GFAP mRNA increases with age in rat and human brain
Abstract
Glial fibrillary acidic protein (GFAP) mRNA was examined by RNA blot hybridization in three age groups of two cohorts of male F-344 rats and in 47 human postmortem brain samples. GFAP mRNA increased in the hippocampus and striatum of 24 versus 6- to 7-month-old rats. Another astrocytic molecular marker, glutamine synthetase mRNA, did not change with age in rat brain. Rat GFAP mRNA prevalence was inversely correlated with serum testosterone but not correlated with serum corticosterone. In human hippocampus, frontal and temporal cortex, GFAP mRNA also increased in older (60-79 years) compared with middle-aged (25-59 years) individuals. In contrast, mitochondrial cytochrome oxidase subunit 1 mRNA did not change between age groups in any region. By combining the three regions for further analysis, GFAP mRNA increased with age irregardless of gender, alcoholism in the middle-aged group, or whether brains were classified as normal or neuropathologic (excluding Alzheimer's disease pathology). These data indicate that increased GFAP protein or GFAP-immunoreactive astrocytes in rats and humans may result from transcriptional or post-transcriptional regulation and extend the number to three species (including mouse) showing an increase in GFAP mRNA with age. Factors that are known to regulate GFAP mRNA expression in young brains are considered as possible causes of age-related increases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Vimentin and GFAP link astrocyte structure and gliovascular function, and are associated with cytoplasmic proteins participating in signal transduction pathways.
“Vimentin and GFAP link astrocyte structure and gliovascular function [90, 92], and are associated with cytoplasmic proteins [92] participating in signal transduction pathways [44, 45, 106, 107].”
From Gliovascular alterations in sporadic and familial Alzheimer's disease: <scp><i>APOE3</i></scp> Christchurch homozygote glioprotection (2023) · cites this paper as [106]
Typically, activated microglia displays ameboid morphologies and induces astrocytic activation.
“Typically, activated microglia displays ameboid morphologies [112] and induces astrocytic activation [106, 113, 114].”
From Gliovascular alterations in sporadic and familial Alzheimer's disease: <scp><i>APOE3</i></scp> Christchurch homozygote glioprotection (2023) · cites this paper as [106]
Increase of amoeboid‐like microglia occurred in both SAD and FAD.
“although increase of amoeboid‐like microglia occurred in both SAD and FAD—as previously described in AD [106, 114, 115]”
From Gliovascular alterations in sporadic and familial Alzheimer's disease: <scp><i>APOE3</i></scp> Christchurch homozygote glioprotection (2023) · cites this paper as [106]
Astrocytic senescence has been reported in brains of aged animals, indicating a correlation between brain ageing and astrocytic senescence.
“Furthermore, astrocytic senescence has been reported in brains of aged animals [118, 124], indicating that there is a correlation between brain ageing and astrocytic senescence.”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [118]
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,725 · see citing works
Fine structural localization of glutamine synthetase in astrocytes of rat brain
Norenberg, M. D., & Martinez-Hernandez, A. (1979) · Brain Research · doi:10.1016/0006-8993(79)90071-4 · Cited by 1,349 · see citing works
An acidic protein isolated from fibrous astrocytes
Eng, L. F., Vanderhaeghen, J. J., Bignami, A., & Gerstl, B. (1971) · Brain Research · doi:10.1016/0006-8993(71)90668-8 · Cited by 1,230 · see citing works
Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization
Giulian, D., Woodward, J., Young, D., Krebs, J., & Lachman, L. B. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02485.1988 · Cited by 583 · see citing works
Hippocampal Aging and Adrenocorticoids: Quantitative Correlations
Landfield, P. W., Waymire, J. C., & LYNCH, G. S. (1978) · Science · doi:10.1126/science.715460 · Cited by 491 · see citing works
May, P. C., Lampert-Etchells, M., Johnson, S. A., Poirier, J., Masters, J. N., & Finch, C. E. (1990) · Neuron · doi:10.1016/0896-6273(90)90342-d · Cited by 339 · see citing works
Self-citationPatterns of gliosis in alzheimer's disease and aging cerebrum
Beach, T. G., Walker, R., & McGeer, E. G. (1989) · Glia · doi:10.1002/glia.440020605 · Cited by 337 · see citing works
Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies
Iqbal, K. (1991) · Wiley eBooks · Cited by 322 · see citing works
Vaughan, D. W., & Peters, A. (1974) · Journal of Neurocytology · doi:10.1007/bf01098730 · Cited by 301 · see citing works
Changes in brain gene expression shared by scrapie and Alzheimer disease.
Duguid, J. R., Bohmont, C. W., Liu, N. G., & Tourtellotte, W. W. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.7260 · Cited by 251 · see citing works
Transforming growth factor-β1 is in plaques in Alzheimer and Down pathologies
van der Wal, E. A., Gómez‐Pinilla, F., & Cotman, C. W. (1993) · Neuroreport · doi:10.1097/00001756-199301000-00018 · Cited by 230 · see citing works
Extensive postmortem stability of RNA from rat and human brain
Johnson, S. A., Morgan, D. G., & Finch, C. E. (1986) · Journal of Neuroscience Research · doi:10.1002/jnr.490160123 · Cited by 224 · see citing works
Self-citationLandfield, P. W., Rose, G., Sandles, L., Wohlstadter, T. C., & LYNCH, G. S. (1977) · Journal of Gerontology · doi:10.1093/geronj/32.1.3 · Cited by 221 · see citing works
Yong, V. W., Moumdjian, R. A., Yong, F. P., Ruijs, T. C. G., Freedman, M. S., Cashman, N. R., & Antel, J. P. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7016 · Cited by 213 · see citing works
Do glucocorticoid concentrations rise with age in the rat?
Sapolsky, R. M. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90025-s · Cited by 209 · see citing works
Neuronal activity up-regulates astroglial gene expression.
Steward, O., Torre, E. R., Tomasulo, R. A., & Lothman, E. W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.15.6819 · Cited by 202 · see citing works
Hansen, L. A., DeTeresa, R. M., Davies, P., & Terry, R. D. (1988) · Neurology · doi:10.1212/wnl.38.1.48 · Cited by 194 · see citing works
Scheff, S. W., Benardo, L. S., & Cotman, C. W. (1980) · Brain Research · doi:10.1016/0006-8993(80)90227-9 · Cited by 186 · see citing works
Cholinergic sprouting in the hippocampus: A proposed role for IL-1
Fagan, A. M., & Gage, F. H. (1990) · Experimental Neurology · doi:10.1016/0014-4886(90)90055-w · Cited by 184 · see citing works
Age-related changes in glial fibrillary acidic protein mRNA in the mouse brain
Goss, J. R., Finch, C. E., & Morgan, D. G. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90056-p · Cited by 170 · see citing works
Self-citationMorgan, T. E., Nichols, N. R., Pasinetti, G. M., & Finch, C. E. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1063 · Cited by 168 · see citing works
Self-citationAn immunohistochemical quantification of fibrous astrocytes in the aging human cerebral cortex
Hansen, L. A., Armstrong, D. M., & Terry, R. D. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90051-0 · Cited by 156 · see citing works
The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain
O'Callaghan, J. P., & Miller, D. B. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90057-q · Cited by 152 · see citing works
Sirevaag, A. M., & Greenough, W. T. (1991) · Brain Research · doi:10.1016/0006-8993(91)90517-y · Cited by 149 · see citing works
Steward, O., Torre, E. R., Phillips, L., & Trimmer, P. A. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-07-02373.1990 · Cited by 143 · see citing works
Nichols, N. R., Osterburg, H. H., Masters, J. N., Millar, S. L., & Finch, C. E. (1990) · Molecular Brain Research · doi:10.1016/0169-328x(90)90066-m · Cited by 135 · see citing works
Self-citationO'Callaghan, J. P., Brinton, R. E., & McEwen, B. S. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08230.x · Cited by 131 · see citing works
Landry, C. F., Ivy, G. O., & Brown, I. R. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490250207 · Cited by 125 · see citing works
Hippocampal aging in rats: A morphometric study of multiple variables in semithin sections
Landfield, P. W., Braun, L. D., Pitler, T. A., Lindsey, J. D., & LYNCH, G. S. (1981) · Neurobiology of Aging · doi:10.1016/0197-4580(81)90034-8 · Cited by 124 · see citing works
Day, J. R., Laping, N. J., McNeill, T. H., Schreiber, S. S., Pasinetti, G. M., & Finch, C. E. (1990) · Molecular Endocrinology · doi:10.1210/mend-4-12-1995 · Cited by 113 · see citing works
Self-citationDay, J., Laping, N., Lampert-Etchells, M., Brown, S. A., O'Callaghan, J., Mcneill, T., & Finch, C. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90512-e · Cited by 112 · see citing works
Self-citationAstrocytes regulate GFAP mRNA levels by cyclic AMP and protein kinase C‐dependent mechanisms
Shafit‐Zagardo, B., Kume-Iwaki, A., & Goldman, J. E. (1988) · Glia · doi:10.1002/glia.440010507 · Cited by 112 · see citing works
Salm, A. K., Smithson, K. G., & Hatton, G. I. (1985) · Cell and Tissue Research · doi:10.1007/bf00225557 · Cited by 112 · see citing works
Image analysis of GFA-positive astrocytes from adolescence to senescence
Bj�rklund, H., Eriksdotter-Nilsson, M., Dahl, D. R., Rose, G., Hoffer, B. J., & Olson, L. (1985) · Experimental Brain Research · doi:10.1007/bf00238964 · Cited by 109 · see citing works
Transforming growth factor-beta 1 (TGF-β1) expression and regulation in rat cortical astrocytes
da Cunha, A., & Vitković, L. (1992) · Journal of Neuroimmunology · doi:10.1016/0165-5728(92)90047-o · Cited by 106 · see citing works
Rapid and reversible astrocytic reaction to afferent activity blockade in chick cochlear nucleus
Canady, K. S., & Rubel, E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-01001.1992 · Cited by 103 · see citing works
Role of the Gonads in the Histologic Aging of the Hypothalamic Arcuate Nucleus1
Schipper, H. M., Brawer, J. R., Nelson, F., Felicio, L. S., & Finch, C. E. (1981) · Biology of Reproduction · doi:10.1095/biolreprod25.2.413 · Cited by 97 · see citing works
Self-citationHypertrophy of astroglial processes in the dentate gyrus of the senescent rat
Geinisman, Y., Bondareff, W., & Dodge, J. T. (1978) · American Journal of Anatomy · doi:10.1002/aja.1001530405 · Cited by 96 · see citing works
Pasinetti, G. M., Nichols, N. R., Tocco, G., et al. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90583-2 · Cited by 94 · see citing works
Self-citationTrangue, P. A., Suarez, I., Olmos, G., Fernández, B., & García‐Segura, L. M. (1987) · Brain Research · doi:10.1016/0006-8993(87)90805-5 · Cited by 90 · see citing works
Selmaj, K. W., Shafit‐Zagardo, B., Aquino, D. A., et al. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08225.x · Cited by 89 · see citing works
PLASMA TESTOSTERONE LEVELS IN C57BL/6J MALE MICE: EFFECTS OF AGE AND DISEASE
Nelson, J. F., Latham, K. R., & Finch, C. E. (1975) · European Journal of Endocrinology · doi:10.1530/acta.0.0800744 · Cited by 82 · see citing works
Self-citationRNA and Protein Metabolism in the Aging Brain
Finch, C. E., & Morgan, D. G. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.000451 · Cited by 82 · see citing works
Self-citationDiamond, M. C., Johnson, R. E., & Gold, M. W. (1977) · Behavioral Biology · doi:10.1016/s0091-6773(77)90965-8 · Cited by 73 · see citing works
Sakai, Y., Rawson, C., Lindburg, K., et al. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8378 · Cited by 72 · see citing works
Cloning of a Gene Whose Expression Is Increased in Scrapie and in Senile Plaques in Human Brain
Wietgrefe, S. W., Zupancic, M., Haase, A. T., Chesebro, B. W., Race, R., Frey, W. H., Rustan, T. D., & Friedman, R. L. (1985) · Science · doi:10.1126/science.3840915 · Cited by 67 · see citing works
JOHNSON, S., ROGERS, J., & Finch, C. E. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90017-1 · Cited by 65 · see citing works
Self-citationChambers, K. C., Thornton, J. E., & Roselli, C. E. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90050-t · Cited by 64 · see citing works
Measurement of GFAP in Hepatic Encephalopathy by ELISA and Transblots
Kretzschmar, H. A., DeArmond, S. J., & Forno, L. S. (1985) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198509000-00002 · Cited by 60 · see citing works
Selective alterations of RNA in rat hippocampus after entorhinal cortex lesioning.
Poirier, J., May, P. C., Osterburg, H. H., Geddes, J. W., Cotman, C. W., & Finch, C. E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.303 · Cited by 56 · see citing works
Self-citationCanady, K. S., Ali‐Osman, F., & Rubel, E. W. (1990) · Glia · doi:10.1002/glia.440030508 · Cited by 55 · see citing works
Laping, N. J., Nichols, N. R., Day, J. R., & Finch, C. E. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90087-e · Cited by 54 · see citing works
Self-citationBrain Poly(A)RNA During Aging: Stability of Yield and Sequence Complexity in Two Rat Strains
Colman, P. D., Kaplan, B. B., Osterburg, H. H., & Finch, C. E. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb06602.x · Cited by 53 · see citing works
Self-citationRiol, H., Fages, C., & Tardy, M. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490320110 · Cited by 50 · see citing works
Astrocytic messenger RNA responses to striatal deafferentation in male rat
Pasinetti, G. M., Cheng, H. W., Morgan, D., Lampert-Etchells, M., McNeill, T. H., & Finch, C. E. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90298-t · Cited by 37 · see citing works
Self-citationCerebral aging: a quantitative study of gliosis in old nude mice
Mandybur, T. I., Ormsby, I., & Zemlan, F. P. (1989) · Acta Neuropathologica · doi:10.1007/bf00687252 · Cited by 36 · see citing works
Johnson, S. A., Rogers, J., & Finch, C. E. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90061-4 · Cited by 36 · see citing works
Self-citationNichols, N. R., Lerner, S. P., Masters, J. N., et al. (1988) · Molecular Endocrinology · doi:10.1210/mend-2-3-284 · Cited by 33 · see citing works
Self-citationLukiw, W. J., Wong, L. J., & McLachlan, D. R. C. (1990) · International Journal of Neuroscience · doi:10.3109/00207459008985953 · Cited by 32 · see citing works
Alterations in Gene Expression with Aging
Danner, D. B., & Holbrook, N. J. (1990) · Elsevier eBooks · doi:10.1016/b978-0-12-627870-5.50012-5 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Normal aging induces A1-like astrocyte reactivity
Clarke, L. E., Liddelow, S. A., Chakraborty, C., Münch, A. E., Heiman, M., & Barres, B. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800165115 · Cited by 1,237 · see citing works
Middeldorp, J., & Hol, E. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.005 · Cited by 1,080 · see citing works
Gene-expression profile of the ageing brain in mice
Lee, C.-K., Weindruch, R., & Prolla, T. A. (2000) · Nature Genetics · doi:10.1038/77046 · Cited by 1,055 · see citing works
Review: microglia of the aged brain: primed to be activated and resistant to regulation
Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792 · see citing works
Astrocytic complexity distinguishes the human brain
Oberheim, N. A., Wang, X., Goldman, S., & Nedergaard, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.08.004 · Cited by 739 · see citing works
Chatterjee, P., Pedrini, S., Stoops, E., Goozee, K., Villemagne, V. L., Asih, P. R., Verberk, I. M. W., Dave, P., Taddei, K., Sohrabi, H. R., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01137-1 · Cited by 439 · see citing works
NF-κB inhibition delays DNA damage–induced senescence and aging in mice
Tilstra, J. S., Robinson, A. R., Wang, J., Gregg, S. Q., Clauson, C. L., Reay, D. P., Nasto, L. A., St Croix, C. M., Usas, A., Vo, N., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci45785 · Cited by 462 · see citing works
Norden, D. M., Muccigrosso, M. M., & Godbout, J. P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.028 · Cited by 413 · see citing works
Blasko, I., Stampfer‐Kountchev, M., Robatscher, P., Veerhuis, R., Eikelenboom, P., & Grubeck‐Loebenstein, B. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00101.x · Cited by 374 · see citing works
Salminen, A., Ojala, J., Kaarniranta, K., Haapasalo, A., Hiltunen, M., & Soininen, H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07738.x · Cited by 333 · see citing works
Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models
Patel, N. V., Gordon, M. N., Connor, K. E., Good, R. A., Engelman, R. W., Mason, J., Morgan, D. G., Morgan, T. E., & Finch, C. E. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.014 · Cited by 329 · see citing works
Self-citationAge and gender effects on microglia and astrocyte numbers in brains of mice
Mouton, P. R., Long, J. M., Lei, D.-L., Howard, V., Jucker, M., Calhoun, M. E., & Ingram, D. K. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03475-3 · Cited by 320 · see citing works
Neuroinflammation in frontotemporal dementia
Bright, F., Werry, E. L., Dobson-Stone, C., Piguet, O., Ittner, L. M., Halliday, G. M., Hodges, J. R., Kiernan, M. C., Loy, C. T., Kassiou, M., et al. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0231-z · Cited by 280 · see citing works
Cellular senescence and the aging brain
Chinta, S. J., Woods, G., Rane, A., Demaria, M., Campisi, J., & Andersen, J. K. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.09.018 · Cited by 282 · see citing works
Garwood, C. J., Ratcliffe, L. E., Simpson, J. E., Heath, P. R., Ince, P. G., & Wharton, S. B. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12338 · Cited by 233 · see citing works
The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction
Morgan, T. E., Xie, Z., Goldsmith, S., Yoshida, T., Lanzrein, A.-S., Stone, D., Rozovsky, I., Perry, G., Smith, M. A., & Finch, C. E. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00334-0 · Cited by 195 · see citing works
Self-citationAstrocyte Senescence and Alzheimer’s Disease: A Review
Han, X., Zhang, T., Liu, H., Mi, Y., & Gou, X. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00148 · Cited by 177 · see citing works
Stereological analysis of astrocyte and microglia in aging mouse hippocampus
Long, J. M., Kalehua, A. N., Muth, N. J., Calhoun, M. E., Jucker, M., Hengemihle, J. M., Ingram, D. K., & Mouton, P. R. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00088-8 · Cited by 163 · see citing works
Denis, I., Potier, B., Vancassel, S., Heberden, C., & Lavialle, M. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.007 · Cited by 150 · see citing works
Park, S., Kim, K., Page, G. P., Allison, D. B., Weindruch, R., & Prolla, T. A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00496.x · Cited by 134 · see citing works
Morgan, T. E., Rozovsky, I., Goldsmith, S. K., Stone, D. J., Yoshida, T., & Finch, C. E. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00120-2 · Cited by 126 · see citing works
Self-citationFrom cellular senescence to Alzheimer’s disease: The role of telomere shortening
Boccardi, V., Pelini, L., Ercolani, S., Ruggiero, C., & Mecocci, P. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.04.003 · Cited by 121 · see citing works
Age-related myelin dynamics revealed by increased oligodendrogenesis and short internodes
Lasiene, J., Matsui, A., Sawa, Y., Wong, F., & Horner, P. J. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00462.x · Cited by 111 · see citing works
Loss of Nfkb1 leads to early onset aging
Bernal, G. M., Wahlstrom, J. S., Crawley, C. D., Cahill, K. E., Pytel, P., Liang, H., Kang, S., Weichselbaum, R. R., & Yamini, B. (2014) · Aging · doi:10.18632/aging.100702 · Cited by 97 · see citing works
Astrocyte-derived extracellular vesicles: A double-edged sword in central nervous system disorders
Zhao, S., Sheng, S., Wang, Y., Ding, L., Xu, X., Xia, X., & Zheng, J. C. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.027 · Cited by 90 · see citing works
Low-dose ladostigil for mild cognitive impairment: A phase 2 placebo-controlled clinical trial
Schneider, L. S., Geffen, Y., Rabinowitz, J., Thomas, R. G., Schmidt, R., Ropele, S., Weinstock, M., & on behalf of the Ladostigil Study Group (2019) · Neurology · doi:10.1212/wnl.0000000000008239 · Cited by 75 · see citing works
Tissue preparation and banking
Webster, M. J. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)58001-x · Cited by 67 · see citing works
Primiani, C. T., Ryan, V. H., Rao, J. S., Cam, M. C., Ahn, K., Modi, H. R., & Rapoport, S. I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110972 · Cited by 56 · see citing works
Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
Bok, E., Jo, M., Lee, S., Lee, B.-R., Kim, J., & Kim, H.-J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030464 · Cited by 53 · see citing works
Major, D. E., Kesslak, J. P., Cotman, C. W., Finch, C. E., & Day, J. R. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00102-4 · Cited by 52 · see citing works
Self-citationInnate immunity and cellular senescence: The good and the bad in the developmental and aged brain
Santoro, A., Spinelli, C. C., Martucciello, S., Nori, S. L., Capunzo, M., Puca, A. A., & Ciaglia, E. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0118-003r · Cited by 50 · see citing works
DNA repair deficiency and senescence in concussed professional athletes involved in contact sports
Schwab, N., Grenier, K., & Hazrati, L.-N. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0822-3 · Cited by 47 · see citing works
Food restriction delays the age-related increase in GFAP mRNA in rat hypothalamus
Nichols, N. R., Finch, C. E., & Nelson, J. F. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)80013-h · Cited by 46 · see citing works
Self-citationBrown, S. J., Christofides, K., Weissleder, C., Huang, X.-F., Shannon Weickert, C., Lim, C. K., & Newell, K. A. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-023-01736-8 · Cited by 44 · see citing works
Van houcke, J., Mariën, V., Zandecki, C., Ayana, R., Pepermans, E., Boonen, K., Seuntjens, E., Baggerman, G., & Arckens, L. (2023) · npj Regenerative Medicine · doi:10.1038/s41536-023-00304-4 · Cited by 29 · see citing works
Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex
Oda, S., Tsuneoka, Y., Yoshida, S., Adachi‐Akahane, S., Ito, M., Kuroda, M., & Funato, H. (2018) · Journal of Comparative Neurology · doi:10.1002/cne.24409 · Cited by 27 · see citing works
Henao‐Restrepo, J., López‐Murillo, C., Valderrama‐Carmona, P., Orozco‐Santa, N., Gomez, J., Gutiérrez‐Vargas, J., Moraga, R., Toledo, J., Littau, J. L., Härtel, S., et al. (2023) · Brain Pathology · doi:10.1111/bpa.13119 · Cited by 11 · see citing works
- Authors
- Nichols, N. R., Day, J. R., Laping, N. J., Johnson, S. A., & Finch, C. E.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Nichols, Nancy R.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1993-09
- Volume
- 14
- Issue
- 5
- Pages
- 421-429
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2027953381
- Cited by
- 413
- References
- 62
- Citations by year
- 2026: 4 · 2025: 19 · 2024: 21 · 2023: 27 · 2022: 22 · 2021: 19 · 2020: 21 · 2019: 16 · 2018: 19 · 2017: 16 · 2016: 7 · 2015: 10 · 2014: 10 · 2013: 9 · 2012: 11
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r35ag007909-03, 5p30hd019445-05, 5r01ag010673-03)
- National Institute on Aging (AG07909, AG 10673)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD 5 P30 HD19445)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- glial fibrillary acidic protein, GFAP mRNA, brain aging, astrocytes, hippocampus, striatum, glutamine synthetase, cytochrome c oxidase subunit I, testosterone, corticosterone, postmortem brain, F-344 rats, alcoholism, transcriptional regulation, post-transcriptional regulation
- MeSH terms
- Adult, Aged, Aging, Animals, Brain Chemistry, Female, Glial Fibrillary Acidic Protein, Humans, Male, Middle Aged, RNA, Messenger, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review