The patients dying after long terminal phase have acidotic brains; implications for biochemical measurements on autopsy tissue
Abstract
Measurement of the frontal cortex and the medulla oblongata pH at autopsy revealed that those brains from individuals who died after long terminal phase had lower pHs than those who died quickly. These low pHs (pH 6.0-6.5) corresponded to lactic acid concentrations (20-25 mM) which are known to be neurotoxic. The cerebrospinal fluid pH and blood pH correlated with the cortical pH. The significance of these observations to the study of the biochemistry and histology on post-mortem human brain tissue and their possible clinical relevance are discussed.
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Very few transcriptomic studies provide information on acute premortem variables or cause of death, which may potentially have a much larger effect on RNA quality and gene expression.
“Additionally, very few transcriptomic studies provide information on acute premortem variables or cause of death, which are particularly important as they may potentially have a much larger effect on RNA quality and gene expression71–76,78–80.”
From Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain (2022) · cites this paper as [71]
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- Authors
- Hardy, J. A., Wester, P., Winblad, B., Gezelius, C., Bring, G., & Eriksson, A.
- Affiliations
- Umeå University (SE)
- Venue
- Journal of Neural Transmission
- Published
- 1985-09
- Volume
- 61
- Issue
- 3-4
- Pages
- 253-264
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W1964433896
- Cited by
- 185
- References
- 14
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 10 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Autopsy Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Biomedical and Chemical Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- terminal phase, brain acidosis, lactic acid, frontal cortex, medulla oblongata, cerebrospinal fluid pH, blood pH, neurotoxicity, autopsy brain tissue
- MeSH terms
- Acidosis, Aged, Brain Chemistry, Death, Female, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Time Factors
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