Pedersen, L. C. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb876 · Cited by 140

Mitochondrial genome maintenance in health and disease

Copeland, W. C., & Longley, M. J. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.03.010 · Cited by 147

Saccharomyces cerevisiae DNA Polymerase δ

Fortune, J. M., Pavlov, Y. I., Welch, C. M., Johansson, E., Burgers, P., & Kunkel, T. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505236200 · Cited by 128

Roles of DNA Polymerases in Replication, Repair, and Recombination in Eukaryotes

Pavlov, Y. I., Shcherbakova, P. V., & Rogozin, I. B. (2006) · International Review of Cytology · doi:10.1016/s0074-7696(06)55002-8 · Cited by 123

A Water-Mediated and Substrate-Assisted Catalytic Mechanism forSulfolobus solfataricusDNA Polymerase IV

Wang, L., Yu, X., Hu, P., Broyde, S. B., & Zhang, Y. (2007) · Journal of the American Chemical Society · doi:10.1021/ja068821c · Cited by 124

The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins

Zhong, X., Garg, P., Stith, C. M. W., McElhinny, S. A. N., Kissling, G. E., Burgers, P., & Kunkel, T. A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl465 · Cited by 124

Neoantigens and genome instability: impact on immunogenomic phenotypes and immunotherapy response

Mardis, E. R. (2019) · Genome Medicine · doi:10.1186/s13073-019-0684-0 · Cited by 124

Replicative DNA polymerase mutations in cancer

Heitzer, E., & Tomlinson, I. P. M. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.12.005 · Cited by 121

Multiple Functions of DNA Polymerases

García–Díaz, M., & Bębenek, K. (2007) · Critical Reviews in Plant Sciences · doi:10.1080/07352680701252817 · Cited by 129

Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations

Stumpf, J. D., & Copeland, W. C. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0530-4 · Cited by 125

Structural Insight into Translesion Synthesis by DNA Pol II

Wang, F., & Yang, W. (2009) · Cell · doi:10.1016/j.cell.2009.11.043 · Cited by 112

DNA Polymerase λ Protects Mouse Fibroblasts against Oxidative DNA Damage and Is Recruited to Sites of DNA Damage/Repair

Braithwaite, E. K., Kedar, P. S., Lan, L., Polosina, Y. Y., Asagoshi, K., Poltoratsky, V. P., Horton, J. K., Miller, H., Teebor, G. W., Yasui, A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500256200 · Cited by 109

DNA Polymerase POLN Participates in Cross-Link Repair and Homologous Recombination

Moldovan, G., Madhavan, M. V., Mirchandani, K. D., McCaffrey, R. M., Vinciguerra, P., & D’Andrea, A. D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01124-09 · Cited by 103

Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo–electron microscopy

Asturias, F. J., Cheung, I. K., Sabouri, N., Chilkova, O., Wepplo, D., & Johansson, E. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1040 · Cited by 102

Structural insight into the substrate specificity of DNA Polymerase μ

Moon, A. F., García–Díaz, M., Bębenek, K., Davis, B. J., Zhong, X., Ramsden, D. A., Kunkel, T. A., & Pedersen, L. C. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1180 · Cited by 99

The difluorotoluene debate—a decade later

Kool, E. T., & Sintim, H. O. (2006) · Chemical Communications · doi:10.1039/b605414e · Cited by 98

DNA polymerase ε and its roles in genome stability

Henninger, E. E., & Pursell, Z. F. (2014) · IUBMB Life · doi:10.1002/iub.1276 · Cited by 97

Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein

MITRA, S., Izumi, T., Boldogh, I., Bhakat, K. K., Chattopadhyay, R., & Szczęsny, B. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.10.010 · Cited by 97

Increased Susceptibility to UV-Induced Skin Carcinogenesis in Polymerase η–deficient Mice

Lin, Q., Clark, A. B., McCulloch, S. D., Yuan, T., Bronson, R. T., Kunkel, T. A., & Kucherlapati, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1862 · Cited by 95

Mutator phenotypes due to DNA replication infidelity

Arana, M. E., & Kunkel, T. A. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.10.003 · Cited by 103

DNA polymerases and human diseases

Sweasy, J. B., Lauper, J. M., & Eckert, K. A. (2006) · Radiation Research · doi:10.1667/rr0706.1 · Cited by 93

Clinical utility of tumor mutational burden in patients with non-small cell lung cancer treated with immunotherapy

Hendriks, L. E. L., Rouleau, É., & Besse, B. (2018) · Translational Lung Cancer Research · doi:10.21037/tlcr.2018.09.22 · Cited by 96

Structural Analysis of Strand Misalignment during DNA Synthesis by a Human DNA Polymerase

García–Díaz, M., Bębenek, K., Krahn, J. M., Pedersen, L. C., & Kunkel, T. A. (2006) · Cell · doi:10.1016/j.cell.2005.10.039 · Cited by 91

The eukaryotic replicative DNA polymerases take shape

Johansson, E., & MacNeill, S. A. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.01.004 · Cited by 90

Inefficient Proofreading and Biased Error Rates during Inaccurate DNA Synthesis by a Mutant Derivative of Saccharomyces cerevisiae DNA Polymerase δ

McElhinny, S. A. N., Stith, C. M. W., Burgers, P., & Kunkel, T. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609591200 · Cited by 90

Structure–function studies of DNA polymerase lambda

García–Díaz, M., Bębenek, K., Gao, G., Pedersen, L. C., London, R. E., & Kunkel, T. A. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.09.001 · Cited by 89

Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance

Young, M. J. (2017) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2017.00074 · Cited by 87

The Mitochondrial DNA Polymerase in Health and Disease

Copeland, W. C. (2009) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-3471-7_11 · Cited by 85

Effect of molecular crowding on DNA polymerase activity

Sasaki, Y., Miyoshi, D., & Sugimoto, N. (2006) · Biotechnology Journal · doi:10.1002/biot.200500032 · Cited by 85

DNA Polymerase ε: A Polymerase of Unusual Size (and Complexity)

Pursell, Z. F., & Kunkel, T. A. (2008) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)00004-4 · Cited by 79

Mismatch Repair–Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase ε

Aksenova, A. Y., Volkov, K. V., Maceluch, J., Pursell, Z. F., Rogozin, I. B., Kunkel, T. A., Pavlov, Y. I., & Johansson, E. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001209 · Cited by 78

Recombination Drives Vertebrate Genome Contraction

Nam, K., & Ellegren, H. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002680 · Cited by 75

RPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase δ

Fortune, J. M., Stith, C. M. W., Kissling, G. E., Burgers, P., & Kunkel, T. A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl403 · Cited by 71

Role of the catalytic metal during polymerization by DNA polymerase lambda

García–Díaz, M., Bębenek, K., Krahn, J. M., Pedersen, L. C., & Kunkel, T. A. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.03.005 · Cited by 69

The role of DNA mismatch repair in immunotherapy of human cancer

He, Y., Zhang, L., Zhou, R., Wang, Y., & Chen, H. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.71714 · Cited by 69

Toward a Deeper Understanding of Enzyme Reactions Using the Coupled ELF/NCI Analysis: Application to DNA Repair Enzymes

Fang, D., Chaudret, R., Piquemal, J., & Cisneros, G. A. (2013) · Journal of Chemical Theory and Computation · doi:10.1021/ct400130b · Cited by 67

Mitochondrial DNA: Inherent Complexities Relevant to Genetic Analyses

Ferreira, T., & Rodrı́guez, S. (2024) · Genes · doi:10.3390/genes15050617 · Cited by 70

Inhibitory effects of myricetin on mammalian DNA polymerase, topoisomerase and human cancer cell proliferation

Shiomi, K., Kuriyama, I., Yoshida, H., & Mizushina, Y. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.01.009 · Cited by 65

Lesion processing: high-fidelity versus lesion-bypass DNA polymerases

Broyde, S. B., Wang, L., Rechkoblit, O., Geacintov, N. E., & Patel, D. J. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.02.004 · Cited by 66

Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.

Krwawicz, J., Arczewska, K. D., Speina, E., Maciejewska, A. M., & Grzesiuk, E. (2007) · Acta Biochimica Polonica · doi:10.18388/abp.2007_3219 · Cited by 66

DNA repair in aging rat neurons

Rao, K. S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.032 · Cited by 65

Catalytic mechanism of human DNA polymerase λ with Mg2+ and Mn2+ from ab initio quantum mechanical/molecular mechanical studies

Cisneros, G. A., Perera, L., García–Díaz, M., Bębenek, K., Kunkel, T. A., & Pedersen, L. G. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.07.007 · Cited by 64

Limited terminal transferase in human DNA polymerase μ defines the required balance between accuracy and efficiency in NHEJ

Andrade, P. B., Martín, M. J., Juárez, R., de Saro, F. J. L., & Blanco, L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908492106 · Cited by 63

Requirements for the Interaction of Mouse Polκ with Ubiquitin and Its Biological Significance

Guo, C., Tang, T.-S., Bienko, M., Đikić, I., & Friedberg, E. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709275200 · Cited by 63

PCNA Loaders and Unloaders—One Ring That Rules Them All

Arbel, M., Choudhary, K., Tfilin, O., & Kupiec, M. (2021) · Genes · doi:10.3390/genes12111812 · Cited by 62

Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse

Perera, L., Freudenthal, B., Beard, W. A., Shock, D. D., Pedersen, L. G., & Wilson, S. H. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511207112 · Cited by 62

Pinophilins A and B, Inhibitors of Mammalian A-, B-, and Y-Family DNA Polymerases and Human Cancer Cell Proliferation

Myobatake, Y., Takeuchi, T., Kuramochi, K., Kuriyama, I., Ishido, T., Hirano, K., Sugawara, F., Yoshida, H., & Mizushina, Y. (2012) · Journal of Natural Products · doi:10.1021/np200523b · Cited by 60

DNA polymerase beta (pol β) inhibitors: A comprehensive overview

Barakat, K., Gajewski, M. M., & Tuszyński, J. A. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.04.008 · Cited by 59

A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases

Dorjsuren, D. G., Wilson, D. M., Beard, W. A., McDonald, J. P., Austin, C. P., Woodgate, R., Wilson, S. H., & Simeonov, A. M. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp641 · Cited by 59

Emerging Roles for Ciz1 in Cell Cycle Regulation and as a Driver of Tumorigenesis

Pauzaite, T., Thacker, U., Tollitt, J., & Copeland, N. A. (2016) · Biomolecules · doi:10.3390/biom7010001 · Cited by 52

Therapeutic targets for altering mitochondrial dysfunction associated with diabetic retinopathy

Kowluru, R. A., & Mishra, M. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1439921 · Cited by 54

DNA polymerases involved in the incorporation of oxidized nucleotides into DNA: Their efficiency and template base preference

Katafuchi, A., & Nohmi, T. (2010) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.06.004 · Cited by 53

Mirror image stereoisomers of the major benzo[a]pyrene N2-dG adduct are bypassed by different lesion-bypass DNA polymerases in E. coli

Seo, K. Y., Nagalingam, A., Miri, S., Yin, J., Chandani, S., Kolbanovskiy, A., Shastry, A., & Loechler, E. L. (2006) · DNA repair · doi:10.1016/j.dnarep.2005.12.009 · Cited by 51

Specific Inhibitors of Mammalian DNA Polymerase Species

Mizushina, Y. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90121 · Cited by 50

DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences

Hile, S. E., & Eckert, K. A. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1089 · Cited by 49

Inhibitory Effects of Glycyrrhetinic Acid on DNA Polymerase and Inflammatory Activities

Ishida, T., Mizushina, Y., Yagi, S., Irino, Y., Nishiumi, S., Miki, I., Kondo, Y., Mizuno, S., Yoshida, H., Azuma, T., et al. (2011) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/650514 · Cited by 48

mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae

Stumpf, J. D., Bailey, C. M., Spell, D., Stillwagon, M., Anderson, K. S., & Copeland, W. C. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq089 · Cited by 47

Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase λ

Takeuchi, T., Ishidoh, T., Iijima, H., Kuriyama, I., Shimazaki, N., Koiwai, O., Kuramochi, K., Kobayashi, S. S., Sugawara, F., Sakaguchi, K., et al. (2006) · Genes to Cells · doi:10.1111/j.1365-2443.2006.00937.x · Cited by 48

Translesion synthesis DNA polymerases and control of genome stability

Polina, V. S. (2006) · Frontiers in bioscience · doi:10.2741/1985 · Cited by 46

Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools

Waisertreiger, I. S.-R., Liston, V. G., Menezes, M. R., Kim, H., Lobachev, K. S., Stepchenkova, E. I., Tahirov, T. H., Rogozin, I. B., & Pavlov, Y. I. (2012) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21735 · Cited by 46

The interface of transcription and DNA replication in the mitochondria

Kasiviswanathan, R., Collins, T., & Copeland, W. C. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.12.005 · Cited by 45

A unique error signature for human DNA polymerase ν

Arana, M. E., Takata, K., García–Díaz, M., Wood, R. D., & Kunkel, T. A. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.09.012 · Cited by 46

Effects of Essential Oils from Herbal Plants and Citrus Fruits on DNA Polymerase Inhibitory, Cancer Cell Growth Inhibitory, Antiallergic, and Antioxidant Activities

Mitoshi, M., Kuriyama, I., Nakayama, H., Miyazato, H., Sugimoto, K., Kobayashi, Y., Jippo, T., Kanazawa, K., Yoshida, H., & Mizushina, Y. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf303377f · Cited by 46

Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability

Hile, S. E., Wang, X., Lee, M., & Eckert, K. A. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr889 · Cited by 47

Mutator alleles of yeast DNA polymerase ζ

Sakamoto, A. N., Stone, J. E., Kissling, G. E., McCulloch, S. D., Pavlov, Y. I., & Kunkel, T. A. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.07.002 · Cited by 44

3-O-methylfunicone, a selective inhibitor of mammalian Y-family DNA polymerases from an Australian sea salt fungal strain

Mizushina, Y., Motoshima, H., Yamaguchi, Y., Takeuchi, T., Hirano, K., Sugawara, F., & Yoshida, H. (2009) · Marine Drugs · doi:10.3390/md7040624 · Cited by 42

Inhibitory effects of α-mangostin on mammalian DNA polymerase, topoisomerase, and human cancer cell proliferation

Mizushina, Y., Kuriyama, I., Nakahara, T., Kawashima, Y., & Yoshida, H. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.027 · Cited by 42

DNA Repair Inhibitors: The Next Major Step to Improve Cancer Therapy

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