Tissue preparation and banking

Webster, Maree J.

doi:10.1016/s0079-6123(06)58001-x

Cited by 67Molecular Biology Techniques and ApplicationsEthics in Clinical ResearchRNA Research and Splicing

Tissue preparation and banking

Webster, Maree J.·2006·Progress in Brain Research

DOI 10.1016/s0079-6123(06)58001-x

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Abstract

With the increasing application of genomic and proteomic technologies to the research of neurological and psychiatric disorders it has become imperative that the postmortem tissue utilized be of the highest quality possible. Every step of the research design, from identifying donors, acquiring sufficient information for accurate diagnosis, to assessing tissue quality has to be carefully considered. In order to obtain high-quality RNA and protein from the postmortem brain tissue a standardized system of brain collection, dissection, and storage must be employed and key ante- and postmortem factors must be considered. Reliable RNA expression and protein data can be obtained from postmortem brains with relatively long postmortem intervals (PMIs) if the agonal factors and acidosis are not severe. While pH values are correlated with RNA integrity number (RIN), a higher pH does not guarantee intact RNA. Consequently RNA integrity must be assessed for every case before it is included in a study. An analysis of anti- and postmortem factors in a large brain collection has revealed that several diagnostic groups have significantly lower pH values than other groups, however, they do not have significantly lower RIN values. Moreover, the lower pH of these groups is not entirely due to agonal factors and/or smoking, indicating that these subjects may have additional metabolic abnormalities that contribute to the lower pH values.

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Very few transcriptomic studies provide information on acute premortem variables or cause of death, which may potentially have a much larger effect on RNA quality and gene expression.
“Additionally, very few transcriptomic studies provide information on acute premortem variables or cause of death, which are particularly important as they may potentially have a much larger effect on RNA quality and gene expression71–76,78–80.”
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Harrison, P. J., Heath, P. R., Eastwood, S. L., Burnet, P. W. J., McDonald, B., & Pearson, R. C. A. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12102-a · Cited by 342 · see citing works
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Kingsbury, A. E., Foster, O. J. F., Nisbet, A. P., Cairns, N. J., Bray, L., Eve, D. J., Lees, A. J., & MARSDEN, C. D. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00219-5 · Cited by 320 · see citing works
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Altar, C. A., Jurata, L. W., Charles, V., Lemire, A., Liu, P., Bukhman, Y., Young, T. A., Bullard, J., Yokoe, H., Webster, M. J., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.031 · Cited by 318 · see citing works
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BARTON, A. J. L., Pearson, R. C. A., Najlerahim, A., & Harrison, P. J. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03532.x · Cited by 269 · see citing works
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Yates, C. M., Butterworth, J., Tennant, M. C., & Gordon, A. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04948.x · Cited by 263 · see citing works
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Li, J. Z., Vawter, M. P., Walsh, D. M., Tomita, H., Evans, S. J., Choudary, P. V., Lopez, J. F., Avelar, A., Shokoohi, V., Chung, T., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh065 · Cited by 261 · see citing works
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Johnson, S. A., Morgan, D. G., & Finch, C. E. (1986) · Journal of Neuroscience Research · doi:10.1002/jnr.490160123 · Cited by 224 · see citing works
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Karry, R., Klein, E., & Ben‐Shachar, D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.012 · Cited by 208 · see citing works
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Eastwood, S. L., McDonald, B., Burnet, P. W. J., Beckwith, J. P., Kerwin, R. W., & Harrison, P. J. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00247-c · Cited by 207 · see citing works
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Preece, P., & Cairns, N. J. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00337-1 · Cited by 206 · see citing works
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Lewis, D. A. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00393-1 · Cited by 197 · see citing works
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Hardy, J. A., Wester, P., Winblad, B., Gezelius, C., Bring, G., & Eriksson, A. (1985) · Journal of Neural Transmission · doi:10.1007/bf01251916 · Cited by 185 · see citing works
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Bauer, M., Gramlich, I., Polzin, S., & Patzelt, D. (2003) · Legal Medicine · doi:10.1016/j.legalmed.2003.08.001 · Cited by 179 · see citing works
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Xavier, G. F., Oliveira-Filho, F. J. B., & Santos, A. M. G. (1999) · Hippocampus · doi:10.1002/(sici)1098-1063(1999)9:6 · Cited by 175 · see citing works
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Webster, M. J., Weickert, C. S., Herman, M. M., & Kleinman, J. E. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00540-0 · Cited by 173 · see citing works
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Halpern, M. E., Güntürkün, O., Hopkins, W. D., & Rogers, L. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3439-05.2005 · Cited by 155 · see citing works
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Johnston, N. L., Cerevnak, J., Shore, A. D., Torrey, E. F., & Yolken, R. H. (1997) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(97)00115-5 · Cited by 141 · see citing works
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Vonsattel, J. P., Aizawa, H., DiFiglia, M., McKee, A. C., MacDonald, M. E., Gusella, J. F., Landwehrmeyer, G. B., Bird, E. D., Richardson, E. P., & Hedley‐Whyte, E. T. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199501000-00006 · Cited by 134 · see citing works
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Bunney, W. E., Bunney, B. G., Vawter, M. P., Tomita, H., Li, J. Z., Evans, S. J., Choudary, P. V., Myers, R., Jones, E. G., Watson, S. J., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.657 · Cited by 132 · see citing works
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Leonard, S. S., Logel, J., Luthman, D., Casanova, M. F., Kirch, D. G., & Freedman, R. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90174-c · Cited by 112 · see citing works
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Inoue, H., Kimura, A., & Tuji, T. (2002) · Forensic Science International · doi:10.1016/s0379-0738(02)00352-3 · Cited by 110 · see citing works
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Kim, S. I., Voshol, H., van Oostrum, J., Hastings, T. G., Cascio, M., & Glucksman, M. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000023618.35579.7c · Cited by 101 · see citing works
High stability of mRNAs postmortem and protocols for their assessment by RT-PCR
Yasojima, K., McGeer, E. G., & McGeer, P. L. (2001) · Brain Research Protocols · doi:10.1016/s1385-299x(01)00119-2 · Cited by 97 · see citing works
Alterations in trkB mRNA in the human prefrontal cortex throughout the lifespan
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Self-citation
Evaluating RNA status for RT-PCR in extracts of postmortem human brain tissue
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Kruijver, F. P. M., Fernández‐Guasti, A., Fodor, M., Kraan, E. M., & Swaab, D. F. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7258 · Cited by 87 · see citing works
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Edgar, P. F., Douglas, J. E., Cooper, G. J. S., et al. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000580 · Cited by 83 · see citing works
A comparative proteome analysis of hippocampal tissue from schizophrenic and Alzheimer's disease individuals
Edgar, P. F., Schönberger, S. J., Dean, B., et al. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000463 · Cited by 79 · see citing works
High-resolution Quantification of Specific mRNA Levels in Human Brain Autopsies and BiopsiesPreprint
Castensson, A., Emilsson, L., Preece, P., & Jazin, A. E. (2000) · Genome Research · doi:10.1101/gr.10.8.1219 · Cited by 78 · see citing works
Terminal coma affects messenger RNA detection in post mortem human temporal cortex
Harrison, P. J., PROCTER, A. W., BARTON, A. J. L., Lowe, S. L., Najlerahim, A., Bertolucci, P. H. F., Bowen, D. M., & Pearson, R. C. A. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90143-l · Cited by 71 · see citing works
Effect of pre- and postmortem variables on specific mRNA levels in human brain
Burke, W. J., O’Malley, K. L., Chung, H. D., Harmon, S., Miller, J. P., & van den Berg, L. H. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90018-s · Cited by 71 · see citing works
Characterisation of messenger RNA extracted post-mortem from the brains of schizophrenic, depressed and control subjects.
Perrett, C. W., Marchbanks, R. M., & Whatley, S. A. (1988) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.3.325 · Cited by 69 · see citing works
The Application of Proteomics to the Human Alcoholic Brain
Lewohl, J. M., Dyk, D. D. V., Craft, G. E., INNES, D. J., Mayfield, R. D., Cobon, G. S., Harris, R. A., & Dodd, P. R. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.002 · Cited by 60 · see citing works
Large-Scale Microarray Studies of Gene Expression in Multiple Regions of the Brain in Schizophrenia and Alzheimer's Disease
Katsel, P., Davis, K. L., & Haroutunian, V. H. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)63003-6 · Cited by 56 · see citing works
Proteomics for the identification of specifically oxidized proteins in brain: Technology and application to the study of neurodegenerative disorders
Butterfield, D. A., & Castegna, A. (2003) · Amino Acids · doi:10.1007/s00726-003-0027-7 · Cited by 52 · see citing works
Electrophoretic, biosensor, and bioactivity analyses of perlecans of different cellular origins
Knox, S. M., Melrose, J., & Whitelock, J. M. (2001) · PROTEOMICS · doi:10.1002/1615-9861(200111)1:12 · Cited by 44 · see citing works
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Kleinman, J. E., Hyde, T. M., Dc, W., & USA (1999) · Taylor & Francis eBooks · doi:10.4324/9780203304273 · Cited by 40 · see citing works
Stability of gene expression in postmortem brain revealed by cDNA gene array analysis
Trotter, S. A., Brill, L. B., & Bennett, J. P. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02644-6 · Cited by 38 · see citing works
Mitochondrial Dysfunction in Bipolar Disorder: from 31P-Magnetic Resonance Spectroscopic Findings to their Molecular Mechanisms
Kato, T. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)63002-4 · Cited by 35 · see citing works
The Postmortem Brain in Psychiatric Research
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Voshol, H., Glucksman, M., & van Oostrum, J. (2003) · Current Molecular Medicine · doi:10.2174/1566524033479645 · Cited by 20 · see citing works
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Jellinger, K. A. (2003) · European Journal of Neurology · doi:10.1046/j.1468-1331.2003.00522_1.x · Cited by 20 · see citing works
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Licinio, J. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001467 · Cited by 20 · see citing works
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Hamacher, M., Klose, J., Rossier, J., et al. (2004) · PROTEOMICS · doi:10.1002/pmic.200400859 · Cited by 20 · see citing works
Extraction and proteomic analysis of proteins from normal and multiple sclerosis postmortem brain
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Knable, M. B., Barci, B. M., Bartko, J. J., Webster, M. J., & Torrey, Ε. F. (2002) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(02)00042-7 · Cited by 14 · see citing works
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Green, R. S., Clark, A. S., Hickey, W. F., Hutsler, J. J., & Gazzaniga, M. S. (1999) · Journal of Neuropsychiatry · doi:10.1176/jnp.11.3.301 · Cited by 11 · see citing works
Frequency of neuropathology in a brain bank from a long-term, domiciliary population
Healy, D. J., Sima, A. A. F., Tapp, A. M., et al. (1996) · Journal of Psychiatric Research · doi:10.1016/0022-3956(95)00039-9 · Cited by 6 · see citing works
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Knable, M. B., Barci, B. M., Webster, M. J., & Torrey, Ε. F. (2002) · Neurobiological foundation of aberrant behaviors · doi:10.1007/978-1-4757-3631-1_8 · Cited by 5 · see citing works
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Kittell, D. A., Hyde, T. M., Herman, M. M., et al. (2019) · CRC Press eBooks · doi:10.4324/9781482283419-3 · Cited by 2 · see citing works
Relevance Of Human Brain Banking In Neuroscience - A National Facility
Shankar, S. K., & Mahadevan, A. S. (1999) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1 · see citing works
Prefrontal cortical projections to the striatum in macaque monkeys: Evidence for an organization related to prefrontal networks
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Authors: Webster, M. J.
Affiliations: Uniformed Services University of the Health Sciences (US)
Corresponding author: Webster, Maree J.
ORCID: Webster, Maree J.
Venue: Progress in Brain Research
Publisher: Elsevier
Published: 2006
Volume: 158
Pages: 3-14
ISSN: 0079-6123 (ISSN-L)
DOI: 10.1016/s0079-6123(06)58001-x
OpenAlex: W1499379327
Cited by: 67
References: 75
Citations by year: 2025: 1 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 2 · 2018: 9 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 2
FWCI: 6.66
Type: book chapter
Language: en
Open access: closed
Locations: Progress in brain research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Molecular Biology Techniques and Applications
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords: postmortem brain, tissue banking, RNA integrity number, postmortem interval, brain pH, acidosis, smoking, neurological disorders, mental illness
MeSH terms: Autopsy, Brain, Histological Techniques, Humans, Postmortem Changes, RNA, Tissue Banks

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