Cited by 185Autopsy Techniques and OutcomesBiomedical and Chemical ResearchCerebrospinal fluid and hydrocephalus

The patients dying after long terminal phase have acidotic brains; implications for biochemical measurements on autopsy tissue

Hardy, J. A., Wester, P., Winblad, B., Gezelius, C., Bring, G., Eriksson, A.·1985·Journal of Neural Transmission

Abstract

Measurement of the frontal cortex and the medulla oblongata pH at autopsy revealed that those brains from individuals who died after long terminal phase had lower pHs than those who died quickly. These low pHs (pH 6.0-6.5) corresponded to lactic acid concentrations (20-25 mM) which are known to be neurotoxic. The cerebrospinal fluid pH and blood pH correlated with the cortical pH. The significance of these observations to the study of the biochemistry and histology on post-mortem human brain tissue and their possible clinical relevance are discussed.

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Crossref · 10.1007/bf01251916

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14 of 14 references verified0 citation errors · 0 not checkable

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  • Very few transcriptomic studies provide information on acute premortem variables or cause of death, which may potentially have a much larger effect on RNA quality and gene expression.

    “Additionally, very few transcriptomic studies provide information on acute premortem variables or cause of death, which are particularly important as they may potentially have a much larger effect on RNA quality and gene expression71–76,78–80.”

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Authors
Hardy, J. A., Wester, P., Winblad, B., Gezelius, C., Bring, G., & Eriksson, A.
Affiliations
Umeå University (SE)
Venue
Journal of Neural Transmission
Published
1985-09
Volume
61
Issue
3-4
Pages
253-264
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
OpenAlex
W1964433896
Cited by
185
References
14
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 10 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 2
FWCI
3.11
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Autopsy Techniques and Outcomes
  • Health Sciences › Medicine › Surgery › Biomedical and Chemical Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
Keywords
terminal phase, brain acidosis, lactic acid, frontal cortex, medulla oblongata, cerebrospinal fluid pH, blood pH, neurotoxicity, autopsy brain tissue
MeSH terms
Acidosis, Aged, Brain Chemistry, Death, Female, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Time Factors

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